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Aliases for PCDHGA4 Gene

Aliases for PCDHGA4 Gene

  • Protocadherin Gamma Subfamily A, 4 2 3 5
  • PCDH-GAMMA-A4 3 4
  • Protocadherin Gamma-A4 3

External Ids for PCDHGA4 Gene

Previous GeneCards Identifiers for PCDHGA4 Gene

  • GC05P140551
  • GC05P141304
  • GC05P140703
  • GC05P140762
  • GC05P140782
  • GC05P140700
  • GC05P140812
  • GC05P140821
  • GC05P140836
  • GC05P140863
  • GC05P140889
  • GC05P140911
  • GC05P140923
  • GC05P140945
  • GC05P140966
  • GC05P140988
  • GC05P141018
  • GC05P141036
  • GC05P141066
  • GC05P135879
  • GC05P141103
  • GC05P141133
  • GC05P141165
  • GC05P141200
  • GC05P141241
  • GC05P141290
  • GC05P141376
  • GC05P141445
  • GC05P141520
  • GC05P141626
  • GC05P141728
  • GC05P141827

Summaries for PCDHGA4 Gene

Entrez Gene Summary for PCDHGA4 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA4 Gene

PCDHGA4 (Protocadherin Gamma Subfamily A, 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA6.

UniProtKB/Swiss-Prot for PCDHGA4 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA4 Gene

Genomics for PCDHGA4 Gene

Regulatory Elements for PCDHGA4 Gene

Enhancers for PCDHGA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G141968 1.2 ENCODE 17.2 +614.5 614542 3.0 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ZNF610 KIAA0141 PCDHGA5 PCDHB12 RNF14 PCDHB11 PCDHB4 PCDHB18P PCDHB15 PCDHB9 PCDHGA6
GH05G141359 0.6 ENCODE 0.7 +5.0 4994 0.1 CTCF ZNF654 FOXA2 CBX5 RAD21 KAT8 PCDHGB2 PCDHGA4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCDHGA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCDHGA4 Gene

141,355,025 bp from pter
141,512,979 bp from pter
157,955 bases
Plus strand

Genomic View for PCDHGA4 Gene

Genes around PCDHGA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHGA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA4 Gene

Proteins for PCDHGA4 Gene

  • Protein details for PCDHGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protocadherin gamma-A4
    Protein Accession:
    Secondary Accessions:
    • Q9Y5D3

    Protein attributes for PCDHGA4 Gene

    931 amino acids
    Molecular mass:
    100589 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGA4 Gene


neXtProt entry for PCDHGA4 Gene

Post-translational modifications for PCDHGA4 Gene

  • Glycosylation at Asn419 and posLast=545545
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGA4 Gene

Domains & Families for PCDHGA4 Gene

Gene Families for PCDHGA4 Gene

Suggested Antigen Peptide Sequences for PCDHGA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCDHGA4: view

No data available for UniProtKB/Swiss-Prot for PCDHGA4 Gene

Function for PCDHGA4 Gene

Molecular function for PCDHGA4 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Gene Ontology (GO) - Molecular Function for PCDHGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGA4: view
genes like me logo Genes that share phenotypes with PCDHGA4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHGA4 Gene

Localization for PCDHGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCDHGA4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDHGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA4: view

Pathways & Interactions for PCDHGA4 Gene

SuperPathways for PCDHGA4 Gene

No Data Available

Interacting Proteins for PCDHGA4 Gene

Gene Ontology (GO) - Biological Process for PCDHGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,IBA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling IBA --
GO:0007283 spermatogenesis IEA --
GO:0007399 nervous system development IBA --
genes like me logo Genes that share ontologies with PCDHGA4: view

No data available for Pathways by source and SIGNOR curated interactions for PCDHGA4 Gene

Drugs & Compounds for PCDHGA4 Gene

(1) Drugs for PCDHGA4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHGA4: view

Transcripts for PCDHGA4 Gene

mRNA/cDNA for PCDHGA4 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA4 Gene

No ASD Table

Relevant External Links for PCDHGA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDHGA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCDHGA4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDHGA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCDHGA4 Gene:


Evidence on tissue expression from TISSUES for PCDHGA4 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with PCDHGA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHGA4 Gene

Orthologs for PCDHGA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCDHGA4 34
  • 99.06 (n)
  • 95 (a)
(Canis familiaris)
Mammalia PCDHGA4 34
  • 84.98 (n)
(Mus musculus)
Mammalia Pcdhga4 34 16
  • 82.39 (n)
(Rattus norvegicus)
Mammalia LOC102553012 34
  • 81.13 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
-- 35
  • 67 (a)
-- 35
  • 66 (a)
-- 35
  • 66 (a)
-- 35
  • 65 (a)
-- 35
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
-- 35
  • 65 (a)
-- 35
  • 63 (a)
(Gallus gallus)
Aves -- 35
  • 50 (a)
-- 35
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
-- 35
  • 55 (a)
-- 35
  • 54 (a)
-- 35
  • 53 (a)
-- 35
  • 53 (a)
-- 35
  • 52 (a)
-- 35
  • 52 (a)
-- 35
  • 51 (a)
Species where no ortholog for PCDHGA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA4 Gene

Gene Tree for PCDHGA4 (if available)
Gene Tree for PCDHGA4 (if available)

Paralogs for PCDHGA4 Gene

genes like me logo Genes that share paralogs with PCDHGA4: view

Variants for PCDHGA4 Gene

Sequence variations from dbSNP and Humsavar for PCDHGA4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs386352347 Uncertain significance 141,485,635(+) CCGTT(A/G)GAAAA intron-variant, reference, synonymous-codon
rs1000014772 -- 141,409,727(+) TGAGC(A/G)CGCAG intron-variant, reference, missense
rs1000022316 -- 141,472,751(+) GAGGC(A/G)GAGGC intron-variant
rs1000098905 -- 141,353,769(+) TAATG(C/T)ATACT intron-variant, upstream-variant-2KB
rs1000136303 -- 141,452,887(+) TTATT(C/T)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA4 Gene

Variant ID Type Subtype PubMed ID
esv25744 CNV gain 19812545
esv2730847 CNV deletion 23290073
esv2759382 CNV gain 17122850
esv3422812 CNV insertion 20981092
esv3606982 CNV loss 21293372
esv3606983 CNV gain 21293372
esv3606984 CNV loss 21293372
esv3606985 CNV gain 21293372
esv3606987 CNV gain 21293372
nsv1123990 CNV deletion 24896259
nsv1125852 CNV tandem duplication 24896259
nsv327707 CNV deletion 16902084
nsv462470 CNV loss 19166990
nsv518799 CNV loss 19592680
nsv519627 CNV loss 19592680
nsv599922 CNV loss 21841781
nsv599923 CNV loss 21841781
nsv823279 CNV gain 20364138
nsv823280 CNV loss 20364138
nsv968259 CNV duplication 23825009
nsv980739 CNV duplication 23825009
nsv980740 CNV duplication 23825009

Variation tolerance for PCDHGA4 Gene

Gene Damage Index Score: 7.96; 84.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDHGA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHGA4 Gene

Disorders for PCDHGA4 Gene

Relevant External Links for PCDHGA4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PCDHGA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHGA4 Gene

Publications for PCDHGA4 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 64
  2. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3 64
  5. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 64

Products for PCDHGA4 Gene

Sources for PCDHGA4 Gene

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