Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCID2 Gene

Aliases for PCID2 Gene

  • PCI Domain Containing 2 2 3
  • CSN12-Like Protein 3 4
  • PCI Domain-Containing Protein 2 3
  • F10 3

External Ids for PCID2 Gene

Previous GeneCards Identifiers for PCID2 Gene

  • GC13M112881
  • GC13M113831
  • GC13M094270

Summaries for PCID2 Gene

Entrez Gene Summary for PCID2 Gene

  • PCID2 is expressed in immature and early-stage B lymphocytes and regulates expression of the mitotic checkpoint protein MAD2 (MAD2L1; MIM 601467) (Nakaya et al., 2010 [PubMed 20870947]).[supplied by OMIM, Jan 2011]

GeneCards Summary for PCID2 Gene

PCID2 (PCI Domain Containing 2) is a Protein Coding gene. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade).

UniProtKB/Swiss-Prot for PCID2 Gene

  • Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCID2 Gene

Genomics for PCID2 Gene

Regulatory Elements for PCID2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCID2 Gene

Start:
113,177,539 bp from pter
End:
113,209,466 bp from pter
Size:
31,928 bases
Orientation:
Minus strand

Genomic View for PCID2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCID2 Gene

Proteins for PCID2 Gene

  • Protein details for PCID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JVF3-PCID2_HUMAN
    Recommended name:
    PCI domain-containing protein 2
    Protein Accession:
    Q5JVF3
    Secondary Accessions:
    • A6NK09
    • Q3ZCX1
    • Q5TC57
    • Q5TC58
    • Q9H7K1
    • Q9HBZ7
    • Q9NUK6
    • Q9NVY1
    • Q9NW44
    • Q9NWH3

    Protein attributes for PCID2 Gene

    Size:
    399 amino acids
    Molecular mass:
    46030 Da
    Quaternary structure:
    • Belongs to the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). Interacts with BRCA2.
    SequenceCaution:
    • Sequence=AAG09695.1; Type=Frameshift; Positions=48; Evidence={ECO:0000305}; Sequence=BAB15768.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCID2 Gene

    Alternative splice isoforms for PCID2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCID2 Gene

Proteomics data for PCID2 Gene at MOPED

Post-translational modifications for PCID2 Gene

  • Ubiquitination at Lys128, Lys201, and Lys213
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PCID2 Gene

Domains for PCID2 Gene

Protein Domains for PCID2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCID2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JVF3

UniProtKB/Swiss-Prot:

PCID2_HUMAN :
  • Q5JVF3
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the CSN12 family.
genes like me logo Genes that share domains with PCID2: view

No data available for Gene Families for PCID2 Gene

Function for PCID2 Gene

Molecular function for PCID2 Gene

UniProtKB/Swiss-Prot Function: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.

Gene Ontology (GO) - Molecular Function for PCID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PCID2: view
genes like me logo Genes that share phenotypes with PCID2: view

Animal Models for PCID2 Gene

MGI Knock Outs for PCID2:

Animal Model Products

CRISPR Products

miRNA for PCID2 Gene

miRTarBase miRNAs that target PCID2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PCID2 Gene

Localization for PCID2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCID2 Gene COMPARTMENTS Subcellular localization image for PCID2 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PCID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PCID2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PCID2 Gene

Pathways for PCID2 Gene

genes like me logo Genes that share pathways with PCID2: view

Gene Ontology (GO) - Biological Process for PCID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IMP 20870947
GO:0043488 regulation of mRNA stability IMP 20870947
GO:0045579 positive regulation of B cell differentiation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IMP 20870947
GO:0048536 spleen development ISS --
genes like me logo Genes that share ontologies with PCID2: view

Transcripts for PCID2 Gene

Unigene Clusters for PCID2 Gene

PCI domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCID2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PCID2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCID2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: -
SP9: - - - - -
SP10: -
SP11: - - - -
SP12: -
SP13:
SP14:

ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PCID2 Gene

GeneLoc Exon Structure for
PCID2
ECgene alternative splicing isoforms for
PCID2

Expression for PCID2 Gene

mRNA expression in normal human tissues for PCID2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCID2 Gene

SOURCE GeneReport for Unigene cluster for PCID2 Gene Hs.508769

genes like me logo Genes that share expressions with PCID2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCID2 Gene

Orthologs for PCID2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCID2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCID2 35
  • 99.66 (n)
  • 99.74 (a)
PCID2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PCID2 35
  • 84.63 (n)
  • 96.24 (a)
PCID2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCID2 35
  • 86.88 (n)
  • 96.74 (a)
PCID2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcid2 35
  • 87.22 (n)
  • 97.24 (a)
Pcid2 16
Pcid2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCID2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCID2 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcid2 35
  • 87.39 (n)
  • 97.74 (a)
chicken
(Gallus gallus)
Aves PCID2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCID2 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5526 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pcid2 35
  • 75.94 (n)
  • 87.22 (a)
Str.1726 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10068 35
zebrafish
(Danio rerio)
Actinopterygii pcid2 35
  • 76.21 (n)
  • 85.43 (a)
pcid2 36
  • 85 (a)
OneToOne
wufa11f03 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008498 35
  • 57.8 (n)
  • 55.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta PCID2 35
  • 54.33 (n)
  • 50.9 (a)
PCID2 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C27F2.10 35
  • 51.95 (n)
  • 46.7 (a)
C27F2.10 36
  • 44 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
OneToOne
THP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EER5 35
  • 49.96 (n)
  • 39.37 (a)
rice
(Oryza sativa)
Liliopsida Os09g0386400 35
  • 48.05 (n)
  • 37.14 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08388 35
  • 47.77 (n)
  • 34.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1B3.08 35
  • 44.48 (n)
  • 34.04 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11106 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.973 36
  • 58 (a)
OneToOne
Species with no ortholog for PCID2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCID2 Gene

ENSEMBL:
Gene Tree for PCID2 (if available)
TreeFam:
Gene Tree for PCID2 (if available)

Paralogs for PCID2 Gene

No data available for Paralogs for PCID2 Gene

Variants for PCID2 Gene

Sequence variations from dbSNP and Humsavar for PCID2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs486407 -- 113,179,185(-) TACTC(C/T)TTTAG intron-variant
rs515863 -- 113,185,433(-) CCTGG(A/G)CTTCC intron-variant
rs524433 -- 113,177,649(-) atgat(A/G)gggtt utr-variant-3-prime
rs545026 -- 113,197,968(+) CCACT(A/G)AGCAG intron-variant
rs546686 -- 113,198,111(+) AAGCA(C/T)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCID2 Gene

Variant ID Type Subtype PubMed ID
nsv901039 CNV Loss 21882294
dgv1797n71 CNV Loss 21882294
nsv901049 CNV Loss 21882294
nsv518044 CNV Gain 19592680
esv25141 CNV Loss 19812545

Relevant External Links for PCID2 Gene

HapMap Linkage Disequilibrium report
PCID2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCID2 Gene

Disorders for PCID2 Gene

No disorders were found for PCID2 Gene.

No data available for UniProtKB/Swiss-Prot for PCID2 Gene

Publications for PCID2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for PCID2 Gene

Sources for PCID2 Gene

Back to Top

Content