PCDHGC4 Gene
protein-coding GIFtS: 36
GCID: GC05P141263
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protocadherin gamma subfamily C, 4
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Aliases
for PCDHGC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protocadherin Gamma Subfamily C, 41 2 | | PCDH-GAMMA-C41 2 | | Protocadherin Gamma-C42 | | PCDH-Gamma-C41 |
Export aliases for PCDHGC4 gene to outside databasesPrevious GC identifers: GC05P140592 GC05P141320 GC05P140717 GC05P140775 GC05P140796 GC05P140735 GC05P140744 GC05P140819 GC05P140844 GC05P140861 GC05P140887 GC05P140909 GC05P140919 GC05P140941 GC05P140962 GC05P140984 GC05P141056 GC05P141077 GC05P136009 GC05P141125 GC05P141138 GC05P141190 GC05P141223 |
Summaries
for PCDHGC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PCDHGC4:
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked onchromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism maybe involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies.Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly relatedsubfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region,containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region,which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the commoncytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in theestablishment and function of specific cell-cell connections in the brain. Alternative splicing has been described forthe gamma cluster genes. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PCDGL_HUMAN, Q9Y5F7Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance ofspecific neuronal connections in the brain
|
Genomic Views
for PCDHGC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PCDHGC4 gene promoter:
ER-alpha NF-1 AML1a YY1 Gfi-1 Meis-1b AREB6 USF-1 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PCDHGC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCDHGC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31PCDHGC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P141263: view genomic region
(about GC identifiers)
Start:
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140,864,741 bp from pter |
End:
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140,892,546 bp from pter |
Size:
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27,806 bases |
Orientation:
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plus strand |
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Proteins
for PCDHGC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PCDGL_HUMAN, Q9Y5F7 (See
protein sequence)Recommended Name: Protocadherin gamma-C4 precursor Size: 938 amino acids; 101214 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: Q495T2 Q9Y5C3Alternative splicing: 2 isoforms: Q9Y5F7-1 Q9Y5F7-2 Explore the universe of human proteins at neXtProt for PCDHGC4: NX_Q9Y5F7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5F7
PCDHGC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_061751.1 NP_115782.1
ENSEMBL proteins: ENSP00000306918
Human Recombinant Protein Products for PCDHGC4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
PCDHGC4 for ontologies About GeneDecksing
PCDHGC4 Antibody Products:
Assay Products for PCDHGC4: |
Protein
Domains /
Families
for PCDHGC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PCDHGC4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y5F7ProtoNet protein and cluster: Q9Y5F7 1 Blocks protein family: IPB002126 Cadherin
UniProtKB/Swiss-Prot: PCDGL_HUMAN, Q9Y5F7Similarity: Contains 6 cadherin domains |
Function
for PCDHGC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PCDGL_HUMAN, Q9Y5F7Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance ofspecific neuronal connections in the brain Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
PCDHGC4 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCDHGC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCDHGC4 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHGC4 |
|
Pathways & Interactions
for PCDHGC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCDHGC4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007156 | homophilic cell adhesion |
IEA | -- |
PCDHGC4 for ontologies About GeneDecksing
|
Drugs & Compounds
for PCDHGC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PCDHGC4
1 HMDB Compound for PCDHGC4 About this table
Search CenterWatch for drugs/clinical trials and news about PCDHGC4 / PCDGL
|
Transcripts
for PCDHGC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PCDHGC4 gene (2 alternative transcripts): NM_018928.2 NM_032406.1 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000306593(uc003lky.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCDHGC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCDHGC4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PCDHGC4 (NM_032406) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCDHGC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHGC4 |
24/737 AceView cDNA sequences (see all 737): AF152328 AL528258 AA338834 AI933744 AF152320 AF152503 BQ681117 CA432562 H96219 NM_032407 AF152325 NM_018916 CD672597 AW517238 BQ717482 NM_032403 F08987 NM_032089 BC006439 NM_032009 BQ018446 AF152517 NM_031993 BQ716279
GeneLoc Exon Structure
|
Expression
for PCDHGC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PCDHGC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PCDHGC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PCDHGC4
SABiosciences Custom PCR Arrays for PCDHGC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCDHGC4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat PCDHGC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCDHGC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCDHGC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHGC4 |
Orthologs
for PCDHGC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PCDHGC4 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for PCDHGC4 (if available)
TreeFam Gene Tree for PCDHGC4 (if available) |
Paralogs
for PCDHGC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PCDHGC4 gene
- PCDHAC12 PCDHB162 PCDHB22 PCDHAC22 PCDHB72 PCDHB152 PCDHGA102 PCDHGA122
- PCDHGB22 PCDHGA82 PCDHGA92 PCDHGB32 PCDHGC32 PCDHGB62 PCDHA62 PCDHGA52
- PCDHA82 PCDHA132 PCDHB52 PCDHB132 PCDHA32 PCDHGA42 PCDHGA72 PCDHA42
- PCDHB42 PCDHB112 PCDHA22 ENSG000002556222 PCDHB142 PCDHB122 PCDHA122 PCDHB82
- PCDHA52 PCDHGB12 PCDHGB42 PCDHA12 PCDHGA22 PCDHA112 PCDHA72 PCDHGA112
- PCDHGA62 PCDHB32 PCDHB62 PCDHGC52 PCDHA102 PCDHA92 PCDHGA12 PCDHB102
- PCDHB12 PCDHGA32 PCDHGB72
18/71 SIMAP similar genes for PCDHGC4 using alignment to 2 protein entries: PCDGL_HUMAN (see all proteins)
(see all similar genes):ME4 PCDHGA2 ME1 PCDHGA11 PCDHGA1 PCDHGA3
PCDHGA7 PCDHGA8 PCDHB13 PCDHB15 PCDHB17 PCDHGA6
PCDHGB4 PCDHB16 PCDHB18 PCDHB3 PCDHB4 PCDHB5
PCDHGC4 for paralogs About GeneDecksing
|
Genomic Variants
for PCDHGC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PCDHGC4
1 CNV: 69211 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCDHGC4 |
|
Disorders
/ Diseases
for PCDHGC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PCDHGC4 for disorders About GeneDecksing
OMIM gene information: 606305
OMIM disorders: --
1  disease for PCDHGC4: About MalaCardsneuronitis
Export disorders for PCDHGC4 gene to outside databases
|
Publications
for PCDHGC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PCDHGC4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PCDHGC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PubMed id 10380929)1, 2, 3 Wu Q. and Maniatis T. (1999)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PubMed id 11230163)1 Wu Q.... Maniatis T. (2001)
- Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)1 Nollet F....van Roy F. (2000)
- Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PubMed id 10716726)1 Wu Q. and Maniatis T. (2000)
- Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PubMed id 10817752)1 Yagi T. and Takeichi M. (2000)
|
External Searches for PCDHGC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PCDHGC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PCDHGC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PCDHGC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PCDHGC4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PCDHGC4 gene:
Search GeneIP for patents involving PCDHGC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PCDHGC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PCDHGC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PCDHGC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCDHGC4 | | | OriGene Protein Over-expression Lysate for PCDHGC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PCDHGC4 | | OriGene 3'-UTR Clone for PCDHGC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCDHGC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCDHGC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PCDHGC4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCDHGC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCDHGC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCDHGC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCDHGC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCDHGC4 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHGC4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for PCDHGC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHGC4 |
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