Aliases for PCDHB3 Gene
Aliases for PCDHB3 Gene
External Ids for PCDHB3 Gene
- HGNC: 8688
- Entrez Gene: 56132
- Ensembl: ENSG00000113205
- OMIM: 606329
- UniProtKB: Q9Y5E6
Previous GeneCards Identifiers for PCDHB3 Gene
- GC05P140296
- GC05P141063
- GC05P140463
- GC05P140508
- GC05P140460
- GC05P135624
- GC05P140480
- GC05P141277
- GC05P141497
- GC05P141604
- GC05P141707
- GC05P141806
Summaries for PCDHB3 Gene
-
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCDHB3 Gene
PCDHB3 (Protocadherin Beta 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHB2.
UniProtKB/Swiss-Prot for PCDHB3 Gene
-
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHB3 Gene
Genomics for PCDHB3 Gene
Regulatory Elements for PCDHB3 Gene
Enhancers for PCDHB3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PCDHB3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PCDHB3 gene promoter:
Regulatory Element Products
Genomic Location for PCDHB3 Gene
- Chromosome:
- 5
- Start:
- 141,100,242 bp from pter
- End:
- 141,103,827 bp from pter
- Size:
- 3,586 bases
- Orientation:
- Plus strand
Genomic View for PCDHB3 Gene
Genes around PCDHB3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.3 by Ensembl
- 5q31.3 by Entrez Gene
- 5q31.3 by HGNC
PCDHB3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PCDHB3 Gene
Proteins for PCDHB3 Gene
-
Protein details for PCDHB3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y5E6-PCDB3_HUMAN
- Recommended name:
- Protocadherin beta-3
- Protein Accession:
- Q9Y5E6
- B2R8P2
Protein attributes for PCDHB3 Gene
- Size:
- 796 amino acids
- Molecular mass:
- 86773 Da
- Quaternary structure:
- No Data Available
Protein Expression for PCDHB3 Gene
Post-translational modifications for PCDHB3 Gene
Other Protein References for PCDHB3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PCDHB3
- Novus Biologicals Antibodies for PCDHB3
- Invitrogen Antibodies for PCDHB3
- antibodies-online Antibodies for PCDHB3: See all 26
- GeneTex PCDHB3 antibody for PCDHB3
Protein Products
-
OriGene Purified Proteins for PCDHB3
- Search Origene for MassSpec and Protein Over-expression Lysates for PCDHB3
- Origene Custom Protein Services for PCDHB3
- antibodies-online Proteins for PCDHB3: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PCDHB3
No data available for DME Specific Peptides for PCDHB3 Gene
Domains & Families for PCDHB3 Gene
Gene Families for PCDHB3 Gene
Protein Domains for PCDHB3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PCDHB3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PCDHB3 Gene
Function for PCDHB3 Gene
Molecular function for PCDHB3 Gene
- UniProtKB/Swiss-Prot Function:
- Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
Phenotypes for PCDHB3 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PCDHB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PCDHB3 gene
- Search ViGene Biosciences for PCDHB3
CRISPR Products
-
OriGene CRISPR knockouts for PCDHB3
-
Applied Biological Materials CRISPR for PCDHB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PCDHB3
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miRNA Products
- Search ViGene Biosciences for PCDHB3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PCDHB3
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-
ViGene Biosciences ready-to-package AAV shRNAs for PCDHB3 gene
Clone Products
-
OriGene ORF clones in human for PCDHB3
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCDHB3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PCDHB3
-
ViGene Biosciences adenoviral particle packaged cDNA for PCDHB3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PCDHB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PCDHB3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHB3 Gene
Localization for PCDHB3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PCDHB3 Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 10380929 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | NAS | 11322959 |
Pathways & Interactions for PCDHB3 Gene
No Data Available
Interacting Proteins for PCDHB3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | TAS | 10380929 |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | IEA | -- |
| GO:0007268 | chemical synaptic transmission | TAS | 12231349 |
| GO:0007399 | nervous system development | TAS | 10380929 |
| GO:0007416 | synapse assembly | TAS | 12231349 |
No data available for Pathways by source and SIGNOR curated interactions for PCDHB3 Gene
Drugs & Compounds for PCDHB3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
Transcripts for PCDHB3 Gene
mRNA/cDNA for PCDHB3 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (10) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PCDHB3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PCDHB3
-
Applied Biological Materials CRISPR for PCDHB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PCDHB3
- GenScript: Design CRISPR guide RNA sequences for PCDHB3
miRNA Products
- Search ViGene Biosciences for PCDHB3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PCDHB3
- Browse OriGene Inhibitory RNA Products For PCDHB3
-
ViGene Biosciences ready-to-package AAV shRNAs for PCDHB3 gene
Clone Products
-
OriGene ORF clones in human for PCDHB3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PCDHB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCDHB3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for PCDHB3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Blymphocyte (26.9), Frontal cortex (14.0), Fetal gut (11.1), and Retina (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDHB3 Gene
NURSA nuclear receptor signaling pathways regulating expression of PCDHB3 Gene:
PCDHB3SOURCE GeneReport for Unigene cluster for PCDHB3 Gene:
Hs.674730Evidence on tissue expression from TISSUES for PCDHB3 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for PCDHB3
-
OriGene qPCR primer pairs for PCDHB3
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHB3 Gene
Orthologs for PCDHB3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PCDHB3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC487168 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pcdhb3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Pcdhb3 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC786512 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | LOC100857544 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pcdh2g17 34 |
|
- Species where no ortholog for PCDHB3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PCDHB3 Gene
Paralogs for PCDHB3 Gene
- PCDHB2 5
- PCDHB15 5
- PCDHB6 5
- PCDHB14 5
- PCDHB4 5
- PCDHB8 5
- PCDHB16 5
- PCDHB5 5
- PCDHB11 5
- PCDHB7 5
- PCDHB9 5
- PCDHB10 5
- PCDHB12 5
- PCDHB1 5
- PCDHGA6 5
- PCDHGA9 5
- PCDHGB5 5
- PCDHGA5 5
- PCDHGA10 5
- PCDHGA2 5
- PCDHGB2 5
- PCDHGB1 5
- PCDHGA7 5
- PCDHGB7 5
- PCDHGA4 5
- PCDHGA1 5
- PCDHGA3 5
- PCDHGA12 5
- PCDHGA11 5
- PCDHGA8 5
- PCDHGB3 5
- PCDHGC5 5
- PCDHGC4 5
(72) SIMAP similar genes for PCDHB3 Gene using alignment to 2 proteins:
- ME1
- PCDHB16
- PCDHB8
- PCDHB2
- PCDHB15
- PCDHB14
- PCDHB13
- PCDHB11
- PCDHB6
- PCDHB4
- DKFZp586I1919
- PCDHB18
- ME4
- PCDHB5
- PCDHB7
- PCDHB9
- PCDHB17
- PCDHB12
- PCDHB10
- ME2
- PCDHB1
- ME3
- PCDHGA3
- PCDHGB7
- PCDHGB6
- PCDHGB2
- PCDHGA6
- PCDHGA2
- PCDHGA10
- PCDHGA1
- PCDHGA12
- PCDHGA4
- PCDHGB5
- PCDHGB4
- PCDHGB3
- PCDHGA9
- PCDHGA7
- PCDHGA11
- ME6
- PCDHGC4
- PCDHGA5
- PCDHA12
- PCDHGA8
- PCDHGC5
- PCDHGB1
- PCDHA8
- PCDHA3
- PCDHA1
- PCDHA13
- PCDHA7
- PCDHA6
- PCDHA5
- PCDHA4
- PCDHA10
- PCDH19
- PCDHAC2
- PCDHAC1
- FAT3
- PCDHA9
- PCDHGC3
- PCDHA2
- PCDHA11
- PCDH10
- PCDH18
- PCDH17
- PCDH12
- PCDH9
- PCDH1
- PCDH11Y
- PCDH8
- PCDH11X
- ME5
Variants for PCDHB3 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000186656 | -- | 141,100,012(+) | TACCA(C/T)CTTGC | upstream-variant-2KB | |
| rs1000522248 | -- | 141,098,256(+) | CCCCC(C/T)TTTAA | upstream-variant-2KB | |
| rs1001310963 | -- | 141,099,442(+) | CAAGC(A/G)CCCAT | upstream-variant-2KB | |
| rs1001356476 | -- | 141,099,050(+) | TTTTA(C/T)ATACA | upstream-variant-2KB | |
| rs1004662548 | -- | 141,104,015(+) | GTCCT(A/T)TTTTT | downstream-variant-500B |
Residual Variation Intolerance Score:
79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.47;
82.07% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PCDHB3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PCDHB3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHB3 Gene
Disorders for PCDHB3 Gene
Relevant External Links for PCDHB3
No disorders were found for PCDHB3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHB3 Gene
Publications for PCDHB3 Gene
- A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 64
- The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. (PMID: 11322959) Vanhalst K. … van Roy F. (FEBS Lett. 2001) 3 4 64
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
- Protocadherins. (PMID: 12231349) Frank M. … Kemler R. (Curr. Opin. Cell Biol. 2002) 3 64
Products for PCDHB3 Gene
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- Invitrogen Antibodies for PCDHB3
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- antibodies-online Antibodies for PCDHB3: See all 26
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- GeneTex PCDHB3 antibody for PCDHB3
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- ViGene Biosciences adenoviral particle packaged cDNA for PCDHB3 gene
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- Search ViGene Biosciences for PCDHB3
- Horizon Cell Lines for PCDHB3
- Cyagen custom Knockout/knockin (KOKI) mouse models for PCDHB3
- VectorBuilder custom plasmid, inducible vectors for PCDHB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCDHB3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PCDHB3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
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