Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCDHGB5 Gene

Aliases for PCDHGB5 Gene

  • Protocadherin Gamma Subfamily B, 5 2 3
  • PCDH-GAMMA-B5 3 4
  • Protocadherin Gamma-B5 3

External Ids for PCDHGB5 Gene

Previous GeneCards Identifiers for PCDHGB5 Gene

  • GC05P140594
  • GC05P141311
  • GC05P140713
  • GC05P140771
  • GC05P140792
  • GC05P140731
  • GC05P140808
  • GC05P140828
  • GC05P140845
  • GC05P140870
  • GC05P140877
  • GC05P140897
  • GC05P140930
  • GC05P140952
  • GC05P140973
  • GC05P140995
  • GC05P141025
  • GC05P141043
  • GC05P141070
  • GC05P141090
  • GC05P141109
  • GC05P141151
  • GC05P141168
  • GC05P141204
  • GC05P141244
  • GC05P141327
  • GC05P141386

Summaries for PCDHGB5 Gene

Entrez Gene Summary for PCDHGB5 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGB5 Gene

PCDHGB5 (Protocadherin Gamma Subfamily B, 5) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for PCDHGB5 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGB5 Gene

Genomics for PCDHGB5 Gene

Regulatory Elements for PCDHGB5 Gene

Genomic Location for PCDHGB5 Gene

Start:
141,397,987 bp from pter
End:
141,512,979 bp from pter
Size:
114,993 bases
Orientation:
Plus strand

Genomic View for PCDHGB5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHGB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGB5 Gene

Proteins for PCDHGB5 Gene

  • Protein details for PCDHGB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5G0-PCDGH_HUMAN
    Recommended name:
    Protocadherin gamma-B5
    Protein Accession:
    Q9Y5G0
    Secondary Accessions:
    • Q52LK8
    • Q9Y5C6

    Protein attributes for PCDHGB5 Gene

    Size:
    923 amino acids
    Molecular mass:
    99875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGB5 Gene

Proteomics data for PCDHGB5 Gene at MOPED

Post-translational modifications for PCDHGB5 Gene

  • Glycosylation at Asn415 and Asn541
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGB5 Gene

Domains for PCDHGB5 Gene

Gene Families for PCDHGB5 Gene

HGNC:
  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHGB5 Gene

Suggested Antigen Peptide Sequences for PCDHGB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5G0

UniProtKB/Swiss-Prot:

PCDGH_HUMAN :
  • Q9Y5G0
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHGB5: view

Function for PCDHGB5 Gene

Molecular function for PCDHGB5 Gene

UniProtKB/Swiss-Prot Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGB5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHGB5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PCDHGB5 Gene

Localization for PCDHGB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGB5 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for PCDHGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PCDHGB5: view

No data available for Subcellular locations from COMPARTMENTS for PCDHGB5 Gene

Pathways for PCDHGB5 Gene

SuperPathways for PCDHGB5 Gene

No Data Available

Interacting Proteins for PCDHGB5 Gene

Gene Ontology (GO) - Biological Process for PCDHGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PCDHGB5: view

No data available for Pathways by source for PCDHGB5 Gene

Compounds for PCDHGB5 Gene

(1) HMDB Compounds for PCDHGB5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDHGB5: view

Transcripts for PCDHGB5 Gene

mRNA/cDNA for PCDHGB5 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHGB5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PCDHGB5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGB5 Gene

No ASD Table

Relevant External Links for PCDHGB5 Gene

GeneLoc Exon Structure for
PCDHGB5
ECgene alternative splicing isoforms for
PCDHGB5

Expression for PCDHGB5 Gene

mRNA expression in normal human tissues for PCDHGB5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PCDHGB5 Gene

genes like me logo Genes that share expressions with PCDHGB5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCDHGB5 Gene

Orthologs for PCDHGB5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PCDHGB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHGB5 35
  • 99.24 (n)
  • 99.24 (a)
cow
(Bos Taurus)
Mammalia PCDHGB5 35
  • 87.51 (n)
  • 88.72 (a)
dog
(Canis familiaris)
Mammalia PCDHGB5 35
  • 86.38 (n)
  • 87.84 (a)
mouse
(Mus musculus)
Mammalia Pcdhgb5 35
  • 83.19 (n)
  • 84.8 (a)
Pcdhgb5 16
rat
(Rattus norvegicus)
Mammalia Pcdhgb5 35
  • 81.94 (n)
  • 83.44 (a)
Species with no ortholog for PCDHGB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGB5 Gene

ENSEMBL:
Gene Tree for PCDHGB5 (if available)
TreeFam:
Gene Tree for PCDHGB5 (if available)

Paralogs for PCDHGB5 Gene

genes like me logo Genes that share paralogs with PCDHGB5: view

No data available for Paralogs for PCDHGB5 Gene

Variants for PCDHGB5 Gene

Sequence variations from dbSNP and Humsavar for PCDHGB5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_048571 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHGB5 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6351n71 CNV Loss 21882294
dgv6352n71 CNV Loss 21882294
dgv6353n71 CNV Loss 21882294
nsv882987 CNV Gain 21882294
nsv882990 CNV Loss 21882294
nsv519627 CNV Loss 19592680
esv267823 CNV Insertion 20981092
nsv518799 CNV Loss 19592680
nsv327707 CNV Loss 16902084
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Relevant External Links for PCDHGB5 Gene

HapMap Linkage Disequilibrium report
PCDHGB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHGB5 Gene

Disorders for PCDHGB5 Gene

Relevant External Links for PCDHGB5

Genetic Association Database (GAD)
PCDHGB5
genes like me logo Genes that share disorders with PCDHGB5: view

No data available for UniProtKB/Swiss-Prot for PCDHGB5 Gene

Publications for PCDHGB5 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  3. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3
  4. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PMID: 10835267) Nollet F. … van Roy F. (J. Mol. Biol. 2000) 3
  5. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3

Products for PCDHGB5 Gene

  • antibodies-online proteins for PCDHGB5
  • antibodies-online antibodies for PCDHGB5
  • antibodies-online kits for PCDHGB5

Sources for PCDHGB5 Gene

Back to Top

Content