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Aliases for PCED1A Gene

Aliases for PCED1A Gene

  • PC-Esterase Domain Containing 1A 2 3 5
  • Family With Sequence Similarity 113, Member A 2 3
  • Sarcoma Antigen NY-SAR-23 3 4
  • C20orf81 3 4
  • FAM113A 3 4
  • PC-Esterase Domain-Containing Protein 1A 3
  • Chromosome 20 Open Reading Frame 81 2
  • Protein FAM113A 4
  • BA12M19.1 3

External Ids for PCED1A Gene

Previous HGNC Symbols for PCED1A Gene

  • C20orf81
  • FAM113A

Summaries for PCED1A Gene

Entrez Gene Summary for PCED1A Gene

  • The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]

GeneCards Summary for PCED1A Gene

PCED1A (PC-Esterase Domain Containing 1A) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is PCED1B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCED1A Gene

Genomics for PCED1A Gene

Regulatory Elements for PCED1A Gene

Enhancers for PCED1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F002867 0.9 Ensembl ENCODE 12.1 -26.4 -26445 0.6 KLF1 PRDM1 PCED1A VPS16 C20orf141 TMEM239 ENSG00000241690 MIR1292 NOP56 ENSG00000228293 IDH3B SNORD56
GH20F002870 0.7 ENCODE 11.6 -31.4 -31376 4.7 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS ZNF263 SP3 SP5 VPS16 PCED1A C20orf141 TMEM239 ENSG00000241690 ITPA PTPRA GC20M002886
GH20F002771 0.2 Ensembl 11.5 +69.5 69542 0.2 CTCF PKNOX1 SIN3A MAX ZIC2 ZNF335 ZFHX2 POLR2A MAZ NRF1 CPXM1 VPS16 PTPRA TMEM239 C20orf141 ENSG00000241690 PCED1A RPL19P1 PIR31974
GH20F002768 1.2 Ensembl ENCODE 11.5 +72.7 72653 1.2 ZNF687 HCFC1 SUZ12 NR3C1 DPF2 MNT RAD21 JUND PBX2 CPXM1 VPS16 PTPRA C20orf141 ENSG00000241690 TMEM239 PCED1A RPL19P1 PIR31974
GH20F002752 0.2 ENCODE 11.4 +88.3 88304 0.2 ZNF76 KLF17 SIN3A ZNF48 RAD21 ZNF2 ZEB1 GLIS2 ZNF143 KLF7 VPS16 PTPRA PCED1A TMEM239 C20orf141 ENSG00000241690 EBF4 SNORD110 SNORD56 SNORD57
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PCED1A on UCSC Golden Path with GeneCards custom track

Promoters for PCED1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000396667 543 1801 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 SP3

Genomic Location for PCED1A Gene

2,835,314 bp from pter
2,841,243 bp from pter
5,930 bases
Minus strand

Genomic View for PCED1A Gene

Genes around PCED1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCED1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCED1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCED1A Gene

Proteins for PCED1A Gene

  • Protein details for PCED1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PC-esterase domain-containing protein 1A
    Protein Accession:
    Secondary Accessions:
    • Q5JUA5
    • Q5JUA6
    • Q6PK19
    • Q86WF5
    • Q96CG7
    • Q9H1Q6
    • Q9H6D1

    Protein attributes for PCED1A Gene

    454 amino acids
    Molecular mass:
    51782 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO65166.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCED1A Gene


neXtProt entry for PCED1A Gene

Post-translational modifications for PCED1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCED1A Gene

Domains & Families for PCED1A Gene

Protein Domains for PCED1A Gene


Suggested Antigen Peptide Sequences for PCED1A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PC-esterase family.
  • Belongs to the PC-esterase family.
genes like me logo Genes that share domains with PCED1A: view

No data available for Gene Families for PCED1A Gene

Function for PCED1A Gene

Gene Ontology (GO) - Molecular Function for PCED1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PCED1A: view

Phenotypes for PCED1A Gene

genes like me logo Genes that share phenotypes with PCED1A: view

Animal Models for PCED1A Gene

MGI Knock Outs for PCED1A:

Animal Model Products

miRNA for PCED1A Gene

miRTarBase miRNAs that target PCED1A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCED1A Gene

Localization for PCED1A Gene

Subcellular locations from

Jensen Localization Image for PCED1A Gene COMPARTMENTS Subcellular localization image for PCED1A gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PCED1A Gene

Pathways & Interactions for PCED1A Gene

SuperPathways for PCED1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCED1A Gene


No data available for Pathways by source and SIGNOR curated interactions for PCED1A Gene

Transcripts for PCED1A Gene

Unigene Clusters for PCED1A Gene

PC-esterase domain containing 1A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCED1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - -
SP7: - - -
SP8: - -

Relevant External Links for PCED1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCED1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCED1A Gene

NURSA nuclear receptor signaling pathways regulating expression of PCED1A Gene:


SOURCE GeneReport for Unigene cluster for PCED1A Gene:

genes like me logo Genes that share expression patterns with PCED1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PCED1A Gene

Orthologs for PCED1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PCED1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCED1A 34 35
  • 99.78 (n)
(Canis familiaris)
Mammalia PCED1A 34 35
  • 91.56 (n)
(Mus musculus)
Mammalia Pced1a 34 16 35
  • 85.37 (n)
(Bos Taurus)
Mammalia PCED1A 34 35
  • 84.54 (n)
(Rattus norvegicus)
Mammalia Pced1a 34
  • 82.66 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
(Danio rerio)
Actinopterygii fam113 35
  • 45 (a)
(Caenorhabditis elegans)
Secernentea D2030.8 35
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8488 35
  • 26 (a)
Species where no ortholog for PCED1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PCED1A Gene

Gene Tree for PCED1A (if available)
Gene Tree for PCED1A (if available)

Paralogs for PCED1A Gene

Paralogs for PCED1A Gene

(2) SIMAP similar genes for PCED1A Gene using alignment to 2 proteins: Pseudogenes for PCED1A Gene

genes like me logo Genes that share paralogs with PCED1A: view

Variants for PCED1A Gene

Sequence variations from dbSNP and Humsavar for PCED1A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111363914 -- 2,839,566(+) AGCTG(C/T)CAGGG intron-variant, upstream-variant-2KB
rs111570962 -- 2,835,243(+) CCACG(C/T)TGGAC downstream-variant-500B
rs112331482 -- 2,835,846(+) TACCT(C/T)CAGAC intron-variant
rs112715178 -- 2,836,853(+) TCCTA(A/G)AAGTG intron-variant
rs113113192 -- 2,837,883(+) TGGCC(C/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCED1A Gene

Variant ID Type Subtype PubMed ID
esv2762056 CNV gain 21179565
esv3645020 CNV gain 21293372
nsv1057464 CNV gain 25217958
nsv3261 CNV deletion 18451855
nsv522009 CNV gain 19592680
nsv833895 CNV loss 17160897
nsv952978 CNV deletion 24416366

Variation tolerance for PCED1A Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCED1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCED1A Gene

Disorders for PCED1A Gene

Relevant External Links for PCED1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PCED1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCED1A Gene

Publications for PCED1A Gene

  1. Novel eukaryotic enzymes modifying cell-surface biopolymers. (PMID: 20056006) Anantharaman V. … Aravind L. (Biol. Direct 2010) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee S.-Y. … Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for PCED1A Gene

Sources for PCED1A Gene

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