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Aliases for PCDHGA12 Gene

Aliases for PCDHGA12 Gene

  • Protocadherin Gamma Subfamily A, 12 2 3 5
  • Fibroblast Cadherin FIB3 2 3
  • Fibroblast Cadherin-3 3 4
  • PCDH-GAMMA-A12 3 4
  • Cadherin 21 2 3
  • Cadherin-21 3 4
  • CDH21 3 4
  • FIB3 3 4
  • KIAA0588 4

External Ids for PCDHGA12 Gene

Previous HGNC Symbols for PCDHGA12 Gene

  • CDH21

Previous GeneCards Identifiers for PCDHGA12 Gene

  • GC05P140597
  • GC05P141318
  • GC05P140721
  • GC05P140780
  • GC05P140800
  • GC05P140740
  • GC05P140815
  • GC05P140838
  • GC05P140927
  • GC05P140949
  • GC05P140970
  • GC05P140992
  • GC05P141022
  • GC05P141052
  • GC05P141080
  • GC05P135955
  • GC05P141119
  • GC05P141144
  • GC05P141182
  • GC05P141213
  • GC05P141252
  • GC05P141298
  • GC05P141379
  • GC05P141448
  • GC05P141523

Summaries for PCDHGA12 Gene

Entrez Gene Summary for PCDHGA12 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA12 Gene

PCDHGA12 (Protocadherin Gamma Subfamily A, 12) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA5.

UniProtKB/Swiss-Prot for PCDHGA12 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Gene Wiki entry for PCDHGA12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA12 Gene

Genomics for PCDHGA12 Gene

Regulatory Elements for PCDHGA12 Gene

Enhancers for PCDHGA12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCDHGA12 on UCSC Golden Path with GeneCards custom track

Promoters for PCDHGA12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCDHGA12 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCDHGA12 Gene

141,430,589 bp from pter
141,512,979 bp from pter
82,391 bases
Plus strand

Genomic View for PCDHGA12 Gene

Genes around PCDHGA12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHGA12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHGA12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA12 Gene

Proteins for PCDHGA12 Gene

  • Protein details for PCDHGA12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protocadherin gamma-A12
    Protein Accession:
    Secondary Accessions:
    • O15100
    • Q6UW70
    • Q9Y5D7

    Protein attributes for PCDHGA12 Gene

    932 amino acids
    Molecular mass:
    100955 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89305.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA25514.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCDHGA12 Gene


neXtProt entry for PCDHGA12 Gene

Proteomics data for PCDHGA12 Gene at MOPED

Post-translational modifications for PCDHGA12 Gene

  • Glycosylation at Asn 265, Asn 419, and Asn 545
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGA12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGA12 Gene

Domains & Families for PCDHGA12 Gene

Gene Families for PCDHGA12 Gene

Protein Domains for PCDHGA12 Gene

Suggested Antigen Peptide Sequences for PCDHGA12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 cadherin domains.
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHGA12: view

Function for PCDHGA12 Gene

Molecular function for PCDHGA12 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Phenotypes for PCDHGA12 Gene

GenomeRNAi human phenotypes for PCDHGA12:
genes like me logo Genes that share phenotypes with PCDHGA12: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHGA12 Gene

Localization for PCDHGA12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA12 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PCDHGA12 Gene COMPARTMENTS Subcellular localization image for PCDHGA12 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDHGA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005911 cell-cell junction IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA12: view

Pathways & Interactions for PCDHGA12 Gene

SuperPathways for PCDHGA12 Gene

No Data Available

Interacting Proteins for PCDHGA12 Gene

Gene Ontology (GO) - Biological Process for PCDHGA12 Gene


No data available for Pathways by source and SIGNOR curated interactions for PCDHGA12 Gene

Drugs & Compounds for PCDHGA12 Gene

(1) Drugs for PCDHGA12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHGA12: view

Transcripts for PCDHGA12 Gene

mRNA/cDNA for PCDHGA12 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA12 Gene

No ASD Table

Relevant External Links for PCDHGA12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDHGA12 Gene

mRNA expression in normal human tissues for PCDHGA12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PCDHGA12 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDHGA12 Gene

genes like me logo Genes that share expression patterns with PCDHGA12: view

Protein tissue co-expression partners for PCDHGA12 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCDHGA12 Gene

Orthologs for PCDHGA12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA12 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PCDHGA12 35
  • 83.11 (n)
  • 79.96 (a)
(Mus musculus)
Mammalia Pcdhga12 35
  • 83.93 (n)
  • 85.71 (a)
Pcdhga12 16
(Pan troglodytes)
Mammalia PCDHGA12 35
  • 99.46 (n)
  • 99.46 (a)
(Rattus norvegicus)
Mammalia Pcdhga12 35
  • 83.75 (n)
  • 85.17 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
-- 36
  • 64 (a)
-- 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 68 (a)
-- 36
  • 66 (a)
-- 36
  • 69 (a)
-- 36
  • 59 (a)
-- 36
  • 70 (a)
(Gallus gallus)
Aves -- 36
  • 50 (a)
-- 36
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
-- 36
  • 53 (a)
-- 36
  • 53 (a)
-- 36
  • 53 (a)
-- 36
  • 55 (a)
-- 36
  • 55 (a)
-- 36
  • 52 (a)
-- 36
  • 52 (a)
Species with no ortholog for PCDHGA12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA12 Gene

Gene Tree for PCDHGA12 (if available)
Gene Tree for PCDHGA12 (if available)

Paralogs for PCDHGA12 Gene

genes like me logo Genes that share paralogs with PCDHGA12: view

Variants for PCDHGA12 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA12 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6352n71 CNV Loss 21882294
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Variation tolerance for PCDHGA12 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for PCDHGA12 Gene

Disorders for PCDHGA12 Gene

Relevant External Links for PCDHGA12

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PCDHGA12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHGA12 Gene

Publications for PCDHGA12 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 67
  2. Multiple cadherins are expressed in human fibroblasts. (PMID: 9199196) Matsuyoshi N. … Imamura S. (Biochem. Biophys. Res. Commun. 1997) 3 23
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for PCDHGA12 Gene

Sources for PCDHGA12 Gene