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Aliases for PCGF3 Gene

Aliases for PCGF3 Gene

  • Polycomb Group Ring Finger 3 2 3
  • RING Finger Protein 3A 3 4
  • Ring Finger Protein 3 2 3
  • RNF3A 3 4
  • RNF3 3 4
  • DONG1 3

External Ids for PCGF3 Gene

Previous HGNC Symbols for PCGF3 Gene

  • RNF3

Summaries for PCGF3 Gene

Entrez Gene Summary for PCGF3 Gene

  • The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCGF3 Gene

PCGF3 (Polycomb Group Ring Finger 3) is a Protein Coding gene. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. An important paralog of this gene is BMI1.

UniProtKB/Swiss-Prot for PCGF3 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCGF3 Gene

Genomics for PCGF3 Gene

Regulatory Elements for PCGF3 Gene

Genomic Location for PCGF3 Gene

Chromosome:
4
Start:
705,748 bp from pter
End:
770,640 bp from pter
Size:
64,893 bases
Orientation:
Plus strand

Genomic View for PCGF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCGF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCGF3 Gene

Proteins for PCGF3 Gene

  • Protein details for PCGF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNV8-PCGF3_HUMAN
    Recommended name:
    Polycomb group RING finger protein 3
    Protein Accession:
    Q3KNV8
    Secondary Accessions:
    • D3DVN1
    • O15262

    Protein attributes for PCGF3 Gene

    Size:
    242 amino acids
    Molecular mass:
    28115 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.

    Alternative splice isoforms for PCGF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCGF3 Gene

Proteomics data for PCGF3 Gene at MOPED

Post-translational modifications for PCGF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PCGF3 Gene

Domains & Families for PCGF3 Gene

Protein Domains for PCGF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q3KNV8

UniProtKB/Swiss-Prot:

PCGF3_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PCGF3: view

Function for PCGF3 Gene

Molecular function for PCGF3 Gene

UniProtKB/Swiss-Prot Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility

Gene Ontology (GO) - Molecular Function for PCGF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21282530
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with PCGF3: view
genes like me logo Genes that share phenotypes with PCGF3: view

Animal Model Products

miRNA for PCGF3 Gene

miRTarBase miRNAs that target PCGF3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCGF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PCGF3 Gene

Localization for PCGF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCGF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCGF3 Gene COMPARTMENTS Subcellular localization image for PCGF3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PCGF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21282530
GO:0005654 nucleoplasm IDA --
GO:0031519 PcG protein complex IDA 21282530
genes like me logo Genes that share ontologies with PCGF3: view

Pathways & Interactions for PCGF3 Gene

genes like me logo Genes that share pathways with PCGF3: view

Pathways by source for PCGF3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for PCGF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PCGF3: view

No data available for SIGNOR curated interactions for PCGF3 Gene

Drugs & Compounds for PCGF3 Gene

No Compound Related Data Available

Transcripts for PCGF3 Gene

Unigene Clusters for PCGF3 Gene

Polycomb group ring finger 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCGF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCGF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: - -
SP6: - -
SP7:

Relevant External Links for PCGF3 Gene

GeneLoc Exon Structure for
PCGF3
ECgene alternative splicing isoforms for
PCGF3

Expression for PCGF3 Gene

mRNA expression in normal human tissues for PCGF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PCGF3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCGF3 Gene



SOURCE GeneReport for Unigene cluster for PCGF3 Gene Hs.144309

genes like me logo Genes that share expression patterns with PCGF3: view

Protein tissue co-expression partners for PCGF3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCGF3 Gene

Orthologs for PCGF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCGF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCGF3 35
  • 90.77 (n)
  • 98.35 (a)
PCGF3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCGF3 35
  • 90.5 (n)
  • 98.35 (a)
PCGF3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcgf3 35
  • 88.52 (n)
  • 97.93 (a)
Pcgf3 16
Pcgf3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCGF3 35
  • 99.04 (n)
  • 100 (a)
PCGF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcgf3 35
  • 88.93 (n)
  • 97.93 (a)
oppossum
(Monodelphis domestica)
Mammalia PCGF3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCGF3 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCGF3 35
  • 82.64 (n)
  • 96.69 (a)
PCGF3 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCGF3 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcgf3 35
  • 76.86 (n)
  • 92.56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002533 35
  • 63.79 (n)
  • 65.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)73Ah 35
  • 64.24 (n)
  • 61.36 (a)
l(3)73Ah 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mig-32 35
  • 43.32 (n)
  • 35.02 (a)
mig-32 36
  • 13 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7639 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for PCGF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PCGF3 Gene

ENSEMBL:
Gene Tree for PCGF3 (if available)
TreeFam:
Gene Tree for PCGF3 (if available)

Paralogs for PCGF3 Gene

Paralogs for PCGF3 Gene

Pseudogenes.org Pseudogenes for PCGF3 Gene

genes like me logo Genes that share paralogs with PCGF3: view

Variants for PCGF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCGF3 Gene

Variant ID Type Subtype PubMed ID
nsv508986 CNV Insertion 20534489
nsv822425 CNV Loss 20364138
dgv1564e1 CNV Complex 17122850
nsv878247 CNV Loss 21882294
nsv829834 CNV Loss 17160897
nsv10414 CNV Gain 18304495
nsv822426 CNV Gain 20364138
esv2726685 CNV Deletion 23290073
esv2726686 CNV Deletion 23290073
esv2726687 CNV Deletion 23290073
esv2726688 CNV Deletion 23290073
nsv10415 CNV Loss 18304495
nsv290420 CNV Loss 16902084
esv2666806 CNV Deletion 23128226
esv2726689 CNV Deletion 23290073
esv22794 CNV Gain+Loss 19812545
esv1002264 CNV Loss 20482838
esv2726690 CNV Deletion 23290073
esv2726691 CNV Deletion 23290073
esv2665221 CNV Deletion 23128226
nsv878253 CNV Loss 21882294
dgv5389n71 CNV Loss 21882294
dgv5390n71 CNV Loss 21882294
esv2726692 CNV Deletion 23290073
esv1347923 CNV Deletion 17803354
esv2726693 CNV Deletion 23290073
esv2741953 CNV Deletion 23290073
nsv878256 CNV Loss 21882294
esv2726694 CNV Deletion 23290073
esv2726697 CNV Deletion 23290073
esv2726698 CNV Deletion 23290073
esv2726699 CNV Deletion 23290073
esv2726700 CNV Deletion 23290073
esv2726701 CNV Deletion 23290073
esv2726702 CNV Deletion 23290073
esv23784 CNV Loss 19812545
esv2726703 CNV Deletion 23290073
nsv4195 CNV Loss 18451855
esv2315321 CNV Deletion 18987734
esv2726704 CNV Deletion 23290073
esv2660636 CNV Deletion 23128226
esv2726705 CNV Deletion 23290073
nsv293714 CNV Loss 16902084
nsv10416 CNV Gain 18304495
nsv513112 CNV Loss 21212237
esv2441628 CNV Deletion 19546169
esv27696 CNV Gain+Loss 19812545
dgv132n6 CNV Loss 16902084
esv2726706 CNV Deletion 23290073
esv2678759 CNV Deletion 23128226
esv1431312 CNV Deletion 17803354
esv1002699 CNV Deletion 20482838
nsv513113 CNV Loss 21212237
nsv10418 CNV Loss 18304495
esv29088 CNV Loss 19812545
esv2726708 CNV Deletion 23290073
esv2670226 CNV Deletion 23128226
esv1335990 CNV Deletion 17803354
nsv818207 CNV Gain 17921354
dgv5391n71 CNV Loss 21882294
nsv520136 CNV Gain 19592680

Variation tolerance for PCGF3 Gene

Residual Variation Intolerance Score: 48.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCGF3 Gene

HapMap Linkage Disequilibrium report
PCGF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PCGF3 Gene

Disorders for PCGF3 Gene

Relevant External Links for PCGF3

Genetic Association Database (GAD)
PCGF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCGF3
genes like me logo Genes that share disorders with PCGF3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCGF3 Gene

Publications for PCGF3 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. An AUTS2-Polycomb complex activates gene expression in the CNS. (PMID: 25519132) Gao Z. … Reinberg D. (Nature 2014) 67
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 67

Products for PCGF3 Gene

Sources for PCGF3 Gene

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