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PCDHAC1 Gene

protein-coding   GIFtS: 38
GCID: GC05P140461

Protocadherin Alpha Subfamily C, 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protocadherin Alpha Subfamily C, 11 2
PCDH-ALPHA-C11 2
Protocadherin Alpha-C12
PCDH-alpha-C13

External Ids:    HGNC: 86761   Entrez Gene: 561352   Ensembl: ENSG000002483837   OMIM: 6063205   UniProtKB: Q9H1583   

Export aliases for PCDHAC1 gene to outside databases

Previous GC identifers: GC05U990126 GC05P140149 GC05P140214 GC05P140221 GC05P140176 GC05P140178 GC05P140286 GC05P140252 GC05P140261 GC05P140271 GC05P140280 GC05P140291 GC05P140301 GC05P140310 GC05P140313 GC05P140320 GC05P140343 GC05P135451 GC05P140354 GC05P140375 GC05P140394 GC05P140408 GC05P140424 GC05P140443


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PCDHAC1 Gene:
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked
on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor
gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes
and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15
N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are
shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin
ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion
proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and
function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional
variants have been suggested but their full-length nature has yet to be determined. (provided by RefSeq, Jul
2008)

GeneCards Summary for PCDHAC1 Gene:
PCDHAC1 (protocadherin alpha subfamily C, 1) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHA2.

UniProtKB/Swiss-Prot: PCDC1_HUMAN, Q9H158
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance
of specific neuronal connections in the brain




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PCDHAC1 gene promoter:
         GR   SRF   AML1a   SRF (504 AA)   GATA-1   HOXA5   SEF-1 (1)   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCDHAC1 promoter sequence
   Search Chromatin IP Primers for PCDHAC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCDHAC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31

PCDHAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCDHAC1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P140461:  view genomic region     (about GC identifiers)

Start:
140,306,302 bp from pter      End:
140,391,929 bp from pter
Size:
85,628 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PCDC1_HUMAN, Q9H158 (See protein sequence)
Recommended Name: Protocadherin alpha-C1 precursor  
Size: 963 amino acids; 103942 Da
Secondary accessions: Q9Y5F5 Q9Y5I5
Alternative splicing: 2 isoforms:  Q9H158-1   Q9H158-2   

Explore the universe of human proteins at neXtProt for PCDHAC1: NX_Q9H158

Explore proteomics data for PCDHAC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn248, Asn274, Asn562
  • Modification sites at PhosphoSitePlus

  • See PCDHAC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_061721.2  NP_114088.2  

    ENSEMBL proteins: 
     ENSP00000253807   ENSP00000386356  

    PCDHAC1 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PCDHAC1 

     
    antibodies-online proteins for PCDHAC1 

     
    antibodies-online peptides for PCDHAC1

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    antibodies-online antibodies for PCDHAC1 (20 products) 

    PCDHAC1 Assay Products:

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    Search eBioscience for ELISAs for PCDHAC1 
    antibodies-online kits for PCDHAC1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PCDHC: Cadherins / Protocadherins : Clustered

    4 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR013164 Cadherin_N
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9H158

    ProtoNet protein and cluster: Q9H158

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: PCDC1_HUMAN, Q9H158
    Similarity: Contains 6 cadherin domains


    Find genes that share domains with PCDHAC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCDC1_HUMAN, Q9H158
    Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance
    of specific neuronal connections in the brain

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with PCDHAC1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pcdhac1):
     normal 

    Find genes that share phenotypes with PCDHAC1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PCDHAC1

    miRNA
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    Block miRNA regulation of human, mouse, rat PCDHAC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCDHAC1 (see all 115):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-4272 hsa-miR-106a hsa-miR-15a hsa-miR-485-3p hsa-miR-4305 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidPCDHAC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PCDHAC1

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    GenScript: all cDNA clones in your preferred vector (see all 2): PCDHAC1 (NM_031882)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCDHAC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHAC1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHAC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PCDC1_HUMAN, Q9H158: Cell membrane; Single-pass type I membrane protein (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS10380929
    GO:0016020membrane ----

    Find genes that share ontologies with PCDHAC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCDHAC1
    Interactions:

        Search GeneGlobe Interaction Network for PCDHAC1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PCDHAC1 (ENSP000002538074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELNENSP000003924234STRING: ENSP00000392423
    CRKENSP000003005744STRING: ENSP00000300574
    HGSENSP000003312014STRING: ENSP00000331201
    PCDHB16ENSP000003542934STRING: ENSP00000354293
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS10380929
    GO:0007156homophilic cell adhesion IEA--
    GO:0007399nervous system development TAS10380929

    Find genes that share ontologies with PCDHAC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCDHAC1 (PCDC1)

    1 HMDB Compound for PCDHAC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PCDHAC1 gene (2 alternative transcripts): 
    NM_018898.3  NM_031882.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253807(uc003lih.2) ENST00000409700(uc003lig.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat PCDHAC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCDHAC1 (see all 115):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-4272 hsa-miR-106a hsa-miR-15a hsa-miR-485-3p hsa-miR-4305 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidPCDHAC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PCDHAC1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHAC1
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      QuantiTect SYBR Green Assays in human, mouse, rat PCDHAC1
      QuantiFast Probe-based Assays in human, mouse, rat PCDHAC1

    Selected AceView cDNA sequences (see all 261):

    BM682903 AF152303 NM_018900 AF169694 AA552914 CA488079 T30761 NM_018908 
    AI161196 BF933281 AF152305 AF152317 AF152475 R53055 NM_031849 NM_018899 
    AF152307 NM_018903 AF152309 AF152306 NM_031883 CA396936 AF152478 BM719606 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PCDHAC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PCDHAC1 Expression
    About this image

    PCDHAC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCDHAC1 Protein Expression
        Custom PCR Arrays for PCDHAC1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHAC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PCDHAC1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcdhac11 , 5 protocadherin alpha subfamily C, 11, 5 85.43(n)1
    84.32(a)1
      18 (19.46 cM)5
    3532361  NM_001003671.11  NP_001003671.11 
     370901365 
    chicken
    (Gallus gallus)
    Aves CCNRC011 cadherin-related neuronal receptor c01 63.72(n)
    60.68(a)
      497223  NM_001111130.1  NP_001104600.1 
    lizard
    (Anolis carolinensis)
    Reptilia PCDHAC16
    protocadherin alpha subfamily C, 1
    56(a)
    1 ↔ 1
    4(77130817-77253686)
    zebrafish
    (Danio rerio)
    Actinopterygii PCDHAC16
    protocadherin alpha subfamily C, 1
    34(a)
    1 ↔ 1
    10(21749947-21758204) ENSDARG00000093123


    ENSEMBL Gene Tree for PCDHAC1 (if available)
    TreeFam Gene Tree for PCDHAC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PCDHAC1 gene
    PCDHA22  PCDH72  PCDH202  PCDH12  PCDHA122  PCDH11Y2  PCDHA52  PCDH122  
    PCDHA112  PCDHA12  PCDH182  PCDH92  PCDH192  PCDH82  PCDH172  PCDHGC32  
    PCDHA72  PCDH11X2  PCDHA62  PCDHA82  PCDH102  PCDHA102  PCDHA132  PCDHA92  
    PCDHA32  PCDHA42  
    Selected SIMAP similar genes for PCDHAC1 using alignment to 2 protein entries:     PCDC1_HUMAN (see all proteins) (see all similar genes):
    PCDHGA3    PCDHAC2    DKFZp586I1919    PCDHB18    PCDHGA11    PCDHA3
    PCDHA6    PCDHA8    PCDHB15    PCDHGA1    PCDHGB1    PCDH10
    PCDHA1    PCDHA10    PCDHA2    PCDHA4    PCDHA7    PCDHB12

    Find genes that share paralogs with PCDHAC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for PCDHAC1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2460741,2,4
    ----see VAR_0485402 mis40--------

    HapMap Linkage Disequilibrium report for PCDHAC1 (140306302 - 140391929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PCDHAC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2505753CNV Deletion19546169
    dgv1856e1CNV Complex17122850
    dgv1857e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PCDHAC1
    DNA2.0 Custom Variant and Variant Library Synthesis for PCDHAC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606320    OMIM disorders: --


    Find genes that share disorders with PCDHAC1           About GenesLikeMe

    Genetic Association Database (GAD): PCDHAC1

    Export disorders for PCDHAC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PCDHAC1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PCDHAC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PubMed id 10380929)1, 2, 3 Wu Q. and Maniatis T. (Cell 1999)
    2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PubMed id 11230163)1 Wu Q.... Maniatis T. (Genome Res. 2001)
    5. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)1 Nollet F....van Roy F. (J. Mol. Biol. 2000)
    6. Genomic organization of the family of CNR cadherin genes in mice and humans. (PubMed id 10662547)1 Sugino H....Yagi T. (Genomics 2000)
    7. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PubMed id 10716726)1 Wu Q. and Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PubMed id 10817752)1 Yagi T. and Takeichi M. (amp 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56135 HGNC: 8676 AceView: PCDHA9 Ensembl:ENSG00000248383 euGenes: HUgn56135
    ECgene: PCDHAC1 H-InvDB: PCDHAC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PCDHAC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PCDHAC1 gene:
    Search GeneIP for patents involving PCDHAC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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