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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PCID2 Gene

protein-coding   GIFtS: 46
GCID: GC13M113831

PCI domain containing 2

 Explore 1 disease affiliated with
PCID2 via our new
 Human Malady Compendium 
Biological research products
for PCID2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
PCI Domain Containing 21 2
CSN12-Like Protein2 3
FLJ113051
F102
PCI Domain-Containing Protein 22

External Ids:    HGNC: 256531   Entrez Gene: 557952   Ensembl: ENSG000001262267   OMIM: 6137135   UniProtKB: Q5JVF33   

Export aliases for PCID2 gene to outside databases

Previous GC identifers: GC13M112881 GC13M094270


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PCID2:
PCID2 is expressed in immature and early-stage B lymphocytes and regulates expression of the mitotic checkpoint protein
MAD2 (MAD2L1; MIM 601467) (Nakaya et al., 2010 (PubMed 20870947)).(supplied by OMIM, Jan 2011)

UniProtKB/Swiss-Prot: PCID2_HUMAN, Q5JVF3
Function: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein
during B cell differentiation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_027140.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PCID2 gene promoter:
         Max1   CUTL1   Arnt   C/EBPalpha   HEN1   CREB   deltaCREB   c-Myb   En-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCID2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PCID2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCID2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

PCID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCID2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M113831:  view genomic region     (about GC identifiers)

Start:
113,831,891 bp from pter      End:
113,863,029 bp from pter
Size:
31,139 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PCID2_HUMAN, Q5JVF3 (See protein sequence)
Recommended Name: PCI domain-containing protein 2  
Size: 399 amino acids; 46030 Da
Sequence caution: Sequence=AAG09695.1; Type=Frameshift; Positions=48; Sequence=BAB15768.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PCID2:
3T5X (3D)    
Secondary accessions: A6NK09 Q3ZCX1 Q5TC57 Q5TC58 Q9H7K1 Q9HBZ7 Q9NUK6 Q9NVY1 Q9NW44 Q9NWH3
Alternative splicing: 4 isoforms:  Q5JVF3-1   Q5JVF3-2   Q5JVF3-3   Q5JVF3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PCID2: NX_Q5JVF3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5JVF3

  • PCID2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001120674.1  NP_001120675.1  NP_001245141.1  NP_001245142.1  NP_060856.2  

    ENSEMBL proteins: 
     ENSP00000337405   ENSP00000364628   ENSP00000364626   ENSP00000246505   ENSP00000364608  
     ENSP00000364606   ENSP00000327335  

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    Uscn Proteins for PCID2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    PCID2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PCID2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013143 PAM
     IPR000717 PCI_dom

    Graphical View of Domain Structure for InterPro Entry Q5JVF3

    ProtoNet protein and cluster: Q5JVF3

    UniProtKB/Swiss-Prot: PCID2_HUMAN, Q5JVF3
    Similarity: Belongs to the CSN12 family
    Similarity: Contains 1 PCI domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PCID2_HUMAN, Q5JVF3
    Function: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein
    during B cell differentiation (By similarity)

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCID2

    1 GenomeRNAi human phenotype for PCID2:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Cul4a/Pcid2Cul4a/tm1Ktc for PCID2
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pcid2):
     cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  immune system 
     mortality/aging 

    PCID2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCID2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for PCID2 (Q5JVF33 ENSP000003374054) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNB1Q149743, ENSP000002901584I2D: score=5 STRING: ENSP00000290158
    NEK6Q9HC983, ENSP000003627024I2D: score=2 STRING: ENSP00000362702
    BRF2Q9HAW03, ENSP000002206594I2D: score=1 STRING: ENSP00000220659
    SMAD2Q157963, ENSP000002621604I2D: score=1 STRING: ENSP00000262160
    SHFM1P608963, ENSP000002485664I2D: score=3 STRING: ENSP00000248566
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043066negative regulation of apoptotic process IMP--
    GO:0043488regulation of mRNA stability IMP--
    GO:0045579positive regulation of B cell differentiation IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IMP--
    GO:0048536spleen development ISS--


    PCID2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PCID2
    Search CenterWatch for drugs/clinical trials and news about PCID2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PCID2 gene (5 alternative transcripts): 
    NM_001127202.2  NM_001127203.2  NM_001258212.1  NM_001258213.1  NM_018386.3  

    Unigene Cluster for PCID2:

    PCI domain containing 2
    Hs.741363  [show with all ESTs]
    Unigene Representative Sequence: AK024478
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337344(uc021rmr.1 uc021rms.1) ENST00000375479(uc021rmq.1)
    ENST00000375477 ENST00000246505(uc021rmt.1) ENST00000375459 ENST00000493650(uc001vtb.2)
    ENST00000463102 ENST00000462653 ENST00000375457(uc001vtg.2) ENST00000351317
    ENST00000463208 ENST00000473462 ENST00000475433 ENST00000484641 ENST00000480971
    ENST00000477095 ENST00000491548 ENST00000462853

    miRNA
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    hsa-miR-607 hsa-miR-520d-5p hsa-miR-3121-3p hsa-miR-524-5p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF183426.1 AK000888.1 AK001185.1 AK001302.1 AK002167.1 AK023313.1 AK024478.1 AK097025.1 
    AK098706.1 AK289462.1 AK309321.1 BC016614.1 BC031246.1 

    23 DOTS entries:

    DT.95224454  DT.101985114  DT.100669206  DT.413424  DT.75135847  DT.120776796  DT.91759923  DT.100669191 
    DT.100669197  DT.100669193  DT.100669190  DT.101975926  DT.91759928  DT.91759931  DT.97847341  DT.120776856 
    DT.100874111  DT.101985113  DT.120776757  DT.86853390  DT.91759927  DT.120776804  DT.120776820 

    24/271 AceView cDNA sequences (see all 271):

    AI093983 BQ892979 CB215111 BI258610 CR614837 BM852886 CA487503 BQ962489 
    AU133826 AU139141 AL546664 BX646419 CB104786 AA337014 CR596556 CB117169 
    BG548771 BX364421 AI240568 BU951575 CB151360 CR596487 BG032949 BP360744 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PCID2 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                    -     -                             -                 -           -     -     -                                               -         
    SP2:                    -     -                       -     -                 -           -     -     -                                               -         
    SP3:                    -     -                       -     -                 -           -     -     -                                               -         
    SP4:                                                  -     -                 -           -     -     -                                               -         
    SP5:                    -     -                       -     -                 -           -     -     -                                               -         

    ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d
    SP1:        -     -                     
    SP2:        -     -                     
    SP3:        -                           
    SP4:        -                           
    SP5:                                    


    ECgene alternative splicing isoforms for PCID2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PCID2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTTCATTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PCID2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PCID2

    SOURCE GeneReport for Unigene cluster: Hs.741363
        SABiosciences Custom PCR Arrays for PCID2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCID2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PCID2 gene from 9/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcid21 , 5 PCI domain containing 21, 5 87.22(n)1
    97.24(a)1
      8 (5.73 cM)5
    2340691  NM_178708.31  NP_848823.21 
     130771895 
    chicken
    (Gallus gallus)
    Aves PCID26
    PCI domain containing 2
    94(a)
    1 ↔ 1
    1(141785076-141798422)
    lizard
    (Anolis carolinensis)
    Reptilia PCID26
    --
    90(a)
    1 ↔ 1
    3(105990516-106009875)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55262 Xenopus laevis transcribed sequence with weak similarity to protein refNP_060856.1 (H.sapiens) hypothetical protein FLJ11305 [Homo sapiens] less 78.38(n)    BJ033488.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11f032 wufa11f03 74.31(n)   335000  BQ618489.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta PCID21 PCI domain-containing protein 2 54.24(n)
    50.9(a)
      39306  NM_140229.2  NP_648486.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C27F2.101 Protein C27F2.10 51.78(n)
    46.7(a)
      175675  NM_065656.7  NP_498057.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EER51 proteasome-like protein 49.96(n)
    39.37(a)
      816475  NM_127514.3  NP_179546.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g03864001 hypothetical protein 48.23(n)
    36.88(a)
      4346949  NM_001069609.1  NP_001063074.1 


    ENSEMBL Gene Tree for PCID2 (if available)
    TreeFam Gene Tree for PCID2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/562 NCBI SNPs in PCID2 are shown (see all 562    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837839341,2
    --113831429(+) CTACAC/TGAGGT 5 -- ds50010--------
    rs1383365491,2
    --113831430(+) TACACA/GAGGTA 5 -- ds50010--------
    rs1409407291,2
    --113831510(+) GCAATA/GGCATG 5 -- ds50010--------
    rs95772131,2
    --113831513(+) ATGGCA/GTGATC 5 -- ds50010--------
    rs95496831,2
    C,--113831552(+) GTTCAG/AGCGAT 5 -- ds50012Minor allele frequency- A:0.25NA 4
    rs95772141,2
    --113831583(+) AGTAGA/CTGGAA 5 -- ds50010--------
    rs1871409831,2
    --113831609(+) ACCACA/GCCCGG 5 -- ds50010--------
    rs1463752031,2
    --113831730(+) ACAGGC/TGTGAG 5 -- ds50010--------
    rs1379335901,2
    --113831803(+) TAAGAG/TTGGAG 5 -- ds50010--------
    rs784472761,2
    C,F,--113831906(+) AGAAAT/ATTTTT 5 -- ut311Minor allele frequency- A:0.20EA 120

    HapMap Linkage Disequilibrium report for PCID2 (113831891 - 113863029 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PCID2
         2 CNVs: 66567 87070

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PCID2 for disorders           About GeneDecksing

    OMIM gene information: 613713    OMIM disorders: --

    1 disease for PCID2:    About MalaCards
    malaria


    Export disorders for PCID2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PCID2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with PCID2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Structural basis for the assembly and nucleic acid bin ding of the TREX-2 transcription-export complex. (PubMed id 22343721)1 Ellisdon A.M....Stewart M. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55795 HGNC: 25653 AceView: FLJ11305 Ensembl:ENSG00000126226 euGenes: HUgn55795
    ECgene: PCID2 H-InvDB: PCID2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PCID2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PCID2 gene:
    Search GeneIP for patents involving PCID2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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