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PCLO Gene

protein-coding   GIFtS: 56
GCID: GC07M082383

Piccolo Presynaptic Cytomatrix Protein

(Previous name: piccolo (presynaptic cytomatrix protein))
  See PCLO-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Piccolo Presynaptic Cytomatrix Protein1 2     Protein Piccolo2
Piccolo (Presynaptic Cytomatrix Protein)1 2     Aczonin3
aczonin1 2     KIAA05593
ACZ2 3     

External Ids:    HGNC: 134061   Entrez Gene: 274452   Ensembl: ENSG000001864727   OMIM: 6049185   UniProtKB: Q9Y6V03   

Export aliases for PCLO gene to outside databases

Previous GC identifers: GC07M080985 GC07M082048 GC07M082061 GC07M081999 GC07M082094 GC07M082266 GC07M076984


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PCLO Gene:
The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing
active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with
bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for PCLO Gene:
PCLO (piccolo presynaptic cytomatrix protein) is a protein-coding gene. Diseases associated with PCLO include major depressive disorder, and bipolar disorder. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding. An important paralog of this gene is BSN.

UniProtKB/Swiss-Prot: PCLO_HUMAN, Q9Y6V0
Function: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic
vesicle trafficking (By similarity)

Gene Wiki entry for PCLO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PCLO gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   C/EBPalpha   AREB6   CHOP-10   E2F-1   E2F   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PCLO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCLO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23-q21.3   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q11.23-q21.3

PCLO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCLO gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M082383:  view genomic region     (about GC identifiers)

Start:
82,383,321 bp from pter      End:
82,792,246 bp from pter
Size:
408,926 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 81,715,437-82,124,409     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PCLO_HUMAN, Q9Y6V0 (See protein sequence)
Recommended Name: Protein piccolo  
Size: 5065 amino acids; 553277 Da
Subunit: Interacts with RABAC1/PRA1, RIMS2 and profilin (By similarity)
Sequence caution: Sequence=AAB97937.1; Type=Erroneous gene model prediction; Sequence=AAD21789.2; Type=Erroneous
gene model prediction;
1 PDB 3D structure from and Proteopedia for PCLO:
1UJD (3D)    
Secondary accessions: A4D1A7 A6NNX9 O43373 O60305 Q08E72 Q9BVC8 Q9UIV2 Q9Y6U9
Alternative splicing: 6 isoforms:  Q9Y6V0-1   Q9Y6V0-2   Q9Y6V0-3   Q9Y6V0-4   Q9Y6V0-5   Q9Y6V0-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PCLO: NX_Q9Y6V0

Explore proteomics data for PCLO at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PCLO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055325.2  NP_149015.2  

    ENSEMBL proteins: 
     ENSP00000334319   ENSP00000388393   ENSP00000404191   ENSP00000397928   ENSP00000393760  

    PCLO Human Recombinant Protein Products:

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    Novus Biologicals PCLO Protein
    Novus Biologicals PCLO Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PCLO

     
    Search eBioscience for Proteins for PCLO 

    PCLO Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PCLO
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    Novus Biologicals PCLO Antibodies
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    LSBio Antibodies in human, mouse, rat for PCLO

    PCLO Assay Products:

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    Cloud-Clone Corp. ELISAs for PCLO
    Cloud-Clone Corp. CLIAs for PCLO
    Search eBioscience for ELISAs for PCLO 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001565 Synaptotagmin
     IPR008899 Znf_piccolo
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6V0

    ProtoNet protein and cluster: Q9Y6V0

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: PCLO_HUMAN, Q9Y6V0
    Domain: C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with
    high specificity and induces a large conformational change
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 PDZ (DHR) domain


    Find genes that share domains with PCLO           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCLO_HUMAN, Q9Y6V0
    Function: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic
    vesicle trafficking (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding ----
    GO:0005522profilin binding ISS--
    GO:0005544calcium-dependent phospholipid binding ISS--
         
    Find genes that share ontologies with PCLO           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Pclo):
     growth/size/body  mortality/aging  nervous system  normal 

    Find genes that share phenotypes with PCLO           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PCLO: Pclotm1Sud Pclotm3.2Sud Pclotm3.3Sud

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCLO
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCLO
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PCLO (see all 72):
    hsa-miR-548j hsa-miR-138-2* hsa-miR-409-5p hsa-miR-548a-5p hsa-miR-376c hsa-miR-3612 hsa-miR-761 hsa-miR-559
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PCLO

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCLO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCLO

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCLO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PCLO_HUMAN, Q9Y6V0: Cell junction, synapse (By similarity). Note=Concentrated at the presynaptic side of
    synaptic junctions (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton NAS10508862
    GO:0008021synaptic vesicle IEA--
    GO:0016020membrane IEA--
    GO:0030054cell junction IEA--
    GO:0045202synapse ISS--

    Find genes that share ontologies with PCLO           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PCLO About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Insulin secretion0.36


    Find genes that share SuperPaths with PCLO           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for PCLO):
        Insulin secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCLO
    Interactions:

        GeneGlobe Interaction Network for PCLO

    Selected Interacting proteins for PCLO (Q9Y6V02, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERC2O150833I2D: score=2 
    GIT1Q9Y2X73I2D: score=2 
    BSNQ9UPA53I2D: score=1 
    GIT2Q141613I2D: score=1 
    GRIA1P422613I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization ISS--
    GO:0008152metabolic process ----
    GO:0016079synaptic vesicle exocytosis NAS10508862
    GO:0017157regulation of exocytosis IEA--
    GO:0019933cAMP-mediated signaling IEA--

    Find genes that share ontologies with PCLO           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCLO

    1 HMDB Compound for PCLO    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PCLO gene (2 alternative transcripts): 
    NM_014510.2  NM_033026.5  

    Unigene Cluster for PCLO:

    Piccolo presynaptic cytomatrix protein
    Hs.12376  [show with all ESTs]
    Unigene Representative Sequence: NM_033026
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333891(uc003uhx.2 uc010lec.3) ENST00000432078 ENST00000423517(uc003uht.1 uc003uhu.1 uc003uhv.2)
    ENST00000426442 ENST00000413807 ENST00000456006 ENST00000437081 ENST00000461143

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PCLO using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCLO (see all 72):
    hsa-miR-548j hsa-miR-138-2* hsa-miR-409-5p hsa-miR-548a-5p hsa-miR-376c hsa-miR-3612 hsa-miR-761 hsa-miR-559
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PCLO (NM_033026)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCLO
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCLO
      QuantiTect SYBR Green Assays in human, mouse, rat PCLO
      QuantiFast Probe-based Assays in human, mouse, rat PCLO

    Additional mRNA sequence: 

    AB011131.1 AK125999.1 AK297315.1 BC001304.1 BC108289.1 BC122565.1 BC125271.1 BX649041.1 
    CR749552.1 Y19188.1 

    17 DOTS entries:

    DT.213534  DT.91739661  DT.97838761  DT.100654980  DT.121128607  DT.100720980  DT.91673395  DT.40193031 
    DT.121100480  DT.440143  DT.91735847  DT.121048130  DT.121120115  DT.40249215  DT.92057798  DT.97815382 
    DT.97771837 

    Selected AceView cDNA sequences (see all 74):

    AA973826 BM728943 NM_033026 T05362 BQ216059 CR612833 AK125999 BU177122 
    F10580 AL157667 BG913494 AB011131 NM_014510 AA319026 CD675028 BQ216869 
    BM449664 AI700582 BX279785 CA412985 BE893465 BX451506 AI018383 BE890980 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PCLO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTCTTTA
    PCLO Expression
    About this image

    PCLO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCLO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12376
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCLO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PCLO gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pclo1 , 5 piccolo (presynaptic cytomatrix protein)1, 5 84.46(n)1
    84.73(a)1
      5 (6.27 cM)5
    268751  NM_011995.41  NP_036125.41 
     145149185 
    chicken
    (Gallus gallus)
    Aves PCLO1 piccolo (presynaptic cytomatrix protein) 71.34(n)
    68.83(a)
      395319  XM_001231454.3  XP_001231455.2 
    lizard
    (Anolis carolinensis)
    Reptilia PCLO6
    piccolo presynaptic cytomatrix protein
    64(a)
    1 ↔ 1
    5(87045941-87377215)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pclo1 piccolo presynaptic cytomatrix protein 66.36(n)
    63.91(a)
      100494439  XM_002935257.2  XP_002935303.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-108d22.41 si:dkey-108d22.4 60.73(n)
    58.84(a)
      100148002  XM_005164671.1  XP_005164728.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F45E4.36
    Protein F45E4.3, isoform a
    26(a)
    1 → many
    IV(7619630-7628234) WBGene00018468


    ENSEMBL Gene Tree for PCLO (if available)
    TreeFam Gene Tree for PCLO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PCLO gene
    BSN2  
    11 SIMAP similar genes for PCLO using alignment to 6 protein entries:     PCLO_HUMAN (see all proteins):
    DKFZp779G1236    LOC392742    DLG4    DOC2A    CHR11SYT    PRKCG
    RIMS1    SYTL2    RASA4    SYT1    SYT11

    Find genes that share paralogs with PCLO           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PCLO (see all 8349)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563038011,2
    C--77034418(+) CTATA-/CATTTTA 1 -- int11Minor allele frequency- CA:0.00NA 2
    rs359727111,2
    C--77077239(+) TGTTT-/ATGTCTA 2 -- int12Minor allele frequency- AT:0.25NA 4
    rs780278131,2
    C--82382850(+) CTTTTC/TTTTTT 1 -- ds50010--------
    rs58853071,2
    C--82382851(+) TTTTC-/TTTTTTT 1 -- ds50010--------
    rs1901405661,2
    --82382855(+) CTTTTC/TTTTTT 1 -- ds50010--------
    rs1424205311,2
    --82382872(+) AAAGGC/TGATTC 1 -- ds50010--------
    rs1820523681,2
    --82382956(+) GACAAA/CTACAC 1 -- ds50010--------
    rs1875817891,2
    --82382997(+) TCAAGA/CAATTA 1 -- ds50010--------
    rs1165122711,2
    F--82383015(+) TAAATC/TAGGAT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1155230731,2
    C,F--82383154(+) ATTTAT/CGAAGC 1 -- ds50011Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for PCLO (82383321 - 82633321 bp, first 250kb of PCLO)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PCLO (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675648CNV Deletion23128226
    esv2641869CNV Deletion19546169
    esv2677988CNV Deletion23128226
    esv1000997CNV Deletion20482838
    esv273156CNV Insertion20981092
    esv1579695CNV Insertion17803354
    esv268993CNV Insertion20981092
    esv269417CNV Insertion20981092
    esv269327CNV Insertion20981092
    nsv888595CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PCLO
    DNA2.0 Custom Variant and Variant Library Synthesis for PCLO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604918    OMIM disorders: --

    2 diseases for PCLO:    
    About MalaCards
    major depressive disorder    bipolar disorder


    Find genes that share disorders with PCLO           About GenesLikeMe

    Genetic Association Database (GAD): PCLO
    Human Genome Epidemiology (HuGE) Navigator: PCLO (8 documents)

    Export disorders for PCLO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PCLO gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with PCLO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    2. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. (PubMed id 19065144)1, 4, 9 Sullivan P.F....Penninx B.W. (Mol. Psychiatry 2009)
    3. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. (PubMed id 21621269)1, 4 Aragam N....Pan Y. (J Affect Disord 2011)
    4. The PCLO gene and depressive disorders: replication in a population-based study. (PubMed id 19942622)1, 4 Hek K....Tiemeier H. (Hum. Mol. Genet. 2010)
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    8. PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians. (PubMed id 18647954)1, 4 Ma L....Baier L.J. (Diabetes 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27445 HGNC: 13406 AceView: PCLO Ensembl:ENSG00000186472 euGenes: HUgn27445
    ECgene: PCLO Kegg: 27445 H-InvDB: PCLO

    (According to HUGE)
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    HUGE: KIAA0559

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PCLO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PCLO gene:
    Search GeneIP for patents involving PCLO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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