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Aliases for PCDHB7 Gene

Aliases for PCDHB7 Gene

  • Protocadherin Beta 7 2 3
  • Protocadherin Beta-7 3
  • PCDH-Beta-7 4
  • PCDH-BETA7 3

External Ids for PCDHB7 Gene

Summaries for PCDHB7 Gene

Entrez Gene Summary for PCDHB7 Gene

  • This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. The transcript for this particular family member uses more than one polyadenylation site. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHB7 Gene

PCDHB7 (Protocadherin Beta 7) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHB7 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Wiki entry for PCDHB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHB7 Gene

Genomics for PCDHB7 Gene

Genomic Location for PCDHB7 Gene

Start:
141,172,619 bp from pter
End:
141,176,383 bp from pter
Size:
3,765 bases
Orientation:
Plus strand

Genomic View for PCDHB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHB7 Gene

Regulatory Elements for PCDHB7 Gene

Proteins for PCDHB7 Gene

  • Protein details for PCDHB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5E2-PCDB7_HUMAN
    Recommended name:
    Protocadherin beta-7
    Protein Accession:
    Q9Y5E2
    Secondary Accessions:
    • A1L3Y8

    Protein attributes for PCDHB7 Gene

    Size:
    793 amino acids
    Molecular mass:
    86707 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PCDHB7 Gene

Proteomics data for PCDHB7 Gene at MOPED

Post-translational modifications for PCDHB7 Gene

  • Glycosylation at Asn169, Asn418, Asn436, and Asn567

Other Protein References for PCDHB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHB7 Gene

Domains for PCDHB7 Gene

Gene Families for PCDHB7 Gene

HGNC:
  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHB7 Gene

UniProtKB/Swiss-Prot:

PCDB7_HUMAN
Domain:
  • Contains 6 cadherin domains.:
    • Q9Y5E2
genes like me logo Genes that share domains with PCDHB7: view

Function for PCDHB7 Gene

Molecular function for PCDHB7 Gene

UniProtKB/Swiss-Prot Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHB7: view

Phenotypes for PCDHB7 Gene

GenomeRNAi human phenotypes for PCDHB7:
genes like me logo Genes that share phenotypes with PCDHB7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PCDHB7 Gene

Localization for PCDHB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHB7 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHB7 Gene COMPARTMENTS Subcellular localization image for PCDHB7 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PCDHB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHB7: view

Pathways for PCDHB7 Gene

SuperPathways for PCDHB7 Gene

No Data Available

Interacting Proteins for PCDHB7 Gene

Gene Ontology (GO) - Biological Process for PCDHB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDHB7: view

No data available for Pathways by source for PCDHB7 Gene

Compounds for PCDHB7 Gene

(1) HMDB Compounds for PCDHB7 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDHB7: view

Transcripts for PCDHB7 Gene

mRNA/cDNA for PCDHB7 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCDHB7 Gene

Protocadherin beta 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHB7 Gene

No ASD Table

Relevant External Links for PCDHB7 Gene

GeneLoc Exon Structure for
PCDHB7
ECgene alternative splicing isoforms for
PCDHB7

Expression for PCDHB7 Gene

mRNA expression in normal human tissues for PCDHB7 Gene

SOURCE GeneReport for Unigene cluster for PCDHB7 Gene Hs.203830

genes like me logo Genes that share expressions with PCDHB7: view

Orthologs for PCDHB7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PCDHB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHB7 36
  • 99.29 (n)
  • 99.24 (a)
PCDHB7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PCDHB7 36
  • 84.87 (n)
  • 81.34 (a)
PCDHB7 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCDHB7 36
  • 85.41 (n)
  • 82.47 (a)
mouse
(Mus musculus)
Mammalia Pcdhb15 36
  • 80.14 (n)
  • 78.77 (a)
Pcdhb15 16
Pcdhb15 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pcdhb15 36
  • 79.84 (n)
  • 77.88 (a)
Species with no ortholog for PCDHB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHB7 Gene

ENSEMBL:
Gene Tree for PCDHB7 (if available)
TreeFam:
Gene Tree for PCDHB7 (if available)

Paralogs for PCDHB7 Gene

genes like me logo Genes that share paralogs with PCDHB7: view

Variants for PCDHB7 Gene

Sequence variations from dbSNP and Humsavar for PCDHB7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1528587 -- 141,171,928(+) CTTCC(A/G)CAAAT upstream-variant-2KB
rs1811236 -- 141,174,903(-) CGCCA(A/C)CACCA reference, missense
rs1811237 -- 141,174,900(-) CACCA(A/C)CAGGT reference, missense
rs1811238 -- 141,174,749(-) AGCCT(C/G)TGCTT missense, reference
rs2907329 -- 141,174,425(-) CCCAC(C/G)CGGAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PCDHB7 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
nsv428127 CNV Loss 18775914
dgv6348n71 CNV Loss 21882294
nsv471634 CNV Gain+Loss 15918152
dgv6349n71 CNV Loss 21882294
dgv1858e1 CNV Complex 17122850
dgv6350n71 CNV Loss 21882294
nsv509092 CNV Insertion 20534489
nsv823266 CNV Gain 20364138
nsv278 CNV Insertion 15895083
nsv5030 CNV Insertion 18451855
nsv471436 CNV Duplication 19718026
dgv1005e201 CNV Deletion 23290073
esv2730842 CNV Deletion 23290073
nsv819721 CNV Gain 19587683
esv28212 CNV Gain 19812545
dgv973n67 CNV Gain 20364138
nsv10756 CNV Gain 18304495
nsv499084 CNV Gain 21111241
esv33618 CNV Gain+Loss 17666407

Relevant External Links for PCDHB7 Gene

HapMap Linkage Disequilibrium report
PCDHB7

Disorders for PCDHB7 Gene

No disorders were found for PCDHB7 Gene.

No data available for UniProtKB/Swiss-Prot for PCDHB7 Gene

Publications for PCDHB7 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. (PMID: 11322959) Vanhalst K. … van Roy F. (FEBS Lett. 2001) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for PCDHB7 Gene

Sources for PCDHB7 Gene

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