Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PCDHA2 Gene

protein-coding   GIFtS: 42
GCID: GC05P140160

Protocadherin Alpha 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protocadherin Alpha 21 2
KIAA0345-Like 121 2
PCDH-ALPHA22
Protocadherin Alpha-22
PCDH-alpha-23

External Ids:    HGNC: 86681   Entrez Gene: 561462   Ensembl: ENSG000002049697   OMIM: 6063085   UniProtKB: Q9Y5H93   

Export aliases for PCDHA2 gene to outside databases

Previous GC identifers: GC05P139991 GC05P140749 GC05P140151 GC05P140206 GC05P140199 GC05P135319


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PCDHA2 Gene:
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked
on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor
gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes
and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15
N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are
shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin
ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion
proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and
function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional
variants have been suggested but their full-length nature has yet to be determined. (provided by RefSeq, Jul
2008)

GeneCards Summary for PCDHA2 Gene: 
PCDHA2 (protocadherin alpha 2) is a protein-coding gene. Diseases associated with PCDHA2 include neuronitis. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHAC1.

UniProtKB/Swiss-Prot: PCDA2_HUMAN, Q9Y5H9
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance
of specific neuronal connections in the brain

Gene Wiki entry for PCDHA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PCDHA2 gene promoter:
         CUTL1   NF-AT   NF-AT4   NF-AT2   COMP1   NF-AT3   c-Myb   NF-kappaB1   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PCDHA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCDHA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31

PCDHA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCDHA2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P140160:  view genomic region     (about GC identifiers)

Start:
140,174,444 bp from pter      End:
140,391,929 bp from pter
Size:
217,486 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PCDA2_HUMAN, Q9Y5H9 (See protein sequence)
Recommended Name: Protocadherin alpha-2 precursor  
Size: 948 amino acids; 102063 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: O75287 Q9BTV3
Alternative splicing: 3 isoforms:  Q9Y5H9-1   Q9Y5H9-2   Q9Y5H9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PCDHA2: NX_Q9Y5H9

Explore proteomics data for PCDHA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5H9

  • PCDHA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PCDHA2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_061728.1  NP_113683.1  NP_113684.1  

    ENSEMBL proteins: 
     ENSP00000430584   ENSP00000431748   ENSP00000367372  

    Human Recombinant Protein Products for PCDHA2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PCDHA2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PCDHA2
    GenScript Custom Purified and Recombinant Proteins Services for PCDHA2
    Novus Biologicals PCDHA2 Proteins
    Novus Biologicals PCDHA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS10380929
    GO:0016020membrane ----

    PCDHA2 for ontologies           About GeneDecksing



    PCDHA2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PCDHA2
    GenScript Custom Superior Antibodies Services for PCDHA2
    Novus Biologicals PCDHA2 Antibodies
    Search for Antibodies for PCDHA2 at Abcam
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PCDHA2
    LSBio Antibodies in human, mouse, rat for PCDHA2 

    Assay Products for PCDHA2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PCDHA2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PCDHA2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PCDHC: Cadherins / Protocadherins : Clustered

    4 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR013164 Cadherin_N
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9Y5H9

    ProtoNet protein and cluster: Q9Y5H9

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: PCDA2_HUMAN, Q9Y5H9
    Similarity: Contains 6 cadherin domains


    PCDHA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCDA2_HUMAN, Q9Y5H9
    Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance
    of specific neuronal connections in the brain

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    PCDHA2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PCDHA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PCDHA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCDHA2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PCDHA2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PCDHA2
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate PCDHA2 (see all 115):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-4272 hsa-miR-106a hsa-miR-15a hsa-miR-485-3p hsa-miR-4305 hsa-miR-3653
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PCDHA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCDHA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PCDHA2
    Sirion Biotech Customized adenovirus for overexpression of PCDHA2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PCDHA2 (see all 10)
    OriGene ORF clones in mouse, rat for PCDHA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PCDHA2 (NM_031495)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCDHA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHA2
    Sirion Biotech Customized lentivirus for stable overexpression of PCDHA2 
                         Customized lentivirus expression plasmids for stable overexpression of PCDHA2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PCDHA2
    Search LifeMap BioReagents cell lines for PCDHA2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCDHA2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PCDHA2 (Q9Y5H93 ENSP000003673724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS10380929
    GO:0007156homophilic cell adhesion IEA--
    GO:0007399nervous system development TAS10380929

    PCDHA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PCDHA2 (PCDA2)

    1 HMDB Compound for PCDHA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about PCDHA2 / PCDA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PCDHA2 gene (3 alternative transcripts): 
    NM_018905.2  NM_031495.1  NM_031496.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520672(uc011czy.2) ENST00000526136(uc003lhd.2) ENST00000378132(uc003lhc.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PCDHA2
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate PCDHA2 (see all 115):
    hsa-miR-194* hsa-miR-3130-5p hsa-miR-4272 hsa-miR-106a hsa-miR-15a hsa-miR-485-3p hsa-miR-4305 hsa-miR-3653
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PCDHA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCDHA2
    Clone
    Products:
         
    OriGene clones in human, mouse for PCDHA2 (see all 10)
    OriGene ORF clones in mouse, rat for PCDHA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PCDHA2 (NM_031495)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCDHA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHA2
    Sirion Biotech Customized lentivirus for stable overexpression of PCDHA2 
                         Customized lentivirus expression plasmids for stable overexpression of PCDHA2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PCDHA2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PCDHA2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCDHA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCDHA2

    24/261 AceView cDNA sequences (see all 261):

    AF152479 NM_031861 NM_018910 CA436984 NM_018911 NM_031501 NM_018907 AA552914 
    BF933281 AI161196 NM_018908 BM719606 NM_031852 AF152315 AF152306 AW470523 
    AF152481 AF152304 BM684041 AF152310 NM_018904 AA757839 AF152308 AF152309 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PCDHA2 expression in normal human tissues (normalized intensities)      PCDHA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PCDHA2 Expression
    About this image


    PCDHA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...

    See PCDHA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PCDHA2
        SABiosciences Custom PCR Arrays for PCDHA2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PCDHA2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PCDHA2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCDHA2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCDHA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PCDHA2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcdha21 , 5 protocadherin alpha 21, 5 84.78(n)1
    87.78(a)1
      18 (19.46 cM)5
    3532341  NM_198117.21  NP_932785.11 
     369392055 
    chicken
    (Gallus gallus)
    Aves PCDHA116
    --
    --
    53(a)
    49(a)
    many ↔ many
    many ↔ many
    13(185486-285392)
    13(292413-317534)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 16)
    Uncharacterized protein
    Protocadherin alpha 14 unspliced isoform; Uncharac...
    (see all 16)
    55(a)
    55(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    4(77393489-77395927)
    4(77284686-77287109)
    zebrafish
    (Danio rerio)
    Actinopterygii pcdh2ab16
    pcdh2ab86
    (see all 35)
    protocadherin 2 alpha b 8
    (see all 35)
    43(a)
    43(a)
    (see all 35)
    many ↔ many
    many ↔ many
    (see all 35)
    14(2495124-2497505)
    14(2517358-2519727)


    ENSEMBL Gene Tree for PCDHA2 (if available)
    TreeFam Gene Tree for PCDHA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PCDHA2 gene
    PCDHAC12  PCDHB162  PCDHB22  PCDHAC22  PCDHB72  PCDHB152  PCDHGA102  PCDHGB22  
    PCDHGA122  PCDHGA92  PCDHGA82  PCDHGC32  PCDHGA52  PCDHA82  PCDHB52  PCDHB132  
    PCDHGA42  PCDHGA72  PCDHB42  PCDHB112  ENSG000002556222  PCDHB142  PCDHB122  PCDHB82  
    PCDHGB12  PCDHGB42  PCDHA52  PCDHGA22  PCDHGA62  PCDHB32  PCDHGA112  PCDHB62  
    PCDHGC42  PCDHGC52  PCDHGA12  PCDHB102  PCDHB12  PCDHGB72  PCDHGA32  
    18/60 SIMAP similar genes for PCDHA2 using alignment to 1 protein entry:     PCDA2_HUMAN(see all similar genes):
    PCDHA4    PCDHA1    PCDHA11    PCDHA5    PCDHA6    PCDHA7
    PCDHA9    PCDHA13    PCDHA3    PCDHA10    PCDHA8    PCDHA12
    PCDHB17    PCDHAC2    PCDHB1    PCDHB14    PCDHGA3    DKFZp586I1919

    PCDHA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3 SNPs in PCDHA2 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0243894
    ----see VAR_0243892 V L mis40--------
    VAR_0591794
    ----see VAR_0591792 E K mis40--------
    VAR_0485234
    ----see VAR_0485232 P L mis40--------

    HapMap Linkage Disequilibrium report for PCDHA2 (140174444 - 140391929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/48 variations for PCDHA2 (see all 48):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657537CNV Deletion23128226
    nsv820841CNV Deletion20802225
    esv2659321CNV Deletion23128226
    dgv1044e199CNV Deletion23128226
    esv2505753CNV Deletion19546169
    esv2730838CNV Deletion23290073
    esv2730839CNV Deletion23290073
    esv2421858CNV Deletion20811451
    dgv1043e199CNV Deletion23128226
    nsv436885CNV Insertion17901297

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PCDHA2
    DNA2.0 Custom Variant and Variant Library Synthesis for PCDHA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606308    OMIM disorders: --

    2 diseases for PCDHA2:    About MalaCards
    neuronitis    


    PCDHA2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PCDHA2

    Export disorders for PCDHA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PCDHA2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with PCDHA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PubMed id 10380929)1, 2, 3 Wu Q. and Maniatis T. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    7. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PubMed id 11230163)1 Wu Q.... Maniatis T. (2001)
    10. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)1 Nollet F....van Roy F. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56146 HGNC: 8668 AceView: PCDHA9 Ensembl:ENSG00000204969 euGenes: HUgn56146
    ECgene: PCDHA2 H-InvDB: PCDHA2

    (According to HUGE)
    About This Section
    HUGE: KIAA0345-like 12

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PCDHA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PCDHA2 gene:
    Search GeneIP for patents involving PCDHA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PCDHA2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PCDHA2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PCDHA2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PCDHA2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PCDHA2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PCDHA2   OriGene Custom Protein Services for PCDHA2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PCDHA2
     QIAGEN SeqTarget long-range PCR primers for resequencing PCDHA2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCDHA2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCDHA2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCDHA2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCDHA2
     GenScript Custom Purified and Recombinant Proteins Services for PCDHA2 GenScript cDNA clones with any tag delivered in your preferred vector for PCDHA2
     GenScript Custom Assay Services for PCDHA2 GenScript Custom Superior Antibodies Services for PCDHA2
     GenScript Custom overexpressing Cell Line Services for PCDHA2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PCDHA2 promoter
     Search Chromatin IP Primers for PCDHA2
     RT2 qPCR Primer Assay in human, mouse / rat PCDHA2
     Search GNC Networks for PCDHA2
     SABiosciences Custom PCR Arrays for PCDHA2
     Search Tocris compounds for PCDHA2 (PCDA2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PCDHA2 antibodies
     PCDHA2 proteins
     PCDHA2 lysates
     Search for Antibodies for PCDHA2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PCDHA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PCDHA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDHA2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PCDHA2
     Browse SwitchGear Promoter luciferase reporter plasmids for PCDHA2
     ThermoFisher Antibodies for PCDHA2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDHA2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PCDHA2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PCDHA2
    Customized:
     lentivirus for stable overexpression of PCDHA2
     lentivirus expression plasmids for stable overexpression of PCDHA2
     adenovirus for overexpression of PCDHA2
     LSBio Antibodies in human, mouse, rat for PCDHA2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PCDHA2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4