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Aliases for PCED1A Gene

Aliases for PCED1A Gene

  • PC-Esterase Domain Containing 1A 2 3 5
  • Family With Sequence Similarity 113, Member A 2 3
  • Sarcoma Antigen NY-SAR-23 3 4
  • C20orf81 3 4
  • FAM113A 3 4
  • Chromosome 20 Open Reading Frame 81 2
  • Protein FAM113A 4
  • BA12M19.1 3

External Ids for PCED1A Gene

Previous HGNC Symbols for PCED1A Gene

  • C20orf81
  • FAM113A

Summaries for PCED1A Gene

Entrez Gene Summary for PCED1A Gene

  • The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]

GeneCards Summary for PCED1A Gene

PCED1A (PC-Esterase Domain Containing 1A) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is PCED1B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCED1A Gene

Genomics for PCED1A Gene

Regulatory Elements for PCED1A Gene

Enhancers for PCED1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCED1A on UCSC Golden Path with GeneCards custom track

Promoters for PCED1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCED1A on UCSC Golden Path with GeneCards custom track

Genomic Location for PCED1A Gene

Chromosome:
20
Start:
2,835,314 bp from pter
End:
2,841,243 bp from pter
Size:
5,930 bases
Orientation:
Minus strand

Genomic View for PCED1A Gene

Genes around PCED1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCED1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCED1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCED1A Gene

Proteins for PCED1A Gene

  • Protein details for PCED1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1Q7-PED1A_HUMAN
    Recommended name:
    PC-esterase domain-containing protein 1A
    Protein Accession:
    Q9H1Q7
    Secondary Accessions:
    • Q5JUA5
    • Q5JUA6
    • Q6PK19
    • Q86WF5
    • Q96CG7
    • Q9H1Q6
    • Q9H6D1

    Protein attributes for PCED1A Gene

    Size:
    454 amino acids
    Molecular mass:
    51782 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO65166.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCED1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCED1A Gene

Proteomics data for PCED1A Gene at MOPED

Post-translational modifications for PCED1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCED1A Gene

No data available for DME Specific Peptides for PCED1A Gene

Domains & Families for PCED1A Gene

Protein Domains for PCED1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCED1A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1Q7

UniProtKB/Swiss-Prot:

PED1A_HUMAN :
  • Belongs to the PC-esterase family.
Family:
  • Belongs to the PC-esterase family.
genes like me logo Genes that share domains with PCED1A: view

No data available for Gene Families for PCED1A Gene

Function for PCED1A Gene

Phenotypes for PCED1A Gene

genes like me logo Genes that share phenotypes with PCED1A: view

Animal Models for PCED1A Gene

MGI Knock Outs for PCED1A:

Animal Model Products

CRISPR Products

miRNA for PCED1A Gene

miRTarBase miRNAs that target PCED1A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCED1A Gene

Localization for PCED1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCED1A Gene COMPARTMENTS Subcellular localization image for PCED1A gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PCED1A Gene

Pathways & Interactions for PCED1A Gene

SuperPathways for PCED1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCED1A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCED1A Gene

Drugs & Compounds for PCED1A Gene

No Compound Related Data Available

Transcripts for PCED1A Gene

Unigene Clusters for PCED1A Gene

PC-esterase domain containing 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCED1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1:
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6:
SP7: - - -
SP8: - -

Relevant External Links for PCED1A Gene

GeneLoc Exon Structure for
PCED1A
ECgene alternative splicing isoforms for
PCED1A

Expression for PCED1A Gene

mRNA expression in normal human tissues for PCED1A Gene

SOURCE GeneReport for Unigene cluster for PCED1A Gene Hs.29341

genes like me logo Genes that share expression patterns with PCED1A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PCED1A Gene

Orthologs for PCED1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PCED1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCED1A 35
  • 84.54 (n)
  • 81.55 (a)
PCED1A 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCED1A 35
  • 91.56 (n)
  • 92.51 (a)
PCED1A 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pced1a 35
  • 85.37 (n)
  • 84.41 (a)
Pced1a 16
Pced1a 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCED1A 35
  • 99.78 (n)
  • 100 (a)
PCED1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pced1a 35
  • 82.66 (n)
  • 80.74 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fam113 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2030.8 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8488 36
  • 26 (a)
OneToMany
Species with no ortholog for PCED1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PCED1A Gene

ENSEMBL:
Gene Tree for PCED1A (if available)
TreeFam:
Gene Tree for PCED1A (if available)

Paralogs for PCED1A Gene

Paralogs for PCED1A Gene

(2) SIMAP similar genes for PCED1A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PCED1A Gene

genes like me logo Genes that share paralogs with PCED1A: view

Variants for PCED1A Gene

Sequence variations from dbSNP and Humsavar for PCED1A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_021945 -
rs11555 -- 2,835,347(+) TTGGT(A/G)ACAGC downstream-variant-500B, utr-variant-3-prime
rs751899 -- 2,838,155(+) GGCTG(C/T)GTCCC intron-variant
rs2274668 -- 2,835,444(+) CCAGT(C/T)CCAGC downstream-variant-500B, utr-variant-3-prime
rs2274669 -- 2,836,175(+) GGAAG(C/G/T)GGGTA intron-variant, nc-transcript-variant, reference, synonymous-codon

Variation tolerance for PCED1A Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCED1A Gene

HapMap Linkage Disequilibrium report
PCED1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PCED1A Gene

Disorders for PCED1A Gene

Relevant External Links for PCED1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCED1A

No disorders were found for PCED1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCED1A Gene

Publications for PCED1A Gene

  1. Novel eukaryotic enzymes modifying cell-surface biopolymers. (PMID: 20056006) Anantharaman V. … Aravind L. (Biol. Direct 2010) 2 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for PCED1A Gene

Sources for PCED1A Gene

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