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Aliases for PCIF1 Gene

Aliases for PCIF1 Gene

  • PDX1 C-Terminal Inhibiting Factor 1 2 3 5
  • C20orf67 3 4
  • Protein Phosphatase 1, Regulatory Subunit 121 3
  • PDX-1 C Terminus-Interacting Factor 1 3
  • Chromosome 20 Open Reading Frame 67 2
  • Regulatory Subunit 121 2
  • Protein Phosphatase 1 2
  • PPP1R121 3

External Ids for PCIF1 Gene

Previous HGNC Symbols for PCIF1 Gene

  • C20orf67

Previous GeneCards Identifiers for PCIF1 Gene

  • GC20P043997
  • GC20P044563
  • GC20P041304

Summaries for PCIF1 Gene

GeneCards Summary for PCIF1 Gene

PCIF1 (PDX1 C-Terminal Inhibiting Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PCIF1 Gene

  • May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCIF1 Gene

Genomics for PCIF1 Gene

Regulatory Elements for PCIF1 Gene

Enhancers for PCIF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCIF1 on UCSC Golden Path with GeneCards custom track

Promoters for PCIF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCIF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCIF1 Gene

45,934,628 bp from pter
45,948,023 bp from pter
13,396 bases
Plus strand

Genomic View for PCIF1 Gene

Genes around PCIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCIF1 Gene

Proteins for PCIF1 Gene

  • Protein details for PCIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphorylated CTD-interacting factor 1
    Protein Accession:
    Secondary Accessions:
    • E1P5P1
    • Q54AB9
    • Q9NT85

    Protein attributes for PCIF1 Gene

    704 amino acids
    Molecular mass:
    80670 Da
    Quaternary structure:
    • Interacts with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.

    Three dimensional structures from OCA and Proteopedia for PCIF1 Gene

neXtProt entry for PCIF1 Gene

Proteomics data for PCIF1 Gene at MOPED

Post-translational modifications for PCIF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCIF1 Gene

Domains & Families for PCIF1 Gene

Gene Families for PCIF1 Gene

Protein Domains for PCIF1 Gene


Suggested Antigen Peptide Sequences for PCIF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit.
  • The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with PCIF1: view

Function for PCIF1 Gene

Molecular function for PCIF1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.
genes like me logo Genes that share phenotypes with PCIF1: view

Animal Model Products

CRISPR Products

miRNA for PCIF1 Gene

miRTarBase miRNAs that target PCIF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCIF1 Gene

Localization for PCIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCIF1 Gene

Subcellular locations from

Jensen Localization Image for PCIF1 Gene COMPARTMENTS Subcellular localization image for PCIF1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 4
cytosol 2

Gene Ontology (GO) - Cellular Components for PCIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with PCIF1: view

Pathways & Interactions for PCIF1 Gene

SuperPathways for PCIF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCIF1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PCIF1 Gene

Drugs & Compounds for PCIF1 Gene

No Compound Related Data Available

Transcripts for PCIF1 Gene

Unigene Clusters for PCIF1 Gene

PDX1 C-terminal inhibiting factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCIF1 Gene

No ASD Table

Relevant External Links for PCIF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCIF1 Gene

mRNA expression in normal human tissues for PCIF1 Gene

Protein differential expression in normal tissues from HIPED for PCIF1 Gene

This gene is overexpressed in Breast (18.2), Peripheral blood mononuclear cells (8.4), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCIF1 Gene

SOURCE GeneReport for Unigene cluster for PCIF1 Gene Hs.472856

mRNA Expression by UniProt/SwissProt for PCIF1 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PCIF1: view

Protein tissue co-expression partners for PCIF1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PCIF1 Gene

Orthologs for PCIF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCIF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PCIF1 35
  • 92.04 (n)
  • 97.61 (a)
PCIF1 36
  • 96 (a)
(Canis familiaris)
Mammalia PCIF1 35
  • 92.12 (n)
  • 98.29 (a)
PCIF1 36
  • 98 (a)
(Mus musculus)
Mammalia Pcif1 35
  • 89.9 (n)
  • 95.31 (a)
Pcif1 16
Pcif1 36
  • 95 (a)
(Pan troglodytes)
Mammalia PCIF1 35
  • 99.91 (n)
  • 100 (a)
PCIF1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pcif1 35
  • 90 (n)
  • 95.59 (a)
(Monodelphis domestica)
Mammalia PCIF1 36
  • 87 (a)
(Gallus gallus)
Aves PCIF1 35
  • 78.73 (n)
  • 87.7 (a)
PCIF1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia PCIF1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcif1 35
  • 69.27 (n)
  • 72.71 (a)
Str.2070 35
(Danio rerio)
Actinopterygii pcif1 35
  • 67.37 (n)
  • 70.59 (a)
pcif1 36
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011933 35
  • 53.6 (n)
  • 44.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11399 35
  • 56.97 (n)
  • 49.24 (a)
CG11399 36
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3903 35
Species with no ortholog for PCIF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCIF1 Gene

Gene Tree for PCIF1 (if available)
Gene Tree for PCIF1 (if available)

Paralogs for PCIF1 Gene

No data available for Paralogs for PCIF1 Gene

Variants for PCIF1 Gene

Sequence variations from dbSNP and Humsavar for PCIF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs7679 -- 45,947,863(+) GATTA(C/T)GGTTC utr-variant-3-prime
rs1057208 -- 45,934,368(+) CCCCA(C/T)GCCCC upstream-variant-2KB
rs1105185 -- 45,937,704(+) GTCAG(G/T)GGTTC intron-variant
rs1111749 -- 45,937,894(+) CAACA(A/G)CCAAT intron-variant
rs1111750 -- 45,945,599(+) CAGAG(C/T)ATACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCIF1 Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897
nsv517296 CNV Loss 19592680
nsv833991 CNV Loss 17160897
dgv4571n71 CNV Loss 21882294
nsv912896 CNV Loss 21882294
nsv912897 CNV Loss 21882294
esv8950 CNV Gain 19470904

Variation tolerance for PCIF1 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PCIF1 Gene

Disorders for PCIF1 Gene

Relevant External Links for PCIF1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PCIF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCIF1 Gene

Publications for PCIF1 Gene

  1. PCIF1, a novel human WW domain-containing protein, interacts with the phosphorylated RNA polymerase II. (PMID: 12565871) Fan H. … Hirose Y. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. (PMID: 15121856) Liu A. … Stoffers D.A. (Mol. Cell. Biol. 2004) 2 3 23
  3. Prolyl isomerase Pin1 shares functional similarity with phosphorylated CTD interacting factor PCIF1 in vertebrate cells. (PMID: 19682092) Yunokuchi I. … Hirose Y. (Genes Cells 2009) 3 23
  4. Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II. (PMID: 18294453) Hirose Y. … Ohkuma Y. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PCIF1 Gene

Sources for PCIF1 Gene