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Aliases for PCDHGA11 Gene

Aliases for PCDHGA11 Gene

  • Protocadherin Gamma Subfamily A, 11 2 3 5
  • PCDH-GAMMA-A11 3 4

External Ids for PCDHGA11 Gene

Previous GeneCards Identifiers for PCDHGA11 Gene

  • GC05P140596
  • GC05P141317
  • GC05P140720
  • GC05P140779
  • GC05P140799
  • GC05P140739
  • GC05P140811
  • GC05P140835
  • GC05P140867
  • GC05P140881
  • GC05P140901
  • GC05P140917
  • GC05P140939
  • GC05P140960
  • GC05P140982
  • GC05P141009
  • GC05P141034
  • GC05P135945
  • GC05P141114
  • GC05P141134
  • GC05P141174
  • GC05P141217
  • GC05P141257
  • GC05P141335
  • GC05P141391
  • GC05P141458
  • GC05P141536

Summaries for PCDHGA11 Gene

Entrez Gene Summary for PCDHGA11 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA11 Gene

PCDHGA11 (Protocadherin Gamma Subfamily A, 11) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA2.

UniProtKB/Swiss-Prot for PCDHGA11 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Gene Wiki entry for PCDHGA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA11 Gene

Genomics for PCDHGA11 Gene

Regulatory Elements for PCDHGA11 Gene

Enhancers for PCDHGA11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCDHGA11 on UCSC Golden Path with GeneCards custom track

Promoters for PCDHGA11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCDHGA11 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCDHGA11 Gene

Chromosome:
5
Start:
141,420,970 bp from pter
End:
141,512,979 bp from pter
Size:
92,010 bases
Orientation:
Plus strand

Genomic View for PCDHGA11 Gene

Genes around PCDHGA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHGA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHGA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA11 Gene

Proteins for PCDHGA11 Gene

  • Protein details for PCDHGA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5H2-PCDGB_HUMAN
    Recommended name:
    Protocadherin gamma-A11
    Protein Accession:
    Q9Y5H2
    Secondary Accessions:
    • B7ZVY8
    • Q9Y5D8
    • Q9Y5D9

    Protein attributes for PCDHGA11 Gene

    Size:
    935 amino acids
    Molecular mass:
    101543 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGA11 Gene

Proteomics data for PCDHGA11 Gene at MOPED

Post-translational modifications for PCDHGA11 Gene

  • Glycosylation at Asn 48, Asn 255, Asn 266, Asn 420, and Asn 546
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGA11 Gene

No data available for DME Specific Peptides for PCDHGA11 Gene

Domains & Families for PCDHGA11 Gene

Gene Families for PCDHGA11 Gene

Protein Domains for PCDHGA11 Gene

Suggested Antigen Peptide Sequences for PCDHGA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5H2

UniProtKB/Swiss-Prot:

PCDGB_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHGA11: view

Function for PCDHGA11 Gene

Molecular function for PCDHGA11 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
genes like me logo Genes that share phenotypes with PCDHGA11: view

Animal Model Products

CRISPR Products

miRNA for PCDHGA11 Gene

miRTarBase miRNAs that target PCDHGA11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHGA11 Gene

Localization for PCDHGA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA11 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHGA11 Gene COMPARTMENTS Subcellular localization image for PCDHGA11 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDHGA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA11: view

Pathways & Interactions for PCDHGA11 Gene

SuperPathways for PCDHGA11 Gene

No Data Available

Interacting Proteins for PCDHGA11 Gene

Gene Ontology (GO) - Biological Process for PCDHGA11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCDHGA11 Gene

Drugs & Compounds for PCDHGA11 Gene

(1) Drugs for PCDHGA11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHGA11: view

Transcripts for PCDHGA11 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA11 Gene

No ASD Table

Relevant External Links for PCDHGA11 Gene

GeneLoc Exon Structure for
PCDHGA11
ECgene alternative splicing isoforms for
PCDHGA11

Expression for PCDHGA11 Gene

mRNA expression in normal human tissues for PCDHGA11 Gene

Protein differential expression in normal tissues from HIPED for PCDHGA11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (46.7) and Ovary (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCDHGA11 Gene



genes like me logo Genes that share expression patterns with PCDHGA11: view

Protein tissue co-expression partners for PCDHGA11 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCDHGA11 Gene

Orthologs for PCDHGA11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCDHGA11 35
  • 84.54 (n)
  • 84.71 (a)
dog
(Canis familiaris)
Mammalia PCDHGA11 35
  • 83.13 (n)
  • 81.73 (a)
mouse
(Mus musculus)
Mammalia Pcdhga11 35
  • 81.84 (n)
  • 82.79 (a)
Pcdhga11 16
chimpanzee
(Pan troglodytes)
Mammalia PCDHGA11 35
  • 99.68 (n)
  • 99.68 (a)
rat
(Rattus norvegicus)
Mammalia Pcdhga11 35
  • 81.99 (n)
  • 83.66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
Species with no ortholog for PCDHGA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA11 Gene

ENSEMBL:
Gene Tree for PCDHGA11 (if available)
TreeFam:
Gene Tree for PCDHGA11 (if available)

Paralogs for PCDHGA11 Gene

genes like me logo Genes that share paralogs with PCDHGA11: view

Variants for PCDHGA11 Gene

Sequence variations from dbSNP and Humsavar for PCDHGA11 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_033711 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA11 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6351n71 CNV Loss 21882294
dgv6352n71 CNV Loss 21882294
nsv882990 CNV Loss 21882294
nsv519627 CNV Loss 19592680
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Variation tolerance for PCDHGA11 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PCDHGA11 Gene

Disorders for PCDHGA11 Gene

Relevant External Links for PCDHGA11

Genetic Association Database (GAD)
PCDHGA11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDHGA11

No disorders were found for PCDHGA11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHGA11 Gene

Publications for PCDHGA11 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 67
  2. Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in astrocytomas. (PMID: 15799819) Waha A. … Waha A. (Neoplasia 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/I^-catenin signaling. (PMID: 21875946) Berndt J.D. … Moon R.T. (J. Cell Biol. 2011) 3
  5. [The methylation analysis of EMP3 and PCDH-gamma-A11 gene in human glioma]. (PMID: 20388442) Jiang Z. … Li X.E. (Zhonghua Wai Ke Za Zhi 2010) 3

Products for PCDHGA11 Gene

Sources for PCDHGA11 Gene

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