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Aliases for PCGF6 Gene

Aliases for PCGF6 Gene

  • Polycomb Group Ring Finger 6 2 3 5
  • Ring Finger Protein 134 2 3
  • RNF134 3 4
  • MBLR 3 4
  • Mel18 And Bmi1-Like RING Finger Protein 3
  • Polycomb Group RING Finger Protein 6 3
  • Mel18 And Bmi1-Like RING Finger 4
  • RING Finger Protein 134 4

External Ids for PCGF6 Gene

Previous HGNC Symbols for PCGF6 Gene

  • RNF134

Previous GeneCards Identifiers for PCGF6 Gene

  • GC10M105053
  • GC10M098693

Summaries for PCGF6 Gene

Entrez Gene Summary for PCGF6 Gene

  • The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCGF6 Gene

PCGF6 (Polycomb Group Ring Finger 6) is a Protein Coding gene. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is COMMD3-BMI1.

UniProtKB/Swiss-Prot for PCGF6 Gene

  • Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Wiki entry for PCGF6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCGF6 Gene

Genomics for PCGF6 Gene

Regulatory Elements for PCGF6 Gene

Enhancers for PCGF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G103226 1.2 Ensembl ENCODE 10.7 +121.0 120968 7.0 FOXA2 ZFP64 ARID4B SIN3A GTF3C2 ZNF121 GATA2 FOS SP5 PPARG PDCD11 GBF1 ENSG00000260461 INA RNU11-3P CNNM2 PCGF6 PFN1P11 PTGES3P4 CYP17A1
GH10G103349 1 ENCODE 0.7 +0.2 235 1.9 HDGF ZNF133 SIN3A DMAP1 GLI4 ZNF2 ZNF48 ETS1 GLIS2 ZNF143 SLK MIR1307 USMG5 PDCD11 RNU11-3P ENSG00000260461 NEURL1-AS1 CALHM2 PCGF6 GC10M103313
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCGF6 on UCSC Golden Path with GeneCards custom track

Promoters for PCGF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032871 334 1601 HDGF ZNF133 SIN3A DMAP1 GLI4 ZNF2 ZNF48 ETS1 GLIS2 ZNF143

Genomic Location for PCGF6 Gene

Chromosome:
10
Start:
103,302,796 bp from pter
End:
103,351,134 bp from pter
Size:
48,339 bases
Orientation:
Minus strand

Genomic View for PCGF6 Gene

Genes around PCGF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCGF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCGF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCGF6 Gene

Proteins for PCGF6 Gene

  • Protein details for PCGF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYE7-PCGF6_HUMAN
    Recommended name:
    Polycomb group RING finger protein 6
    Protein Accession:
    Q9BYE7
    Secondary Accessions:
    • A8K3R4
    • Q5SYD1
    • Q5SYD6
    • Q96ID9
    • Q96SJ1

    Protein attributes for PCGF6 Gene

    Size:
    350 amino acids
    Molecular mass:
    39047 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8.

    Three dimensional structures from OCA and Proteopedia for PCGF6 Gene

    Alternative splice isoforms for PCGF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCGF6 Gene

Post-translational modifications for PCGF6 Gene

  • Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro.
  • Ubiquitination at Lys239 and Lys290
  • Modification sites at PhosphoSitePlus

Other Protein References for PCGF6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCGF6 Gene

Domains & Families for PCGF6 Gene

Gene Families for PCGF6 Gene

Protein Domains for PCGF6 Gene

Suggested Antigen Peptide Sequences for PCGF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCGF6: view

No data available for UniProtKB/Swiss-Prot for PCGF6 Gene

Function for PCGF6 Gene

Molecular function for PCGF6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Ontology (GO) - Molecular Function for PCGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IDA 8521824
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 8521824
GO:0005515 protein binding IPI 21282530
genes like me logo Genes that share ontologies with PCGF6: view
genes like me logo Genes that share phenotypes with PCGF6: view

Animal Model Products

CRISPR Products

miRNA for PCGF6 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCGF6 Gene

Localization for PCGF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCGF6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCGF6 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for PCGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 21282530
GO:0031519 PcG protein complex TAS 8521824
GO:0035102 PRC1 complex IDA 19636380
genes like me logo Genes that share ontologies with PCGF6: view

Pathways & Interactions for PCGF6 Gene

genes like me logo Genes that share pathways with PCGF6: view

Pathways by source for PCGF6 Gene

Gene Ontology (GO) - Biological Process for PCGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 8521824
genes like me logo Genes that share ontologies with PCGF6: view

No data available for SIGNOR curated interactions for PCGF6 Gene

Drugs & Compounds for PCGF6 Gene

No Compound Related Data Available

Transcripts for PCGF6 Gene

Unigene Clusters for PCGF6 Gene

Polycomb group ring finger 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCGF6 Gene

No ASD Table

Relevant External Links for PCGF6 Gene

GeneLoc Exon Structure for
PCGF6
ECgene alternative splicing isoforms for
PCGF6

Expression for PCGF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCGF6 Gene

Protein differential expression in normal tissues from HIPED for PCGF6 Gene

This gene is overexpressed in Breast (50.9) and Lung (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCGF6 Gene



Protein tissue co-expression partners for PCGF6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCGF6 Gene:

PCGF6

SOURCE GeneReport for Unigene cluster for PCGF6 Gene:

Hs.335808

mRNA Expression by UniProt/SwissProt for PCGF6 Gene:

Q9BYE7-PCGF6_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PCGF6 Gene

  • Liver(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with PCGF6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCGF6 Gene

Orthologs for PCGF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCGF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCGF6 34 35
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia PCGF6 34
  • 94.09 (n)
-- 35
  • 94 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PCGF6 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCGF6 34 35
  • 92.45 (n)
mouse
(Mus musculus)
Mammalia Pcgf6 34 16 35
  • 89.1 (n)
rat
(Rattus norvegicus)
Mammalia Pcgf6 34
  • 88.46 (n)
oppossum
(Monodelphis domestica)
Mammalia PCGF6 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCGF6 34 35
  • 74.89 (n)
lizard
(Anolis carolinensis)
Reptilia PCGF6 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcgf6 34
  • 74.31 (n)
zebrafish
(Danio rerio)
Actinopterygii pcgf6 34 35
  • 62.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10855 35
  • 28 (a)
OneToOne
Species where no ortholog for PCGF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCGF6 Gene

ENSEMBL:
Gene Tree for PCGF6 (if available)
TreeFam:
Gene Tree for PCGF6 (if available)

Paralogs for PCGF6 Gene

Paralogs for PCGF6 Gene

(7) SIMAP similar genes for PCGF6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PCGF6 Gene

genes like me logo Genes that share paralogs with PCGF6: view

Variants for PCGF6 Gene

Sequence variations from dbSNP and Humsavar for PCGF6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000075044 -- 103,306,156(+) GCAAT(A/G)GTGCC intron-variant
rs1000113339 -- 103,343,982(+) GTTTA(C/T)GGCAA intron-variant
rs1000141326 -- 103,344,342(+) CCTCG(C/G)TTCAC intron-variant
rs1000145571 -- 103,346,252(+) TTTGG(A/G)AGGCC intron-variant
rs1000218133 -- 103,309,075(+) GAAGG(A/G)ACTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCGF6 Gene

Variant ID Type Subtype PubMed ID
dgv39e215 CNV deletion 23714750
esv2664207 CNV deletion 23128226
esv2740273 CNV deletion 23290073
esv3624411 CNV loss 21293372
esv8301 CNV loss 19470904
nsv1069072 CNV deletion 25765185
nsv1125509 CNV tandem duplication 24896259
nsv1134049 CNV deletion 24896259
nsv1146943 CNV deletion 26484159
nsv25055 CNV deletion 16902084
nsv509365 CNV insertion 20534489
nsv955924 CNV deletion 24416366

Variation tolerance for PCGF6 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.79; 95.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCGF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCGF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCGF6 Gene

Disorders for PCGF6 Gene

Relevant External Links for PCGF6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCGF6

No disorders were found for PCGF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCGF6 Gene

Publications for PCGF6 Gene

  1. MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation. (PMID: 12167161) Akasaka T. … Koga H. (Genes Cells 2002) 2 3 4 64
  2. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3 4 64
  3. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 3 4 64
  4. Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. (PMID: 17320162) Lee M.G. … Shiekhattar R. (Cell 2007) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for PCGF6 Gene

Sources for PCGF6 Gene

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