Aliases for PCDHA4 Gene
Aliases for PCDHA4 Gene
External Ids for PCDHA4 Gene
- HGNC: 8670
- Entrez Gene: 56144
- Ensembl: ENSG00000204967
- OMIM: 606310
- UniProtKB: Q9UN74
Previous GeneCards Identifiers for PCDHA4 Gene
- GC05P140004
- GC05P140751
- GC05P140153
- GC05P140208
- GC05P140201
- GC05P140170
- GC05P140180
- GC05P140182
- GC05P140183
- GC05P140184
- GC05P140185
- GC05P140186
- GC05P140188
- GC05P140189
- GC05P140190
- GC05P135331
- GC05P141236
- GC05P141483
- GC05P141591
- GC05P141693
- GC05P141795
Summaries for PCDHA4 Gene
-
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCDHA4 Gene
PCDHA4 (Protocadherin Alpha 4) is a Protein Coding gene. Among its related pathways are Reelin Pathway (Cajal-Retzius cells). GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHA3.
UniProtKB/Swiss-Prot for PCDHA4 Gene
-
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHA4 Gene
Genomics for PCDHA4 Gene
Regulatory Elements for PCDHA4 Gene
Enhancers for PCDHA4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PCDHA4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PCDHA4 gene promoter:
Regulatory Element Products
Genomic Location for PCDHA4 Gene
- Chromosome:
- 5
- Start:
- 140,806,929 bp from pter
- End:
- 141,012,344 bp from pter
- Size:
- 205,416 bases
- Orientation:
- Plus strand
Genomic View for PCDHA4 Gene
Genes around PCDHA4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.3 by Ensembl
- 5q31.3 by Entrez Gene
- 5q31.3 by HGNC
PCDHA4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PCDHA4 Gene
Proteins for PCDHA4 Gene
-
Protein details for PCDHA4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UN74-PCDA4_HUMAN
- Recommended name:
- Protocadherin alpha-4
- Protein Accession:
- Q9UN74
- O75285
- Q2M253
Protein attributes for PCDHA4 Gene
- Size:
- 947 amino acids
- Molecular mass:
- 102293 Da
- Quaternary structure:
-
- Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins. Interacts with FYN.
Post-translational modifications for PCDHA4 Gene
Other Protein References for PCDHA4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PCDHA4
- Novus Biologicals Antibodies for PCDHA4
- Invitrogen Antibodies for PCDHA4
- antibodies-online Antibodies for PCDHA4: See all 29
- GeneTex PCDHA4 antibody for PCDHA4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PCDHA4
Protein Products
- R&D Systems Proteins and Enzymes for PCDHA4 (Protocadherin alpha 4)
-
OriGene Purified Proteins for PCDHA4
- Search Origene for MassSpec and Protein Over-expression Lysates for PCDHA4
- Origene Custom Protein Services for PCDHA4
- antibodies-online Proteins for PCDHA4: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PCDHA4
Assay Products
- antibodies-online Kits for PCDHA4: See all 7
No data available for DME Specific Peptides for PCDHA4 Gene
Domains & Families for PCDHA4 Gene
Gene Families for PCDHA4 Gene
Protein Domains for PCDHA4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PCDHA4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UN74UniProtKB/Swiss-Prot:
PCDA4_HUMAN :- Cadherin 1 to cadherin 4 domains mediate homophilic trans-interaction, the interaction with an identical protocadherin expressed by a neighboring cell. This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin. The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane. Each cadherin domain binds three calcium ions.
- Domain:
-
- Cadherin 1 to cadherin 4 domains mediate homophilic trans-interaction, the interaction with an identical protocadherin expressed by a neighboring cell. This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin. The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane. Each cadherin domain binds three calcium ions.
Function for PCDHA4 Gene
Molecular function for PCDHA4 Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | ISS | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0042802 | identical protein binding | ISS | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for PCDHA4 Gene
- GenomeRNAi human phenotypes for PCDHA4:
Animal Model Products
-
Taconic Biosciences Mouse Models for PCDHA4
- Cyagen custom Knockout/knockin (KOKI) mouse models for PCDHA4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PCDHA4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PCDHA4 gene
- Search ViGene Biosciences for PCDHA4
CRISPR Products
-
OriGene CRISPR knockouts for PCDHA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PCDHA4
- GenScript: Design CRISPR guide RNA sequences for PCDHA4
miRNA for PCDHA4 Gene
- miRTarBase miRNAs that target PCDHA4
-
- hsa-mir-148b-3p (MIRT019262)
- hsa-mir-26b-5p (MIRT028998)
- hsa-mir-181a-5p (MIRT053674)
- hsa-mir-221-3p (MIRT053722)
- hsa-mir-7152-5p (MIRT619214)
- hsa-mir-3074-5p (MIRT619215)
- hsa-mir-27b-5p (MIRT619216)
- hsa-mir-627-3p (MIRT619217)
- hsa-mir-1914-5p (MIRT619218)
- hsa-mir-6882-3p (MIRT659435)
- hsa-mir-7157-3p (MIRT659436)
- hsa-mir-6737-3p (MIRT659437)
- hsa-mir-5008-3p (MIRT659438)
miRNA Products
- Search ViGene Biosciences for PCDHA4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PCDHA4
- Browse OriGene Inhibitory RNA Products For PCDHA4
-
ViGene Biosciences ready-to-package AAV shRNAs for PCDHA4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PCDHA4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCDHA4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PCDHA4
-
ViGene Biosciences adenoviral particle packaged cDNA for PCDHA4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PCDHA4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PCDHA4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHA4 Gene
Localization for PCDHA4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PCDHA4 Gene
- Cell membrane; Single-pass type I membrane protein. Note=Detected in dendrites and synapses. {ECO:0000250 UniProtKB:O88689}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 10380929 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for PCDHA4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Reelin Pathway (Cajal-Retzius cells) | ||
Pathways by source for PCDHA4 Gene
1 Qiagen pathway for PCDHA4 Gene
Interacting Proteins for PCDHA4 Gene
Selected Interacting proteins:
Q9UN74-PCDA4_HUMAN
ENSP00000435300
for PCDHA4 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | TAS,IEA | 10380929 |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | IEA | -- |
| GO:0007267 | cell-cell signaling | IBA | -- |
| GO:0007399 | nervous system development | TAS | 10380929 |
No data available for SIGNOR curated interactions for PCDHA4 Gene
Drugs & Compounds for PCDHA4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
Transcripts for PCDHA4 Gene
mRNA/cDNA for PCDHA4 Gene
- (2) REFSEQ mRNAs :
- (261) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PCDHA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PCDHA4
- GenScript: Design CRISPR guide RNA sequences for PCDHA4
miRNA Products
- Search ViGene Biosciences for PCDHA4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PCDHA4
- Browse OriGene Inhibitory RNA Products For PCDHA4
-
ViGene Biosciences ready-to-package AAV shRNAs for PCDHA4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PCDHA4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCDHA4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for PCDHA4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Mesenchymal Stem Cells Subcutaneous White Adipose
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Subcutaneous White Adipose
mRNA differential expression in normal tissues according to GTEx for PCDHA4 Gene
This gene is overexpressed in Pancreas (x4.1) and Brain - Cerebellar Hemisphere (x4.1).
NURSA nuclear receptor signaling pathways regulating expression of PCDHA4 Gene:
PCDHA4Evidence on tissue expression from TISSUES for PCDHA4 Gene
- Lung(4)
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for PCDHA4
-
OriGene qPCR primer pairs and template standards for PCDHA4
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHA4 Gene
Orthologs for PCDHA4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LOC787538 34 |
|
||
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Pcdha4 34 16 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pcdha4 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | PCDHA11 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101734840 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pcdh2ab1 35 |
|
ManyToMany | |
| pcdh2ab12 35 |
|
ManyToMany | |||
| pcdh2ab3 35 |
|
ManyToMany | |||
| CT573264.5 35 |
|
ManyToMany | |||
| pcdh1a6 35 |
|
ManyToMany | |||
| pcdh2ab8 35 |
|
ManyToMany | |||
| CR847851.6 35 |
|
ManyToMany | |||
| CR847851.8 35 |
|
ManyToMany | |||
| CT573264.4 35 |
|
ManyToMany | |||
| pcdh2ab11 35 |
|
ManyToMany | |||
| pcdh2ab2 35 35 |
|
ManyToMany | |||
| pcdh2ab6 35 |
|
ManyToMany | |||
| pcdh2ab7 35 |
|
ManyToMany | |||
| pcdh2ab9 35 |
|
ManyToMany | |||
| pcdh2ab10 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| CSA.7308 35 |
|
ManyToMany |
- Species where no ortholog for PCDHA4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PCDHA4 Gene
Paralogs for PCDHA4 Gene
(70) SIMAP similar genes for PCDHA4 Gene using alignment to 2 proteins:
- PCDHA9
- PCDHA7
- PCDHA2
- PCDHA3
- PCDHA6
- PCDHA1
- PCDHA5
- PCDHA11
- PCDHA13
- PCDHA8
- PCDHA10
- PCDHA12
- ME6
- PCDHB8
- PCDHB18
- PCDHB17
- PCDHB13
- PCDHAC2
- ME4
- ME1
- PCDHB3
- PCDHB2
- PCDHB16
- PCDHB14
- PCDHB12
- PCDHB10
- PCDHAC1
- PCDHB9
- PCDH10
- PCDHB11
- PCDHGA3
- PCDHGC3
- PCDHGA6
- PCDHB7
- PCDHB5
- PCDHB15
- DKFZp586I1919
- FAT3
- PCDHGA10
- PCDHB6
- PCDHGB1
- PCDHB4
- PCDHB1
- PCDHGA7
- PCDHGA11
- PCDHGA1
- PCDHGC5
- PCDHGA8
- PCDH17
- ME3
- ME2
- PCDHGC4
- PCDHGB7
- PCDHGB5
- PCDHGB4
- PCDHGA9
- PCDHGA12
- PCDHGB3
- PCDHGA4
- PCDHGA2
- PCDH19
- PCDHGB6
- PCDHGB2
- PCDH1
- PCDHGA5
- PCDH18
- PCDH12
- ME5
- CDH22
- PCDH8
Variants for PCDHA4 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs193920994 | Uncertain significance | 140,857,214(+) | TCTGA(C/T)GCCTC | intron-variant, reference, missense | |
| rs386352346 | Uncertain significance | 140,929,288(+) | GATTC(A/G)GAATA | intron-variant, reference, missense | |
| rs1000079934 | -- | 140,816,794(+) | CCAGC(C/T)TTTTT | intron-variant | |
| rs1000122176 | -- | 140,965,777(+) | TTTGC(C/T)TACAG | intron-variant, upstream-variant-2KB | |
| rs1000135835 | -- | 140,820,198(+) | GTTTC(A/G)ACGAT | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
26.48;
99.78% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PCDHA4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PCDHA4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHA4 Gene
Disorders for PCDHA4 Gene
Relevant External Links for PCDHA4
No disorders were found for PCDHA4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHA4 Gene
Publications for PCDHA4 Gene
- A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 64
- The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
- Genomic organization of the family of CNR cadherin genes in mice and humans. (PMID: 10662547) Sugino H. … Yagi T. (Genomics 2000) 2 3 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64
Products for PCDHA4 Gene
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- Taconic Biosciences Mouse Models for PCDHA4
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- antibodies-online Antibodies for PCDHA4: See all 29
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- antibodies-online Proteins for PCDHA4: See all 5
- Search antibodies-online for peptides
- GeneTex PCDHA4 antibody for PCDHA4
- Search GeneTex for Proteins for PCDHA4
- ViGene Biosciences adenoviral particle packaged cDNA for PCDHA4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PCDHA4 gene
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- Search ViGene Biosciences for PCDHA4
- Santa Cruz Biotechnology (SCBT) Antibodies for PCDHA4
- Search Santa Cruz Biotechnology (SCBT) for PCDHA4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PCDHA4
- Horizon Cell Lines for PCDHA4
- Cyagen custom Knockout/knockin (KOKI) mouse models for PCDHA4
- VectorBuilder custom plasmid, inducible vectors for PCDHA4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCDHA4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PCDHA4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer