Aliases for PCK2 Gene
External Ids for PCK2 Gene
Previous GeneCards Identifiers for PCK2 Gene
This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
GeneCards Summary for PCK2 Gene
PCK2 (Phosphoenolpyruvate Carboxykinase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with PCK2 include pepck 1 deficiency and pepck deficiency, mitochondrial. Among its related pathways are Adipocytokine signaling pathway and AMPK signaling pathway. GO annotations related to this gene include GTP binding and purine nucleotide binding. An important paralog of this gene is PCK1.
UniProtKB/Swiss-Prot for PCK2 Gene
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.