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Aliases for PCDHGA10 Gene

Aliases for PCDHGA10 Gene

  • Protocadherin Gamma Subfamily A, 10 2 3 5
  • PCDH-GAMMA-A10 3 4
  • Protocadherin Gamma-A10 3

External Ids for PCDHGA10 Gene

Previous GeneCards Identifiers for PCDHGA10 Gene

  • GC05P140595
  • GC05P141315
  • GC05P140719
  • GC05P140777
  • GC05P140798
  • GC05P140737
  • GC05P140741
  • GC05P140854
  • GC05P140875
  • GC05P140880
  • GC05P140900
  • GC05P140934
  • GC05P140956
  • GC05P140977
  • GC05P141001
  • GC05P141016
  • GC05P141032
  • GC05P135937
  • GC05P141113
  • GC05P141155
  • GC05P141173
  • GC05P141207
  • GC05P141247
  • GC05P141334
  • GC05P141390
  • GC05P141457
  • GC05P141535
  • GC05P141638
  • GC05P141739

Summaries for PCDHGA10 Gene

Entrez Gene Summary for PCDHGA10 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA10 Gene

PCDHGA10 (Protocadherin Gamma Subfamily A, 10) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA9.

UniProtKB/Swiss-Prot for PCDHGA10 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA10 Gene

Genomics for PCDHGA10 Gene

Regulatory Elements for PCDHGA10 Gene

Enhancers for PCDHGA10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F141506 1.8 FANTOM5 Ensembl ENCODE 11.6 +103.5 103492 20.0 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 DIAPH1 PCDHGB6 TMCO6 PCDHGA2 LOC102723915 PCDHGC5 PCDHGA11 HDAC3 PCDHGC4 RN7SL68P
GH05F140563 1.1 ENCODE 9.7 -848.1 -848061 3.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 YY1 ZNF207 CD14 PCDHGB1 HARS PCDHGA9 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 PCDHA5
GH05F141527 0.9 Ensembl ENCODE 11.6 +116.3 116256 2.9 HLF CEBPB JUNB RELA JUND ZNF302 EED IKZF1 FOS CREM PCDHGB6 PCDHGA11 PCDHGB7 PCDHGA10 PCDHGC4 LOC100505658 DIAPH1 PCDHGC5 PCDHGB4 PCDHGA7
GH05F141665 1.1 Ensembl ENCODE 9.3 +252.2 252214 0.4 ELF3 CTCF CBX3 ESRRA JUN RAD21 RARA ZNF366 EED ZNF143 RELL2 HDAC3 PCDH12 RNF14 DIAPH1 LOC102723915 PCDHGA10 FCHSD1 GC05M141678
GH05F141417 0.6 ENCODE 0.8 +4.6 4564 1.0 CTCF NRF1 TRIM22 RAD21 IKZF1 SMC3 ZNF143 MLLT1 BCL6 PCDHGB6 PCDHGA10 PCDHGB7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCDHGA10 on UCSC Golden Path with GeneCards custom track

Promoters for PCDHGA10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001292013 413 1201 CTCF TRIM22 RAD21 YY1 CBX5 IKZF1 SMC3 ZNF143 ZSCAN29

Genomic Location for PCDHGA10 Gene

Chromosome:
5
Start:
141,412,987 bp from pter
End:
141,512,979 bp from pter
Size:
99,993 bases
Orientation:
Plus strand

Genomic View for PCDHGA10 Gene

Genes around PCDHGA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHGA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHGA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA10 Gene

Proteins for PCDHGA10 Gene

  • Protein details for PCDHGA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5H3-PCDGA_HUMAN
    Recommended name:
    Protocadherin gamma-A10
    Protein Accession:
    Q9Y5H3
    Secondary Accessions:
    • Q9Y5E0

    Protein attributes for PCDHGA10 Gene

    Size:
    936 amino acids
    Molecular mass:
    101447 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGA10 Gene

Post-translational modifications for PCDHGA10 Gene

  • Glycosylation at Asn 51, Asn 423, and Asn 549
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGA10 Gene

Domains & Families for PCDHGA10 Gene

Gene Families for PCDHGA10 Gene

Protein Domains for PCDHGA10 Gene

Suggested Antigen Peptide Sequences for PCDHGA10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5H3

UniProtKB/Swiss-Prot:

PCDGA_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHGA10: view

Function for PCDHGA10 Gene

Molecular function for PCDHGA10 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Gene Ontology (GO) - Molecular Function for PCDHGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGA10: view
genes like me logo Genes that share phenotypes with PCDHGA10: view

Animal Model Products

miRNA for PCDHGA10 Gene

miRTarBase miRNAs that target PCDHGA10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHGA10 Gene

Localization for PCDHGA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA10 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCDHGA10 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDHGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA10: view

Pathways & Interactions for PCDHGA10 Gene

SuperPathways for PCDHGA10 Gene

No Data Available

Interacting Proteins for PCDHGA10 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381611%0d%0a9606.ENSP00000346155%0d%0a9606.ENSP00000346155%0d%0a9606.ENSP00000344456%0d%0a9606.ENSP00000311113%0d%0a9606.ENSP00000362481%0d%0a
Selected Interacting proteins: ENSP00000381611 Q9Y5H3-PCDGA_HUMAN for PCDHGA10 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PCDHGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,IBA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling IBA --
GO:0007399 nervous system development IBA --
genes like me logo Genes that share ontologies with PCDHGA10: view

No data available for Pathways by source and SIGNOR curated interactions for PCDHGA10 Gene

Drugs & Compounds for PCDHGA10 Gene

(1) Drugs for PCDHGA10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHGA10: view

Transcripts for PCDHGA10 Gene

mRNA/cDNA for PCDHGA10 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA10 Gene

No ASD Table

Relevant External Links for PCDHGA10 Gene

GeneLoc Exon Structure for
PCDHGA10
ECgene alternative splicing isoforms for
PCDHGA10

Expression for PCDHGA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCDHGA10 Gene

Protein differential expression in normal tissues from HIPED for PCDHGA10 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCDHGA10 Gene



Protein tissue co-expression partners for PCDHGA10 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCDHGA10 Gene:

PCDHGA10
genes like me logo Genes that share expression patterns with PCDHGA10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCDHGA10 Gene

Orthologs for PCDHGA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCDHGA10 34
  • 87.97 (n)
dog
(Canis familiaris)
Mammalia PCDHGA10 34
  • 85.4 (n)
rat
(Rattus norvegicus)
Mammalia Pcdhga10 34
  • 84.79 (n)
mouse
(Mus musculus)
Mammalia Pcdhga10 34 16
  • 84.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 52 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
Species where no ortholog for PCDHGA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA10 Gene

ENSEMBL:
Gene Tree for PCDHGA10 (if available)
TreeFam:
Gene Tree for PCDHGA10 (if available)

Paralogs for PCDHGA10 Gene

genes like me logo Genes that share paralogs with PCDHGA10: view

Variants for PCDHGA10 Gene

Sequence variations from dbSNP and Humsavar for PCDHGA10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs386352347 Uncertain significance 141,485,635(+) CCGTT(A/G)GAAAA intron-variant, reference, synonymous-codon
rs1002519 -- 141,489,436(-) GCCCA(A/G)TTGCA intron-variant, reference, synonymous-codon
rs10035418 -- 141,437,664(+) CGAAG(A/G)GATGT intron-variant
rs10038103 -- 141,414,849(+) CTGGA(C/T)CAGAA intron-variant, reference, synonymous-codon
rs10040701 -- 141,508,490(+) TTTCC(A/G)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA10 Gene

Variant ID Type Subtype PubMed ID
nsv980740 CNV duplication 23825009
nsv599923 CNV loss 21841781
nsv599922 CNV loss 21841781
nsv519627 CNV loss 19592680
nsv518799 CNV loss 19592680
nsv462470 CNV loss 19166990
nsv327707 CNV deletion 16902084
nsv1125852 CNV tandem duplication 24896259
nsv1123990 CNV deletion 24896259
esv3606987 CNV gain 21293372
esv2759382 CNV gain 17122850
esv2730847 CNV deletion 23290073
esv25744 CNV gain 19812545

Variation tolerance for PCDHGA10 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDHGA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCDHGA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHGA10 Gene

Disorders for PCDHGA10 Gene

Relevant External Links for PCDHGA10

Genetic Association Database (GAD)
PCDHGA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDHGA10

No disorders were found for PCDHGA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHGA10 Gene

Publications for PCDHGA10 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  3. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3 64
  4. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 64
  5. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3 64

Products for PCDHGA10 Gene

Sources for PCDHGA10 Gene

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