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Aliases for PCF11 Gene

Aliases for PCF11 Gene

  • PCF11 Cleavage And Polyadenylation Factor Subunit 2 3
  • PCF11, Cleavage And Polyadenylation Factor II Subunit, Homolog (S. Cerevisiae) 2
  • PCF11, Cleavage And Polyadenylation Factor Subunit, Homolog (S. Cerevisiae) 2
  • Pre-MRNA Cleavage Complex II Protein Pcf11 4
  • KIAA0824 4

External Ids for PCF11 Gene

Previous GeneCards Identifiers for PCF11 Gene

  • GC11P085194
  • GC11P084407
  • GC11P083090
  • GC11P082594
  • GC11P082545
  • GC11P082868
  • GC11P079165

Summaries for PCF11 Gene

GeneCards Summary for PCF11 Gene

PCF11 (PCF11 Cleavage And Polyadenylation Factor Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include mRNA binding and RNA polymerase II core binding.

UniProtKB/Swiss-Prot for PCF11 Gene

  • Component of pre-mRNA cleavage complex II

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCF11 Gene

Genomics for PCF11 Gene

Regulatory Elements for PCF11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCF11 Gene

Chromosome:
11
Start:
83,156,988 bp from pter
End:
83,187,451 bp from pter
Size:
30,464 bases
Orientation:
Plus strand

Genomic View for PCF11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PCF11 Gene

Proteins for PCF11 Gene

  • Protein details for PCF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94913-PCF11_HUMAN
    Recommended name:
    Pre-mRNA cleavage complex 2 protein Pcf11
    Protein Accession:
    O94913
    Secondary Accessions:
    • A6H8W7
    • O43671
    • Q6P0X8

    Protein attributes for PCF11 Gene

    Size:
    1555 amino acids
    Molecular mass:
    173050 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC03107.1; Type=Frameshift; Positions=712; Evidence={ECO:0000305}; Sequence=AAC03107.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA74847.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PCF11 Gene

Proteomics data for PCF11 Gene at MOPED

Post-translational modifications for PCF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCF11 Gene

No data available for DME Specific Peptides for PCF11 Gene

Domains & Families for PCF11 Gene

Protein Domains for PCF11 Gene

Suggested Antigen Peptide Sequences for PCF11 Gene

Graphical View of Domain Structure for InterPro Entry

O94913

UniProtKB/Swiss-Prot:

PCF11_HUMAN :
  • Contains 1 CID domain.
Domain:
  • Contains 1 CID domain.
genes like me logo Genes that share domains with PCF11: view

No data available for Gene Families for PCF11 Gene

Function for PCF11 Gene

Molecular function for PCF11 Gene

UniProtKB/Swiss-Prot Function:
Component of pre-mRNA cleavage complex II

Gene Ontology (GO) - Molecular Function for PCF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IBA --
GO:0003729 mRNA binding IBA --
genes like me logo Genes that share ontologies with PCF11: view
genes like me logo Genes that share phenotypes with PCF11: view

Animal Model Products

miRNA for PCF11 Gene

miRTarBase miRNAs that target PCF11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PCF11 Gene

Localization for PCF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCF11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCF11 Gene COMPARTMENTS Subcellular localization image for PCF11 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PCF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005849 mRNA cleavage factor complex NAS 11060040
genes like me logo Genes that share ontologies with PCF11: view

Pathways & Interactions for PCF11 Gene

genes like me logo Genes that share pathways with PCF11: view

Gene Ontology (GO) - Biological Process for PCF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IBA --
GO:0006379 mRNA cleavage NAS 11060040
genes like me logo Genes that share ontologies with PCF11: view

No data available for SIGNOR curated interactions for PCF11 Gene

Drugs & Compounds for PCF11 Gene

No Compound Related Data Available

Transcripts for PCF11 Gene

Unigene Clusters for PCF11 Gene

PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCF11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16
SP1: - - - -
SP2: -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for PCF11 Gene

GeneLoc Exon Structure for
PCF11
ECgene alternative splicing isoforms for
PCF11

Expression for PCF11 Gene

mRNA expression in normal human tissues for PCF11 Gene

Protein differential expression in normal tissues from HIPED for PCF11 Gene

This gene is overexpressed in Brain (28.8), Cerebrospinal fluid (14.0), and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCF11 Gene



SOURCE GeneReport for Unigene cluster for PCF11 Gene Hs.128959

genes like me logo Genes that share expression patterns with PCF11: view

Protein tissue co-expression partners for PCF11 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCF11 Gene

Orthologs for PCF11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PCF11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC510604 35
  • 92.47 (n)
  • 94.2 (a)
PCF11 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCF11 35
  • 95.2 (n)
  • 97.56 (a)
PCF11 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcf11 35
  • 91.59 (n)
  • 93.93 (a)
Pcf11 16
Pcf11 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCF11 35
  • 98.53 (n)
  • 98.23 (a)
PCF11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcf11 35
  • 91.69 (n)
  • 94.25 (a)
oppossum
(Monodelphis domestica)
Mammalia PCF11 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCF11 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCF11 35
  • 74.93 (n)
  • 76.04 (a)
PCF11 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCF11 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10887 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8613 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18893 35
pcf11 35
  • 58.44 (n)
  • 54.36 (a)
pcf11 36
  • 45 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6287 35
fruit fly
(Drosophila melanogaster)
Insecta CG10228 37
  • 43 (a)
Pcf11 36
  • 14 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pcf-11 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PCF11 36
  • 25 (a)
OneToOne
PCF11 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5693 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToOne
Species with no ortholog for PCF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCF11 Gene

ENSEMBL:
Gene Tree for PCF11 (if available)
TreeFam:
Gene Tree for PCF11 (if available)

Paralogs for PCF11 Gene

No data available for Paralogs for PCF11 Gene

Variants for PCF11 Gene

Sequence variations from dbSNP and Humsavar for PCF11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10801 -- 83,185,744(-) ATGGT(A/G)TCCAT utr-variant-3-prime
rs471880 -- 83,180,290(+) ACCAC(A/G)TTGGT intron-variant
rs504171 -- 83,174,486(+) agtgt(G/T)gggtt intron-variant
rs518454 -- 83,178,212(-) tgaaa(C/G)cccat intron-variant
rs535469 -- 83,181,462(-) AGCCT(G/T)GGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCF11 Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV Loss 17666407

Variation tolerance for PCF11 Gene

Residual Variation Intolerance Score: 9.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCF11 Gene

HapMap Linkage Disequilibrium report
PCF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCF11 Gene

Disorders for PCF11 Gene

Relevant External Links for PCF11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCF11
genes like me logo Genes that share disorders with PCF11: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCF11 Gene

Publications for PCF11 Gene

  1. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. (PMID: 11060040) de Vries H. … Keller W. (EMBO J. 2000) 2 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for PCF11 Gene

Sources for PCF11 Gene

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