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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PCGF5 Gene

protein-coding   GIFtS: 49
GCID: GC10P092979

polycomb group ring finger 5

(Previous name: ring finger protein (C3HC4 type) 159 )
(Previous symbol: RNF159)
 Explore 1 disease affiliated with
PCGF5 via our new
 Human Malady Compendium 
Biological research products
for PCGF5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Polycomb Group Ring Finger 51 2
RNF1591 2 3
Ring Finger Protein (C3HC4 Type) 1591 2
RING Finger Protein 1592 3
MGC162021
Polycomb Group RING Finger Protein 52

External Ids:    HGNC: 282641   Entrez Gene: 843332   Ensembl: ENSG000001806287   UniProtKB: Q86SE93   

Export aliases for PCGF5 gene to outside databases

Previous GC identifers: GC10P092913 GC10P086610


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PCGF5_HUMAN, Q86SE9
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the
transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts
via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',
rendering chromatin heritably changed in its expressibility

Gene Wiki entry for PCGF5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PCGF5 gene promoter:
         HOXA9   HOXA9B   Spz1   AML1a   Meis-1a   RSRFC4   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCGF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for PCGF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCGF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.32   Ensembl cytogenetic band:  10q23.32   HGNC cytogenetic band: 10q23.33

PCGF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCGF5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P092979:  view genomic region     (about GC identifiers)

Start:
92,979,908 bp from pter      End:
93,044,088 bp from pter
Size:
64,181 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PCGF5_HUMAN, Q86SE9 (See protein sequence)
Recommended Name: Polycomb group RING finger protein 5  
Size: 256 amino acids; 29714 Da
Subunit: Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8
Subcellular location: Nucleus
Secondary accessions: B7Z892 D3DR33 Q6PK47 Q86TD0
Alternative splicing: 2 isoforms:  Q86SE9-1   Q86SE9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PCGF5: NX_Q86SE9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86SE9

  • PCGF5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243478.1  NP_001244030.1  NP_115749.2  

    ENSEMBL proteins: 
     ENSP00000337500   ENSP00000445704   ENSP00000360752  

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    Uscn Proteins for PCGF5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005813centrosome IDA--
    GO:0031519PcG protein complex IDA--


    PCGF5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PCGF5 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR018957 Znf_C3HC4_RING-type

    Graphical View of Domain Structure for InterPro Entry Q86SE9

    ProtoNet protein and cluster: Q86SE9

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: PCGF5_HUMAN, Q86SE9
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PCGF5_HUMAN, Q86SE9
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the
    transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts
    via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',
    rendering chromatin heritably changed in its expressibility

    miRNA
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    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate PCGF5 (see all 115):
    hsa-miR-520e hsa-miR-520f hsa-miR-631 hsa-miR-15a hsa-miR-199a-3p hsa-miR-30d hsa-miR-890 hsa-miR-30a
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    PCGF5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PCGF5:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCGF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for PCGF5 (Q86SE91, 3 ENSP000003375004) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF2Q994961, 3, ENSP000003564804EBI-2827999,EBI-722416 I2D: score=2 STRING: ENSP00000356480
    RING1Q065871, ENSP000003637874EBI-2827999,EBI-752313 STRING: ENSP00000363787
    CBX8Q9HC521, ENSP000002693854EBI-2827999,EBI-712912 STRING: ENSP00000269385
    JUNP054123I2D: score=2 
    BMI1ENSP000003658514STRING: ENSP00000365851
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    PCGF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PCGF5
    Search CenterWatch for drugs/clinical trials and news about PCGF5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PCGF5 gene (3 alternative transcripts): 
    NM_001256549.1  NM_001257101.1  NM_032373.4  

    Unigene Cluster for PCGF5:

    Polycomb group ring finger 5
    Hs.500512  [show with all ESTs]
    Unigene Representative Sequence: NM_032373
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496708 ENST00000490164(uc001khg.3) ENST00000336126(uc001khh.3 uc010qnk.2 uc001khi.3)
    ENST00000543648 ENST00000371687

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    hsa-miR-520e hsa-miR-520f hsa-miR-631 hsa-miR-15a hsa-miR-199a-3p hsa-miR-30d hsa-miR-890 hsa-miR-30a
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    Additional cDNA sequence: 

    AK055625.1 AK303014.1 AL832003.2 AL832496.1 BC007377.2 BC044910.1 BC051845.1 NR_046310.1 
    NR_046435.1 

    10 DOTS entries:

    DT.310798  DT.75189488  DT.112996  DT.112995  DT.91640829  DT.100745651  DT.91751419  DT.91978791 
    DT.97801384  DT.99928913 

    24/224 AceView cDNA sequences (see all 224):

    AI693823 AI753580 AW167860 BQ023375 BU619767 AA917989 AA258666 CA389100 
    AA306769 AI582393 AI866905 BC051845 CD369625 BM761892 BF112072 CD369282 
    BM662052 BM761949 AA115026 BM511761 CD369734 AA732568 AI022972 AI364160 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PCGF5 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:              -     -     -                 -     -                                                               
    SP2:                                            -     -                                                               
    SP3:                                            -     -     -                                                         
    SP4:                    -     -                 -     -                                                               
    SP5:              -     -     -                                                                                       


    ECgene alternative splicing isoforms for PCGF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PCGF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAAATACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    PCGF5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Extraembryonic endoderm-like cells (Generation of extrae...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PCGF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PCGF5

    SOURCE GeneReport for Unigene cluster: Hs.500512
        SABiosciences Expression via Pathway-Focused PCR Arrays including PCGF5: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCGF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PCGF5 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PCGF51 polycomb group ring finger 5 85.94(n)
    93.75(a)
      423796  XM_421668.3  XP_421668.1 
    lizard
    (Anolis carolinensis)
    Reptilia PCGF56
    --
    88(a)
    1 ↔ 1
    GL343219.1(818301-844053)
    zebrafish
    (Danio rerio)
    Actinopterygii wufd20c052 Transcribed sequence with weak similarity to protein pirJC4296 (D.melanogaster) JC4296 ring finger protein - fruit fly (Drosophila melanogaster) less 78.88(n)    57056698 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DRIP26
    DRIP16
    (see all 3)
    E3 ubiquitin protein ligase DRIP1
    (see all 3)
    14(a)
    14(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(13026000-13030661)
    1(2078911-2081939)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 4)
    zinc finger, C3HC4 type domain containing protein,...
    zinc finger, C3HC4 type domain containing protein,...
    (see all 4)
    14(a)
    13(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    3(33260062-33265172)
    3(30433004-30438158)


    ENSEMBL Gene Tree for PCGF5 (if available)
    TreeFam Gene Tree for PCGF5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PCGF5 gene
    PCGF22  BMI12  PCGF62  PCGF12  PCGF32  
    6 SIMAP similar genes for PCGF5 using alignment to 1 protein entry:     PCGF5_HUMAN:
    PCGF2    PCGF3    PCGF1    BMI1    COMMD3    PCGF6

    PCGF5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2001 NCBI SNPs in PCGF5 are shown (see all 2001    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884748061,2
    --92920885(+) TCCTAC/TTGGAC 2 -- us2k10--------
    rs1127791911,2
    --92920907(+) GGTTCC/TGGCTG 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1466835741,2
    --92920916(+) TGTCTA/CCTCTC 2 -- us2k10--------
    rs1916550771,2
    --92920987(+) TCACCC/TTACCC 2 -- us2k10--------
    rs744499791,2
    F,--92921047(+) AATTAT/CTGCTA 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1134430721,2
    C,--92921072(+) AAGAAAACTT/
            
    TACTT
    2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs111864771,2
    C,F,--92921214(+) CGACAA/GANNNN 2 -- us2k15Minor allele frequency- G:0.18WA NA EA 362
    rs1449625531,2
    C,--92921224(+) CACTA-/CCCTAA 2 -- us2k10--------
    rs1830495461,2
    --92921242(+) GGAAGA/GCTCTT 2 -- us2k10--------
    rs1402374831,2
    --92921286(+) ATGTCG/TACTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PCGF5 (92979908 - 93044088 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PCGF5: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCGF5
    DNA2.0 Custom Variant and Variant Library Synthesis for PCGF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PCGF5 for disorders           About GeneDecksing

    1 disease for PCGF5:    About MalaCards
    alzheimer's disease

    Human Genome Epidemiology (HuGE) Navigator: PCGF5 (1 document)

    Export disorders for PCGF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PCGF5 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with PCGF5)
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    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. (PubMed id 8076819)1, 3 Matoba R....Matsubara K. (1994)
    4. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    5. PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
    6. Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskele ton organization. (PubMed id 21859857)1 Luo T....McBride J.W. (2011)
    7. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)2 Vandamme J.... Angrand P.O. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. An Ehrlichia chaffeensis tandem repeat protein interac ts with multiple host targets involved in cell signaling, transcriptional regula tion, and vesicle trafficking. (PubMed id 19273555)1 Wakeel A....McBride J.W. (2009)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84333 HGNC: 28264 AceView: RNF159 Ensembl:ENSG00000180628 euGenes: HUgn84333
    ECgene: PCGF5 H-InvDB: PCGF5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PCGF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PCGF5 gene:
    Search GeneIP for patents involving PCGF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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