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Aliases for PCDHA10 Gene

Aliases for PCDHA10 Gene

  • Protocadherin Alpha 10 2 3 5
  • Ortholog To Mouse CNR8 2 3
  • KIAA0345-Like 4 2 3
  • PCDH-Alpha-10 3 4
  • CNRS8 3 4
  • Protocadherin Alpha-10 3
  • PCDH-ALPHA10 3
  • CNRN8 3
  • CRNR8 3
  • CNR8 3

External Ids for PCDHA10 Gene

Previous HGNC Symbols for PCDHA10 Gene

  • CNRS8

Previous GeneCards Identifiers for PCDHA10 Gene

  • GC05P140052
  • GC05P140757
  • GC05P140159
  • GC05P140202
  • GC05P140195
  • GC05P140166
  • GC05P140226
  • GC05P140231
  • GC05P140236
  • GC05P140244
  • GC05P140254
  • GC05P140263
  • GC05P140273
  • GC05P140282
  • GC05P140293
  • GC05P140303
  • GC05P140312
  • GC05P140323
  • GC05P140344
  • GC05P135380
  • GC05P140356
  • GC05P140371
  • GC05P140386
  • GC05P140400
  • GC05P140416
  • GC05P140429
  • GC05P140448
  • GC05P141274
  • GC05P141494
  • GC05P141601
  • GC05P141701

Summaries for PCDHA10 Gene

Entrez Gene Summary for PCDHA10 Gene

  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHA10 Gene

PCDHA10 (Protocadherin Alpha 10) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHA12.

UniProtKB/Swiss-Prot for PCDHA10 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHA10 Gene

Genomics for PCDHA10 Gene

Regulatory Elements for PCDHA10 Gene

Enhancers for PCDHA10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F140663 0.6 ENCODE 11.2 -191.1 -191106 2.8 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TMCO6 LOC102723915 VTRNA1-1 FCHSD1 SRA1 PCDHA2 PCDHA3 PCDHA10 PCDHA7 HDAC3
GH05F140036 1.4 FANTOM5 Ensembl ENCODE 11.1 -815.4 -815397 7.0 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF207 FOS DEK ZNF263 PCDHA2 PCDHA3 PCDHA7 PURA PCDHA10 DNAJC18 PFDN1 PCDHA4 PCDHA5 NRG2
GH05F140588 1.2 FANTOM5 Ensembl ENCODE 10.8 -265.5 -265483 4.4 HDGF CREB3L1 ZFP64 ARID4B SIN3A ZNF2 ZNF48 ZNF143 DEK ZNF263 TMCO6 APBB3 CD14 EIF4EBP3 PCDHB19P LINC01024 PCDHB17P SLC35A4 PCDHA2 LOC101929719
GH05F141039 1.1 FANTOM5 Ensembl ENCODE 9.8 +184.7 184652 2.6 PKNOX1 ATF1 ARID4B SIN3A ZNF48 YY1 ELK1 CBX5 ZNF143 KLF7 PCDHB16 PCDHA4 PCDHA1 PCDHA2 HARS PCDHA9 PCDHA5 PCDHA8 PCDHA7 PCDHB8
GH05F140594 1.3 FANTOM5 Ensembl ENCODE 9.8 -259.9 -259883 4.0 NFIA MIER1 CREB3L1 CEBPB MIER2 REST ZIC2 YY1 ZNF766 ATF3 CD14 APBB3 SRA1 TMCO6 PCDHA1 PCDHA2 HARS MIR6831 SLC35A4 PCDHA5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PCDHA10 on UCSC Golden Path with GeneCards custom track

Promoters for PCDHA10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001874415 217 200 CTCF ZNF585B POLR2A GLIS1 ZNF600 ZNF2 MAFK

Genomic Location for PCDHA10 Gene

Chromosome:
5
Start:
140,855,883 bp from pter
End:
141,012,344 bp from pter
Size:
156,462 bases
Orientation:
Plus strand

Genomic View for PCDHA10 Gene

Genes around PCDHA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHA10 Gene

Proteins for PCDHA10 Gene

  • Protein details for PCDHA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5I2-PCDAA_HUMAN
    Recommended name:
    Protocadherin alpha-10
    Protein Accession:
    Q9Y5I2
    Secondary Accessions:
    • A1L493
    • O75280
    • Q9NRU2

    Protein attributes for PCDHA10 Gene

    Size:
    948 amino acids
    Molecular mass:
    102875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHA10 Gene

Post-translational modifications for PCDHA10 Gene

  • Glycosylation at Asn 256, Asn 264, and Asn 547
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHA10 Gene

Antibody Products

  • Abcam antibodies for PCDHA10

No data available for DME Specific Peptides for PCDHA10 Gene

Domains & Families for PCDHA10 Gene

Gene Families for PCDHA10 Gene

Protein Domains for PCDHA10 Gene

Suggested Antigen Peptide Sequences for PCDHA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5I2

UniProtKB/Swiss-Prot:

PCDAA_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHA10: view

Function for PCDHA10 Gene

Molecular function for PCDHA10 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Gene Ontology (GO) - Molecular Function for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHA10: view
genes like me logo Genes that share phenotypes with PCDHA10: view

Animal Model Products

miRNA for PCDHA10 Gene

miRTarBase miRNAs that target PCDHA10

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHA10 Gene

Localization for PCDHA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHA10 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHA10 Gene COMPARTMENTS Subcellular localization image for PCDHA10 gene
Compartment Confidence
plasma membrane 4
extracellular 3

Gene Ontology (GO) - Cellular Components for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 10380929
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHA10: view

Pathways & Interactions for PCDHA10 Gene

SuperPathways for PCDHA10 Gene

No Data Available

Interacting Proteins for PCDHA10 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304234%0d%0a9606.ENSP00000300574%0d%0a9606.ENSP00000362481%0d%0a9606.ENSP00000311113%0d%0a9606.ENSP00000344456%0d%0a9606.ENSP00000346155%0d%0a
Selected Interacting proteins: Q9Y5I2-PCDAA_HUMAN ENSP00000304234 for PCDHA10 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 10380929
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling IBA --
GO:0007399 nervous system development TAS 10380929
genes like me logo Genes that share ontologies with PCDHA10: view

No data available for Pathways by source and SIGNOR curated interactions for PCDHA10 Gene

Drugs & Compounds for PCDHA10 Gene

(1) Drugs for PCDHA10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHA10: view

Transcripts for PCDHA10 Gene

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHA10 Gene

No ASD Table

Relevant External Links for PCDHA10 Gene

GeneLoc Exon Structure for
PCDHA10
ECgene alternative splicing isoforms for
PCDHA10

Expression for PCDHA10 Gene

mRNA expression in normal human tissues for PCDHA10 Gene

mRNA differential expression in normal tissues according to GTEx for PCDHA10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.2) and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for PCDHA10 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDHA10 Gene



Protein tissue co-expression partners for PCDHA10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCDHA10 Gene:

PCDHA10
genes like me logo Genes that share expression patterns with PCDHA10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PCDHA10 Gene

Orthologs for PCDHA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHA10 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia PCDHA10 34
  • 88.19 (n)
mouse
(Mus musculus)
Mammalia Pcdha9 34 16
  • 83.14 (n)
rat
(Rattus norvegicus)
Mammalia Pcdha10 34
  • 83.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves PCDHA11 35
  • 53 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 57 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii pcdh1a6 35
  • 42 (a)
ManyToMany
pcdh2ab1 35
  • 42 (a)
ManyToMany
pcdh2ab11 35
  • 42 (a)
ManyToMany
pcdh2ab3 35
  • 42 (a)
ManyToMany
pcdh2ab8 35
  • 42 (a)
ManyToMany
AL929558.4 35
  • 41 (a)
ManyToMany
CT573264.5 35
  • 41 (a)
ManyToMany
pcdh1a3 35
  • 41 (a)
ManyToMany
pcdh2ab6 35
  • 41 (a)
ManyToMany
pcdh2ab7 35
  • 41 (a)
ManyToMany
CR847851.3 35
  • 40 (a)
ManyToMany
CR847851.4 35
  • 40 (a)
ManyToMany
CR847851.5 35 35
  • 40 (a)
ManyToMany
CR847851.6 35
  • 40 (a)
ManyToMany
CR847851.8 35
  • 40 (a)
ManyToMany
CT573264.4 35
  • 40 (a)
ManyToMany
pcdh2aa1 35 35
  • 40 (a)
ManyToMany
pcdh2aa15 35
  • 40 (a)
ManyToMany
pcdh2ab10 35
  • 40 (a)
ManyToMany
pcdh2ab2 35 35
  • 40 (a)
ManyToMany
pcdh2ab9 35
  • 40 (a)
ManyToMany
AL929558.3 35
  • 39 (a)
ManyToMany
CR847851.1 35
  • 39 (a)
ManyToMany
pcdh2aa3 35 35
  • 39 (a)
ManyToMany
pcdh2ab12 35 35
  • 39 (a)
ManyToMany
pcdh2ac 35
  • 38 (a)
ManyToMany
CABZ01112358.1 35
  • 36 (a)
ManyToMany
pcdhb 35
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
CSA.7308 35
  • 19 (a)
ManyToMany
Species where no ortholog for PCDHA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDHA10 Gene

ENSEMBL:
Gene Tree for PCDHA10 (if available)
TreeFam:
Gene Tree for PCDHA10 (if available)

Paralogs for PCDHA10 Gene

genes like me logo Genes that share paralogs with PCDHA10: view

Variants for PCDHA10 Gene

Sequence variations from dbSNP and Humsavar for PCDHA10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs193920994 Uncertain significance 140,857,214(+) TCTGA(C/T)GCCTC intron-variant, reference, missense
rs386352346 Uncertain significance 140,929,288(+) GATTC(A/G)GAATA intron-variant, reference, missense
rs10036183 -- 140,996,918(+) ATATT(A/T)AAAAA intron-variant
rs10040019 -- 140,921,372(+) TATTT(A/C)TACAT intron-variant
rs10053583 -- 140,896,113(+) gccaa(A/T)gtact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCDHA10 Gene

Variant ID Type Subtype PubMed ID
dgv10093n54 CNV loss 21841781
dgv10094n54 CNV loss 21841781
dgv10095n54 CNV loss 21841781
dgv10097n54 CNV loss 21841781
dgv10098n54 CNV loss 21841781
dgv10099n54 CNV loss 21841781
dgv10100n54 CNV loss 21841781
dgv10101n54 CNV loss 21841781
dgv10102n54 CNV loss 21841781
dgv10103n54 CNV loss 21841781
dgv10104n54 CNV loss 21841781
dgv10105n54 CNV loss 21841781
dgv1043e199 CNV deletion 23128226
dgv138e203 CNV loss 21179565
dgv1652e212 CNV loss 25503493
dgv1653e212 CNV loss 25503493
dgv3182n106 CNV deletion 24896259
dgv971n67 CNV loss 20364138
esv2421858 CNV deletion 20811451
esv2505753 CNV deletion 19546169
esv26168 CNV gain 19812545
esv2657537 CNV deletion 23128226
esv2730839 CNV deletion 23290073
esv2759382 CNV gain 17122850
esv29977 CNV gain 17803354
esv33939 CNV gain+loss 17666407
esv3566721 CNV deletion 23714750
esv3606958 CNV loss 21293372
esv3606959 CNV gain 21293372
esv3890744 CNV loss 25118596
nsv1031849 CNV loss 25217958
nsv10753 CNV gain 18304495
nsv10754 CNV gain 18304495
nsv1135376 CNV deletion 24896259
nsv1161301 OTHER complex 26073780
nsv442962 CNV loss 18776908
nsv514324 CNV loss 21397061
nsv599841 CNV loss 21841781
nsv599894 CNV loss 21841781
nsv599902 CNV loss 21841781
nsv599903 CNV loss 21841781
nsv599904 CNV loss 21841781
nsv819207 CNV gain 19587683
nsv820841 CNV deletion 20802225
nsv823262 CNV gain 20364138
nsv823263 CNV gain 20364138
nsv823264 CNV gain 20364138
nsv830508 CNV loss 17160897
nsv964954 CNV duplication 23825009
nsv964955 CNV duplication 23825009
nsv964956 CNV duplication 23825009
nsv968252 CNV duplication 23825009
nsv968992 CNV duplication 23825009

Variation tolerance for PCDHA10 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.16; 93.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDHA10 Gene

Human Gene Mutation Database (HGMD)
PCDHA10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCDHA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHA10 Gene

Disorders for PCDHA10 Gene

Relevant External Links for PCDHA10

Genetic Association Database (GAD)
PCDHA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDHA10

No disorders were found for PCDHA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHA10 Gene

Publications for PCDHA10 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64
  4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for PCDHA10 Gene

Sources for PCDHA10 Gene

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