Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PCF11 Gene

protein-coding   GIFtS: 53
GCID: GC11P082868

PCF11, cleavage and polyadenylation factor subunit, homolog...

(Previous names: PCF11, cleavage and polyadenylation factor II subunit,...)
  Search for PCF11
in our new
 Human Malady Compendium 
Biological research products
for PCF11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
PCF11, Cleavage And Polyadenylation Factor Subunit, Homolog (S.
Cerevisiae)1 2
     PCF11, Cleavage And Polyadenylation Factor II Subunit, Homolog2
KIAA08241 3     PCF11p Homolog2
Pre-MRNA Cleavage Complex II Protein Pcf112 3     Pre-MRNA Cleavage Complex 2 Protein Pcf112
PCF11, Cleavage And Polyadenylation Factor II Subunit, Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 300971   Entrez Gene: 515852   Ensembl: ENSG000001654947   OMIM: 6088765   UniProtKB: O949133   

Export aliases for PCF11 gene to outside databases

Previous GC identifers: GC11P085194 GC11P084407 GC11P083090 GC11P082594 GC11P082545 GC11P079165


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PCF11_HUMAN, O94913
Function: Component of pre-mRNA cleavage complex II




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PCF11 gene promoter:
         E2F-3a   E2F-4   E2F-5   GATA-3   Tal-1   E2F-2   YY1   E47   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCF11 promoter sequence
   Search SABiosciences Chromatin IP Primers for PCF11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q13

PCF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCF11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P082868:  view genomic region     (about GC identifiers)

Start:
82,868,030 bp from pter      End:
82,898,493 bp from pter
Size:
30,464 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PCF11_HUMAN, O94913 (See protein sequence)
Recommended Name: Pre-mRNA cleavage complex 2 protein Pcf11  
Size: 1555 amino acids; 173050 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAC03107.1; Type=Frameshift; Positions=712; Sequence=AAC03107.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA74847.1; Type=Erroneous initiation;
Secondary accessions: A6H8W7 O43671 Q6P0X8

Explore the universe of human proteins at neXtProt for PCF11: NX_O94913

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O94913

  • PCF11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056969.2  
    ENSEMBL proteins: 
     ENSP00000298281   ENSP00000434540   ENSP00000431567   ENSP00000436806   ENSP00000437076  
    Reactome Protein details: O94913
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for PCF11 
    GenScript Custom Purified and Recombinant Proteins Services for PCF11
    Novus Biologicals PCF11 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PCF11

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005849mRNA cleavage factor complex NAS11060040


    PCF11 for ontologies           About GeneDecksing



    PCF11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PCF11 
    GenScript Custom Superior Antibodies Services for PCF11
    Novus Biologicals PCF11 Antibodies
    Search for Antibodies for PCF11 at Abcam  
    Uscn Antibodies for PCF11
    Search ThermoFisher Antibodies for PCF11

    Assay Products for PCF11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PCF11
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PCF11


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PCF11 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006569 RNA_polymerase_II_lsu_CTD
     IPR006903 RNA_pol_II-bd
     IPR008942 ENTH_VHS

    Graphical View of Domain Structure for InterPro Entry O94913

    ProtoNet protein and cluster: O94913

    1 Blocks protein family: IPB006569 Regulation of nuclear pre-mRNA protein

    UniProtKB/Swiss-Prot: PCF11_HUMAN, O94913
    Similarity: Contains 1 CID domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PCF11_HUMAN, O94913
    Function: Component of pre-mRNA cleavage complex II

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: PCF11
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PCF11
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate PCF11 (see all 16):
    hsa-miR-548k hsa-miR-374a hsa-miR-3622b-3p hsa-miR-556-3p hsa-miR-412 hsa-miR-3650 hsa-miR-548p hsa-miR-374b
    SwitchGear 3'UTR luciferase reporter plasmidPCF11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PCF11 (see all 4)
    OriGene shRNA RFP: PCF11
    OriGene siRNA: PCF11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCF11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PCF11

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCF11 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCF11
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PCF11 (NM_015885)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCF11 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PCF11
    Search LifeMap BioReagents cell lines for PCF11

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCF11

    8 GenomeRNAi human phenotypes for PCF11:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased S DNA content 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce  Nuclear pre-40S maturation def  S arrest 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination1.00
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    Post-Elongation Processing of the Transcript1.00
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 1.00
    2mRNA Splicing - Major Pathway
    mRNA Splicing1.00
    Processing of Capped Intron-Containing Pre-mRNA0.96
    mRNA Splicing - Major Pathway1.00
    mRNA Processing0.82
    3Post-Elongation Processing of Intronless pre-mRNA
    Processing of Capped Intronless Pre-mRNA1.00
    Processing of Intronless Pre-mRNAs0.61
    Post-Elongation Processing of Intronless pre-mRNA1.00
    4Transcription
    Transcription1.00
    RNA Polymerase II Transcription0.69
    5mRNA surveillance pathway
    mRNA surveillance pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/15        Reactome Pathways for PCF11 (see all 15)
        mRNA Splicing - Major Pathway
    mRNA Splicing
    RNA Polymerase II Transcription
    Transcription
    Cleavage of Growing Transcript in the Termination Region


    1         Kegg Pathway  (Kegg details for PCF11):
        mRNA surveillance pathway


    PCF11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/607 Interacting proteins for PCF11 (O949132, 3 ENSP000002982814) via UniProtKB, MINT, STRING, and/or I2D (see all 607)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 I2D: score=1 STRING: ENSP00000326261
    POLR2GP624873, ENSP000003017884I2D: score=2 STRING: ENSP00000301788
    ALYREFQ86V813, ENSP000003318174I2D: score=1 STRING: ENSP00000331817
    CPSF3Q9UKF62, ENSP000002381124MINT-7945693 STRING: ENSP00000238112
    CPSF4O956392, ENSP000002924764MINT-7945693 STRING: ENSP00000292476
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006379mRNA cleavage NAS11060040
    GO:0006397mRNA processing TAS--


    PCF11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PCF11
    Search CenterWatch for drugs/clinical trials and news about PCF11 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PCF11 gene: 
    NM_015885.3  

    Unigene Clusters for PCF11:

    PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)
    Hs.128959  [show with all ESTs], Hs.731825  [show with all ESTs]
    Unigene Representative Sequences: NM_015885, BX440040
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298281(uc010rsu.1 uc001ozx.4) ENST00000530660 ENST00000530304
    ENST00000533018 ENST00000526160 ENST00000530906 ENST00000528336

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: PCF11
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PCF11
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate PCF11 (see all 16):
    hsa-miR-548k hsa-miR-374a hsa-miR-3622b-3p hsa-miR-556-3p hsa-miR-412 hsa-miR-3650 hsa-miR-548p hsa-miR-374b
    SwitchGear 3'UTR luciferase reporter plasmidPCF11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PCF11 (see all 4)
    OriGene shRNA RFP: PCF11
    OriGene siRNA: PCF11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCF11
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCF11 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCF11
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PCF11 (NM_015885)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCF11 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCF11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PCF11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCF11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCF11

    Additional cDNA sequence: AF086097.1 

    19 DOTS entries:

    DT.212811  DT.100797590  DT.97858936  DT.97790166  DT.110241  DT.91686964  DT.120721826  DT.120721843 
    DT.120721962  DT.95209225  DT.95275585  DT.95299359  DT.97770451  DT.100737692  DT.100797592  DT.100797593 
    DT.100840316  DT.120721868  DT.92426381 

    24/210 AceView cDNA sequences (see all 210):

    AI160519 BF589073 BQ436024 BX956592 CA868393 BX477222 BU950428 AW118175 
    AW079870 AI383455 BE159504 BE900709 AA580151 BM795455 CR601694 BU607485 
    BM679801 CR595078 CB159490 AA668949 AI240255 AI435927 BC065384 AL704817 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PCF11 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16
    SP1:                                                              -     -                 -                       -                                 
    SP2:                                                                                                              -                                 
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for PCF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PCF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PCF11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PCF11

    SOURCE GeneReport for Unigene clusters: Hs.128959 Hs.731825
        SABiosciences Custom PCR Arrays for PCF11
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCF11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PCF11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCF11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCF11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCF11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PCF11 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcf111 , 5 cleavage and polyadenylation factor subunit homolog more1, 5 91.59(n)1
    93.93(a)1
      7 (51.56 cM)5
    747371  NM_029078.31  NP_083354.31 
     926437125 
    chicken
    (Gallus gallus)
    Aves PCF111 PCF11, cleavage and polyadenylation factor subunit, more 75.11(n)
    76.1(a)
      419021  XM_417214.3  XP_417214.3 
    lizard
    (Anolis carolinensis)
    Reptilia PCF116
    --
    68(a)
    1 ↔ 1
    3(202082288-202106670)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.86132 Xenopus laevis transcribed sequence with moderate similarity more 75.61(n)    BX847770.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.188932 Transcribed sequence with moderate similarity to protein more 80.19(n)    CK028345.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102283 mRNA cleavage 43(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea pcf-116
    Polyadenylation and cleavage factor homolog 11
    22(a)
    1 ↔ 1
    III(5024930-5029388)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G436206
    AT1G665006
    (see all 4)
    Pre-mRNA cleavage complex II
    (see all 4)
    18(a)
    17(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    5(17522520-17524001)
    1(24811149-24812650)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    ZOS9-20 - C2H2 zinc finger protein, expressed
    15(a)
    14(a)
    many → 1
    many → 1
    8(5117738-5127137)
    9(22565971-22572226)


    ENSEMBL Gene Tree for PCF11 (if available)
    TreeFam Gene Tree for PCF11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/518 NCBI SNPs in PCF11 are shown (see all 518    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71143601,2
    C,F,H,--82866228(+) TTGGAC/TGTTAT 1 -- us2k1 tfbs312Minor allele frequency- T:0.10NS EA NA WA 1402
    rs1400656551,2
    --82866343(+) GAAGAC/TCAGTT 1 -- us2k10--------
    rs1451829951,2
    --82866383(+) GTGTGA/GTATCA 1 -- us2k10--------
    rs1390373951,2
    --82866495(+) AACTC-/AAAG  
            
    AAACA
    1 -- us2k10--------
    rs1509555081,2
    --82866539(+) GGGACA/CAGTAA 1 -- us2k10--------
    rs37638111,2
    C,F,A,H,--82866567(-) AAAAAT/CAAACA 1 -- us2k1 tfbs36Minor allele frequency- C:0.29NA WA 14
    rs1429379851,2
    C,--82866574(+) TTTTT-/GAGAGAG 1 -- us2k10--------
    rs1394690341,2
    --82866640(+) AACCTC/TTGCCT 1 -- us2k10--------
    rs1496544341,2
    --82866884(+) ATCTCA/GGCTCA 1 -- us2k10--------
    rs37638101,2
    C,F,--82866999(-) CTCTAT/CTAAAA 1 -- us2k14Minor allele frequency- C:0.38NA WA 8

    HapMap Linkage Disequilibrium report for PCF11 (82868030 - 82898493 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PCF11
         1 CNV: 6945

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCF11
    DNA2.0 Custom Variant and Variant Library Synthesis for PCF11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PCF11 for disorders           About MalaCards

    PCF11 for disorders           About GeneDecksing

    OMIM gene information: 608876    OMIM disorders: --


    Export disorders for PCF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PCF11 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with PCF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. (PubMed id 11060040)1, 2, 3 de Vries H....Keller W. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    10. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51585 HGNC: 30097 AceView: PCF11 Ensembl:ENSG00000165494 euGenes: HUgn51585
    ECgene: PCF11 Kegg: 51585 H-InvDB: PCF11

    (According to HUGE)
    About This Section
    HUGE: KIAA0824

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PCF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PCF11 gene:
    Search GeneIP for patents involving PCF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PCF11  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PCF11   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCF11  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PCF11   OriGene 3'-UTR Clone for PCF11  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCF11   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCF11  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PCF11   OriGene Custom Protein Services for PCF11  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PCF11
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCF11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCF11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCF11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCF11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCF11
     GenScript Custom Purified and Recombinant Proteins Services for PCF11 GenScript cDNA clones with any tag delivered in your preferred vector for PCF11
     GenScript Custom Assay Services for PCF11 GenScript Custom Superior Antibodies Services for PCF11
     GenScript Custom overexpressing Cell Line Services for PCF11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PCF11 promoter
     Search Chromatin IP Primers for PCF11
     RT2 qPCR Primer Assay in human, mouse / rat PCF11
     Search GNC Networks for PCF11
     SABiosciences Custom PCR Arrays for PCF11
     Search Tocris compounds for PCF11
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PCF11 antibodies
     PCF11 proteins
     Search for Antibodies for PCF11 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PCF11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PCF11 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PCF11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCF11
     SwitchGear 3'UTR luciferase reporter plasmids for PCF11
     SwitchGear Promoter luciferase reporter plasmids for PCF11
     Search ThermoFisher Antibodies for PCF11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCF11
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PCF11 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4