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Aliases for PCDHGB4 Gene

Aliases for PCDHGB4 Gene

  • Protocadherin Gamma Subfamily B, 4 2 3
  • Fibroblast Cadherin FIB2 2 3
  • Fibroblast Cadherin-2 3 4
  • PCDH-GAMMA-B4 3 4
  • Cadherin 20 2 3
  • Cadherin-20 3 4
  • CDH20 3 4
  • Fib2 3 4

External Ids for PCDHGB4 Gene

Previous GeneCards Identifiers for PCDHGB4 Gene

  • GC05P140583
  • GC05P141309
  • GC05P140712
  • GC05P140770
  • GC05P140791
  • GC05P140729
  • GC05P140807
  • GC05P140827
  • GC05P140843
  • GC05P140869
  • GC05P140894
  • GC05P140916
  • GC05P140929
  • GC05P140951
  • GC05P140972
  • GC05P140994
  • GC05P141024
  • GC05P141042
  • GC05P141069
  • GC05P141089
  • GC05P141107
  • GC05P141148
  • GC05P141166
  • GC05P141201
  • GC05P141242
  • GC05P141324
  • GC05P141384
  • GC05P141452

Summaries for PCDHGB4 Gene

Entrez Gene Summary for PCDHGB4 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGB4 Gene

PCDHGB4 (Protocadherin Gamma Subfamily B, 4) is a Protein Coding gene. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHGB4 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGB4 Gene

Genomics for PCDHGB4 Gene

Regulatory Elements for PCDHGB4 Gene

Genomic Location for PCDHGB4 Gene

Chromosome:
5
Start:
141,387,698 bp from pter
End:
141,512,979 bp from pter
Size:
125,282 bases
Orientation:
Plus strand

Genomic View for PCDHGB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHGB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGB4 Gene

Proteins for PCDHGB4 Gene

  • Protein details for PCDHGB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN71-PCDGG_HUMAN
    Recommended name:
    Protocadherin gamma-B4
    Protein Accession:
    Q9UN71
    Secondary Accessions:
    • O15099
    • Q2M267
    • Q9UN64

    Protein attributes for PCDHGB4 Gene

    Size:
    923 amino acids
    Molecular mass:
    99927 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGB4 Gene

Proteomics data for PCDHGB4 Gene at MOPED

Post-translational modifications for PCDHGB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCDHGB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PCDHGB4 Gene

Domains & Families for PCDHGB4 Gene

Gene Families for PCDHGB4 Gene

Protein Domains for PCDHGB4 Gene

Suggested Antigen Peptide Sequences for PCDHGB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UN71

UniProtKB/Swiss-Prot:

PCDGG_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHGB4: view

Function for PCDHGB4 Gene

Molecular function for PCDHGB4 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHGB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PCDHGB4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHGB4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHGB4 Gene

Localization for PCDHGB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGB4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHGB4 Gene COMPARTMENTS Subcellular localization image for PCDHGB4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDHGB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane NAS 9199196
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGB4: view

Pathways & Interactions for PCDHGB4 Gene

genes like me logo Genes that share pathways with PCDHGB4: view

Pathways by source for PCDHGB4 Gene

Interacting Proteins for PCDHGB4 Gene

Gene Ontology (GO) - Biological Process for PCDHGB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9199196
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules NAS 9199196
genes like me logo Genes that share ontologies with PCDHGB4: view

No data available for SIGNOR curated interactions for PCDHGB4 Gene

Drugs & Compounds for PCDHGB4 Gene

(1) Drugs for PCDHGB4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with PCDHGB4: view

Transcripts for PCDHGB4 Gene

mRNA/cDNA for PCDHGB4 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHGB4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGB4 Gene

No ASD Table

Relevant External Links for PCDHGB4 Gene

GeneLoc Exon Structure for
PCDHGB4
ECgene alternative splicing isoforms for
PCDHGB4

Expression for PCDHGB4 Gene

mRNA expression in normal human tissues for PCDHGB4 Gene

Protein differential expression in normal tissues from HIPED for PCDHGB4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDHGB4 Gene



genes like me logo Genes that share expression patterns with PCDHGB4: view

Protein tissue co-expression partners for PCDHGB4 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCDHGB4 Gene

Orthologs for PCDHGB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCDHGB4 35
  • 86.86 (n)
  • 87.33 (a)
dog
(Canis familiaris)
Mammalia PCDHGB4 35
  • 85.13 (n)
  • 84.57 (a)
mouse
(Mus musculus)
Mammalia Pcdhgb4 35
  • 83.17 (n)
  • 84.73 (a)
Pcdhgb4 16
chimpanzee
(Pan troglodytes)
Mammalia PCDHGB4 35
  • 99.42 (n)
  • 99.13 (a)
PCDHGB4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102552705 35
  • 81.38 (n)
  • 83.1 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
Species with no ortholog for PCDHGB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGB4 Gene

ENSEMBL:
Gene Tree for PCDHGB4 (if available)
TreeFam:
Gene Tree for PCDHGB4 (if available)

Paralogs for PCDHGB4 Gene

Pseudogenes.org Pseudogenes for PCDHGB4 Gene

genes like me logo Genes that share paralogs with PCDHGB4: view

Variants for PCDHGB4 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDHGB4 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6351n71 CNV Loss 21882294
dgv6352n71 CNV Loss 21882294
dgv6353n71 CNV Loss 21882294
nsv882987 CNV Gain 21882294
nsv882990 CNV Loss 21882294
nsv823280 CNV Loss 20364138
nsv519627 CNV Loss 19592680
esv267823 CNV Insertion 20981092
nsv518799 CNV Loss 19592680
nsv327707 CNV Loss 16902084
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Variation tolerance for PCDHGB4 Gene

Residual Variation Intolerance Score: 55.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDHGB4 Gene

HapMap Linkage Disequilibrium report
PCDHGB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PCDHGB4 Gene

Disorders for PCDHGB4 Gene

Relevant External Links for PCDHGB4

Genetic Association Database (GAD)
PCDHGB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDHGB4
genes like me logo Genes that share disorders with PCDHGB4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHGB4 Gene

Publications for PCDHGB4 Gene

  1. Cadherin-19 expression is restricted to myelin-forming cells in the chicken embryo. (PMID: 19850111) Lin J. … Redies C. (Neuroscience 2010) 23 67
  2. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 67
  3. Multiple cadherins are expressed in human fibroblasts. (PMID: 9199196) Matsuyoshi N. … Imamura S. (Biochem. Biophys. Res. Commun. 1997) 23 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for PCDHGB4 Gene

Sources for PCDHGB4 Gene

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