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Aliases for PCGF3 Gene

Aliases for PCGF3 Gene

  • Polycomb Group Ring Finger 3 2 3
  • RING Finger Protein 3A 3 4
  • Ring Finger Protein 3 2 3
  • RNF3A 3 4
  • RNF3 3 4
  • Polycomb Group RING Finger Protein 3 3
  • DONG1 3

External Ids for PCGF3 Gene

Previous HGNC Symbols for PCGF3 Gene

  • RNF3

Summaries for PCGF3 Gene

Entrez Gene Summary for PCGF3 Gene

  • The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCGF3 Gene

PCGF3 (Polycomb Group Ring Finger 3) is a Protein Coding gene. An important paralog of this gene is BMI1.

UniProtKB/Swiss-Prot for PCGF3 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCGF3 Gene

Genomics for PCGF3 Gene

Regulatory Elements for PCGF3 Gene

Genomic Location for PCGF3 Gene

Start:
705,748 bp from pter
End:
770,640 bp from pter
Size:
64,893 bases
Orientation:
Plus strand

Genomic View for PCGF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCGF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCGF3 Gene

Proteins for PCGF3 Gene

  • Protein details for PCGF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNV8-PCGF3_HUMAN
    Recommended name:
    Polycomb group RING finger protein 3
    Protein Accession:
    Q3KNV8
    Secondary Accessions:
    • D3DVN1
    • O15262

    Protein attributes for PCGF3 Gene

    Size:
    242 amino acids
    Molecular mass:
    28115 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.

    Alternative splice isoforms for PCGF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCGF3 Gene

Proteomics data for PCGF3 Gene at MOPED

Post-translational modifications for PCGF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCGF3 Gene

Domains for PCGF3 Gene

Gene Families for PCGF3 Gene

HGNC:
  • PCGF :Polycomb group ring fingers
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for PCGF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q3KNV8

UniProtKB/Swiss-Prot:

PCGF3_HUMAN :
  • Q3KNV8
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PCGF3: view

Function for PCGF3 Gene

Molecular function for PCGF3 Gene

UniProtKB/Swiss-Prot Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility

Gene Ontology (GO) - Molecular Function for PCGF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21282530
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with PCGF3: view

Phenotypes for PCGF3 Gene

MGI mutant phenotypes for PCGF3:
inferred from 1 alleles
GenomeRNAi human phenotypes for PCGF3:
genes like me logo Genes that share phenotypes with PCGF3: view

Animal Model Products

CRISPR Products

miRNA for PCGF3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCGF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PCGF3 Gene

Localization for PCGF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCGF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCGF3 Gene COMPARTMENTS Subcellular localization image for PCGF3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PCGF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21282530
GO:0005654 nucleoplasm IDA --
GO:0031519 PcG protein complex IDA 21282530
genes like me logo Genes that share ontologies with PCGF3: view

Pathways for PCGF3 Gene

SuperPathways for PCGF3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat
    • Polycomb & Trithorax Complexes in human,mouse,rat
    • Ubiquitin Ligases in human,mouse,rat

Gene Ontology (GO) - Biological Process for PCGF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PCGF3: view

No data available for Pathways by source for PCGF3 Gene

Transcripts for PCGF3 Gene

Unigene Clusters for PCGF3 Gene

Polycomb group ring finger 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCGF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCGF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: - -
SP6: - -
SP7:

Relevant External Links for PCGF3 Gene

GeneLoc Exon Structure for
PCGF3
ECgene alternative splicing isoforms for
PCGF3

Expression for PCGF3 Gene

mRNA expression in normal human tissues for PCGF3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCGF3 Gene

SOURCE GeneReport for Unigene cluster for PCGF3 Gene Hs.144309

genes like me logo Genes that share expressions with PCGF3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCGF3 Gene

Orthologs for PCGF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCGF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCGF3 35
  • 99.04 (n)
  • 100 (a)
PCGF3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PCGF3 35
  • 90.77 (n)
  • 98.35 (a)
PCGF3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCGF3 35
  • 90.5 (n)
  • 98.35 (a)
PCGF3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcgf3 35
  • 88.52 (n)
  • 97.93 (a)
Pcgf3 16
Pcgf3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCGF3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCGF3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcgf3 35
  • 88.93 (n)
  • 97.93 (a)
chicken
(Gallus gallus)
Aves PCGF3 35
  • 82.64 (n)
  • 96.69 (a)
PCGF3 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCGF3 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcgf3 35
  • 76.86 (n)
  • 92.56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002533 35
  • 63.79 (n)
  • 65.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)73Ah 35
  • 64.24 (n)
  • 61.36 (a)
l(3)73Ah 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mig-32 35
  • 43.32 (n)
  • 35.02 (a)
mig-32 36
  • 13 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7639 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for PCGF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PCGF3 Gene

ENSEMBL:
Gene Tree for PCGF3 (if available)
TreeFam:
Gene Tree for PCGF3 (if available)

Paralogs for PCGF3 Gene

Paralogs for PCGF3 Gene

Pseudogenes.org Pseudogenes for PCGF3 Gene

genes like me logo Genes that share paralogs with PCGF3: view

Variants for PCGF3 Gene

Sequence variations from dbSNP and Humsavar for PCGF3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1894 -- 768,062(-) CAAAT(A/G)TATAT utr-variant-3-prime
rs7336 -- 766,470(+) CTCAA(G/T)TGTAG utr-variant-3-prime
rs747504 -- 740,889(+) CTTTG(A/G)GCAGC intron-variant
rs899389 -- 752,183(+) GAAGC(C/G)GCCTC intron-variant
rs899390 -- 752,650(+) TGGGG(G/T)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCGF3 Gene

Variant ID Type Subtype PubMed ID
nsv508986 CNV Insertion 20534489
nsv822425 CNV Loss 20364138
dgv1564e1 CNV Complex 17122850
nsv878247 CNV Loss 21882294
nsv829834 CNV Loss 17160897
nsv10414 CNV Gain 18304495
nsv822426 CNV Gain 20364138
esv2726685 CNV Deletion 23290073
esv2726686 CNV Deletion 23290073
esv2726687 CNV Deletion 23290073
esv2726688 CNV Deletion 23290073
nsv10415 CNV Loss 18304495
nsv290420 CNV Loss 16902084
esv2666806 CNV Deletion 23128226
esv2726689 CNV Deletion 23290073
esv22794 CNV Gain+Loss 19812545
esv1002264 CNV Loss 20482838
esv2726690 CNV Deletion 23290073
esv2726691 CNV Deletion 23290073
esv2665221 CNV Deletion 23128226
nsv878253 CNV Loss 21882294
dgv5389n71 CNV Loss 21882294
dgv5390n71 CNV Loss 21882294
esv2726692 CNV Deletion 23290073
esv1347923 CNV Deletion 17803354
esv2726693 CNV Deletion 23290073
esv2741953 CNV Deletion 23290073
nsv878256 CNV Loss 21882294
esv2726694 CNV Deletion 23290073
esv2726697 CNV Deletion 23290073
esv2726698 CNV Deletion 23290073
esv2726699 CNV Deletion 23290073
esv2726700 CNV Deletion 23290073
esv2726701 CNV Deletion 23290073
esv2726702 CNV Deletion 23290073
esv23784 CNV Loss 19812545
esv2726703 CNV Deletion 23290073
nsv4195 CNV Loss 18451855
esv2315321 CNV Deletion 18987734
esv2726704 CNV Deletion 23290073
esv2660636 CNV Deletion 23128226
esv2726705 CNV Deletion 23290073
nsv293714 CNV Loss 16902084
nsv10416 CNV Gain 18304495
nsv513112 CNV Loss 21212237
esv2441628 CNV Deletion 19546169
esv27696 CNV Gain+Loss 19812545
dgv132n6 CNV Loss 16902084
esv2726706 CNV Deletion 23290073
esv2678759 CNV Deletion 23128226
esv1431312 CNV Deletion 17803354
esv1002699 CNV Deletion 20482838
nsv513113 CNV Loss 21212237
nsv10418 CNV Loss 18304495
esv29088 CNV Loss 19812545
esv2726708 CNV Deletion 23290073
esv2670226 CNV Deletion 23128226
esv1335990 CNV Deletion 17803354
nsv818207 CNV Gain 17921354
dgv5391n71 CNV Loss 21882294
nsv520136 CNV Gain 19592680

Relevant External Links for PCGF3 Gene

HapMap Linkage Disequilibrium report
PCGF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCGF3 Gene

Disorders for PCGF3 Gene

Relevant External Links for PCGF3

Genetic Association Database (GAD)
PCGF3
genes like me logo Genes that share disorders with PCGF3: view

No data available for UniProtKB/Swiss-Prot for PCGF3 Gene

Publications for PCGF3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3 4
  3. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PMID: 22443383) Oudot-Mellakh T. … Morange P.E. (Br. J. Haematol. 2012) 3 48
  4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for PCGF3 Gene

Sources for PCGF3 Gene

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