Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCDHA5 Gene

Aliases for PCDHA5 Gene

  • Protocadherin Alpha 5 2 3
  • Ortholog Of Mouse CNR6 2 3
  • KIAA0345-Like 9 2 3
  • PCDH-Alpha-5 3 4
  • CNRS6 3 4
  • Protocadherin Alpha-5 3
  • CNRN6 3
  • CRNR6 3
  • CNR6 3

External Ids for PCDHA5 Gene

Previous HGNC Symbols for PCDHA5 Gene

  • CNRS6

Previous GeneCards Identifiers for PCDHA5 Gene

  • GC05P140017
  • GC05P140752
  • GC05P140154
  • GC05P140209
  • GC05P140216
  • GC05P140171
  • GC05P140181
  • GC05P140325
  • GC05P140341
  • GC05P135346
  • GC05P140361
  • GC05P140376
  • GC05P140391
  • GC05P140405
  • GC05P140421
  • GC05P140438
  • GC05P140455

Summaries for PCDHA5 Gene

Entrez Gene Summary for PCDHA5 Gene

  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHA5 Gene

PCDHA5 (Protocadherin Alpha 5) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDHA5 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Wiki entry for PCDHA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHA5 Gene

Genomics for PCDHA5 Gene

Regulatory Elements for PCDHA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCDHA5 Gene

140,821,604 bp from pter
141,012,344 bp from pter
190,741 bases
Plus strand

Genomic View for PCDHA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHA5 Gene

Proteins for PCDHA5 Gene

  • Protein details for PCDHA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protocadherin alpha-5
    Protein Accession:
    Secondary Accessions:
    • O75284
    • Q8N4R3

    Protein attributes for PCDHA5 Gene

    936 amino acids
    Molecular mass:
    102048 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHA5 Gene


neXtProt entry for PCDHA5 Gene

Proteomics data for PCDHA5 Gene at MOPED

Post-translational modifications for PCDHA5 Gene

  • Glycosylation at Asn264 and Asn547
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHA5 Gene

Antibody Products

No data available for DME Specific Peptides for PCDHA5 Gene

Domains for PCDHA5 Gene

Gene Families for PCDHA5 Gene

Protein Domains for PCDHA5 Gene

Suggested Antigen Peptide Sequences for PCDHA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 cadherin domains.
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHA5: view

Function for PCDHA5 Gene

Molecular function for PCDHA5 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHA5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHA5 Gene

Localization for PCDHA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHA5 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PCDHA5 Gene COMPARTMENTS Subcellular localization image for PCDHA5 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PCDHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10380929
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PCDHA5: view

Pathways for PCDHA5 Gene

SuperPathways for PCDHA5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCDHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 10380929
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007399 nervous system development TAS 10380929
genes like me logo Genes that share ontologies with PCDHA5: view

No data available for Pathways by source for PCDHA5 Gene

Drugs for PCDHA5 Gene

(1) HMDB Compounds for PCDHA5 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with PCDHA5: view

Transcripts for PCDHA5 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHA5 Gene

No ASD Table

Relevant External Links for PCDHA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDHA5 Gene

mRNA expression in normal human tissues for PCDHA5 Gene

mRNA differential expression in normal tissues according to GTEx for PCDHA5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.3), Brain - Frontal Cortex (BA9) (6.8), Brain - Cerebellum (5.6), and Brain - Anterior cingulate cortex (BA24) (4.7).
genes like me logo Genes that share expressions with PCDHA5: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for PCDHA5 Gene

Orthologs for PCDHA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PCDHA5 35
  • 84.38 (n)
  • 84.67 (a)
  • 84 (a)
(Mus musculus)
Mammalia Pcdha5 35
  • 85.43 (n)
  • 87.62 (a)
Pcdha5 16
(Pan troglodytes)
Mammalia PCDHA5 35
  • 99.39 (n)
  • 99.04 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Pcdha5 35
  • 84.6 (n)
  • 86.61 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 66 (a)
-- 36
  • 68 (a)
(Gallus gallus)
Aves -- 36
  • 48 (a)
PCDHA11 36
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
-- 36
  • 56 (a)
-- 36
  • 56 (a)
-- 36
  • 54 (a)
-- 36
  • 58 (a)
-- 36
  • 58 (a)
-- 36
  • 56 (a)
-- 36
  • 57 (a)
-- 36
  • 56 (a)
-- 36
  • 57 (a)
-- 36
  • 57 (a)
-- 36
  • 58 (a)
-- 36
  • 56 (a)
-- 36
  • 55 (a)
-- 36
  • 51 (a)
-- 36
  • 55 (a)
(Danio rerio)
Actinopterygii CR847851.6 36
  • 41 (a)
CR847851.8 36
  • 41 (a)
CT573264.4 36
  • 41 (a)
CT573264.5 36
  • 41 (a)
pcdh1a6 36
  • 41 (a)
pcdh2ab1 36
  • 42 (a)
pcdh2ab10 36
  • 41 (a)
pcdh2ab11 36
  • 41 (a)
pcdh2ab12 36
  • 42 (a)
pcdh2ab2 36
  • 41 (a)
pcdh2ab2 36
  • 41 (a)
pcdh2ab3 36
  • 42 (a)
pcdh2ab6 36
  • 41 (a)
pcdh2ab7 36
  • 41 (a)
pcdh2ab8 36
  • 42 (a)
pcdh2ab9 36
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
CSA.7308 36
  • 20 (a)
Species with no ortholog for PCDHA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDHA5 Gene

Gene Tree for PCDHA5 (if available)
Gene Tree for PCDHA5 (if available)

Paralogs for PCDHA5 Gene

genes like me logo Genes that share paralogs with PCDHA5: view

Variants for PCDHA5 Gene

Sequence variations from dbSNP and Humsavar for PCDHA5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_048526 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHA5 Gene

Variant ID Type Subtype PubMed ID
nsv830508 CNV Loss 17160897
nsv882950 CNV Loss 21882294
dgv6343n71 CNV Loss 21882294
dgv1856e1 CNV Complex 17122850
dgv1857e1 CNV Complex 17122850
nsv882952 CNV Loss 21882294
dgv6344n71 CNV Loss 21882294
dgv970n67 CNV Gain 20364138
esv8310 CNV Loss 19470904
esv2659321 CNV Deletion 23128226
nsv882956 CNV Loss 21882294
nsv882957 CNV Loss 21882294
dgv6345n71 CNV Loss 21882294
nsv882960 CNV Gain 21882294
esv2730838 CNV Deletion 23290073
nsv10752 CNV Gain+Loss 18304495
dgv6346n71 CNV Loss 21882294
esv21596 CNV Gain 19812545
nsv882965 CNV Gain+Loss 21882294
nsv436885 CNV Insertion 17901297
esv27071 CNV Loss 19812545
esv33939 CNV Gain+Loss 17666407
dgv6347n71 CNV Loss 21882294
nsv823251 CNV Gain 20364138
dgv1043e199 CNV Deletion 23128226
esv2730839 CNV Deletion 23290073
esv26168 CNV Gain 19812545
dgv971n67 CNV Loss 20364138
nsv820841 CNV Deletion 20802225
nsv10753 CNV Gain 18304495
nsv819207 CNV Gain 19587683
dgv972n67 CNV Gain 20364138
dgv1044e199 CNV Deletion 23128226
esv29977 CNV Gain 17803354
nsv514324 CNV Loss 21397061
esv2421858 CNV Deletion 20811451
nsv442962 CNV CNV 18776908
dgv724n27 CNV Loss 19166990
nsv437955 CNV Loss 16468122
nsv515909 CNV Loss 19592680
esv2657537 CNV Deletion 23128226
nsv823262 CNV Gain 20364138
nsv823263 CNV Gain 20364138
nsv823264 CNV Gain 20364138
nsv882970 CNV Loss 21882294
nsv10754 CNV Gain 18304495
esv2505753 CNV Deletion 19546169

Relevant External Links for PCDHA5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHA5 Gene

Disorders for PCDHA5 Gene

Relevant External Links for PCDHA5

Genetic Association Database (GAD)

No disorders were found for PCDHA5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PCDHA5 Gene

Publications for PCDHA5 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. Genomic organization of the family of CNR cadherin genes in mice and humans. (PMID: 10662547) Sugino H. … Yagi T. (Genomics 2000) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3

Products for PCDHA5 Gene

Sources for PCDHA5 Gene

Back to Top