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Aliases for PCGF2 Gene

Aliases for PCGF2 Gene

  • Polycomb Group Ring Finger 2 2 3
  • DNA-Binding Protein Mel-18 3 4
  • Ring Finger Protein 110 2 3
  • Zinc Finger Protein 144 3 4
  • RNF110 3 4
  • ZNF144 3 4
  • RING Finger Protein 110 4
  • MEL-18 3
  • MEL18 4

External Ids for PCGF2 Gene

Previous HGNC Symbols for PCGF2 Gene

  • ZNF144
  • RNF110

Previous GeneCards Identifiers for PCGF2 Gene

  • GC17M034144
  • GC17M036890
  • GC17M032686

Summaries for PCGF2 Gene

Entrez Gene Summary for PCGF2 Gene

  • The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCGF2 Gene

PCGF2 (Polycomb Group Ring Finger 2) is a Protein Coding gene. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for PCGF2 Gene

  • Transcriptional repressor. Binds specifically to the DNA sequence 5-GACTNGACT-3. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).

Gene Wiki entry for PCGF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCGF2 Gene

Genomics for PCGF2 Gene

Regulatory Elements for PCGF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCGF2 Gene

Chromosome:
17
Start:
38,733,897 bp from pter
End:
38,749,817 bp from pter
Size:
15,921 bases
Orientation:
Minus strand

Genomic View for PCGF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCGF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCGF2 Gene

Proteins for PCGF2 Gene

  • Protein details for PCGF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35227-PCGF2_HUMAN
    Recommended name:
    Polycomb group RING finger protein 2
    Protein Accession:
    P35227
    Secondary Accessions:
    • A6NGD8

    Protein attributes for PCGF2 Gene

    Size:
    344 amino acids
    Molecular mass:
    37788 Da
    Quaternary structure:
    • Exists as both a monomer and homodimer (By similarity). Component of a PRC1-like complex. Interacts WITH CBX8, RING1 AND RNF2.

neXtProt entry for PCGF2 Gene

Proteomics data for PCGF2 Gene at MOPED

Post-translational modifications for PCGF2 Gene

  • Phosphorylated. Homodimer formation is regulated by phosphorylation state with unphosphorylated protein forming homodimers (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCGF2 Gene

Antibody Products

No data available for DME Specific Peptides for PCGF2 Gene

Domains & Families for PCGF2 Gene

Protein Domains for PCGF2 Gene

Suggested Antigen Peptide Sequences for PCGF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35227

UniProtKB/Swiss-Prot:

PCGF2_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PCGF2: view

Function for PCGF2 Gene

Molecular function for PCGF2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds specifically to the DNA sequence 5-GACTNGACT-3. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).

Gene Ontology (GO) - Molecular Function for PCGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8325509
GO:0005515 protein binding IPI 19636380
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PCGF2: view
genes like me logo Genes that share phenotypes with PCGF2: view

Animal Models for PCGF2 Gene

MGI Knock Outs for PCGF2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCGF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PCGF2 Gene

Localization for PCGF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCGF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCGF2 Gene COMPARTMENTS Subcellular localization image for PCGF2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PCGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 19636380
GO:0001739 sex chromatin IEA --
GO:0005634 nucleus IDA 21282530
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body IEA --
genes like me logo Genes that share ontologies with PCGF2: view

Pathways & Interactions for PCGF2 Gene

genes like me logo Genes that share pathways with PCGF2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PCGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19636380
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with PCGF2: view

No data available for SIGNOR curated interactions for PCGF2 Gene

Drugs & Compounds for PCGF2 Gene

No Compound Related Data Available

Transcripts for PCGF2 Gene

Unigene Clusters for PCGF2 Gene

Polycomb group ring finger 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCGF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCGF2 Gene

No ASD Table

Relevant External Links for PCGF2 Gene

GeneLoc Exon Structure for
PCGF2
ECgene alternative splicing isoforms for
PCGF2

Expression for PCGF2 Gene

mRNA expression in normal human tissues for PCGF2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PCGF2 Gene



SOURCE GeneReport for Unigene cluster for PCGF2 Gene Hs.371617

mRNA Expression by UniProt/SwissProt for PCGF2 Gene

P35227-PCGF2_HUMAN
Tissue specificity: Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle
genes like me logo Genes that share expression patterns with PCGF2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for PCGF2 Gene

Orthologs for PCGF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCGF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCGF2 35
  • 92.15 (n)
  • 96.51 (a)
dog
(Canis familiaris)
Mammalia PCGF2 35
  • 92.15 (n)
  • 96.51 (a)
mouse
(Mus musculus)
Mammalia Pcgf2 35
  • 88.5 (n)
  • 95.91 (a)
Pcgf2 16
chimpanzee
(Pan troglodytes)
Mammalia PCGF2 35
  • 99.61 (n)
  • 99.42 (a)
rat
(Rattus norvegicus)
Mammalia Pcgf2 35
  • 88.79 (n)
  • 95.91 (a)
chicken
(Gallus gallus)
Aves PCGF2 35
  • 76.86 (n)
  • 79.94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcgf2 35
  • 69.41 (n)
  • 68.99 (a)
Species with no ortholog for PCGF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCGF2 Gene

ENSEMBL:
Gene Tree for PCGF2 (if available)
TreeFam:
Gene Tree for PCGF2 (if available)

Paralogs for PCGF2 Gene

(8) SIMAP similar genes for PCGF2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PCGF2: view

No data available for Paralogs for PCGF2 Gene

Variants for PCGF2 Gene

Sequence variations from dbSNP and Humsavar for PCGF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs123843 -- 38,744,184(+) CCCAC(A/G)TTCTG intron-variant
rs228229 -- 38,743,968(+) CAGAT(C/G)CCAAG intron-variant
rs228230 -- 38,745,286(+) gagat(C/T)gcgcc intron-variant
rs741030 -- 38,744,729(-) CAGGG(A/G/T)ACCAT intron-variant
rs933457 -- 38,740,854(+) GCCCA(A/G)GACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCGF2 Gene

Variant ID Type Subtype PubMed ID
nsv833438 CNV Loss 17160897
nsv908196 CNV Loss 21882294
nsv470585 CNV Loss 18288195
nsv833439 CNV Loss 17160897

Variation tolerance for PCGF2 Gene

Residual Variation Intolerance Score: 29.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCGF2 Gene

HapMap Linkage Disequilibrium report
PCGF2
Human Gene Mutation Database (HGMD)
PCGF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCGF2 Gene

Disorders for PCGF2 Gene

Relevant External Links for PCGF2

Genetic Association Database (GAD)
PCGF2
Human Genome Epidemiology (HuGE) Navigator
PCGF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCGF2
genes like me logo Genes that share disorders with PCGF2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCGF2 Gene

Publications for PCGF2 Gene

  1. Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif. (PMID: 8325509) Ishida A. … Kanno M. (Gene 1993) 2 23 67
  2. The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance. (PMID: 19585577) Wang W. … Habuchi T. (Int. J. Cancer 2009) 23 67
  3. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 23 67
  4. Mel-18 interacts with RanGAP1 and inhibits its sumoylation. (PMID: 18706886) Zhang J. … Sarge K.D. (Biochem. Biophys. Res. Commun. 2008) 23 67
  5. Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia. (PMID: 18410541) Grubach L. … Ostergaard M. (Eur. J. Haematol. 2008) 23 67

Products for PCGF2 Gene

Sources for PCGF2 Gene

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