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Aliases for PCDHA10 Gene

Aliases for PCDHA10 Gene

  • Protocadherin Alpha 10 2 3 5
  • Ortholog To Mouse CNR8 2 3
  • KIAA0345-Like 4 2 3
  • PCDH-Alpha-10 3 4
  • CNRS8 3 4
  • PCDH-ALPHA10 3
  • CNRN8 3
  • CRNR8 3
  • CNR8 3

External Ids for PCDHA10 Gene

Previous HGNC Symbols for PCDHA10 Gene

  • CNRS8

Previous GeneCards Identifiers for PCDHA10 Gene

  • GC05P140052
  • GC05P140757
  • GC05P140159
  • GC05P140202
  • GC05P140195
  • GC05P140166
  • GC05P140226
  • GC05P140231
  • GC05P140236
  • GC05P140244
  • GC05P140254
  • GC05P140263
  • GC05P140273
  • GC05P140282
  • GC05P140293
  • GC05P140303
  • GC05P140312
  • GC05P140323
  • GC05P140344
  • GC05P135380
  • GC05P140356
  • GC05P140371
  • GC05P140386
  • GC05P140400
  • GC05P140416
  • GC05P140429
  • GC05P140448
  • GC05P141274
  • GC05P141494

Summaries for PCDHA10 Gene

Entrez Gene Summary for PCDHA10 Gene

  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHA10 Gene

PCDHA10 (Protocadherin Alpha 10) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA5.

UniProtKB/Swiss-Prot for PCDHA10 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHA10 Gene

Genomics for PCDHA10 Gene

Regulatory Elements for PCDHA10 Gene

Enhancers for PCDHA10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCDHA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCDHA10 Gene

Chromosome:
5
Start:
140,855,883 bp from pter
End:
141,012,344 bp from pter
Size:
156,462 bases
Orientation:
Plus strand

Genomic View for PCDHA10 Gene

Genes around PCDHA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHA10 Gene

Proteins for PCDHA10 Gene

  • Protein details for PCDHA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5I2-PCDAA_HUMAN
    Recommended name:
    Protocadherin alpha-10
    Protein Accession:
    Q9Y5I2
    Secondary Accessions:
    • A1L493
    • O75280
    • Q9NRU2

    Protein attributes for PCDHA10 Gene

    Size:
    948 amino acids
    Molecular mass:
    102875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHA10 Gene

Proteomics data for PCDHA10 Gene at MOPED

Post-translational modifications for PCDHA10 Gene

  • Glycosylation at Asn 256, Asn 264, and Asn 547
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHA10 Gene

Antibody Products

No data available for DME Specific Peptides for PCDHA10 Gene

Domains & Families for PCDHA10 Gene

Gene Families for PCDHA10 Gene

Protein Domains for PCDHA10 Gene

Suggested Antigen Peptide Sequences for PCDHA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5I2

UniProtKB/Swiss-Prot:

PCDAA_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHA10: view

Function for PCDHA10 Gene

Molecular function for PCDHA10 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
genes like me logo Genes that share phenotypes with PCDHA10: view

Animal Model Products

CRISPR Products

miRNA for PCDHA10 Gene

miRTarBase miRNAs that target PCDHA10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHA10 Gene

Localization for PCDHA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHA10 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHA10 Gene COMPARTMENTS Subcellular localization image for PCDHA10 gene
Compartment Confidence
plasma membrane 4
extracellular 3

Gene Ontology (GO) - Cellular Components for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PCDHA10: view

Pathways & Interactions for PCDHA10 Gene

SuperPathways for PCDHA10 Gene

No Data Available

Interacting Proteins for PCDHA10 Gene

Gene Ontology (GO) - Biological Process for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS 10380929
genes like me logo Genes that share ontologies with PCDHA10: view

No data available for Pathways by source and SIGNOR curated interactions for PCDHA10 Gene

Drugs & Compounds for PCDHA10 Gene

(1) Drugs for PCDHA10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PCDHA10: view

Transcripts for PCDHA10 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHA10 Gene

No ASD Table

Relevant External Links for PCDHA10 Gene

GeneLoc Exon Structure for
PCDHA10
ECgene alternative splicing isoforms for
PCDHA10

Expression for PCDHA10 Gene

mRNA expression in normal human tissues for PCDHA10 Gene

mRNA differential expression in normal tissues according to GTEx for PCDHA10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.2) and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for PCDHA10 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDHA10 Gene



genes like me logo Genes that share expression patterns with PCDHA10: view

Protein tissue co-expression partners for PCDHA10 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PCDHA10 Gene

Orthologs for PCDHA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHA10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PCDHA10 35
  • 88.19 (n)
  • 86.34 (a)
mouse
(Mus musculus)
Mammalia Pcdha9 35
  • 83.14 (n)
  • 83.42 (a)
Pcdha9 16
chimpanzee
(Pan troglodytes)
Mammalia PCDHA10 35
  • 99.29 (n)
  • 98.99 (a)
PCDHA10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcdha10 35
  • 83.1 (n)
  • 83.63 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 47 (a)
ManyToMany
PCDHA11 36
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii AL929558.3 36
  • 39 (a)
ManyToMany
AL929558.4 36
  • 41 (a)
ManyToMany
CABZ01112358.1 36
  • 36 (a)
ManyToMany
CR847851.1 36
  • 39 (a)
ManyToMany
CR847851.3 36
  • 40 (a)
ManyToMany
CR847851.4 36
  • 40 (a)
ManyToMany
CR847851.5 36
  • 40 (a)
ManyToMany
CR847851.5 36
  • 39 (a)
ManyToMany
CR847851.6 36
  • 40 (a)
ManyToMany
CR847851.8 36
  • 40 (a)
ManyToMany
CT573264.4 36
  • 40 (a)
ManyToMany
CT573264.5 36
  • 41 (a)
ManyToMany
pcdh1a3 36
  • 41 (a)
ManyToMany
pcdh1a6 36
  • 42 (a)
ManyToMany
pcdh2aa1 36
  • 40 (a)
ManyToMany
pcdh2aa1 36
  • 40 (a)
ManyToMany
pcdh2aa15 36
  • 40 (a)
ManyToMany
pcdh2aa3 36
  • 39 (a)
ManyToMany
pcdh2aa3 36
  • 39 (a)
ManyToMany
pcdh2ab1 36
  • 42 (a)
ManyToMany
pcdh2ab10 36
  • 40 (a)
ManyToMany
pcdh2ab11 36
  • 42 (a)
ManyToMany
pcdh2ab12 36
  • 39 (a)
ManyToMany
pcdh2ab12 36
  • 42 (a)
ManyToMany
pcdh2ab2 36
  • 40 (a)
ManyToMany
pcdh2ab2 36
  • 40 (a)
ManyToMany
pcdh2ab3 36
  • 42 (a)
ManyToMany
pcdh2ab6 36
  • 41 (a)
ManyToMany
pcdh2ab7 36
  • 41 (a)
ManyToMany
pcdh2ab8 36
  • 42 (a)
ManyToMany
pcdh2ab9 36
  • 40 (a)
ManyToMany
pcdh2ac 36
  • 38 (a)
ManyToMany
pcdhb 36
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
CSA.7308 36
  • 19 (a)
ManyToMany
Species with no ortholog for PCDHA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDHA10 Gene

ENSEMBL:
Gene Tree for PCDHA10 (if available)
TreeFam:
Gene Tree for PCDHA10 (if available)

Paralogs for PCDHA10 Gene

genes like me logo Genes that share paralogs with PCDHA10: view

Variants for PCDHA10 Gene

Sequence variations from dbSNP and Humsavar for PCDHA10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_048535 -
VAR_048536 -
VAR_048537 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHA10 Gene

Variant ID Type Subtype PubMed ID
nsv830508 CNV Loss 17160897
dgv6343n71 CNV Loss 21882294
dgv1856e1 CNV Complex 17122850
dgv1857e1 CNV Complex 17122850
dgv6344n71 CNV Loss 21882294
nsv882956 CNV Loss 21882294
nsv882957 CNV Loss 21882294
esv33939 CNV Gain+Loss 17666407
dgv6347n71 CNV Loss 21882294
dgv1043e199 CNV Deletion 23128226
esv2730839 CNV Deletion 23290073
esv26168 CNV Gain 19812545
dgv971n67 CNV Loss 20364138
nsv820841 CNV Deletion 20802225
nsv10753 CNV Gain 18304495
nsv819207 CNV Gain 19587683
esv29977 CNV Gain 17803354
nsv514324 CNV Loss 21397061
esv2421858 CNV Deletion 20811451
nsv442962 CNV CNV 18776908
nsv823262 CNV Gain 20364138
nsv823263 CNV Gain 20364138
nsv823264 CNV Gain 20364138
nsv882970 CNV Loss 21882294
nsv10754 CNV Gain 18304495
esv2505753 CNV Deletion 19546169

Variation tolerance for PCDHA10 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.16; 93.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDHA10 Gene

Human Gene Mutation Database (HGMD)
PCDHA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHA10 Gene

Disorders for PCDHA10 Gene

Relevant External Links for PCDHA10

Genetic Association Database (GAD)
PCDHA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDHA10

No disorders were found for PCDHA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHA10 Gene

Publications for PCDHA10 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4 67
  2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  3. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3

Products for PCDHA10 Gene

Sources for PCDHA10 Gene

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