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Aliases for PCDHB7 Gene

Aliases for PCDHB7 Gene

  • Protocadherin Beta 7 2 3 5
  • PCDH-Beta-7 4
  • PCDH-BETA7 3

External Ids for PCDHB7 Gene

Previous GeneCards Identifiers for PCDHB7 Gene

  • GC05P140368
  • GC05P141135
  • GC05P140535
  • GC05P140580
  • GC05P140532
  • GC05P135697
  • GC05P140553
  • GC05P141360
  • GC05P141351
  • GC05P141501

Summaries for PCDHB7 Gene

Entrez Gene Summary for PCDHB7 Gene

  • This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. The transcript for this particular family member uses more than one polyadenylation site. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHB7 Gene

PCDHB7 (Protocadherin Beta 7) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHB7 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Gene Wiki entry for PCDHB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHB7 Gene

Genomics for PCDHB7 Gene

Regulatory Elements for PCDHB7 Gene

Enhancers for PCDHB7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCDHB7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCDHB7 Gene

Chromosome:
5
Start:
141,172,619 bp from pter
End:
141,176,383 bp from pter
Size:
3,765 bases
Orientation:
Plus strand

Genomic View for PCDHB7 Gene

Genes around PCDHB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHB7 Gene

Proteins for PCDHB7 Gene

  • Protein details for PCDHB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5E2-PCDB7_HUMAN
    Recommended name:
    Protocadherin beta-7
    Protein Accession:
    Q9Y5E2
    Secondary Accessions:
    • A1L3Y8

    Protein attributes for PCDHB7 Gene

    Size:
    793 amino acids
    Molecular mass:
    86707 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PCDHB7 Gene

Proteomics data for PCDHB7 Gene at MOPED

Post-translational modifications for PCDHB7 Gene

  • Glycosylation at Asn 169, Asn 418, Asn 436, and Asn 567
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHB7 Gene

Domains & Families for PCDHB7 Gene

Gene Families for PCDHB7 Gene

Protein Domains for PCDHB7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5E2

UniProtKB/Swiss-Prot:

PCDB7_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHB7: view

Function for PCDHB7 Gene

Molecular function for PCDHB7 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
genes like me logo Genes that share phenotypes with PCDHB7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PCDHB7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHB7 Gene

Localization for PCDHB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHB7 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHB7 Gene COMPARTMENTS Subcellular localization image for PCDHB7 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PCDHB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHB7: view

Pathways & Interactions for PCDHB7 Gene

SuperPathways for PCDHB7 Gene

No Data Available

Interacting Proteins for PCDHB7 Gene

Gene Ontology (GO) - Biological Process for PCDHB7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCDHB7 Gene

Drugs & Compounds for PCDHB7 Gene

(1) Drugs for PCDHB7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHB7: view

Transcripts for PCDHB7 Gene

mRNA/cDNA for PCDHB7 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCDHB7 Gene

Protocadherin beta 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHB7 Gene

No ASD Table

Relevant External Links for PCDHB7 Gene

GeneLoc Exon Structure for
PCDHB7
ECgene alternative splicing isoforms for
PCDHB7

Expression for PCDHB7 Gene

mRNA expression in normal human tissues for PCDHB7 Gene

SOURCE GeneReport for Unigene cluster for PCDHB7 Gene Hs.203830

genes like me logo Genes that share expression patterns with PCDHB7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PCDHB7 Gene

Orthologs for PCDHB7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PCDHB7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCDHB7 35
  • 84.87 (n)
  • 81.34 (a)
PCDHB7 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCDHB7 35
  • 85.41 (n)
  • 82.47 (a)
mouse
(Mus musculus)
Mammalia Pcdhb15 35
  • 80.14 (n)
  • 78.77 (a)
Pcdhb15 16
Pcdhb15 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCDHB7 35
  • 99.29 (n)
  • 99.24 (a)
PCDHB7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcdhb15 35
  • 79.84 (n)
  • 77.88 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
Species with no ortholog for PCDHB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHB7 Gene

ENSEMBL:
Gene Tree for PCDHB7 (if available)
TreeFam:
Gene Tree for PCDHB7 (if available)

Paralogs for PCDHB7 Gene

genes like me logo Genes that share paralogs with PCDHB7: view

Variants for PCDHB7 Gene

Sequence variations from dbSNP and Humsavar for PCDHB7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2910313 - 141,174,000(+) ACGAT(C/G)TCCCC reference, missense
rs17286891 - 141,173,193(+) GTGCT(A/G)AACTA reference, missense
rs17096946 - 141,173,394(+) GCGGG(A/G/T)AGGGG reference, missense
rs13189280 - 141,174,559(+) CGAGC(C/T)GTTGC reference, missense
rs13174866 - 141,174,561(+) AGCCG(G/T)TGCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PCDHB7 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
nsv428127 CNV Loss 18775914
dgv6348n71 CNV Loss 21882294
nsv471634 CNV Gain+Loss 15918152
dgv6349n71 CNV Loss 21882294
dgv1858e1 CNV Complex 17122850
dgv6350n71 CNV Loss 21882294
nsv509092 CNV Insertion 20534489
nsv823266 CNV Gain 20364138
nsv278 CNV Insertion 15895083
nsv5030 CNV Insertion 18451855
nsv471436 CNV Duplication 19718026
dgv1005e201 CNV Deletion 23290073
esv2730842 CNV Deletion 23290073
nsv819721 CNV Gain 19587683
esv28212 CNV Gain 19812545
dgv973n67 CNV Gain 20364138
nsv10756 CNV Gain 18304495
nsv499084 CNV Gain 21111241
esv33618 CNV Gain+Loss 17666407

Variation tolerance for PCDHB7 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.45; 95.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PCDHB7 Gene

Disorders for PCDHB7 Gene

Relevant External Links for PCDHB7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDHB7

No disorders were found for PCDHB7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHB7 Gene

Publications for PCDHB7 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3
  5. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. (PMID: 11322959) Vanhalst K. … van Roy F. (FEBS Lett. 2001) 3

Products for PCDHB7 Gene

Sources for PCDHB7 Gene

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