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Aliases for PCDHAC1 Gene

Aliases for PCDHAC1 Gene

  • Protocadherin Alpha Subfamily C, 1 2 3
  • PCDH-ALPHA-C1 2 3 4
  • Protocadherin Alpha-C1 3

External Ids for PCDHAC1 Gene

Previous GeneCards Identifiers for PCDHAC1 Gene

  • GC05U990126
  • GC05P140149
  • GC05P140214
  • GC05P140221
  • GC05P140176
  • GC05P140178
  • GC05P140286
  • GC05P140252
  • GC05P140261
  • GC05P140271
  • GC05P140280
  • GC05P140291
  • GC05P140301
  • GC05P140310
  • GC05P140313
  • GC05P140320
  • GC05P140343
  • GC05P135451
  • GC05P140354
  • GC05P140375
  • GC05P140394
  • GC05P140408
  • GC05P140424
  • GC05P140443
  • GC05P140461

Summaries for PCDHAC1 Gene

Entrez Gene Summary for PCDHAC1 Gene

  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHAC1 Gene

PCDHAC1 (Protocadherin Alpha Subfamily C, 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDHAC1 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHAC1 Gene

Genomics for PCDHAC1 Gene

Regulatory Elements for PCDHAC1 Gene

Genomic Location for PCDHAC1 Gene

Start:
140,926,369 bp from pter
End:
141,012,344 bp from pter
Size:
85,976 bases
Orientation:
Plus strand

Genomic View for PCDHAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHAC1 Gene

Proteins for PCDHAC1 Gene

  • Protein details for PCDHAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H158-PCDC1_HUMAN
    Recommended name:
    Protocadherin alpha-C1
    Protein Accession:
    Q9H158
    Secondary Accessions:
    • Q9Y5F5
    • Q9Y5I5

    Protein attributes for PCDHAC1 Gene

    Size:
    963 amino acids
    Molecular mass:
    103942 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHAC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHAC1 Gene

Proteomics data for PCDHAC1 Gene at MOPED

Post-translational modifications for PCDHAC1 Gene

  • Glycosylation at Asn38, Asn248, Asn274, and Asn562
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHAC1 Gene

Domains for PCDHAC1 Gene

Gene Families for PCDHAC1 Gene

HGNC:
  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHAC1 Gene

Suggested Antigen Peptide Sequences for PCDHAC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H158

UniProtKB/Swiss-Prot:

PCDC1_HUMAN :
  • Q9H158
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHAC1: view

Function for PCDHAC1 Gene

Molecular function for PCDHAC1 Gene

UniProtKB/Swiss-Prot Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHAC1: view

Phenotypes for PCDHAC1 Gene

MGI mutant phenotypes for PCDHAC1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PCDHAC1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHAC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PCDHAC1 Gene

Localization for PCDHAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHAC1 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for PCDHAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10380929
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PCDHAC1: view

No data available for Subcellular locations from COMPARTMENTS for PCDHAC1 Gene

Pathways for PCDHAC1 Gene

SuperPathways for PCDHAC1 Gene

No Data Available

Interacting Proteins for PCDHAC1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000253807%0d%0a9606.ENSP00000346155%0d%0a9606.ENSP00000344456%0d%0a9606.ENSP00000311113%0d%0a9606.ENSP00000362481%0d%0a
Selected Interacting proteins: ENSP00000253807 for PCDHAC1 Gene via STRING

Gene Ontology (GO) - Biological Process for PCDHAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 10380929
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007399 nervous system development TAS 10380929
genes like me logo Genes that share ontologies with PCDHAC1: view

No data available for Pathways by source for PCDHAC1 Gene

Compounds for PCDHAC1 Gene

(1) HMDB Compounds for PCDHAC1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDHAC1: view

Transcripts for PCDHAC1 Gene

mRNA/cDNA for PCDHAC1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHAC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PCDHAC1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHAC1 Gene

No ASD Table

Relevant External Links for PCDHAC1 Gene

GeneLoc Exon Structure for
PCDHAC1
ECgene alternative splicing isoforms for
PCDHAC1

Expression for PCDHAC1 Gene

mRNA expression in normal human tissues for PCDHAC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDHAC1 Gene

genes like me logo Genes that share expressions with PCDHAC1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCDHAC1 Gene

Orthologs for PCDHAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHAC1 35
  • 99.55 (n)
  • 99.17 (a)
cow
(Bos Taurus)
Mammalia PCDHAC1 36
  • 40 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcdhac1 35
  • 85.43 (n)
  • 84.32 (a)
Pcdhac1 16
platypus
(Ornithorhynchus anatinus)
Mammalia PCDHAC1 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcdhac1 35
  • 85.05 (n)
  • 83.7 (a)
chicken
(Gallus gallus)
Aves CCNRC01 35
  • 63.72 (n)
  • 60.68 (a)
lizard
(Anolis carolinensis)
Reptilia PCDHAC1 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PCDHAC1 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
CSA.7308 36
  • 20 (a)
ManyToMany
Species with no ortholog for PCDHAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDHAC1 Gene

ENSEMBL:
Gene Tree for PCDHAC1 (if available)
TreeFam:
Gene Tree for PCDHAC1 (if available)

Paralogs for PCDHAC1 Gene

genes like me logo Genes that share paralogs with PCDHAC1: view

Variants for PCDHAC1 Gene

Sequence variations from dbSNP and Humsavar for PCDHAC1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_048540 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHAC1 Gene

Variant ID Type Subtype PubMed ID
dgv1856e1 CNV Complex 17122850
dgv1857e1 CNV Complex 17122850
esv2505753 CNV Deletion 19546169

Relevant External Links for PCDHAC1 Gene

HapMap Linkage Disequilibrium report
PCDHAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHAC1 Gene

Disorders for PCDHAC1 Gene

Relevant External Links for PCDHAC1

Genetic Association Database (GAD)
PCDHAC1
genes like me logo Genes that share disorders with PCDHAC1: view

No data available for UniProtKB/Swiss-Prot for PCDHAC1 Gene

Publications for PCDHAC1 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. Genomic organization of the family of CNR cadherin genes in mice and humans. (PMID: 10662547) Sugino H. … Yagi T. (Genomics 2000) 3
  3. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  4. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3
  5. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PMID: 10835267) Nollet F. … van Roy F. (J. Mol. Biol. 2000) 3

Products for PCDHAC1 Gene

Sources for PCDHAC1 Gene

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