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Aliases for PCDHG@ Gene

Aliases for PCDHG@ Gene

  • Protocadherin Gamma Cluster 2 3
  • PCDHG 3 6
  • Protocadherin Gamma Cluster Extended 3
  • PCDH2 3
  • PCDH4 3

External Ids for PCDHG@ Gene

Previous GeneCards Identifiers for PCDHG@ Gene

  • GC05U990121
  • GC05P141095
  • GC05P141129

Summaries for PCDHG@ Gene

Entrez Gene Summary for PCDHG@ Gene

  • The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. The clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma cluster includes 22 genes divided into 3 subfamilies, all part of the cadherin superfamily. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. In addition, ORNT2 and TAF2F are included in the cluster due to their localization between protocadherin clusters beta and gamma on chromosome five. The protocadherin genes are organized in a tandem array of 22 large, variable region exons followed by a constant region, which contains 3 exons shared by all protocadherin genes in the cluster. Each variable region exon encodes an extracellular domain comprised of 6 cadherin ectodomains and a transmembrane region. The constant region exons encode a common cytoplasmic tail. These neural adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHG@ Gene

PCDHG@ (Protocadherin Gamma Cluster) is a Gene Cluster.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHG@ Gene

Genomics for PCDHG@ Gene

Genomic Location for PCDHG@ Gene

141,330,685 bp from pter
141,512,979 bp from pter
182,295 bases
Plus strand

Genomic View for PCDHG@ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHG@ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHG@ Gene

No data available for Regulatory Elements for PCDHG@ Gene

Proteins for PCDHG@ Gene

Post-translational modifications for PCDHG@ Gene

No Post-translational modifications

No data available for DME Specific Peptides for PCDHG@ Gene

Domains for PCDHG@ Gene

Gene Families for PCDHG@ Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCDHG@: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PCDHG@ Gene

Function for PCDHG@ Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHG@ Gene

Localization for PCDHG@ Gene

Subcellular locations from

Jensen Localization Image for PCDHG@ Gene COMPARTMENTS Subcellular localization image for PCDHG@ gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PCDHG@ Gene

Pathways for PCDHG@ Gene

SuperPathways for PCDHG@ Gene

No Data Available

Interacting Proteins for PCDHG@ Gene

Gene Ontology (GO) - Biological Process for PCDHG@ Gene


No data available for Pathways by source for PCDHG@ Gene

Transcripts for PCDHG@ Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHG@ Gene

No ASD Table

Relevant External Links for PCDHG@ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

No data available for mRNA/cDNA for PCDHG@ Gene

Expression for PCDHG@ Gene

No Expression Related Data Available

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for PCDHG@ Gene

Orthologs for PCDHG@ Gene

No data available for Orthologs and Evolution for PCDHG@ Gene

Paralogs for PCDHG@ Gene

No data available for Paralogs for PCDHG@ Gene

Variants for PCDHG@ Gene

Relevant External Links for PCDHG@ Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for PCDHG@ Gene

Disorders for PCDHG@ Gene

No disorders were found for PCDHG@ Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PCDHG@ Gene

Publications for PCDHG@ Gene

  1. Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. (PMID: 19956686) Dallosso A.R. … Malik K. (PLoS Genet. 2009) 3 23
  2. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3
  3. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  4. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3
  5. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PMID: 10835267) Nollet F. … van Roy F. (J. Mol. Biol. 2000) 3

Products for PCDHG@ Gene

Sources for PCDHG@ Gene

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