Aliases for PCDHGB5 Gene
Aliases for PCDHGB5 Gene
External Ids for PCDHGB5 Gene
- HGNC: 8712
- Entrez Gene: 56101
- Ensembl: ENSG00000276547
- OMIM: 606302
- UniProtKB: Q9Y5G0
Previous GeneCards Identifiers for PCDHGB5 Gene
- GC05P140594
- GC05P141311
- GC05P140713
- GC05P140771
- GC05P140792
- GC05P140731
- GC05P140808
- GC05P140828
- GC05P140845
- GC05P140870
- GC05P140877
- GC05P140897
- GC05P140930
- GC05P140952
- GC05P140973
- GC05P140995
- GC05P141025
- GC05P141043
- GC05P141070
- GC05P141090
- GC05P141109
- GC05P141151
- GC05P141168
- GC05P141204
- GC05P141244
- GC05P141327
- GC05P141386
- GC05P141454
- GC05P141531
- GC05P141634
- GC05P141736
- GC05P141835
- GC05P141938
- GC05P142042
Summaries for PCDHGB5 Gene
-
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCDHGB5 Gene
PCDHGB5 (Protocadherin Gamma Subfamily B, 5) is a Protein Coding gene. Diseases associated with PCDHGB5 include Protocadherin-Gamma Gene Cluster. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGB4.
UniProtKB/Swiss-Prot for PCDHGB5 Gene
-
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Additional gene information for PCDHGB5 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGB5 Gene
Genomics for PCDHGB5 Gene
GeneHancer (GH) Regulatory Elements for PCDHGB5 Gene
Regulatory Element Products
Genomic Locations for PCDHGB5 Gene
- chr5:141,397,987-141,512,979
- (GRCh38/hg38)
- Size:
- 114,993 bases
- Orientation:
- Plus strand
- chr5:140,777,695-140,892,546
- (GRCh37/hg19)
Genomic View for PCDHGB5 Gene
- Cytogenetic band:
-
- 5q31.3 by Ensembl
- 5q31.3 by Entrez Gene
- 5q31 by HGNC


RefSeq DNA sequence for PCDHGB5 Gene
Proteins for PCDHGB5 Gene
-
Protein details for PCDHGB5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y5G0-PCDGH_HUMAN
- Recommended name:
- Protocadherin gamma-B5
- Protein Accession:
- Q9Y5G0
- Q52LK8
- Q9Y5C6
Protein attributes for PCDHGB5 Gene
- Size:
- 923 amino acids
- Molecular mass:
- 99875 Da
- Quaternary structure:
- No Data Available
Protein Expression for PCDHGB5 Gene
Post-translational modifications for PCDHGB5 Gene
- Glycosylation at Asn415 and isoforms=2541
Other Protein References for PCDHGB5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Assay Products
No data available for DME Specific Peptides for PCDHGB5 Gene
Domains & Families for PCDHGB5 Gene
Gene Families for PCDHGB5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for PCDHGB5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PCDHGB5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PCDHGB5 Gene
Function for PCDHGB5 Gene
Molecular function for PCDHGB5 Gene
- UniProtKB/Swiss-Prot Function:
- Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005509 | calcium ion binding | IEA | -- |
Phenotypes for PCDHGB5 Gene
- GenomeRNAi human phenotypes for PCDHGB5:
Animal Model Products
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHGB5 Gene
Localization for PCDHGB5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PCDHGB5 Gene
- Cell membrane; Single-pass type I membrane protein.
- Cytosol (2)
- Nucleus (2)
- Plasma membrane (2)
- Vesicles (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0005887 | integral component of plasma membrane | IBA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0070062 | extracellular exosome | HDA,IDA | 19199708 |
No data available for Subcellular locations from COMPARTMENTS for PCDHGB5 Gene
Pathways & Interactions for PCDHGB5 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IBA | -- |
GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | IEA | -- |
GO:0007267 | cell-cell signaling | IBA | -- |
GO:0007399 | nervous system development | IBA | -- |
GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for PCDHGB5 Gene
Drugs & Compounds for PCDHGB5 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
calcium | Approved | Nutra | 0 |
Transcripts for PCDHGB5 Gene
mRNA/cDNA for PCDHGB5 Gene
- (2) REFSEQ mRNAs :
- (737) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PCDHGB5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PCDHGB5 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PCDHGB5 Gene
NURSA nuclear receptor signaling pathways regulating expression of PCDHGB5 Gene:
PCDHGB5Primer Products
-
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHGB5 Gene
Orthologs for PCDHGB5 Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PCDHGB5 33 |
|
||
cow (Bos Taurus) |
Mammalia | PCDHGB5 33 |
|
||
dog (Canis familiaris) |
Mammalia | PCDHGB5 33 |
|
||
mouse (Mus musculus) |
Mammalia | Pcdhgb5 33 16 |
|
||
rat (Rattus norvegicus) |
Mammalia | Pcdhgb5 33 |
|
- Species where no ortholog for PCDHGB5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for PCDHGB5 Gene
Paralogs for PCDHGB5 Gene
(61) SIMAP similar genes for PCDHGB5 Gene using alignment to 1 proteins:
- PCDHGB4
- PCDHGB6
- PCDHGB7
- PCDHGB1
- PCDHGB2
- PCDHGC3
- PCDHGB3
- PCDHGA9
- PCDHGA11
- PCDHGA8
- PCDHGA1
- PCDHGA2
- PCDHGA5
- PCDHGA4
- PCDHGA12
- PCDHGA3
- PCDHGA7
- PCDHGA6
- PCDHGA10
- PCDHB13
- PCDHB6
- DKFZp586I1919
- PCDHB8
- PCDHB18
- PCDHB17
- PCDHB16
- PCDHB14
- PCDHGC5
- PCDHB9
- PCDHB7
- PCDHB5
- PCDHB3
- PCDHB2
- PCDHB11
- PCDHGC4
- PCDHB4
- PCDHB15
- PCDHB12
- PCDHB10
- PCDHB1
- PCDHA8
- PCDHA3
- PCDH18
- PCDHAC1
- PCDH17
- PCDHAC2
- PCDH10
- PCDH19
- PCDHA13
- PCDHA6
- PCDHA5
- PCDHA10
- PCDHA4
- PCDHA7
- PCDHA2
- PCDHA11
- PCDHA9
- PCDHA12
- PCDHA1
- PCDH12
- PCDH1
Pseudogenes.org Pseudogenes for PCDHGB5 Gene
Variants for PCDHGB5 Gene
SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs386352347 | uncertain-significance, not provided | 141,485,635(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs1000014772 | -- | 141,409,727(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs1000022316 | -- | 141,472,751(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs1000136303 | -- | 141,452,887(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
rs1000138324 | -- | 141,499,091(+) | A/C | genic_downstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv25744 | CNV | gain | 19812545 |
esv2730847 | CNV | deletion | 23290073 |
esv2759382 | CNV | gain | 17122850 |
esv3422812 | CNV | insertion | 20981092 |
esv3606987 | CNV | gain | 21293372 |
nsv1123990 | CNV | deletion | 24896259 |
nsv1125852 | CNV | tandem duplication | 24896259 |
nsv327707 | CNV | deletion | 16902084 |
nsv462470 | CNV | loss | 19166990 |
nsv518799 | CNV | loss | 19592680 |
nsv519627 | CNV | loss | 19592680 |
nsv599922 | CNV | loss | 21841781 |
nsv599923 | CNV | loss | 21841781 |
nsv968259 | CNV | duplication | 23825009 |
nsv980740 | CNV | duplication | 23825009 |
Additional Variant Information for PCDHGB5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PCDHGB5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PCDHGB5 Gene
Disorders for PCDHGB5 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
protocadherin-gamma gene cluster |
|
|
Additional Disease Information for PCDHGB5
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PCDHGB5 Gene
Publications for PCDHGB5 Gene
- A striking organization of a large family of human neural cadherin-like cell adhesion genes. (PMID: 10380929) Wu Q … Maniatis T (Cell 1999) 2 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M … Yates JR (Journal of proteome research 2009) 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 22 available PCDHGB5 Antibodies ranked by validation data
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Sources for PCDHGB5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
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