Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCIF1 Gene

Aliases for PCIF1 Gene

  • PDX1 C-Terminal Inhibiting Factor 1 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 121 2 3
  • C20orf67 3 4
  • Phosphorylated CTD-Interacting Factor 1 3
  • PDX-1 C Terminus-Interacting Factor 1 3
  • Chromosome 20 Open Reading Frame 67 2
  • PPP1R121 3

External Ids for PCIF1 Gene

Previous HGNC Symbols for PCIF1 Gene

  • C20orf67

Previous GeneCards Identifiers for PCIF1 Gene

  • GC20P043997
  • GC20P044563
  • GC20P041304

Summaries for PCIF1 Gene

GeneCards Summary for PCIF1 Gene

PCIF1 (PDX1 C-Terminal Inhibiting Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PCIF1 Gene

  • May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCIF1 Gene

Genomics for PCIF1 Gene

Regulatory Elements for PCIF1 Gene

Enhancers for PCIF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G045334 2 FANTOM5 Ensembl ENCODE dbSUPER 33.3 -592.5 -592548 14.4 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 NCOA5 PCIF1 ZNF335 ZSWIM1 CD40 SPATA25 DBNDD2 SYS1-DBNDD2 SYS1 PIGT
GH20G045880 1.1 ENCODE 33.3 -53.4 -53369 1.4 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 NCOA5 PCIF1 TP53RK CD40 ZNF335 WFDC3 RPS2P7 NEURL2 SYS1 ZSWIM1
GH20G045967 1.5 ENCODE dbSUPER 21.5 +36.2 36246 5.8 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC NCOA5 ZNF663P CD40 TP53RK PCIF1 SYS1 ZNF334 ENSG00000271984 PLTP ZNF335
GH20G046111 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +176.7 176749 0.8 HDGF PKNOX1 TBL1XR1 BMI1 YBX1 EGR1 ZNF366 SCRT2 ZNF207 RELB CD40 NCOA5 PCIF1 SLC12A5-AS1 SLC12A5 ZNF663P SYS1 ZNF335 GC20P046113 RPL13P2
GH20G044965 1.8 FANTOM5 ENCODE dbSUPER 11.9 -965.7 -965703 7.5 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 STK4 SYS1 PCIF1 PABPC1L WFDC5 TOMM34 SERINC3 YWHAB ADA ENSG00000252021
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCIF1 on UCSC Golden Path with GeneCards custom track

Promoters for PCIF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137724 372 2401 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for PCIF1 Gene

Chromosome:
20
Start:
45,934,628 bp from pter
End:
45,948,023 bp from pter
Size:
13,396 bases
Orientation:
Plus strand

Genomic View for PCIF1 Gene

Genes around PCIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCIF1 Gene

Proteins for PCIF1 Gene

  • Protein details for PCIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4Z3-PCIF1_HUMAN
    Recommended name:
    Phosphorylated CTD-interacting factor 1
    Protein Accession:
    Q9H4Z3
    Secondary Accessions:
    • E1P5P1
    • Q54AB9
    • Q9NT85

    Protein attributes for PCIF1 Gene

    Size:
    704 amino acids
    Molecular mass:
    80670 Da
    Quaternary structure:
    • Interacts with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.

    Three dimensional structures from OCA and Proteopedia for PCIF1 Gene

neXtProt entry for PCIF1 Gene

Post-translational modifications for PCIF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCIF1 Gene

No data available for DME Specific Peptides for PCIF1 Gene

Domains & Families for PCIF1 Gene

Gene Families for PCIF1 Gene

Protein Domains for PCIF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCIF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4Z3

UniProtKB/Swiss-Prot:

PCIF1_HUMAN :
  • The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit.
Domain:
  • The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit.
genes like me logo Genes that share domains with PCIF1: view

Function for PCIF1 Gene

Molecular function for PCIF1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.
genes like me logo Genes that share phenotypes with PCIF1: view

Animal Model Products

miRNA for PCIF1 Gene

miRTarBase miRNAs that target PCIF1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCIF1 Gene

Localization for PCIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCIF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCIF1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 4
cytosol 2

Gene Ontology (GO) - Cellular Components for PCIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0015630 microtubule cytoskeleton IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with PCIF1: view

Pathways & Interactions for PCIF1 Gene

SuperPathways for PCIF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with PCIF1: view

No data available for Pathways by source and SIGNOR curated interactions for PCIF1 Gene

Drugs & Compounds for PCIF1 Gene

No Compound Related Data Available

Transcripts for PCIF1 Gene

Unigene Clusters for PCIF1 Gene

PDX1 C-terminal inhibiting factor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCIF1 Gene

No ASD Table

Relevant External Links for PCIF1 Gene

GeneLoc Exon Structure for
PCIF1
ECgene alternative splicing isoforms for
PCIF1

Expression for PCIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCIF1 Gene

Protein differential expression in normal tissues from HIPED for PCIF1 Gene

This gene is overexpressed in Breast (18.2), Peripheral blood mononuclear cells (8.4), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCIF1 Gene



Protein tissue co-expression partners for PCIF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCIF1 Gene:

PCIF1

SOURCE GeneReport for Unigene cluster for PCIF1 Gene:

Hs.472856

mRNA Expression by UniProt/SwissProt for PCIF1 Gene:

Q9H4Z3-PCIF1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PCIF1 Gene

  • Muscle(4.3)
  • Pancreas(4.3)
  • Liver(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with PCIF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCIF1 Gene

Orthologs for PCIF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCIF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCIF1 34 35
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia PCIF1 34 35
  • 92.12 (n)
cow
(Bos Taurus)
Mammalia PCIF1 34 35
  • 92.04 (n)
rat
(Rattus norvegicus)
Mammalia Pcif1 34
  • 90 (n)
mouse
(Mus musculus)
Mammalia Pcif1 34 16 35
  • 89.9 (n)
oppossum
(Monodelphis domestica)
Mammalia PCIF1 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCIF1 34 35
  • 78.73 (n)
lizard
(Anolis carolinensis)
Reptilia PCIF1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcif1 34
  • 69.27 (n)
Str.2070 34
zebrafish
(Danio rerio)
Actinopterygii pcif1 34 35
  • 67.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11399 34 35
  • 56.97 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011933 34
  • 53.6 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3903 34
Species where no ortholog for PCIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCIF1 Gene

ENSEMBL:
Gene Tree for PCIF1 (if available)
TreeFam:
Gene Tree for PCIF1 (if available)

Paralogs for PCIF1 Gene

No data available for Paralogs for PCIF1 Gene

Variants for PCIF1 Gene

Sequence variations from dbSNP and Humsavar for PCIF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000389174 -- 45,944,235(+) GGGCT(C/T)TCTTT intron-variant
rs1000518165 -- 45,935,640(+) TCACA(C/T)AGGAA intron-variant
rs1000987793 -- 45,934,384(+) GCGCA(C/T)GCTCA upstream-variant-2KB, utr-variant-3-prime
rs1001096743 -- 45,938,341(+) CCTTC(C/G)CTAGT intron-variant
rs1001133934 -- 45,946,290(+) TTGGC(A/G)TCAGC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PCIF1 Gene

Variant ID Type Subtype PubMed ID
esv8950 CNV gain 19470904
nsv517296 CNV loss 19592680
nsv833990 CNV loss 17160897
nsv833991 CNV loss 17160897

Variation tolerance for PCIF1 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCIF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCIF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCIF1 Gene

Disorders for PCIF1 Gene

Relevant External Links for PCIF1

Genetic Association Database (GAD)
PCIF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCIF1

No disorders were found for PCIF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCIF1 Gene

Publications for PCIF1 Gene

  1. PCIF1, a novel human WW domain-containing protein, interacts with the phosphorylated RNA polymerase II. (PMID: 12565871) Fan H. … Hirose Y. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 22 64
  2. Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. (PMID: 15121856) Liu A. … Stoffers D.A. (Mol. Cell. Biol. 2004) 2 3 22 64
  3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 46 64
  4. Prolyl isomerase Pin1 shares functional similarity with phosphorylated CTD interacting factor PCIF1 in vertebrate cells. (PMID: 19682092) Yunokuchi I. … Hirose Y. (Genes Cells 2009) 3 22 64
  5. Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II. (PMID: 18294453) Hirose Y. … Ohkuma Y. (Biochem. Biophys. Res. Commun. 2008) 3 22 64

Products for PCIF1 Gene

Sources for PCIF1 Gene

Content
Loading form....