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Aliases for PCDHA12 Gene

Aliases for PCDHA12 Gene

  • Protocadherin Alpha 12 2 3
  • KIAA0345-Like 2 2 3
  • PCDH-Alpha-12 3 4
  • Protocadherin Alpha-12 3
  • PCDH-ALPHA12 3

External Ids for PCDHA12 Gene

Summaries for PCDHA12 Gene

Entrez Gene Summary for PCDHA12 Gene

  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHA12 Gene

PCDHA12 (Protocadherin Alpha 12) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDHA12 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Wiki entry for PCDHA12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHA12 Gene

Genomics for PCDHA12 Gene

Genomic Location for PCDHA12 Gene

Start:
140,875,302 bp from pter
End:
141,012,344 bp from pter
Size:
137,043 bases
Orientation:
Plus strand

Genomic View for PCDHA12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHA12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHA12 Gene

Regulatory Elements for PCDHA12 Gene

Proteins for PCDHA12 Gene

  • Protein details for PCDHA12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN75-PCDAC_HUMAN
    Recommended name:
    Protocadherin alpha-12
    Protein Accession:
    Q9UN75
    Secondary Accessions:
    • O75278
    • Q2M1N8

    Protein attributes for PCDHA12 Gene

    Size:
    941 amino acids
    Molecular mass:
    101652 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHA12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHA12 Gene

Proteomics data for PCDHA12 Gene at MOPED

Post-translational modifications for PCDHA12 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn257, Asn265, and Asn548

Other Protein References for PCDHA12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHA12 Gene

Domains for PCDHA12 Gene

Gene Families for PCDHA12 Gene

HGNC:
  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHA12 Gene

UniProtKB/Swiss-Prot:

PCDAC_HUMAN
Domain:
  • Contains 6 cadherin domains.:
    • Q9UN75
genes like me logo Genes that share domains with PCDHA12: view

Function for PCDHA12 Gene

Molecular function for PCDHA12 Gene

UniProtKB/Swiss-Prot Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHA12: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PCDHA12 Gene

Localization for PCDHA12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHA12 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for PCDHA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHA12: view

Pathways for PCDHA12 Gene

SuperPathways for PCDHA12 Gene

No Data Available

Interacting Proteins for PCDHA12 Gene

Gene Ontology (GO) - Biological Process for PCDHA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDHA12: view

No data available for Pathways by source for PCDHA12 Gene

Compounds for PCDHA12 Gene

(1) HMDB Compounds for PCDHA12 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDHA12: view

Transcripts for PCDHA12 Gene

mRNA/cDNA for PCDHA12 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHA12 Gene

No ASD Table

Relevant External Links for PCDHA12 Gene

GeneLoc Exon Structure for
PCDHA12
ECgene alternative splicing isoforms for
PCDHA12

Expression for PCDHA12 Gene

mRNA expression in normal human tissues for PCDHA12 Gene

mRNA differential expression in normal tissues according to GTEx for PCDHA12 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.2), Brain - Cerebellum (5.0), and Testis (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDHA12 Gene

genes like me logo Genes that share expressions with PCDHA12: view

Orthologs for PCDHA12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHA12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHA12 36
  • 99.47 (n)
  • 99.68 (a)
mouse
(Mus musculus)
Mammalia Pcdha10 36
  • 77.97 (n)
  • 78.99 (a)
Pcdha9 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 67 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pcdha11 36
  • 78.31 (n)
  • 78.53 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 46 (a)
ManyToMany
PCDHA11 37
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 51 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
-- 37
  • 55 (a)
ManyToMany
-- 37
  • 55 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR847851.6 37
  • 41 (a)
ManyToMany
CR847851.8 37
  • 41 (a)
ManyToMany
CT573264.4 37
  • 41 (a)
ManyToMany
CT573264.5 37
  • 42 (a)
ManyToMany
pcdh1a6 37
  • 41 (a)
ManyToMany
pcdh2ab1 37
  • 43 (a)
ManyToMany
pcdh2ab10 37
  • 41 (a)
ManyToMany
pcdh2ab11 37
  • 42 (a)
ManyToMany
pcdh2ab12 37
  • 42 (a)
ManyToMany
pcdh2ab2 37
  • 41 (a)
ManyToMany
pcdh2ab2 37
  • 41 (a)
ManyToMany
pcdh2ab3 37
  • 42 (a)
ManyToMany
pcdh2ab6 37
  • 41 (a)
ManyToMany
pcdh2ab7 37
  • 41 (a)
ManyToMany
pcdh2ab8 37
  • 42 (a)
ManyToMany
pcdh2ab9 37
  • 41 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
ManyToMany
CSA.7308 37
  • 19 (a)
ManyToMany
Species with no ortholog for PCDHA12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDHA12 Gene

ENSEMBL:
Gene Tree for PCDHA12 (if available)
TreeFam:
Gene Tree for PCDHA12 (if available)

Paralogs for PCDHA12 Gene

genes like me logo Genes that share paralogs with PCDHA12: view

Variants for PCDHA12 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDHA12 Gene

Variant ID Type Subtype PubMed ID
dgv6343n71 CNV Loss 21882294
dgv1856e1 CNV Complex 17122850
dgv1857e1 CNV Complex 17122850
dgv6344n71 CNV Loss 21882294
nsv882956 CNV Loss 21882294
nsv882957 CNV Loss 21882294
nsv823264 CNV Gain 20364138
nsv882970 CNV Loss 21882294
nsv10754 CNV Gain 18304495
esv2505753 CNV Deletion 19546169

Relevant External Links for PCDHA12 Gene

HapMap Linkage Disequilibrium report
PCDHA12

No data available for Sequence variations from dbSNP and Humsavar for PCDHA12 Gene

Disorders for PCDHA12 Gene

Relevant External Links for PCDHA12

Genetic Association Database (GAD)
PCDHA12
genes like me logo Genes that share disorders with PCDHA12: view

No data available for UniProtKB/Swiss-Prot for PCDHA12 Gene

Publications for PCDHA12 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3

Products for PCDHA12 Gene

Sources for PCDHA12 Gene

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