Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Suite
- Affiliated Databases
  
  Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

PCDHB3 Gene

protein-coding GIFtS: 45
GCID: GC05P140480

Protocadherin Beta 3

Try our

MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Protocadherin Beta 3¹ ²
PCDH-BETA3²
Protocadherin Beta-3²
PCDH-beta-3³

External Ids:	HGNC: 8688¹	Entrez Gene: 56132²	Ensembl: ENSG00000113205⁷	OMIM: 606329⁵	UniProtKB: Q9Y5E6³

Export aliases for PCDHB3 gene to outside databases

Previous GC identifers: GC05P140296 GC05P141063 GC05P140463 GC05P140508 GC05P140460 GC05P135624

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PCDHB3 Gene:

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked

on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and

T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6

extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The

extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the

alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common

3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins.

Their specific functions are unknown but they most likely play a critical role in the establishment and function

of specific cell-cell neural connections. (provided by RefSeq, Jul 2008)

GeneCards Summary for PCDHB3 Gene:

PCDHB3 (protocadherin beta 3) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHB16.

UniProtKB/Swiss-Prot: PCDB3_HUMAN, Q9Y5E6

Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance

of specific neuronal connections in the brain

Gene Wiki entry for PCDHB3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Regulatory transcription factor binding sites in the PCDHB3 gene promoter:
Pax-3 AML1a ATF-2 Sox9 CUTL1 c-Jun Tal-1beta C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PCDHB3 promoter sequence

Search Chromatin IP Primers for PCDHB3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCDHB3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31

PCDHB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCDHB3 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P140480: view genomic region (about GC identifiers)

Start:	140,480,234 bp from pter	End:	140,483,406 bp from pter
Size:	3,173 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: PCDB3_HUMAN, Q9Y5E6 (See protein sequence)

Recommended Name: Protocadherin beta-3 precursor

Size: 796 amino acids; 86773 Da

Secondary accessions: B2R8P2

Explore the universe of human proteins at neXtProt for PCDHB3: NX_Q9Y5E6

Explore proteomics data for PCDHB3 at MOPED

Post-translational modifications:

Glycosylation² at Asn169, Asn418, Asn436, Asn567

Modification sites at PhosphoSitePlus

See PCDHB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_061760.1

ENSEMBL proteins:

ENSP00000231130

PCDHB3 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for PCDHB3 OriGene Custom MassSpec OriGene Custom Protein Services for PCDHB3
	GenScript Custom Purified and Recombinant Proteins Services for PCDHB3
	Novus Biologicals PCDHB3 Protein Novus Biologicals PCDHB3 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for PCDHB3
	Search GeneTex for Proteins for PCDHB3
	antibodies-online proteins for PCDHB3 (3 products)
	antibodies-online peptides for PCDHB3

PCDHB3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for PCDHB3 OriGene Custom Antibody Services for PCDHB3
	Novus Biologicals PCDHB3 Antibodies
	Abcam antibodies for PCDHB3
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for PCDHB3
	antibodies-online antibodies for PCDHB3 (32 products)

PCDHB3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for PCDHB3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PCDHB3
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for PCDHB3
	antibodies-online kits for PCDHB3 (2 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

PCDHC: Cadherins / Protocadherins : Clustered

4 InterPro protein domains:

IPR015919 Cadherin-like

IPR013164 Cadherin_N

IPR020894 Cadherin_CS

IPR002126 Cadherin

Graphical View of Domain Structure for InterPro Entry Q9Y5E6

ProtoNet protein and cluster: Q9Y5E6

1 Blocks protein domain: IPB002126 Cadherin

UniProtKB/Swiss-Prot: PCDB3_HUMAN, Q9Y5E6

Similarity: Contains 6 cadherin domains

Find genes that share domains with PCDHB3 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PCDB3_HUMAN, Q9Y5E6

Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance

of specific neuronal connections in the brain

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

Find genes that share ontologies with PCDHB3 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for PCDHB3

miRNA Products:		Block miRNA regulation of human, mouse, rat PCDHB3 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate PCDHB3:
		hsa-miR-4272
		SwitchGear 3'UTR luciferase reporter plasmid: PCDHB3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PCDHB3
		Predesigned siRNA for gene silencing in human, mouse, rat PCDHB3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PCDHB3

Clone Products:		OriGene clones in human, mouse for PCDHB3 (see all 6) OriGene ORF clones in mouse, rat for PCDHB3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PCDHB3 (NM_018937)
		Sino Biological Human cDNA Clone for PCDHB3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCDHB3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHB3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PCDHB3
		Browse ESI BIO Cell Lines and PureStem Progenitors for PCDHB3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHB3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

PCDB3_HUMAN, Q9Y5E6: Cell membrane; Single-pass type I membrane protein (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
extracellular	2
cytosol	1
endoplasmic reticulum	1
golgi apparatus	1
lysosome	1
mitochondrion	1
peroxisome	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral component of plasma membrane	TAS	10380929
GO:0016020	membrane	--	--
GO:0016021	integral component of membrane	NAS	11322959

Find genes that share ontologies with PCDHB3 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for PCDHB3
Interactions:

Search GeneGlobe Interaction Network for PCDHB3

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	10380929
GO:0007156	homophilic cell adhesion	IEA	--
GO:0007268	synaptic transmission	TAS	12231349
GO:0007399	nervous system development	TAS	10380929
GO:0007416	synapse assembly	TAS	12231349

Find genes that share ontologies with PCDHB3 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for PCDHB3 (PCDB3)

1 HMDB Compound for PCDHB3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for PCDHB3 gene:

NM_018937.3

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000231130(uc003lio.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat PCDHB3 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate PCDHB3:
		hsa-miR-4272
		SwitchGear 3'UTR luciferase reporter plasmid: PCDHB3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PCDHB3
		Predesigned siRNA for gene silencing in human, mouse, rat PCDHB3

Clone Products:		OriGene clones in human, mouse for PCDHB3 (see all 6) OriGene ORF clones in mouse, rat for PCDHB3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PCDHB3 (NM_018937)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCDHB3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHB3

Primer Products:		OriGene qPCR primer pairs and template standards for PCDHB3 OriGene qSTAR qPCR primer pairs in human, mouse for PCDHB3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat PCDHB3
		QuantiTect SYBR Green Assays in human, mouse, rat PCDHB3
		QuantiFast Probe-based Assays in human, mouse, rat PCDHB3

10 AceView cDNA sequences:

AF152496 AF217755 BF477839 NM_018937 AW452497 BF477537 AW302546 BV198750

AI905980 BQ306284

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PCDHB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATGACTGAGG

About this image

PCDHB3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Eye (Sensory Organs)
Retina

PCDHB3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

PCDHB3 Protein Expression

Custom PCR Arrays for PCDHB3

Primer Products:		OriGene qPCR primer pairs and template standards for PCDHB3 OriGene qSTAR qPCR primer pairs in human, mouse for PCDHB3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat PCDHB3
		QuantiTect SYBR Green Assays in human, mouse, rat PCDHB3
		QuantiFast Probe-based Assays in human, mouse, rat PCDHB3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHB3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PCDHB3 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Pcdhb3^{1 , 5}	protocadherin beta 3^{1, 5}	80.28(n)¹ 78.87(a)¹	18 (19.46 cM)⁵ 93874¹ NM_053128.2¹ NP_444358.2¹ 37300799⁵
chicken (Gallus gallus)	Aves	LOC100857544¹	protocadherin beta-4-like	58.8(n) 50.85(a)	100857544 XM_004944735.1 XP_004944792.1
zebrafish (Danio rerio)	Actinopterygii	pcdh2g17¹	protocadherin 2 gamma 17	52.45(n) 47.19(a)	554064 NM_001024189.1 NP_001019360.1

ENSEMBL Gene Tree for PCDHB3 (if available)
TreeFam Gene Tree for PCDHB3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for PCDHB3 gene

PCDHB16² PCDHB2² PCDHAC2² PCDHB7² PCDHB15² PCDHGA10² PCDHGA12² PCDHGB2²

PCDHGA9² PCDHGA8² PCDHGB3² PCDHGB6² PCDHGA5² PCDHB5² PCDHB13² PCDHGA4²

PCDHGA7² PCDHB4² PCDHB11² ENSG00000255622² PCDHB14² PCDHB12² PCDHB8² PCDHGB1²

PCDHGB4² PCDHGA2² PCDHGA6² PCDHGA11² PCDHB6² PCDHGC4² PCDHGC5² PCDHGA1²

PCDHB10² PCDHB1² PCDHGA3² PCDHGB7²

Selected SIMAP similar genes for PCDHB3 using alignment to 2 protein entries: PCDB3_HUMAN (see all proteins) (see all similar genes):

ME1 PCDHB16 PCDHB11 PCDHB13 PCDHB14 PCDHB15

PCDHB2 PCDHB8 DKFZp586I1919 ME4 PCDHB18 PCDHB4

PCDHB6 PCDHB5 PCDHB10 PCDHB12 PCDHB17 PCDHB7

Find genes that share paralogs with PCDHB3 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186686639^1,2		--	140478260(+)	`ATATTG/TAAATA`	1	--	us2k¹		0	--	--	--	--
rs189606584^1,2		--	140478392(+)	`TTGTCA/GCTTTC`	1	--	us2k¹		0	--	--	--	--
rs148190621^1,2	C	--	140478806(+)	`CAAATA/GATAGC`	1	--	us2k¹		0	--	--	--	--
rs183332548^1,2		--	140478981(+)	`AACAAA/CCTTGC`	1	--	us2k¹		0	--	--	--	--
rs187706521^1,2		--	140478991(+)	`CAATGA/GCTTCC`	1	--	us2k¹		0	--	--	--	--
rs144271353^1,2	C	--	140479009(+)	`CTTAG-/AATAATAA`	1	--	us2k¹		0	--	--	--	--
rs36113538^1,2	C	--	140479016(+)	`AATAATAA/-AATCC`	2	--	us2k¹ cds¹		1		NA	2
rs31851^1,2	C,F,A,H	--	140479105(-)	`TGAAGG/TACAGT`	1	--	us2k¹ tfbs³		22		MN NS EA NA WA CSA	2420
rs13183611^1,2	C,F,A,H	--	140479121(+)	`TATCTA/CTTAAT`	1	--	us2k¹ tfbs³		7		NS EA NA	612
rs116021130^1,2	C,F	--	140479219(+)	`TGCACC/GTTGGG`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for PCDHB3 (140480234 - 140483406 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for PCDHB3: About this table

Variant ID	Type	Subtype	PubMed ID
dgv6348n71	CNV	Loss	21882294
nsv522785	CNV	Loss	19592680
nsv428127	CNV	Loss	18775914
nsv882971	CNV	Loss	21882294
nsv516514	CNV	Gain	19592680
dgv1857e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PCDHB3

DNA2.0 Custom Variant and Variant Library Synthesis for PCDHB3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 606329 OMIM disorders: --

Find genes that share disorders with PCDHB3 About GenesLikeMe

Genetic Association Database (GAD): PCDHB3

Export disorders for PCDHB3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PCDHB3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with PCDHB3)

A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PubMed id 10380929)^{1, 2, 3} Wu Q. and Maniatis T. (Cell 1999)
The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. (PubMed id 11322959)^{1, 2} Vanhalst K.... van Roy F. (FEBS Lett. 2001)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (Nat. Genet. 2004)
Protocadherins. (PubMed id 12231349)¹ Frank M. and Kemler R. (Curr. Opin. Cell Biol. 2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PubMed id 11230163)¹ Wu Q.... Maniatis T. (Genome Res. 2001)
Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)¹ Nollet F....van Roy F. (J. Mol. Biol. 2000)
Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PubMed id 10716726)¹ Wu Q. and Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000)
Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PubMed id 10817752)¹ Yagi T. and Takeichi M. (amp 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 56132	HGNC: 8688	AceView: PCDHB3	Ensembl:ENSG00000113205	euGenes: HUgn56132
ECgene: PCDHB3	H-InvDB: PCDHB3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PCDHB3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PCDHB3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PCDHB3 gene:
Search GeneIP for patents involving PCDHB3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for PCDHB3		OriGene RNAi products in human, mouse, rat for PCDHB3
	OriGene qPCR primer pairs and template standards for PCDHB3		OriGene Protein Over-expression Lysate for PCDHB3
	OriGene Custom Mass Spec		OriGene clones in human, mouse for PCDHB3
	OriGene qSTAR qPCR primer pairs in human, mouse for PCDHB3		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for PCDHB3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PCDHB3		OriGene Custom Protein Services for PCDHB3

	Block miRNA regulation of human, mouse, rat PCDHB3 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing PCDHB3
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCDHB3		Predesigned siRNA for gene silencing in human, mouse, rat PCDHB3
	QuantiFast Probe-based Assays in human, mouse, rat PCDHB3		QuantiTect SYBR Green Assays in human, mouse, rat PCDHB3
	Custom PCR Arrays for PCDHB3		Search Chromatin IP Primers for PCDHB3
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat PCDHB3		Search GeneGlobe Interaction Network for PCDHB3
	Regulatory tfbs in PCDHB3 promoter

	GenScript Custom Purified and Recombinant Proteins Services for PCDHB3		GenScript cDNA clones with any tag delivered in your preferred vector for PCDHB3
	GenScript Custom Assay Services for PCDHB3		GenScript Custom overexpressing Cell Line Services for PCDHB3
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for PCDHB3 (PCDB3)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for PCDHB3
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PCDHB3 antibodies
	PCDHB3 proteins
	PCDHB3 lysates

	Antibodies for PCDHB3
	See all of Abcam's Antibodies, Kits and Proteins for PCDHB3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Browse ESI BIO Cell Lines and PureStem Progenitors for PCDHB3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHB3

	SwitchGear 3'UTR luciferase reporter plasmids for PCDHB3
	SwitchGear Promoter luciferase reporter plasmids for PCDHB3

ThermoFisher Antibodies for PCDHB3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHB3

Browse compounds at ApexBio

Search Addgene for plasmids for PCDHB3

	Search eBioscience for proteins for PCDHB3
	Search eBioscience for elisas for PCDHB3
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for PCDHB3

	antibodies-online antibodies for PCDHB3 (32 products)
	antibodies-online kits for PCDHB3 (2 products)
	antibodies-online peptides for PCDHB3
	antibodies-online proteins for PCDHB3 (3 products)

Search GeneTex for proteins for PCDHB3

GeneCards Home - Full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015 , 3 Feb 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PCDHB3 gene at Home site.

Version: 3.12.352 5 Mar 2015
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4

GeneCards Suite

Advanced Search

Export list of displayed genes

PCDHB3 Gene

Protocadherin Beta 3

Aliases
for PCDHB3 gene

Summaries
for PCDHB3 gene

Genomic Views
for PCDHB3 gene

Proteins
for PCDHB3 gene

PCDHB3 Human Recombinant Protein Products:

PCDHB3 Antibody Products:

PCDHB3 Assay Products:

Domains /
Families
for PCDHB3 gene

Function
for PCDHB3 gene

Localization
for PCDHB3 gene

Pathways & Interactions
for PCDHB3 gene

Drugs & Compounds
for PCDHB3 gene

Transcripts
for PCDHB3 gene

Expression
for PCDHB3 gene

Orthologs
for PCDHB3 gene

Paralogs
for PCDHB3 gene

Genomic Variants
for PCDHB3 gene

Disorders / Diseases
for PCDHB3 gene

Publications
for PCDHB3 gene

External Searches for PCDHB3 gene

Genome Databases showing PCDHB3 gene

Other Databases showing PCDHB3 gene

Specialized Databases showing PCDHB3 gene

Intellectual Property
for PCDHB3 gene

Products
for PCDHB3 gene

View Random Gene

GeneCards Suite

Advanced Search

Export list of displayed genes

PCDHB3 Gene

Protocadherin Beta 3

Aliasesfor PCDHB3 gene

Summariesfor PCDHB3 gene

Genomic Viewsfor PCDHB3 gene

Proteinsfor PCDHB3 gene

PCDHB3 Human Recombinant Protein Products:

PCDHB3 Antibody Products:

PCDHB3 Assay Products:

Domains /Familiesfor PCDHB3 gene

Functionfor PCDHB3 gene

Localizationfor PCDHB3 gene

Pathways & Interactionsfor PCDHB3 gene

Drugs & Compoundsfor PCDHB3 gene

Transcriptsfor PCDHB3 gene

Expression for PCDHB3 gene

Orthologsfor PCDHB3 gene

Paralogsfor PCDHB3 gene

Genomic Variantsfor PCDHB3 gene

Disorders / Diseasesfor PCDHB3 gene

Publicationsfor PCDHB3 gene

External Searches for PCDHB3 gene

Genome Databases showing PCDHB3 gene

Other Databases showing PCDHB3 gene

Specialized Databases showing PCDHB3 gene

Intellectual Propertyfor PCDHB3 gene

Productsfor PCDHB3 gene

View Random Gene

Aliases
for PCDHB3 gene

Summaries
for PCDHB3 gene

Genomic Views
for PCDHB3 gene

Proteins
for PCDHB3 gene

Domains /
Families
for PCDHB3 gene

Function
for PCDHB3 gene

Localization
for PCDHB3 gene

Pathways & Interactions
for PCDHB3 gene

Drugs & Compounds
for PCDHB3 gene

Transcripts
for PCDHB3 gene

Expression
for PCDHB3 gene

Orthologs
for PCDHB3 gene

Paralogs
for PCDHB3 gene

Genomic Variants
for PCDHB3 gene

Disorders / Diseases
for PCDHB3 gene

Publications
for PCDHB3 gene

Intellectual Property
for PCDHB3 gene

Products
for PCDHB3 gene