Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCDHGA8 Gene

Aliases for PCDHGA8 Gene

  • Protocadherin Gamma Subfamily A, 8 2 3 5
  • PCDH-GAMMA-A8 3 4
  • Protocadherin Gamma-A8 3
  • KIAA0327 4

External Ids for PCDHGA8 Gene

Previous GeneCards Identifiers for PCDHGA8 Gene

  • GC05P140587
  • GC05P141310
  • GC05P140707
  • GC05P140766
  • GC05P140786
  • GC05P140725
  • GC05P140852
  • GC05P140858
  • GC05P140884
  • GC05P140906
  • GC05P140921
  • GC05P140943
  • GC05P140964
  • GC05P140986
  • GC05P141007
  • GC05P141049
  • GC05P135916
  • GC05P141108
  • GC05P141150
  • GC05P141167
  • GC05P141203
  • GC05P141243
  • GC05P141325
  • GC05P141385
  • GC05P141453
  • GC05P141530
  • GC05P141633
  • GC05P141735
  • GC05P141834

Summaries for PCDHGA8 Gene

Entrez Gene Summary for PCDHGA8 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA8 Gene

PCDHGA8 (Protocadherin Gamma Subfamily A, 8) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA9.

UniProtKB/Swiss-Prot for PCDHGA8 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA8 Gene

Genomics for PCDHGA8 Gene

Regulatory Elements for PCDHGA8 Gene

Enhancers for PCDHGA8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G141968 1.2 ENCODE 11.6 +579.4 579410 3.0 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ZNF610 KIAA0141 PCDHGA5 PCDHB12 RNF14 PCDHB11 PCDHB4 PCDHB18P PCDHB15 PCDHB9 PCDHGA6
GH05G141597 1.3 Ensembl ENCODE dbSUPER 5.6 +209.3 209281 4.1 PKNOX1 ZBTB21 MAX CEBPG YY1 RARA GATA2 EED ETV6 RELB RELL2 HDAC3 FCHSD1 LOC100505658 PCDHGA8 RPS27AP10 GC05P141943 LOC102723915
GH05G141610 0.5 dbSUPER 4.5 +221.9 221904 2.6 ZNF362 IRF1 RELB ARAP3 FCHSD1 PCDHGA6 PCDHB17P PCDHGA8 HARS LOC102723915 RPS27AP10 GC05P141943
GH05G141811 1.4 FANTOM5 ENCODE dbSUPER 1.6 +421.7 421711 1.4 CTCF MXI1 TEAD4 MAX RBBP5 SALL2 CHD7 ZNF2 RAD21 TEAD3 PCDHGB2 PCDHGC3 PCDHGC4 NDFIP1 PCDHA5 PCDHA10 PCDHAC2 PCDHGB1 PCDHB17P HDAC3
GH05G140996 0.5 FANTOM5 1.7 -393.6 -393582 0.3 ZNF121 ZNF512 ZSCAN5C PCDHGC4 PCDHA13 PCDHGA6 PCDHA3 PCDHA2 PCDHB12 PCDHA4 PCDHGA8 PCDHB15 PCDHA6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCDHGA8 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCDHGA8 Gene

Chromosome:
5
Start:
141,390,157 bp from pter
End:
141,512,979 bp from pter
Size:
122,823 bases
Orientation:
Plus strand

Genomic View for PCDHGA8 Gene

Genes around PCDHGA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHGA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHGA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA8 Gene

Proteins for PCDHGA8 Gene

  • Protein details for PCDHGA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5G5-PCDG8_HUMAN
    Recommended name:
    Protocadherin gamma-A8
    Protein Accession:
    Q9Y5G5
    Secondary Accessions:
    • A7MCZ4
    • O15039

    Protein attributes for PCDHGA8 Gene

    Size:
    932 amino acids
    Molecular mass:
    101480 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20785.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCDHGA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGA8 Gene

Post-translational modifications for PCDHGA8 Gene

  • Glycosylation at Asn47, Asn414, Asn419, posLast=545545, and Asn685
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGA8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGA8 Gene

Domains & Families for PCDHGA8 Gene

Gene Families for PCDHGA8 Gene

Suggested Antigen Peptide Sequences for PCDHGA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCDHGA8: view

No data available for UniProtKB/Swiss-Prot for PCDHGA8 Gene

Function for PCDHGA8 Gene

Molecular function for PCDHGA8 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Gene Ontology (GO) - Molecular Function for PCDHGA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGA8: view
genes like me logo Genes that share phenotypes with PCDHGA8: view

Animal Model Products

CRISPR Products

miRNA for PCDHGA8 Gene

miRTarBase miRNAs that target PCDHGA8

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHGA8 Gene

Localization for PCDHGA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA8 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCDHGA8 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDHGA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA8: view

Pathways & Interactions for PCDHGA8 Gene

SuperPathways for PCDHGA8 Gene

No Data Available

Interacting Proteins for PCDHGA8 Gene

Gene Ontology (GO) - Biological Process for PCDHGA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling IBA --
GO:0007399 nervous system development IBA --
genes like me logo Genes that share ontologies with PCDHGA8: view

No data available for Pathways by source and SIGNOR curated interactions for PCDHGA8 Gene

Drugs & Compounds for PCDHGA8 Gene

(1) Drugs for PCDHGA8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHGA8: view

Transcripts for PCDHGA8 Gene

mRNA/cDNA for PCDHGA8 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA8 Gene

No ASD Table

Relevant External Links for PCDHGA8 Gene

GeneLoc Exon Structure for
PCDHGA8
ECgene alternative splicing isoforms for
PCDHGA8

Expression for PCDHGA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCDHGA8 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCDHGA8 Gene:

PCDHGA8

Evidence on tissue expression from TISSUES for PCDHGA8 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with PCDHGA8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHGA8 Gene

Orthologs for PCDHGA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHGA8 34
  • 98.93 (n)
cow
(Bos Taurus)
Mammalia PCDHGA8 34
  • 86.01 (n)
dog
(Canis familiaris)
Mammalia PCDHGA8 34
  • 83.94 (n)
mouse
(Mus musculus)
Mammalia Pcdhga8 34 16
  • 83.35 (n)
rat
(Rattus norvegicus)
Mammalia Pcdhga8 34
  • 82.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 50 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
Species where no ortholog for PCDHGA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA8 Gene

ENSEMBL:
Gene Tree for PCDHGA8 (if available)
TreeFam:
Gene Tree for PCDHGA8 (if available)

Paralogs for PCDHGA8 Gene

genes like me logo Genes that share paralogs with PCDHGA8: view

Variants for PCDHGA8 Gene

Sequence variations from dbSNP and Humsavar for PCDHGA8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs386352347 Uncertain significance 141,485,635(+) CCGTT(A/G)GAAAA intron-variant, reference, synonymous-codon
rs1000014772 -- 141,409,727(+) TGAGC(A/G)CGCAG intron-variant, reference, missense
rs1000022316 -- 141,472,751(+) GAGGC(A/G)GAGGC intron-variant
rs1000136303 -- 141,452,887(+) TTATT(C/T)CACTT intron-variant
rs1000138324 -- 141,499,091(+) GGCAC(A/C)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA8 Gene

Variant ID Type Subtype PubMed ID
esv25744 CNV gain 19812545
esv2730847 CNV deletion 23290073
esv2759382 CNV gain 17122850
esv3422812 CNV insertion 20981092
esv3606984 CNV loss 21293372
esv3606985 CNV gain 21293372
esv3606987 CNV gain 21293372
nsv1123990 CNV deletion 24896259
nsv1125852 CNV tandem duplication 24896259
nsv327707 CNV deletion 16902084
nsv462470 CNV loss 19166990
nsv518799 CNV loss 19592680
nsv519627 CNV loss 19592680
nsv599922 CNV loss 21841781
nsv599923 CNV loss 21841781
nsv823280 CNV loss 20364138
nsv968259 CNV duplication 23825009
nsv980740 CNV duplication 23825009

Variation tolerance for PCDHGA8 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.08; 90.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDHGA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCDHGA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHGA8 Gene

Disorders for PCDHGA8 Gene

Relevant External Links for PCDHGA8

Genetic Association Database (GAD)
PCDHGA8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDHGA8

No disorders were found for PCDHGA8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHGA8 Gene

Publications for PCDHGA8 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3 64

Products for PCDHGA8 Gene

Sources for PCDHGA8 Gene

Content
Loading form....