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Aliases for PCDHGB2 Gene

Aliases for PCDHGB2 Gene

  • Protocadherin Gamma Subfamily B, 2 2 3
  • PCDH-GAMMA-B2 3 4
  • Protocadherin Gamma-B2 3

External Ids for PCDHGB2 Gene

Summaries for PCDHGB2 Gene

Entrez Gene Summary for PCDHGB2 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGB2 Gene

PCDHGB2 (Protocadherin Gamma Subfamily B, 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHGB2 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGB2 Gene

Genomics for PCDHGB2 Gene

Genomic Location for PCDHGB2 Gene

Start:
141,360,042 bp from pter
End:
141,512,979 bp from pter
Size:
152,938 bases
Orientation:
Plus strand

Genomic View for PCDHGB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHGB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGB2 Gene

Regulatory Elements for PCDHGB2 Gene

Proteins for PCDHGB2 Gene

  • Protein details for PCDHGB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5G2-PCDGE_HUMAN
    Recommended name:
    Protocadherin gamma-B2
    Protein Accession:
    Q9Y5G2
    Secondary Accessions:
    • Q3MIJ3
    • Q9UN65

    Protein attributes for PCDHGB2 Gene

    Size:
    931 amino acids
    Molecular mass:
    100875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGB2 Gene

Proteomics data for PCDHGB2 Gene at MOPED

Post-translational modifications for PCDHGB2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn419 and Asn545

Other Protein References for PCDHGB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGB2 Gene

Domains for PCDHGB2 Gene

Gene Families for PCDHGB2 Gene

HGNC:
  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHGB2 Gene

UniProtKB/Swiss-Prot:

PCDGE_HUMAN
Domain:
  • Contains 6 cadherin domains.:
    • Q9Y5G2
genes like me logo Genes that share domains with PCDHGB2: view

Function for PCDHGB2 Gene

Molecular function for PCDHGB2 Gene

UniProtKB/Swiss-Prot Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGB2: view

Phenotypes for PCDHGB2 Gene

GenomeRNAi human phenotypes for PCDHGB2:
genes like me logo Genes that share phenotypes with PCDHGB2: view

miRNA for PCDHGB2 Gene

miRTarBase miRNAs that target PCDHGB2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PCDHGB2 Gene

Localization for PCDHGB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGB2 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for PCDHGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGB2: view

Pathways for PCDHGB2 Gene

SuperPathways for PCDHGB2 Gene

No Data Available

Interacting Proteins for PCDHGB2 Gene

Gene Ontology (GO) - Biological Process for PCDHGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDHGB2: view

No data available for Pathways by source for PCDHGB2 Gene

Compounds for PCDHGB2 Gene

(1) HMDB Compounds for PCDHGB2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDHGB2: view

Transcripts for PCDHGB2 Gene

mRNA/cDNA for PCDHGB2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGB2 Gene

No ASD Table

Relevant External Links for PCDHGB2 Gene

GeneLoc Exon Structure for
PCDHGB2
ECgene alternative splicing isoforms for
PCDHGB2

Expression for PCDHGB2 Gene

mRNA expression in normal human tissues for PCDHGB2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCDHGB2 Gene

genes like me logo Genes that share expressions with PCDHGB2: view

Orthologs for PCDHGB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHGB2 36
  • 99.18 (n)
  • 98.6 (a)
cow
(Bos Taurus)
Mammalia PCDHGB2 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCDHGB2 36
  • 85.2 (n)
  • 83.81 (a)
mouse
(Mus musculus)
Mammalia Pcdhgb2 36
  • 82.73 (n)
  • 82.8 (a)
Pcdhgb2 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 63 (a)
ManyToMany
-- 37
  • 61 (a)
ManyToMany
-- 37
  • 57 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 59 (a)
ManyToMany
-- 37
  • 58 (a)
ManyToMany
-- 37
  • 57 (a)
ManyToMany
-- 37
  • 56 (a)
ManyToMany
-- 37
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 50 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 51 (a)
ManyToMany
-- 37
  • 51 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 51 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
Species with no ortholog for PCDHGB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGB2 Gene

ENSEMBL:
Gene Tree for PCDHGB2 (if available)
TreeFam:
Gene Tree for PCDHGB2 (if available)

Paralogs for PCDHGB2 Gene

Pseudogenes.org Pseudogenes for PCDHGB2 Gene

genes like me logo Genes that share paralogs with PCDHGB2: view

Variants for PCDHGB2 Gene

Sequence variations from dbSNP and Humsavar for PCDHGB2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_048568 -
VAR_061071 -
VAR_061072 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHGB2 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6351n71 CNV Loss 21882294
dgv6352n71 CNV Loss 21882294
dgv6353n71 CNV Loss 21882294
nsv882987 CNV Gain 21882294
nsv882990 CNV Loss 21882294
nsv823279 CNV Gain 20364138
nsv823280 CNV Loss 20364138
nsv519627 CNV Loss 19592680
esv267823 CNV Insertion 20981092
nsv518799 CNV Loss 19592680
nsv327707 CNV Loss 16902084
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Relevant External Links for PCDHGB2 Gene

HapMap Linkage Disequilibrium report
PCDHGB2

Disorders for PCDHGB2 Gene

Relevant External Links for PCDHGB2

Genetic Association Database (GAD)
PCDHGB2
genes like me logo Genes that share disorders with PCDHGB2: view

No data available for UniProtKB/Swiss-Prot for PCDHGB2 Gene

Publications for PCDHGB2 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  3. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3
  4. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PMID: 10835267) Nollet F. … van Roy F. (J. Mol. Biol. 2000) 3
  5. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3

Products for PCDHGB2 Gene

Sources for PCDHGB2 Gene

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