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Aliases for PCDHB10 Gene

Aliases for PCDHB10 Gene

  • Protocadherin Beta 10 2 3
  • PCDH-Beta-10 3 4
  • PCDH-BETA10 3
  • PCHB10 3

External Ids for PCDHB10 Gene

Previous GeneCards Identifiers for PCDHB10 Gene

  • GC05P140388
  • GC05P141154
  • GC05P140555
  • GC05P140600
  • GC05P140552
  • GC05P140572
  • GC05P135717
  • GC05P140574
  • GC05P140577
  • GC05P140688
  • GC05P141281
  • GC05P141363
  • GC05P141423

Summaries for PCDHB10 Gene

Entrez Gene Summary for PCDHB10 Gene

  • This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHB10 Gene

PCDHB10 (Protocadherin Beta 10) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHB10 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Wiki entry for PCDHB10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHB10 Gene

Genomics for PCDHB10 Gene

Regulatory Elements for PCDHB10 Gene

Genomic Location for PCDHB10 Gene

Chromosome:
5
Start:
141,187,319 bp from pter
End:
141,195,642 bp from pter
Size:
8,324 bases
Orientation:
Plus strand

Genomic View for PCDHB10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHB10 Gene

Proteins for PCDHB10 Gene

  • Protein details for PCDHB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN67-PCDBA_HUMAN
    Recommended name:
    Protocadherin beta-10
    Protein Accession:
    Q9UN67
    Secondary Accessions:
    • Q96T99

    Protein attributes for PCDHB10 Gene

    Size:
    800 amino acids
    Molecular mass:
    87621 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PCDHB10 Gene

Proteomics data for PCDHB10 Gene at MOPED

Post-translational modifications for PCDHB10 Gene

  • Glycosylation at Asn 169, Asn 181, Asn 418, Asn 436, and Asn 567
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHB10 Gene

Domains & Families for PCDHB10 Gene

Gene Families for PCDHB10 Gene

Protein Domains for PCDHB10 Gene

Suggested Antigen Peptide Sequences for PCDHB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UN67

UniProtKB/Swiss-Prot:

PCDBA_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHB10: view

Function for PCDHB10 Gene

Molecular function for PCDHB10 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHB10: view

Phenotypes for PCDHB10 Gene

GenomeRNAi human phenotypes for PCDHB10:
genes like me logo Genes that share phenotypes with PCDHB10: view

Animal Model Products

CRISPR Products

miRNA for PCDHB10 Gene

miRTarBase miRNAs that target PCDHB10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHB10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHB10 Gene

Localization for PCDHB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHB10 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHB10 Gene COMPARTMENTS Subcellular localization image for PCDHB10 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDHB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 11322959
genes like me logo Genes that share ontologies with PCDHB10: view

Pathways & Interactions for PCDHB10 Gene

SuperPathways for PCDHB10 Gene

No Data Available

Interacting Proteins for PCDHB10 Gene

Gene Ontology (GO) - Biological Process for PCDHB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007268 synaptic transmission TAS 12231349
GO:0007416 synapse assembly TAS 12231349
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules NAS 11322959
genes like me logo Genes that share ontologies with PCDHB10: view

No data available for Pathways by source and SIGNOR curated interactions for PCDHB10 Gene

Drugs & Compounds for PCDHB10 Gene

(1) Drugs for PCDHB10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with PCDHB10: view

Transcripts for PCDHB10 Gene

mRNA/cDNA for PCDHB10 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCDHB10 Gene

Protocadherin beta 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHB10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHB10 Gene

No ASD Table

Relevant External Links for PCDHB10 Gene

GeneLoc Exon Structure for
PCDHB10
ECgene alternative splicing isoforms for
PCDHB10

Expression for PCDHB10 Gene

mRNA expression in normal human tissues for PCDHB10 Gene

Protein differential expression in normal tissues from HIPED for PCDHB10 Gene

This gene is overexpressed in Lung (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDHB10 Gene



SOURCE GeneReport for Unigene cluster for PCDHB10 Gene Hs.657953

genes like me logo Genes that share expression patterns with PCDHB10: view

Protein tissue co-expression partners for PCDHB10 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCDHB10 Gene

Orthologs for PCDHB10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PCDHB10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCDHB12 35
  • 85.86 (n)
  • 81.85 (a)
PCDHB10 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCDHB10 35
  • 98.5 (n)
  • 97.87 (a)
PCDHB10 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcdhb18 16
Pcdhb18 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
Species with no ortholog for PCDHB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHB10 Gene

ENSEMBL:
Gene Tree for PCDHB10 (if available)
TreeFam:
Gene Tree for PCDHB10 (if available)

Paralogs for PCDHB10 Gene

Pseudogenes.org Pseudogenes for PCDHB10 Gene

genes like me logo Genes that share paralogs with PCDHB10: view

Variants for PCDHB10 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDHB10 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
nsv428127 CNV Loss 18775914
dgv6348n71 CNV Loss 21882294
nsv471634 CNV Gain+Loss 15918152
dgv6349n71 CNV Loss 21882294
dgv1858e1 CNV Complex 17122850
dgv6350n71 CNV Loss 21882294
nsv823266 CNV Gain 20364138
dgv1005e201 CNV Deletion 23290073
nsv499084 CNV Gain 21111241
esv2664767 CNV Deletion 23128226
nsv5031 CNV Insertion 18451855
nsv882981 CNV Gain 21882294
esv2730844 CNV Deletion 23290073
esv2730845 CNV Deletion 23290073
esv2730846 CNV Deletion 23290073

Variation tolerance for PCDHB10 Gene

Residual Variation Intolerance Score: 99.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.29; 81.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDHB10 Gene

HapMap Linkage Disequilibrium report
PCDHB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PCDHB10 Gene

Disorders for PCDHB10 Gene

Relevant External Links for PCDHB10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDHB10
genes like me logo Genes that share disorders with PCDHB10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHB10 Gene

Publications for PCDHB10 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 67
  2. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PMID: 22645275) Usenovic M. … Krainc D. (Hum. Mol. Genet. 2012) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for PCDHB10 Gene

Sources for PCDHB10 Gene

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