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Aliases for PCDHB@ Gene

Aliases for PCDHB@ Gene

  • Protocadherin Beta Cluster 2 3
  • PCDH3 3

External Ids for PCDHB@ Gene

Previous GeneCards Identifiers for PCDHB@ Gene

  • GC05U990122
  • GC05P140431
  • GC05P140442
  • GC05P140453
  • GC05P141410
  • GC05P141549
  • GC05P141655
  • GC05P141755
  • GC05P141856
  • GC05P141964
  • GC05P142063

Summaries for PCDHB@ Gene

Entrez Gene Summary for PCDHB@ Gene

  • The protocadherin beta cluster is one of three related gene clusters tandemly linked on chromosome five. The protocadherin genes have an immunoglobulin-like genomic organization, suggesting that a novel mechanism may be involved in their regulation and expression. The beta cluster contains 16 genes and 3 pseudogenes. Each gene product contains 6 extracellular cadherin domains and a cytoplasmic tail that diverges from other cadherin superfamily members. Unlike the alpha and gamma clusters, the beta cluster has a variable region but lacks a constant region. Without this downstream region of shared exons, each transcript encodes a unique cytoplasmic tail. The specific functions of these one-exon gene products are unknown; however, they are thought to play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHB@ Gene

PCDHB@ (Protocadherin Beta Cluster) is a Gene Cluster. Diseases associated with PCDHB@ include Protocadherin-Beta Gene Cluster.

Additional gene information for PCDHB@ Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHB@ Gene

Genomics for PCDHB@ Gene

GeneHancer (GH) Regulatory Elements for PCDHB@ Gene

Promoters and enhancers for PCDHB@ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I141051 Enhancer 0.7 Ensembl ENCODE 550.8 +0.1 107 0.6 SCRT1 E2F1 RFX1 SCRT2 SIN3A EZH2 PCDHB1 PCDHB@ ENSG00000279558 LOC101926905
GH05I141052 Promoter 0.5 EPDnew 550.8 -0.4 -354 0.1 PCDHB1 PCDHB@ GC05P142219 LOC101926905
GH05I141094 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 0.3 +43.4 43354 1.4 ARID4B SIN3A ZNF2 RAD21 ZNF48 ZSCAN9 ZNF143 MIXL1 ZNF654 MIER2 PCDHB2 GC05M141097 LOC101926905 PIR41040 PIR50728 PIR61536 PCDHB@
GH05I141084 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.3 +33.4 33351 1.4 CTCF SAP130 RAD21 YY1 ZNF335 E2F1 ZNF23 GATA3 POLR2A ZNF143 PCDHAC2 PCDHB17P PCDHB1 MALINC1 IGIP PCDHGC4 PCDHB3 PCDHB10 PCDHAC1 PCDHA12
GH05I141135 Promoter 1.3 EPDnew Ensembl 0.2 +84.1 84085 0.6 CTCF POLR2A ZNF143 BACH1 RAD21 YY1 PCDHB5 PCDHB6 ENSG00000272154 PCDHB@
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PCDHB@ on UCSC Golden Path with GeneCards custom track

Genomic Locations for PCDHB@ Gene

Genomic Locations for PCDHB@ Gene
chr5:141,051,394-141,248,234
(GRCh38/hg38)
Size:
196,841 bases
Orientation:
Plus strand
chr5:140,430,979-140,627,802
(GRCh37/hg19)

Genomic View for PCDHB@ Gene

Genes around PCDHB@ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHB@ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHB@ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHB@ Gene

Proteins for PCDHB@ Gene

Post-translational modifications for PCDHB@ Gene

No Post-translational modifications

No data available for DME Specific Peptides for PCDHB@ Gene

Domains & Families for PCDHB@ Gene

Gene Families for PCDHB@ Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCDHB@: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PCDHB@ Gene

Function for PCDHB@ Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHB@ Gene

Localization for PCDHB@ Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PCDHB@ Gene

Pathways & Interactions for PCDHB@ Gene

SuperPathways for PCDHB@ Gene

No Data Available

Interacting Proteins for PCDHB@ Gene

Gene Ontology (GO) - Biological Process for PCDHB@ Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCDHB@ Gene

Drugs & Compounds for PCDHB@ Gene

No Compound Related Data Available

Transcripts for PCDHB@ Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHB@ Gene

No ASD Table

Relevant External Links for PCDHB@ Gene

GeneLoc Exon Structure for
PCDHB@
ECgene alternative splicing isoforms for
PCDHB@

No data available for mRNA/cDNA for PCDHB@ Gene

Expression for PCDHB@ Gene

NURSA nuclear receptor signaling pathways regulating expression of PCDHB@ Gene:

PCDHB@
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHB@ Gene

Orthologs for PCDHB@ Gene

No data available for Orthologs and Evolution for PCDHB@ Gene

Paralogs for PCDHB@ Gene

No data available for Paralogs for PCDHB@ Gene

Variants for PCDHB@ Gene

Additional Variant Information for PCDHB@ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCDHB@

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for PCDHB@ Gene

Disorders for PCDHB@ Gene

MalaCards: The human disease database

(1) MalaCards diseases for PCDHB@ Gene - From: OMIM

Disorder Aliases PubMed IDs
protocadherin-beta gene cluster
  • pcdhb@
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PCDHB@: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for PCDHB@ Gene

Publications for PCDHB@ Gene

  1. A striking organization of a large family of human neural cadherin-like cell adhesion genes. (PMID: 10380929) Wu Q … Maniatis T (Cell 1999) 2 3 58
  2. Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. (PMID: 19956686) Dallosso AR … Malik K (PLoS genetics 2009) 3 58
  3. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q … Maniatis T (Genome research 2001) 3 58
  4. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. (PMID: 11322959) Vanhalst K … van Roy F (FEBS letters 2001) 3 58
  5. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q … Maniatis T (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 58

Products for PCDHB@ Gene

Sources for PCDHB@ Gene

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