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Aliases for PCDHGA6 Gene

Aliases for PCDHGA6 Gene

  • Protocadherin Gamma Subfamily A, 6 2 3
  • PCDH-GAMMA-A6 3 4
  • Protocadherin Gamma-A6 3

External Ids for PCDHGA6 Gene

Summaries for PCDHGA6 Gene

Entrez Gene Summary for PCDHGA6 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA6 Gene

PCDHGA6 (Protocadherin Gamma Subfamily A, 6) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHGA6 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA6 Gene

Genomics for PCDHGA6 Gene

Genomic Location for PCDHGA6 Gene

141,373,914 bp from pter
141,512,979 bp from pter
139,066 bases
Plus strand

Genomic View for PCDHGA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHGA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA6 Gene

Regulatory Elements for PCDHGA6 Gene

Proteins for PCDHGA6 Gene

  • Protein details for PCDHGA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protocadherin gamma-A6
    Protein Accession:
    Secondary Accessions:
    • A6H8K7
    • B2RN55
    • Q9Y5D1

    Protein attributes for PCDHGA6 Gene

    932 amino acids
    Molecular mass:
    100871 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGA6 Gene


neXtProt entry for PCDHGA6 Gene

Proteomics data for PCDHGA6 Gene at MOPED

Post-translational modifications for PCDHGA6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn81, Asn419, Asn545, and Asn685

Other Protein References for PCDHGA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGA6 Gene

Domains for PCDHGA6 Gene

Gene Families for PCDHGA6 Gene

  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHGA6 Gene


  • Contains 6 cadherin domains.:
    • Q9Y5G7
genes like me logo Genes that share domains with PCDHGA6: view

Function for PCDHGA6 Gene

Molecular function for PCDHGA6 Gene

UniProtKB/Swiss-Prot Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHGA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGA6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PCDHGA6 Gene

Localization for PCDHGA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA6 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for PCDHGA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA6: view

Pathways for PCDHGA6 Gene

SuperPathways for PCDHGA6 Gene

No Data Available

Interacting Proteins for PCDHGA6 Gene

Gene Ontology (GO) - Biological Process for PCDHGA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDHGA6: view

No data available for Pathways by source for PCDHGA6 Gene

Compounds for PCDHGA6 Gene

(1) HMDB Compounds for PCDHGA6 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with PCDHGA6: view

Transcripts for PCDHGA6 Gene

mRNA/cDNA for PCDHGA6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA6 Gene

No ASD Table

Relevant External Links for PCDHGA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDHGA6 Gene

mRNA expression in normal human tissues for PCDHGA6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCDHGA6 Gene

genes like me logo Genes that share expressions with PCDHGA6: view

Orthologs for PCDHGA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCDHGA6 36
  • 99.57 (n)
  • 99.46 (a)
(Bos Taurus)
Mammalia PCDHGA6 36
  • 83.5 (n)
  • 84.36 (a)
(Canis familiaris)
Mammalia PCDHGB3 36
  • 81.2 (n)
  • 77.61 (a)
(Mus musculus)
Mammalia Pcdhga6 36
  • 81.13 (n)
  • 79.93 (a)
Pcdhga6 16
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
-- 37
  • 65 (a)
-- 37
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 66 (a)
-- 37
  • 66 (a)
-- 37
  • 64 (a)
-- 37
  • 69 (a)
-- 37
  • 58 (a)
-- 37
  • 66 (a)
(Rattus norvegicus)
Mammalia LOC102552796 36
  • 80.68 (n)
  • 78.33 (a)
(Gallus gallus)
Aves -- 37
  • 50 (a)
-- 37
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 54 (a)
-- 37
  • 55 (a)
-- 37
  • 54 (a)
-- 37
  • 54 (a)
-- 37
  • 56 (a)
-- 37
  • 57 (a)
-- 37
  • 53 (a)
-- 37
  • 52 (a)
Species with no ortholog for PCDHGA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA6 Gene

Gene Tree for PCDHGA6 (if available)
Gene Tree for PCDHGA6 (if available)

Paralogs for PCDHGA6 Gene

genes like me logo Genes that share paralogs with PCDHGA6: view

Variants for PCDHGA6 Gene

Sequence variations from dbSNP and Humsavar for PCDHGA6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_048560 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA6 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6351n71 CNV Loss 21882294
dgv6352n71 CNV Loss 21882294
dgv6353n71 CNV Loss 21882294
nsv882987 CNV Gain 21882294
nsv882990 CNV Loss 21882294
nsv823279 CNV Gain 20364138
nsv823280 CNV Loss 20364138
nsv519627 CNV Loss 19592680
esv267823 CNV Insertion 20981092
nsv518799 CNV Loss 19592680
nsv327707 CNV Loss 16902084
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Relevant External Links for PCDHGA6 Gene

HapMap Linkage Disequilibrium report

Disorders for PCDHGA6 Gene

Relevant External Links for PCDHGA6

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with PCDHGA6: view

No data available for UniProtKB/Swiss-Prot for PCDHGA6 Gene

Publications for PCDHGA6 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  3. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3
  4. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PMID: 10835267) Nollet F. … van Roy F. (J. Mol. Biol. 2000) 3
  5. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3

Products for PCDHGA6 Gene

Sources for PCDHGA6 Gene

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