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PCDHA4 Gene

protein-coding   GIFtS: 50
GCID: GC05P140186

Protocadherin Alpha 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protocadherin Alpha 41 2     CNRN12
KIAA0345-Like 101 2     CRNR12
Ortholog Of Mouse CNR11 2     PCDH-ALPHA42
PCDH-alpha-42 3     Protocadherin Alpha-42
CNR12     

External Ids:    HGNC: 86701   Entrez Gene: 561442   Ensembl: ENSG000002049677   OMIM: 6063105   UniProtKB: Q9UN743   

Export aliases for PCDHA4 gene to outside databases

Previous GC identifers: GC05P140004 GC05P140751 GC05P140153 GC05P140208 GC05P140201 GC05P140170 GC05P140180 GC05P140182 GC05P140183 GC05P140184 GC05P140185 GC05P140188 GC05P140189 GC05P140190 GC05P135331


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PCDHA4 Gene:
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked
on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor
gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes
and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15
N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are
shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin
ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion
proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and
function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional
variants have been suggested but their full-length nature has yet to be determined. (provided by RefSeq, Jul
2008)

GeneCards Summary for PCDHA4 Gene:
PCDHA4 (protocadherin alpha 4) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHAC1.

UniProtKB/Swiss-Prot: PCDA4_HUMAN, Q9UN74
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance
of specific neuronal connections in the brain

summary for PCDHA4 Gene:
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor
group of G-protein-coupled receptors that also includes CB2 and GPR55. They are found mainly in the
terminals of central and peripheral neurons where they usually mediate inhibition of neurotransmitter
release. They can also be present on some non-neuronal cells, including immune cells.

Gene Wiki entry for PCDHA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PCDHA4 gene promoter:
         CUTL1   NF-AT   Gfi-1   NF-AT4   NF-AT2   COMP1   NF-AT3   c-Myb   NF-kappaB1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCDHA4 promoter sequence
   Search Chromatin IP Primers for PCDHA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCDHA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31

PCDHA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCDHA4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P140186:  view genomic region     (about GC identifiers)

Start:
140,186,659 bp from pter      End:
140,391,929 bp from pter
Size:
205,271 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PCDA4_HUMAN, Q9UN74 (See protein sequence)
Recommended Name: Protocadherin alpha-4 precursor  
Size: 947 amino acids; 102293 Da
Subunit: Interacts with FYN (By similarity)
Secondary accessions: O75285 Q2M253
Alternative splicing: 2 isoforms:  Q9UN74-1   Q9UN74-2   

Explore the universe of human proteins at neXtProt for PCDHA4: NX_Q9UN74

Explore proteomics data for PCDHA4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn139, Asn257, Asn265, Asn548
  • Modification sites at PhosphoSitePlus

  • See PCDHA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_061730.1  NP_113688.1  

    ENSEMBL proteins: 
     ENSP00000423470   ENSP00000435300   ENSP00000349344  

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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PCDHC: Cadherins / Protocadherins : Clustered

    4 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR013164 Cadherin_N
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9UN74

    ProtoNet protein and cluster: Q9UN74

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: PCDA4_HUMAN, Q9UN74
    Similarity: Contains 6 cadherin domains


    Find genes that share domains with PCDHA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCDA4_HUMAN, Q9UN74
    Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance
    of specific neuronal connections in the brain

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with PCDHA4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCDHA4
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    miRTarBase miRNAs that target PCDHA4:
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    Block miRNA regulation of human, mouse, rat PCDHA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCDHA4 (see all 93):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-4272 hsa-miR-106a hsa-miR-15a hsa-miR-485-3p hsa-miR-4305 hsa-miR-3653
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PCDA4_HUMAN, Q9UN74: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane TAS10380929
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with PCDHA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PCDHA4 About    
    See pathways by source

    SuperPathContained pathways About
    1Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PCDHA4
        Reelin Pathway (Cajal-Retzius cells)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCDHA4
    Interactions:

        Search GeneGlobe Interaction Network for PCDHA4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for PCDHA4 (Q9UN742, 3 ENSP000003493444) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP1P516932, 3MINT-65771 I2D: score=4 
    C14orf1Q9UKR52, 3MINT-65780 I2D: score=4 
    CCDC90BQ9GZT62, 3MINT-65777 I2D: score=4 
    GAPDHP044062, 3MINT-65769 I2D: score=4 
    GDF9O603832, 3MINT-65768 I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS10380929
    GO:0007156homophilic cell adhesion IEA--
    GO:0007399nervous system development TAS10380929

    Find genes that share ontologies with PCDHA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PCDHA4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ACEA Potent, highly selective CB1 agonist [220556-69-4]
    AM 251Potent CB1 antagonist. Also GPR55 agonist[183232-66-8]
    SR 141716ASelective CB1 receptor antagonist[158681-13-1]
    Tocrifluor T1117Novel fluorescent cannabinoid ligand. Fluorescent form of AM 251 (Cat. No. 1117)[1186195-59-4]
    AM 281 Potent, selective CB1 antagonist/inverse agonist [202463-68-1]

    1 HMDB Compound for PCDHA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PCDHA4 gene (2 alternative transcripts): 
    NM_018907.3  NM_031500.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512229 ENST00000530339(uc003lhh.1 uc003lhi.2) ENST00000356878(uc011daa.2)

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    Selected qRT-PCR Assays for microRNAs that regulate PCDHA4 (see all 93):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-4272 hsa-miR-106a hsa-miR-15a hsa-miR-485-3p hsa-miR-4305 hsa-miR-3653
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat PCDHA4
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCDHA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHA4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PCDHA4
      QuantiTect SYBR Green Assays in human, mouse, rat PCDHA4
      QuantiFast Probe-based Assays in human, mouse, rat PCDHA4

    Selected AceView cDNA sequences (see all 261):

    AF152479 NM_018909 NM_031496 F05011 NM_014005 BF933281 AA973493 AF169689 
    AI268404 AW572498 AI969295 NM_031861 AF152312 AA757839 AF152486 NM_018901 
    AF152487 AA552914 AA384862 AF152305 AF169695 AF152303 BM719606 AF152314 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PCDHA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PCDHA4 Expression
    About this image


    PCDHA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
    PCDHA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCDHA4 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PCDHA4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcdha41 , 5 protocadherin alpha 41, 5 83.95(n)1
    86.38(a)1
      18 (19.46 cM)5
    129361  NM_007766.21  NP_031792.11 
     369526895 
    chicken
    (Gallus gallus)
    Aves PCDHA116
    --
    Uncharacterized protein
    54(a)
    47(a)
    many ↔ many
    many ↔ many
    13(185486-285392)
    13(292413-317534)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 16)
    Protocadherin alpha 10 unspliced isoform; Uncharac...
    Protocadherin alpha 5 unspliced isoform; Uncharact...
    (see all 16)
    58(a)
    57(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    4(77317799-77320222)
    4(77380556-77382976)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017348401 protocadherin alpha-7-like 54.85(n)
    50(a)
      101734840  XM_004913150.1  XP_004913207.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pcdh2ab126
    pcdh2ab16
    (see all 16)
    protocadherin 2 alpha b 1
    (see all 16)
    43(a)
    43(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    14(2719870-2722245) ENSDARG00000087974
    14(2495124-2497505) ENSDARG00000071904


    ENSEMBL Gene Tree for PCDHA4 (if available)
    TreeFam Gene Tree for PCDHA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PCDHA4 gene
    PCDHAC12  PCDHA22  PCDH72  PCDH202  PCDH12  PCDHA122  PCDH11Y2  PCDHA52  
    PCDH122  PCDHA112  PCDHA12  PCDH182  PCDH92  PCDH192  PCDH82  PCDH172  
    PCDHGC32  PCDHA72  PCDH11X2  PCDHA62  PCDHA82  PCDH102  PCDHA102  PCDHA132  
    PCDHA92  PCDHA32  
    Selected SIMAP similar genes for PCDHA4 using alignment to 2 protein entries:     PCDA4_HUMAN (see all proteins) (see all similar genes):
    PCDHA2    PCDHA7    PCDHA9    PCDHA3    PCDHA1    PCDHA6
    PCDHA11    PCDHA5    PCDHA13    PCDHA8    PCDHA10    PCDHA12
    ME6    ME1    ME4    PCDHAC2    PCDHB13    PCDHB17

    Find genes that share paralogs with PCDHA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for PCDHA4    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114591121,2
    C--140186225(+) GGGTGA/-AAGAG 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs38223461,2,4
    ----see VAR_0243902 mis40--------
    rs111676051,2,4
    ----see VAR_0591802 mis40--------

    HapMap Linkage Disequilibrium report for PCDHA4 (140186659 - 140391929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PCDHA4 (see all 48):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657537CNV Deletion23128226
    nsv820841CNV Deletion20802225
    esv2659321CNV Deletion23128226
    dgv1044e199CNV Deletion23128226
    esv2505753CNV Deletion19546169
    esv2730838CNV Deletion23290073
    esv2730839CNV Deletion23290073
    esv2421858CNV Deletion20811451
    dgv1043e199CNV Deletion23128226
    nsv436885CNV Insertion17901297

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606310    OMIM disorders: --


    Find genes that share disorders with PCDHA4           About GenesLikeMe

    Genetic Association Database (GAD): PCDHA4

    Export disorders for PCDHA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PCDHA4 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with PCDHA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PubMed id 10380929)1, 2, 3 Wu Q. and Maniatis T. (Cell 1999)
    2. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
    3. Genomic organization of the family of CNR cadherin genes in mice and humans. (PubMed id 10662547)1, 3 Sugino H....Yagi T. (Genomics 2000)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    5. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PubMed id 11230163)1 Wu Q.... Maniatis T. (Genome Res. 2001)
    9. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)1 Nollet F....van Roy F. (J. Mol. Biol. 2000)
    10. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PubMed id 10716726)1 Wu Q. and Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56144 HGNC: 8670 AceView: PCDHA9 Ensembl:ENSG00000204967 euGenes: HUgn56144
    ECgene: PCDHA4 H-InvDB: PCDHA4

    (According to HUGE)
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    HUGE: KIAA0345-like 10" KIAA0345-like 10

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PCDHA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PCDHA4 gene:
    Search GeneIP for patents involving PCDHA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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