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Aliases for PCDHAC2 Gene

Aliases for PCDHAC2 Gene

  • Protocadherin Alpha Subfamily C, 2 2 3
  • PCDH-ALPHA-C2 3 4
  • Protocadherin Alpha-C2 3

External Ids for PCDHAC2 Gene

Previous GeneCards Identifiers for PCDHAC2 Gene

  • GC05P140079
  • GC05P140761
  • GC05P140215
  • GC05P140222
  • GC05P140177
  • GC05P140179
  • GC05P140326
  • GC05P140345
  • GC05P135490

Summaries for PCDHAC2 Gene

Entrez Gene Summary for PCDHAC2 Gene

  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHAC2 Gene

PCDHAC2 (Protocadherin Alpha Subfamily C, 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHAC2 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Wiki entry for PCDHAC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHAC2 Gene

Genomics for PCDHAC2 Gene

Regulatory Elements for PCDHAC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCDHAC2 Gene

140,966,162 bp from pter
141,012,344 bp from pter
46,183 bases
Plus strand

Genomic View for PCDHAC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHAC2 Gene

Proteins for PCDHAC2 Gene

  • Protein details for PCDHAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protocadherin alpha-C2
    Protein Accession:
    Secondary Accessions:
    • Q2M3V1
    • Q9Y5F4

    Protein attributes for PCDHAC2 Gene

    1007 amino acids
    Molecular mass:
    109450 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHAC2 Gene


neXtProt entry for PCDHAC2 Gene

Proteomics data for PCDHAC2 Gene at MOPED

Post-translational modifications for PCDHAC2 Gene

  • Glycosylation at Asn280, Asn436, Asn586, and Asn657
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PCDHAC2 Gene

Domains for PCDHAC2 Gene

Gene Families for PCDHAC2 Gene

Protein Domains for PCDHAC2 Gene

Suggested Antigen Peptide Sequences for PCDHAC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 cadherin domains.
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHAC2: view

Function for PCDHAC2 Gene

Molecular function for PCDHAC2 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHAC2: view

Phenotypes for PCDHAC2 Gene

MGI mutant phenotypes for PCDHAC2:
inferred from 1 alleles
GenomeRNAi human phenotypes for PCDHAC2:
genes like me logo Genes that share phenotypes with PCDHAC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHAC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHAC2 Gene

Localization for PCDHAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHAC2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PCDHAC2 Gene COMPARTMENTS Subcellular localization image for PCDHAC2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PCDHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10380929
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PCDHAC2: view

Pathways for PCDHAC2 Gene

SuperPathways for PCDHAC2 Gene

No Data Available

Interacting Proteins for PCDHAC2 Gene

Gene Ontology (GO) - Biological Process for PCDHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 10380929
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007399 nervous system development TAS 10380929
genes like me logo Genes that share ontologies with PCDHAC2: view

No data available for Pathways by source for PCDHAC2 Gene

Drugs for PCDHAC2 Gene

(1) HMDB Compounds for PCDHAC2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with PCDHAC2: view

Transcripts for PCDHAC2 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHAC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHAC2 Gene

No ASD Table

Relevant External Links for PCDHAC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDHAC2 Gene

mRNA expression in normal human tissues for PCDHAC2 Gene

mRNA differential expression in normal tissues according to GTEx for PCDHAC2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.7), Brain - Frontal Cortex (BA9) (6.0), and Brain - Anterior cingulate cortex (BA24) (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDHAC2 Gene

genes like me logo Genes that share expressions with PCDHAC2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for PCDHAC2 Gene

Orthologs for PCDHAC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHAC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Pcdhac2 35
  • 89.3 (n)
  • 93.14 (a)
Pcdhac2 16
Pcdha2 36
  • 93 (a)
(Pan troglodytes)
Mammalia PCDHAC2 35
  • 99.74 (n)
  • 99.9 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Pcdhac2 35
  • 89.13 (n)
  • 93.24 (a)
(Bos Taurus)
Mammalia PCDHGC3 36
  • 40 (a)
(Canis familiaris)
Mammalia PCDHAC2 36
  • 94 (a)
(Monodelphis domestica)
Mammalia PCDHAC2 36
  • 40 (a)
(Gallus gallus)
Aves PCDHAC2 35
  • 70.98 (n)
  • 71.92 (a)
  • 41 (a)
(Anolis carolinensis)
Reptilia PCDHAC2 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcdhac2 35
  • 63.96 (n)
  • 63.96 (a)
(Danio rerio)
Actinopterygii pcdh2ac 35
  • 57.5 (n)
  • 53.53 (a)
  • 44 (a)
Species with no ortholog for PCDHAC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDHAC2 Gene

Gene Tree for PCDHAC2 (if available)
Gene Tree for PCDHAC2 (if available)

Paralogs for PCDHAC2 Gene

genes like me logo Genes that share paralogs with PCDHAC2: view

Variants for PCDHAC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDHAC2 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850

Relevant External Links for PCDHAC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PCDHAC2 Gene

Disorders for PCDHAC2 Gene

Relevant External Links for PCDHAC2

Genetic Association Database (GAD)

No disorders were found for PCDHAC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PCDHAC2 Gene

Publications for PCDHAC2 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. Genomic organization of the family of CNR cadherin genes in mice and humans. (PMID: 10662547) Sugino H. … Yagi T. (Genomics 2000) 3
  3. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  4. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3
  5. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PMID: 10835267) Nollet F. … van Roy F. (J. Mol. Biol. 2000) 3

Products for PCDHAC2 Gene

Sources for PCDHAC2 Gene

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