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Aliases for PCDHGA3 Gene

Aliases for PCDHGA3 Gene

  • Protocadherin Gamma Subfamily A, 3 2 3
  • PCDH-GAMMA-A3 3 4
  • Protocadherin Gamma-A3 3

External Ids for PCDHGA3 Gene

Summaries for PCDHGA3 Gene

Entrez Gene Summary for PCDHGA3 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA3 Gene

PCDHGA3 (Protocadherin Gamma Subfamily A, 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHGA3 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA3 Gene

Genomics for PCDHGA3 Gene

Genomic Location for PCDHGA3 Gene

Start:
141,343,829 bp from pter
End:
141,512,979 bp from pter
Size:
169,151 bases
Orientation:
Plus strand

Genomic View for PCDHGA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA3 Gene

Regulatory Elements for PCDHGA3 Gene

Proteins for PCDHGA3 Gene

  • Protein details for PCDHGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5H0-PCDG3_HUMAN
    Recommended name:
    Protocadherin gamma-A3
    Protein Accession:
    Q9Y5H0
    Secondary Accessions:
    • Q9Y5D4

    Protein attributes for PCDHGA3 Gene

    Size:
    932 amino acids
    Molecular mass:
    100971 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGA3 Gene

Proteomics data for PCDHGA3 Gene at MOPED

Post-translational modifications for PCDHGA3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn265, Asn419, Asn545, and Asn685

Other Protein References for PCDHGA3 Gene

No data available for DME Specific Peptides for PCDHGA3 Gene

Domains for PCDHGA3 Gene

Gene Families for PCDHGA3 Gene

HGNC:
  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHGA3 Gene

UniProtKB/Swiss-Prot:

PCDG3_HUMAN
Domain:
  • Contains 6 cadherin domains.:
    • Q9Y5H0
genes like me logo Genes that share domains with PCDHGA3: view

Function for PCDHGA3 Gene

Molecular function for PCDHGA3 Gene

UniProtKB/Swiss-Prot Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGA3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PCDHGA3 Gene

Localization for PCDHGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA3 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for PCDHGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA3: view

Pathways for PCDHGA3 Gene

SuperPathways for PCDHGA3 Gene

No Data Available

Interacting Proteins for PCDHGA3 Gene

Gene Ontology (GO) - Biological Process for PCDHGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDHGA3: view

No data available for Pathways by source for PCDHGA3 Gene

Compounds for PCDHGA3 Gene

(1) HMDB Compounds for PCDHGA3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDHGA3: view

Transcripts for PCDHGA3 Gene

mRNA/cDNA for PCDHGA3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA3 Gene

No ASD Table

Relevant External Links for PCDHGA3 Gene

GeneLoc Exon Structure for
PCDHGA3
ECgene alternative splicing isoforms for
PCDHGA3

Expression for PCDHGA3 Gene

mRNA expression in normal human tissues for PCDHGA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDHGA3 Gene

genes like me logo Genes that share expressions with PCDHGA3: view

Orthologs for PCDHGA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHGA3 36
  • 99.32 (n)
  • 99.25 (a)
cow
(Bos Taurus)
Mammalia PCDHGA3 37
  • 86 (a)
OneToOne
PCDHGB1 36
  • 85.63 (n)
  • 86.71 (a)
dog
(Canis familiaris)
Mammalia PCDHGA3 36
  • 84.57 (n)
  • 83.04 (a)
mouse
(Mus musculus)
Mammalia Pcdhga3 36
  • 83.3 (n)
  • 85.84 (a)
Pcdhga3 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 65 (a)
ManyToMany
-- 37
  • 66 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 67 (a)
ManyToMany
-- 37
  • 66 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 68 (a)
ManyToMany
-- 37
  • 59 (a)
ManyToMany
-- 37
  • 66 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pcdhga3 36
  • 84.06 (n)
  • 86.53 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 50 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 53 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 51 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
Species with no ortholog for PCDHGA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA3 Gene

ENSEMBL:
Gene Tree for PCDHGA3 (if available)
TreeFam:
Gene Tree for PCDHGA3 (if available)

Paralogs for PCDHGA3 Gene

genes like me logo Genes that share paralogs with PCDHGA3: view

Variants for PCDHGA3 Gene

Sequence variations from dbSNP and Humsavar for PCDHGA3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_055588 -
VAR_055589 -
VAR_059190 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA3 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6351n71 CNV Loss 21882294
dgv6352n71 CNV Loss 21882294
dgv6353n71 CNV Loss 21882294
nsv882987 CNV Gain 21882294
nsv882990 CNV Loss 21882294
nsv823279 CNV Gain 20364138
nsv823280 CNV Loss 20364138
nsv519627 CNV Loss 19592680
esv267823 CNV Insertion 20981092
nsv518799 CNV Loss 19592680
nsv327707 CNV Loss 16902084
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Relevant External Links for PCDHGA3 Gene

HapMap Linkage Disequilibrium report
PCDHGA3

Disorders for PCDHGA3 Gene

Relevant External Links for PCDHGA3

Genetic Association Database (GAD)
PCDHGA3
Human Genome Epidemiology (HuGE) Navigator
PCDHGA3
genes like me logo Genes that share disorders with PCDHGA3: view

No data available for UniProtKB/Swiss-Prot for PCDHGA3 Gene

Publications for PCDHGA3 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4
  4. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  5. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3

Products for PCDHGA3 Gene

Sources for PCDHGA3 Gene

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