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Aliases for PCDHGA10 Gene

Aliases for PCDHGA10 Gene

  • Protocadherin Gamma Subfamily A, 10 2 3 5
  • PCDH-GAMMA-A10 3 4

External Ids for PCDHGA10 Gene

Previous GeneCards Identifiers for PCDHGA10 Gene

  • GC05P140595
  • GC05P141315
  • GC05P140719
  • GC05P140777
  • GC05P140798
  • GC05P140737
  • GC05P140741
  • GC05P140854
  • GC05P140875
  • GC05P140880
  • GC05P140900
  • GC05P140934
  • GC05P140956
  • GC05P140977
  • GC05P141001
  • GC05P141016
  • GC05P141032
  • GC05P135937
  • GC05P141113
  • GC05P141155
  • GC05P141173
  • GC05P141207
  • GC05P141247
  • GC05P141334
  • GC05P141390
  • GC05P141457
  • GC05P141535

Summaries for PCDHGA10 Gene

Entrez Gene Summary for PCDHGA10 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA10 Gene

PCDHGA10 (Protocadherin Gamma Subfamily A, 10) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHGA10 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA10 Gene

Genomics for PCDHGA10 Gene

Regulatory Elements for PCDHGA10 Gene

Promoters for PCDHGA10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCDHGA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCDHGA10 Gene

Chromosome:
5
Start:
141,412,987 bp from pter
End:
141,512,979 bp from pter
Size:
99,993 bases
Orientation:
Plus strand

Genomic View for PCDHGA10 Gene

Genes around PCDHGA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHGA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHGA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA10 Gene

Proteins for PCDHGA10 Gene

  • Protein details for PCDHGA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5H3-PCDGA_HUMAN
    Recommended name:
    Protocadherin gamma-A10
    Protein Accession:
    Q9Y5H3
    Secondary Accessions:
    • Q9Y5E0

    Protein attributes for PCDHGA10 Gene

    Size:
    936 amino acids
    Molecular mass:
    101447 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGA10 Gene

Proteomics data for PCDHGA10 Gene at MOPED

Post-translational modifications for PCDHGA10 Gene

  • Glycosylation at Asn 51, Asn 423, and Asn 549
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PCDHGA10 Gene

Domains & Families for PCDHGA10 Gene

Gene Families for PCDHGA10 Gene

Protein Domains for PCDHGA10 Gene

Suggested Antigen Peptide Sequences for PCDHGA10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5H3

UniProtKB/Swiss-Prot:

PCDGA_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHGA10: view

Function for PCDHGA10 Gene

Molecular function for PCDHGA10 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
genes like me logo Genes that share phenotypes with PCDHGA10: view

Animal Model Products

CRISPR Products

miRNA for PCDHGA10 Gene

miRTarBase miRNAs that target PCDHGA10

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHGA10 Gene

Localization for PCDHGA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA10 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHGA10 Gene COMPARTMENTS Subcellular localization image for PCDHGA10 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDHGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA10: view

Pathways & Interactions for PCDHGA10 Gene

SuperPathways for PCDHGA10 Gene

No Data Available

Interacting Proteins for PCDHGA10 Gene

Gene Ontology (GO) - Biological Process for PCDHGA10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCDHGA10 Gene

Drugs & Compounds for PCDHGA10 Gene

(1) Drugs for PCDHGA10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHGA10: view

Transcripts for PCDHGA10 Gene

mRNA/cDNA for PCDHGA10 Gene

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA10 Gene

No ASD Table

Relevant External Links for PCDHGA10 Gene

GeneLoc Exon Structure for
PCDHGA10
ECgene alternative splicing isoforms for
PCDHGA10

Expression for PCDHGA10 Gene

mRNA expression in normal human tissues for PCDHGA10 Gene

Protein differential expression in normal tissues from HIPED for PCDHGA10 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCDHGA10 Gene



genes like me logo Genes that share expression patterns with PCDHGA10: view

Protein tissue co-expression partners for PCDHGA10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCDHGA10 Gene

Orthologs for PCDHGA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCDHGA10 35
  • 87.97 (n)
  • 89.58 (a)
dog
(Canis familiaris)
Mammalia PCDHGA10 35
  • 85.4 (n)
  • 85.52 (a)
mouse
(Mus musculus)
Mammalia Pcdhga10 35
  • 84.59 (n)
  • 87.54 (a)
Pcdhga10 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pcdhga10 35
  • 84.79 (n)
  • 86.87 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 50 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
Species with no ortholog for PCDHGA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA10 Gene

ENSEMBL:
Gene Tree for PCDHGA10 (if available)
TreeFam:
Gene Tree for PCDHGA10 (if available)

Paralogs for PCDHGA10 Gene

genes like me logo Genes that share paralogs with PCDHGA10: view

Variants for PCDHGA10 Gene

Sequence variations from dbSNP and Humsavar for PCDHGA10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_048566 -
VAR_048567 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA10 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6351n71 CNV Loss 21882294
dgv6352n71 CNV Loss 21882294
nsv882990 CNV Loss 21882294
nsv519627 CNV Loss 19592680
nsv518799 CNV Loss 19592680
nsv327707 CNV Loss 16902084
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Variation tolerance for PCDHGA10 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDHGA10 Gene

HapMap Linkage Disequilibrium report
PCDHGA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHGA10 Gene

Disorders for PCDHGA10 Gene

Relevant External Links for PCDHGA10

Genetic Association Database (GAD)
PCDHGA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDHGA10

No disorders were found for PCDHGA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHGA10 Gene

Publications for PCDHGA10 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3
  4. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  5. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3

Products for PCDHGA10 Gene

Sources for PCDHGA10 Gene

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