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Aliases for PCGF6 Gene

Aliases for PCGF6 Gene

  • Polycomb Group Ring Finger 6 2 3 5
  • Ring Finger Protein 134 2 3
  • RNF134 3 4
  • MBLR 3 4
  • Mel18 And Bmi1-Like RING Finger Protein 3
  • Mel18 And Bmi1-Like RING Finger 4
  • RING Finger Protein 134 4

External Ids for PCGF6 Gene

Previous HGNC Symbols for PCGF6 Gene

  • RNF134

Previous GeneCards Identifiers for PCGF6 Gene

  • GC10M105053
  • GC10M098693

Summaries for PCGF6 Gene

Entrez Gene Summary for PCGF6 Gene

  • The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCGF6 Gene

PCGF6 (Polycomb Group Ring Finger 6) is a Protein Coding gene. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is PCGF5.

UniProtKB/Swiss-Prot for PCGF6 Gene

  • Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Wiki entry for PCGF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCGF6 Gene

Genomics for PCGF6 Gene

Regulatory Elements for PCGF6 Gene

Enhancers for PCGF6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCGF6 on UCSC Golden Path with GeneCards custom track

Promoters for PCGF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCGF6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCGF6 Gene

Chromosome:
10
Start:
103,302,796 bp from pter
End:
103,351,134 bp from pter
Size:
48,339 bases
Orientation:
Minus strand

Genomic View for PCGF6 Gene

Genes around PCGF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCGF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCGF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCGF6 Gene

Proteins for PCGF6 Gene

  • Protein details for PCGF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYE7-PCGF6_HUMAN
    Recommended name:
    Polycomb group RING finger protein 6
    Protein Accession:
    Q9BYE7
    Secondary Accessions:
    • A8K3R4
    • Q5SYD1
    • Q5SYD6
    • Q96ID9
    • Q96SJ1

    Protein attributes for PCGF6 Gene

    Size:
    350 amino acids
    Molecular mass:
    39047 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8.

    Three dimensional structures from OCA and Proteopedia for PCGF6 Gene

    Alternative splice isoforms for PCGF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCGF6 Gene

Proteomics data for PCGF6 Gene at MOPED

Post-translational modifications for PCGF6 Gene

  • Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro.
  • Ubiquitination at Lys 239 and Lys 290
  • Modification sites at PhosphoSitePlus

Other Protein References for PCGF6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCGF6 Gene

Domains & Families for PCGF6 Gene

Gene Families for PCGF6 Gene

Protein Domains for PCGF6 Gene

Suggested Antigen Peptide Sequences for PCGF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYE7

UniProtKB/Swiss-Prot:

PCGF6_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PCGF6: view

Function for PCGF6 Gene

Molecular function for PCGF6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Ontology (GO) - Molecular Function for PCGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 8521824
GO:0005515 protein binding IEA,IPI 21282530
genes like me logo Genes that share ontologies with PCGF6: view
genes like me logo Genes that share phenotypes with PCGF6: view

Animal Model Products

miRNA for PCGF6 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCGF6 Gene

Localization for PCGF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCGF6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCGF6 Gene COMPARTMENTS Subcellular localization image for PCGF6 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for PCGF6 Gene

Pathways & Interactions for PCGF6 Gene

genes like me logo Genes that share pathways with PCGF6: view

Pathways by source for PCGF6 Gene

Gene Ontology (GO) - Biological Process for PCGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with PCGF6: view

No data available for SIGNOR curated interactions for PCGF6 Gene

Drugs & Compounds for PCGF6 Gene

No Compound Related Data Available

Transcripts for PCGF6 Gene

Unigene Clusters for PCGF6 Gene

Polycomb group ring finger 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCGF6 Gene

No ASD Table

Relevant External Links for PCGF6 Gene

GeneLoc Exon Structure for
PCGF6
ECgene alternative splicing isoforms for
PCGF6

Expression for PCGF6 Gene

mRNA expression in normal human tissues for PCGF6 Gene

Protein differential expression in normal tissues from HIPED for PCGF6 Gene

This gene is overexpressed in Breast (50.9) and Lung (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCGF6 Gene



SOURCE GeneReport for Unigene cluster for PCGF6 Gene Hs.335808

mRNA Expression by UniProt/SwissProt for PCGF6 Gene

Q9BYE7-PCGF6_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PCGF6: view

Protein tissue co-expression partners for PCGF6 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PCGF6 Gene

Orthologs for PCGF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCGF6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCGF6 35
  • 94.09 (n)
  • 96.45 (a)
-- 36
  • 94 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PCGF6 35
  • 92.45 (n)
  • 94.84 (a)
PCGF6 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcgf6 35
  • 89.1 (n)
  • 93.85 (a)
Pcgf6 16
Pcgf6 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCGF6 35
  • 99.71 (n)
  • 99.71 (a)
PCGF6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcgf6 35
  • 88.46 (n)
  • 93.53 (a)
oppossum
(Monodelphis domestica)
Mammalia PCGF6 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCGF6 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCGF6 35
  • 74.89 (n)
  • 80.67 (a)
PCGF6 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCGF6 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcgf6 35
  • 74.31 (n)
  • 77.92 (a)
zebrafish
(Danio rerio)
Actinopterygii pcgf6 35
  • 62.05 (n)
  • 62.34 (a)
pcgf6 36
  • 53 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10855 36
  • 28 (a)
OneToOne
Species with no ortholog for PCGF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCGF6 Gene

ENSEMBL:
Gene Tree for PCGF6 (if available)
TreeFam:
Gene Tree for PCGF6 (if available)

Paralogs for PCGF6 Gene

Paralogs for PCGF6 Gene

(7) SIMAP similar genes for PCGF6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PCGF6 Gene

genes like me logo Genes that share paralogs with PCGF6: view

Variants for PCGF6 Gene

Sequence variations from dbSNP and Humsavar for PCGF6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3004636 -- 103,314,827(+) catgg(G/T)gcctg intron-variant
rs1878548 -- 103,322,983(+) TTCTA(A/G)AGAGG intron-variant
rs1878549 -- 103,323,043(+) TTTTA(A/G)AAATA intron-variant
rs3062789 -- 103,322,836(+) ACACA(-/C/CA)AAAAG intron-variant
rs3062791 -- 103,316,013(-) tctct(A/C)tATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCGF6 Gene

Variant ID Type Subtype PubMed ID
nsv509365 CNV Insertion 20534489
esv2664207 CNV Deletion 23128226
esv8301 CNV Loss 19470904
esv2740273 CNV Deletion 23290073
nsv25055 CNV Loss 16902084

Variation tolerance for PCGF6 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.79; 95.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PCGF6 Gene

Disorders for PCGF6 Gene

Relevant External Links for PCGF6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCGF6

No disorders were found for PCGF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCGF6 Gene

Publications for PCGF6 Gene

  1. MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation. (PMID: 12167161) Akasaka T. … Koga H. (Genes Cells 2002) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. (PMID: 26151332) Taherbhoy A.M. … Cochran A.G. (Nat Commun 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PCGF6 Gene

Sources for PCGF6 Gene

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