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Aliases for PCDHG@ Gene

Aliases for PCDHG@ Gene

  • Protocadherin Gamma Cluster 2 3
  • Protocadherin Gamma Cluster Extended 3
  • PCDH2 3
  • PCDH4 3
  • PCDHG 3

External Ids for PCDHG@ Gene

Previous GeneCards Identifiers for PCDHG@ Gene

  • GC05U990121
  • GC05P141095
  • GC05P141129
  • GC05P141432

Summaries for PCDHG@ Gene

Entrez Gene Summary for PCDHG@ Gene

  • The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. The clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma cluster includes 22 genes divided into 3 subfamilies, all part of the cadherin superfamily. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. In addition, ORNT2 and TAF2F are included in the cluster due to their localization between protocadherin clusters beta and gamma on chromosome five. The protocadherin genes are organized in a tandem array of 22 large, variable region exons followed by a constant region, which contains 3 exons shared by all protocadherin genes in the cluster. Each variable region exon encodes an extracellular domain comprised of 6 cadherin ectodomains and a transmembrane region. The constant region exons encode a common cytoplasmic tail. These neural adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHG@ Gene

PCDHG@ (Protocadherin Gamma Cluster) is a Gene Cluster.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHG@ Gene

Genomics for PCDHG@ Gene

Genomic Location for PCDHG@ Gene

Chromosome:
5
Start:
141,330,685 bp from pter
End:
141,512,979 bp from pter
Size:
182,295 bases
Orientation:
Plus strand

Genomic View for PCDHG@ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PCDHG@ Gene

No data available for Regulatory Elements for PCDHG@ Gene

Proteins for PCDHG@ Gene

Post-translational modifications for PCDHG@ Gene

No Post-translational modifications

No data available for DME Specific Peptides for PCDHG@ Gene

Domains & Families for PCDHG@ Gene

Gene Families for PCDHG@ Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCDHG@: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PCDHG@ Gene

Function for PCDHG@ Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHG@ Gene

Localization for PCDHG@ Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PCDHG@ Gene

Pathways & Interactions for PCDHG@ Gene

SuperPathways for PCDHG@ Gene

No Data Available

Interacting Proteins for PCDHG@ Gene

Gene Ontology (GO) - Biological Process for PCDHG@ Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCDHG@ Gene

Drugs & Compounds for PCDHG@ Gene

No Compound Related Data Available

Transcripts for PCDHG@ Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHG@ Gene

No ASD Table

Relevant External Links for PCDHG@ Gene

GeneLoc Exon Structure for
PCDHG@
ECgene alternative splicing isoforms for
PCDHG@

No data available for mRNA/cDNA for PCDHG@ Gene

Expression for PCDHG@ Gene

No Expression Related Data Available

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PCDHG@ Gene

Orthologs for PCDHG@ Gene

No data available for Orthologs and Evolution for PCDHG@ Gene

Paralogs for PCDHG@ Gene

No data available for Paralogs for PCDHG@ Gene

Variants for PCDHG@ Gene

Relevant External Links for PCDHG@ Gene

HapMap Linkage Disequilibrium report
PCDHG@

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for PCDHG@ Gene

Disorders for PCDHG@ Gene

genes like me logo Genes that share disorders with PCDHG@: view

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for PCDHG@ Gene

Publications for PCDHG@ Gene

  1. Control of CNS synapse development by {gamma}-protocadherin-mediated astrocyte-neuron contact. (PMID: 19776259) Garrett A.M. … Weiner J.A. (J. Neurosci. 2009) 23 67
  2. Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. (PMID: 19956686) Dallosso A.R. … Malik K. (PLoS Genet. 2009) 23 67
  3. Gamma protocadherin expression in the embryonic chick nervous system. (PMID: 17200686) Cronin K.D. … Capehart A.A. (Int. J. Biol. Sci. 2007) 23 67
  4. Differential expression of individual gamma-protocadherins during mouse brain development. (PMID: 15964765) Frank M. … Kemler R. (Mol. Cell. Neurosci. 2005) 23 67
  5. The b1 isoform of protocadherin-gamma (Pcdhgamma) interacts with the microtubule-destabilizing protein SCG10. (PMID: 15581637) Gayet O. … Kallenbach S. (FEBS Lett. 2004) 23 67

Products for PCDHG@ Gene

Sources for PCDHG@ Gene

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