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Aliases for PCDHA@ Gene

Aliases for PCDHA@ Gene

  • Protocadherin Alpha Cluster, Complex Locus 2 3
  • Protocadherin Alpha Cluster 2 3
  • Cadherin-Related Neuronal Receptor 1 3
  • CNRS1 3
  • CNR1 3

External Ids for PCDHA@ Gene

Previous HGNC Symbols for PCDHA@ Gene

  • CNRS1

Previous GeneCards Identifiers for PCDHA@ Gene

  • GC05U990123
  • GC05P140147

Summaries for PCDHA@ Gene

Entrez Gene Summary for PCDHA@ Gene

  • The protocadherin alpha gene cluster is one of three related clusters tandemly linked on chromosome five. The clusters have a genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 genes and 1 pseudogene, which are members of the cadherin superfamily and related to the mouse CNR genes. The sequence of the 13 upstream genes and the pseudogene are highly similar to one another, while a subfamily (C) contains two more distantly related coding sequences. The alpha cluster genes are organized in a tandem array of 15 large, variable region exons followed by a constant region, which contains 3 exons shared by all genes in the cluster. Each variable region exon encodes an extracellular domain comprised of 6 cadherin ectodomains and a transmembrane region. The constant region exons encode a common cytoplasmic tail. These neural adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the alpha cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHA@ Gene

PCDHA@ (Protocadherin Alpha Cluster, Complex Locus) is a Gene Cluster. Among its related pathways are Ras signaling pathway and Signaling by GPCR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHA@ Gene

Genomics for PCDHA@ Gene

Genomic Location for PCDHA@ Gene

140,786,291 bp from pter
141,012,344 bp from pter
226,054 bases
Plus strand

Genomic View for PCDHA@ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHA@ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHA@ Gene

No data available for Regulatory Elements for PCDHA@ Gene

Proteins for PCDHA@ Gene

Post-translational modifications for PCDHA@ Gene

No Post-translational modifications

No data available for DME Specific Peptides for PCDHA@ Gene

Domains for PCDHA@ Gene

Gene Families for PCDHA@ Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCDHA@: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PCDHA@ Gene

Function for PCDHA@ Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHA@ Gene

Localization for PCDHA@ Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PCDHA@ Gene

Transcripts for PCDHA@ Gene

mRNA/cDNA for PCDHA@ Gene

(66) Additional mRNA sequences :

Unigene Clusters for PCDHA@ Gene

Protocadherin alpha cluster, complex locus:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHA@ Gene

No ASD Table

Relevant External Links for PCDHA@ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDHA@ Gene

mRNA expression in normal human tissues for PCDHA@ Gene

mRNA expression in normal human tissues for PCDHA@ Gene

SOURCE GeneReport for Unigene cluster for PCDHA@ Gene Hs.199343

genes like me logo Genes that share expressions with PCDHA@: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for PCDHA@ Gene

Orthologs for PCDHA@ Gene

No data available for Orthologs and Evolution for PCDHA@ Gene

Paralogs for PCDHA@ Gene

No data available for Paralogs for PCDHA@ Gene

Variants for PCDHA@ Gene

Relevant External Links for PCDHA@ Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for PCDHA@ Gene

Disorders for PCDHA@ Gene

Relevant External Links for PCDHA@

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PCDHA@ Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PCDHA@ Gene

Publications for PCDHA@ Gene

  1. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3 23
  2. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3
  3. Genomic organization of the family of CNR cadherin genes in mice and humans. (PMID: 10662547) Sugino H. … Yagi T. (Genomics 2000) 2 3
  4. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PMID: 19054571) GregA^rio S.P. … Dias-Neto E. (Psychiatry Res 2009) 3 48
  5. Protocadherin I+ (PCDHA) as a novel susceptibility gene for autism. (PMID: 23031252) Anitha A. … Mori N. (J Psychiatry Neurosci 2013) 3

Products for PCDHA@ Gene

Sources for PCDHA@ Gene

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