Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PCF11 Gene

protein-coding   GIFtS: 55
GCID: GC11P082868

PCF11 Cleavage And Polyadenylation Factor Subunit

(Previous names: PCF11, cleavage and polyadenylation factor II subunit, homolog...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
PCF11 Cleavage And Polyadenylation Factor Subunit1 2     PCF11, Cleavage And Polyadenylation Factor II Subunit, Homolog2
Pre-MRNA Cleavage Complex II Protein Pcf112 3     PCF11, Cleavage And Polyadenylation Factor Subunit, Homolog2
KIAA08243 5     PCF11p Homolog2
PCF11, Cleavage And Polyadenylation Factor II Subunit, Homolog (S.
Cerevisiae)1
     Pre-MRNA Cleavage Complex 2 Protein Pcf112
PCF11, Cleavage And Polyadenylation Factor Subunit, Homolog (S.
Cerevisiae)1
     

External Ids:    HGNC: 300971   Entrez Gene: 515852   Ensembl: ENSG000001654947   OMIM: 6088765   UniProtKB: O949133   

Export aliases for PCF11 gene to outside databases

Previous GC identifers: GC11P085194 GC11P084407 GC11P083090 GC11P082594 GC11P082545 GC11P079165


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for PCF11 Gene:
PCF11 (PCF11 cleavage and polyadenylation factor subunit) is a protein-coding gene. Diseases associated with PCF11 include age related macular degeneration, and obesity.

UniProtKB/Swiss-Prot: PCF11_HUMAN, O94913
Function: Component of pre-mRNA cleavage complex II




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PCF11 gene promoter:
         E2F-3a   E2F-4   E2F-5   GATA-3   Tal-1   E2F-2   YY1   E47   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCF11 promoter sequence
   Search Chromatin IP Primers for PCF11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q13

PCF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCF11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P082868:  view genomic region     (about GC identifiers)

Start:
82,868,030 bp from pter      End:
82,898,493 bp from pter
Size:
30,464 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PCF11_HUMAN, O94913 (See protein sequence)
Recommended Name: Pre-mRNA cleavage complex 2 protein Pcf11  
Size: 1555 amino acids; 173050 Da
Sequence caution: Sequence=AAC03107.1; Type=Frameshift; Positions=712; Sequence=AAC03107.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA74847.1; Type=Erroneous
initiation;
Secondary accessions: A6H8W7 O43671 Q6P0X8

Explore the universe of human proteins at neXtProt for PCF11: NX_O94913

Explore proteomics data for PCF11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PCF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056969.2  
    ENSEMBL proteins: 
     ENSP00000298281   ENSP00000434540   ENSP00000431567   ENSP00000436806   ENSP00000437076  
    Reactome Protein details: O94913

    PCF11 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PCF11
    GenScript Custom Purified and Recombinant Proteins Services for PCF11
    Novus Biologicals PCF11 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PCF11

    PCF11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PCF11
    Novus Biologicals PCF11 Antibodies
    Abcam antibodies for PCF11
    Cloud-Clone Corp. Antibodies for PCF11
    Search ThermoFisher Antibodies for PCF11
    LSBio Antibodies in human, mouse, rat for PCF11

    PCF11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PCF11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PCF11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PCF11
    Cloud-Clone Corp. CLIAs for PCF11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR006569 CID_dom
     IPR006903 RNA_pol_II-bd
     IPR008942 ENTH_VHS

    Graphical View of Domain Structure for InterPro Entry O94913

    ProtoNet protein and cluster: O94913

    1 Blocks protein domain: IPB006569 Regulation of nuclear pre-mRNA protein

    UniProtKB/Swiss-Prot: PCF11_HUMAN, O94913
    Similarity: Contains 1 CID domain


    PCF11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCF11_HUMAN, O94913
    Function: Component of pre-mRNA cleavage complex II

    Phenotypes:
         8 GenomeRNAi human phenotypes for PCF11:

     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased S DNA content 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce  Nuclear pre-40S maturation def  S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCF11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PCF11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCF11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PCF11

    miRNA
    Products:
        
    miRTarBase miRNAs that target PCF11:
    hsa-let-7c-5p (MIRT051836), hsa-mir-15a-5p (MIRT051315)

    Block miRNA regulation of human, mouse, rat PCF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCF11 (see all 16):
    hsa-miR-548k hsa-miR-374a hsa-miR-3622b-3p hsa-miR-556-3p hsa-miR-412 hsa-miR-3650 hsa-miR-548p hsa-miR-374b
    SwitchGear 3'UTR luciferase reporter plasmidPCF11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PCF11
    Predesigned siRNA for gene silencing in human, mouse, rat PCF11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PCF11

    Clone
    Products:
         
    OriGene clones in human, mouse for PCF11 (see all 6)
    OriGene ORF clones in mouse, rat for PCF11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PCF11 (NM_015885)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCF11

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PCF11
    Browse ESI BIO Cell Lines and PureStem Progenitors for PCF11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCF11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PCF11_HUMAN, O94913: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005849mRNA cleavage factor complex NAS11060040

    PCF11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PCF11 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    Processing of Capped Intronless Pre-mRNA0.52
    Cleavage of Growing Transcript in the Termination Region0.80
    Processing of Intronless Pre-mRNAs0.00
    mRNA 3-end processing0.80
    2mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    3Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    4Gene Expression
    Gene Expression0.40
    5mRNA surveillance pathway
    mRNA surveillance pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for PCF11
        mRNA Splicing - Major Pathway
    mRNA 3'-end processing
    Processing of Intronless Pre-mRNAs
    Cleavage of Growing Transcript in the Termination Region


    1 Kegg Pathway  (Kegg details for PCF11):
        mRNA surveillance pathway


    PCF11 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCF11
    Interactions:

        Search GeneGlobe Interaction Network for PCF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PCF11 (O949132, 3 ENSP000002982814) via UniProtKB, MINT, STRING, and/or I2D (see all 683)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 I2D: score=1 STRING: ENSP00000326261
    POLR2GP624873, ENSP000003017884I2D: score=2 STRING: ENSP00000301788
    ALYREFQ86V813, ENSP000003318174I2D: score=1 STRING: ENSP00000331817
    CPSF7Q8N6842, ENSP000003454124MINT-7945693 STRING: ENSP00000345412
    HNRNPA2B1P226262, ENSP000003466944MINT-7945693 STRING: ENSP00000346694
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006379mRNA cleavage NAS11060040
    GO:0008380RNA splicing TAS--

    PCF11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCF11



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PCF11 gene: 
    NM_015885.3  

    Unigene Cluster for PCF11:

    PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)
    Hs.128959  [show with all ESTs]
    Unigene Representative Sequence: NM_015885
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298281(uc010rsu.1 uc001ozx.4) ENST00000530660 ENST00000530304
    ENST00000533018 ENST00000530906 ENST00000528336
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PCF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCF11 (see all 16):
    hsa-miR-548k hsa-miR-374a hsa-miR-3622b-3p hsa-miR-556-3p hsa-miR-412 hsa-miR-3650 hsa-miR-548p hsa-miR-374b
    SwitchGear 3'UTR luciferase reporter plasmidPCF11 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PCF11
    Predesigned siRNA for gene silencing in human, mouse, rat PCF11
    Clone
    Products:
         
    OriGene clones in human, mouse for PCF11 (see all 6)
    OriGene ORF clones in mouse, rat for PCF11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PCF11 (NM_015885)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCF11
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PCF11
    OriGene qSTAR qPCR primer pairs in human, mouse for PCF11
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PCF11
      QuantiTect SYBR Green Assays in human, mouse, rat PCF11
      QuantiFast Probe-based Assays in human, mouse, rat PCF11

    Additional mRNA sequence: 

    AB020631.1 AF046935.1 AK025103.1 AK302606.1 BC065384.1 BC110432.1 BC146778.1 

    19 DOTS entries:

    DT.212811  DT.97858936  DT.100797590  DT.97790166  DT.91686964  DT.110241  DT.120721843  DT.120721962 
    DT.95209225  DT.95275585  DT.95299359  DT.97770451  DT.100797592  DT.100797593  DT.100840316  DT.120721868 
    DT.100737692  DT.120721826  DT.92426381 

    Selected AceView cDNA sequences (see all 210):

    CD369136 AA878737 AB020631 AI208048 BQ222411 BQ436024 AW079870 CA868393 
    AA668949 CB266751 AW438915 AK025103 BF589073 BX440042 BM795455 AI961458 
    AI160519 BM679801 BE900709 BU950428 AA580151 AI089136 T06184 BU581229 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PCF11 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16
    SP1:                                                              -     -                 -                       -                                 
    SP2:                                                                                                              -                                 
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for PCF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PCF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PCF11 Expression
    About this image

    PCF11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCF11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128959
        Custom PCR Arrays for PCF11
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PCF11
    OriGene qSTAR qPCR primer pairs in human, mouse for PCF11
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PCF11
    QuantiTect SYBR Green Assays in human, mouse, rat PCF11
    QuantiFast Probe-based Assays in human, mouse, rat PCF11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCF11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PCF11 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcf111 , 5 cleavage and polyadenylation factor subunit homolog more1, 5 91.59(n)1
    93.93(a)1
      7 (51.56 cM)5
    747371  NM_029078.31  NP_083354.31 
     926437125 
    chicken
    (Gallus gallus)
    Aves PCF111 PCF11, cleavage and polyadenylation factor subunit, more 74.93(n)
    76.04(a)
      419021  XM_417214.4  XP_417214.3 
    lizard
    (Anolis carolinensis)
    Reptilia PCF116
    PCF11 cleavage and polyadenylation factor subunit
    68(a)
    1 ↔ 1
    3(202080465-202106670)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.86132 Xenopus laevis transcribed sequence with moderate similarity more 75.61(n)    BX847770.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.188932 Transcribed sequence with moderate similarity to protein more 80.19(n)    CK028345.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102283 mRNA cleavage 43(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea pcf-116
    Protein PCF-11, isoform b (pcf-11) mRNA, complete ...
    26(a)
    1 ↔ 1
    III(5024966-5029635) WBGene00020092
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PCF11(YDR228C)4 mRNA 3' end processing factor, essential component more   --   4(923806-921926) 851814  NP_010514.1 


    ENSEMBL Gene Tree for PCF11 (if available)
    TreeFam Gene Tree for PCF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PCF11 (see all 697)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71143601,2
    C,F,H--82866228(+) TTGGAC/TGTTAT 1 -- us2k1 tfbs312Minor allele frequency- T:0.10NS EA NA WA 1402
    rs1400656551,2
    --82866343(+) GAAGAC/TCAGTT 1 -- us2k10--------
    rs1451829951,2
    --82866383(+) GTGTGA/GTATCA 1 -- us2k10--------
    rs1390373951,2
    C--82866495(+) AACTC-/AAAG  
            
    AAACA
    1 -- us2k10--------
    rs1509555081,2
    C--82866539(+) GGGACA/CAGTAA 1 -- us2k10--------
    rs37638111,2
    C,F,A,H--82866567(-) AAAAAT/CAAACA 1 -- us2k1 tfbs36Minor allele frequency- C:0.29NA WA 14
    rs1429379851,2
    C--82866574(+) TTTTT-/GAGAGAG 1 -- us2k10--------
    rs1394690341,2
    --82866640(+) AACCTC/TTGCCT 1 -- us2k10--------
    rs1496544341,2
    C--82866884(+) ATCTCA/GGCTCA 1 -- us2k10--------
    rs37638101,2
    C,F--82866999(-) CTCTAT/CTAAAA 1 -- us2k14Minor allele frequency- C:0.38NA WA 8

    HapMap Linkage Disequilibrium report for PCF11 (82868030 - 82898493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PCF11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33531CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PCF11
    DNA2.0 Custom Variant and Variant Library Synthesis for PCF11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608876    OMIM disorders: --

    4 diseases for PCF11:    
    About MalaCards
    age related macular degeneration    obesity    multiple myeloma    myeloma


    PCF11 for disorders           About GeneDecksing


    Export disorders for PCF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PCF11 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with PCF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. (PubMed id 11060040)1, 2, 3 de Vries H....Keller W. (EMBO J. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    4. Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. (PubMed id 23326517)1 Holliday E.G....Wang J.J. (PLoS ONE 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (J. Clin. Invest. 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51585 HGNC: 30097 AceView: PCF11 Ensembl:ENSG00000165494 euGenes: HUgn51585
    ECgene: PCF11 Kegg: 51585 H-InvDB: PCF11

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0824

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PCF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PCF11 gene:
    Search GeneIP for patents involving PCF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PCF11  
     OriGene qPCR primer pairs and template standards for PCF11   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PCF11  
     OriGene qSTAR qPCR primer pairs in human, mouse for PCF11   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PCF11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PCF11   OriGene Custom Protein Services for PCF11  

     
     
     Block miRNA regulation of human, mouse, rat PCF11 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PCF11
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCF11 Predesigned siRNA for gene silencing in human, mouse, rat PCF11
     QuantiFast Probe-based Assays in human, mouse, rat PCF11 QuantiTect SYBR Green Assays in human, mouse, rat PCF11
     Custom PCR Arrays for PCF11 Search Chromatin IP Primers for PCF11
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PCF11  Search GeneGlobe Interaction Network for PCF11
     Regulatory tfbs in PCF11 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PCF11 GenScript cDNA clones with any tag delivered in your preferred vector for PCF11
     GenScript Custom Assay Services for PCF11 GenScript Custom overexpressing Cell Line Services for PCF11
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PCF11
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PCF11 antibodies
     PCF11 proteins
     Antibodies for PCF11
     See all of Abcam's Antibodies, Kits and Proteins for PCF11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PCF11
     Antibodies for PCF11
     ELISAs for PCF11
     CLIAs for PCF11



     Browse ESI BIO Cell Lines and PureStem Progenitors for PCF11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCF11
     SwitchGear 3'UTR luciferase reporter plasmids for PCF11
     SwitchGear Promoter luciferase reporter plasmids for PCF11
     Search ThermoFisher Antibodies for PCF11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCF11
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCF11
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PCF11
     LSBio Antibodies in human, mouse, rat for PCF11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PCF11 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4