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Aliases for PCDHGA5 Gene

Aliases for PCDHGA5 Gene

  • Protocadherin Gamma Subfamily A, 5 2 3 5
  • PCDH-GAMMA-A5 3 4
  • Cadherin ME3 2 3
  • CDH-GAMMA-A5 3
  • ME3 3

External Ids for PCDHGA5 Gene

Previous GeneCards Identifiers for PCDHGA5 Gene

  • GC05P140560
  • GC05P141306
  • GC05P140704
  • GC05P140763
  • GC05P140783
  • GC05P140722
  • GC05P140816
  • GC05P140823
  • GC05P140840
  • GC05P140865
  • GC05P140891
  • GC05P140913
  • GC05P140925
  • GC05P140947
  • GC05P140968
  • GC05P140990
  • GC05P141021
  • GC05P141053
  • GC05P141083
  • GC05P135888
  • GC05P141120
  • GC05P141145
  • GC05P141183
  • GC05P141214
  • GC05P141253
  • GC05P141280
  • GC05P141381
  • GC05P141449
  • GC05P141524

Summaries for PCDHGA5 Gene

Entrez Gene Summary for PCDHGA5 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA5 Gene

PCDHGA5 (Protocadherin Gamma Subfamily A, 5) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA8.

UniProtKB/Swiss-Prot for PCDHGA5 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA5 Gene

Genomics for PCDHGA5 Gene

Regulatory Elements for PCDHGA5 Gene

Enhancers for PCDHGA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCDHGA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCDHGA5 Gene

141,364,232 bp from pter
141,512,979 bp from pter
148,748 bases
Plus strand

Genomic View for PCDHGA5 Gene

Genes around PCDHGA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHGA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHGA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA5 Gene

Proteins for PCDHGA5 Gene

  • Protein details for PCDHGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protocadherin gamma-A5
    Protein Accession:
    Secondary Accessions:
    • Q2M3F5
    • Q9Y5D2

    Protein attributes for PCDHGA5 Gene

    931 amino acids
    Molecular mass:
    100935 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGA5 Gene


neXtProt entry for PCDHGA5 Gene

Proteomics data for PCDHGA5 Gene at MOPED

Post-translational modifications for PCDHGA5 Gene

  • Glycosylation at Asn 419 and Asn 545
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGA5 Gene

Domains & Families for PCDHGA5 Gene

Gene Families for PCDHGA5 Gene

Protein Domains for PCDHGA5 Gene

Suggested Antigen Peptide Sequences for PCDHGA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 cadherin domains.
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHGA5: view

Function for PCDHGA5 Gene

Molecular function for PCDHGA5 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
genes like me logo Genes that share phenotypes with PCDHGA5: view

Animal Model Products

CRISPR Products

miRNA for PCDHGA5 Gene

miRTarBase miRNAs that target PCDHGA5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHGA5 Gene

Localization for PCDHGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA5 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PCDHGA5 Gene COMPARTMENTS Subcellular localization image for PCDHGA5 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDHGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA5: view

Pathways & Interactions for PCDHGA5 Gene

SuperPathways for PCDHGA5 Gene

No Data Available

Interacting Proteins for PCDHGA5 Gene

Gene Ontology (GO) - Biological Process for PCDHGA5 Gene


No data available for Pathways by source and SIGNOR curated interactions for PCDHGA5 Gene

Drugs & Compounds for PCDHGA5 Gene

(1) Drugs for PCDHGA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHGA5: view

Transcripts for PCDHGA5 Gene

mRNA/cDNA for PCDHGA5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA5 Gene

No ASD Table

Relevant External Links for PCDHGA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDHGA5 Gene

mRNA expression in normal human tissues for PCDHGA5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDHGA5 Gene

genes like me logo Genes that share expression patterns with PCDHGA5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PCDHGA5 Gene

Orthologs for PCDHGA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PCDHGA5 35
  • 82.53 (n)
  • 81.16 (a)
(Mus musculus)
Mammalia Pcdhga5 35
  • 82.9 (n)
  • 84.93 (a)
Pcdhga5 16
(Pan troglodytes)
Mammalia PCDHGA5 35
  • 99.36 (n)
  • 99.36 (a)
(Rattus norvegicus)
Mammalia Pcdhga5 35
  • 82.13 (n)
  • 84.28 (a)
(Bos Taurus)
Mammalia PCDHGA5 36
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
-- 36
  • 65 (a)
-- 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 67 (a)
-- 36
  • 65 (a)
-- 36
  • 68 (a)
-- 36
  • 58 (a)
-- 36
  • 66 (a)
(Gallus gallus)
Aves -- 36
  • 51 (a)
-- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
-- 36
  • 54 (a)
-- 36
  • 53 (a)
-- 36
  • 54 (a)
-- 36
  • 56 (a)
-- 36
  • 56 (a)
-- 36
  • 52 (a)
-- 36
  • 53 (a)
Species with no ortholog for PCDHGA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA5 Gene

Gene Tree for PCDHGA5 (if available)
Gene Tree for PCDHGA5 (if available)

Paralogs for PCDHGA5 Gene

genes like me logo Genes that share paralogs with PCDHGA5: view

Variants for PCDHGA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA5 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6351n71 CNV Loss 21882294
dgv6352n71 CNV Loss 21882294
dgv6353n71 CNV Loss 21882294
nsv882987 CNV Gain 21882294
nsv882990 CNV Loss 21882294
nsv823279 CNV Gain 20364138
nsv823280 CNV Loss 20364138
nsv519627 CNV Loss 19592680
esv267823 CNV Insertion 20981092
nsv518799 CNV Loss 19592680
nsv327707 CNV Loss 16902084
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Variation tolerance for PCDHGA5 Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for PCDHGA5 Gene

Disorders for PCDHGA5 Gene

Relevant External Links for PCDHGA5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PCDHGA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHGA5 Gene

Publications for PCDHGA5 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3
  4. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  5. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3

Products for PCDHGA5 Gene

Sources for PCDHGA5 Gene