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Aliases for PCDHA10 Gene

Aliases for PCDHA10 Gene

  • Protocadherin Alpha 10 2 3
  • Ortholog To Mouse CNR8 2 3
  • KIAA0345-Like 4 2 3
  • PCDH-Alpha-10 3 4
  • CNRS8 3 4
  • Protocadherin Alpha-10 3
  • PCDH-ALPHA10 3
  • CNRN8 3
  • CRNR8 3
  • CNR8 3

External Ids for PCDHA10 Gene

Previous HGNC Symbols for PCDHA10 Gene

  • CNRS8

Previous GeneCards Identifiers for PCDHA10 Gene

  • GC05P140052
  • GC05P140757
  • GC05P140159
  • GC05P140202
  • GC05P140195
  • GC05P140166
  • GC05P140226
  • GC05P140231
  • GC05P140236
  • GC05P140244
  • GC05P140254
  • GC05P140263
  • GC05P140273
  • GC05P140282
  • GC05P140293
  • GC05P140303
  • GC05P140312
  • GC05P140323
  • GC05P140344
  • GC05P135380
  • GC05P140356
  • GC05P140371
  • GC05P140386
  • GC05P140400
  • GC05P140416
  • GC05P140429
  • GC05P140448

Summaries for PCDHA10 Gene

Entrez Gene Summary for PCDHA10 Gene

  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHA10 Gene

PCDHA10 (Protocadherin Alpha 10) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDHA10 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHA10 Gene

Genomics for PCDHA10 Gene

Regulatory Elements for PCDHA10 Gene

Genomic Location for PCDHA10 Gene

Start:
140,855,883 bp from pter
End:
141,012,344 bp from pter
Size:
156,462 bases
Orientation:
Plus strand

Genomic View for PCDHA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHA10 Gene

Proteins for PCDHA10 Gene

  • Protein details for PCDHA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5I2-PCDAA_HUMAN
    Recommended name:
    Protocadherin alpha-10
    Protein Accession:
    Q9Y5I2
    Secondary Accessions:
    • A1L493
    • O75280
    • Q9NRU2

    Protein attributes for PCDHA10 Gene

    Size:
    948 amino acids
    Molecular mass:
    102875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHA10 Gene

Proteomics data for PCDHA10 Gene at MOPED

Post-translational modifications for PCDHA10 Gene

  • Glycosylation at Asn256, Asn264, and Asn547
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHA10 Gene

No data available for DME Specific Peptides for PCDHA10 Gene

Domains for PCDHA10 Gene

Gene Families for PCDHA10 Gene

HGNC:
  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHA10 Gene

Suggested Antigen Peptide Sequences for PCDHA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5I2

UniProtKB/Swiss-Prot:

PCDAA_HUMAN :
  • Q9Y5I2
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHA10: view

Function for PCDHA10 Gene

Molecular function for PCDHA10 Gene

UniProtKB/Swiss-Prot Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHA10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHA10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PCDHA10 Gene

Localization for PCDHA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHA10 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHA10 Gene COMPARTMENTS Subcellular localization image for PCDHA10 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005887 integral component of plasma membrane TAS 10380929
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PCDHA10: view

Pathways for PCDHA10 Gene

SuperPathways for PCDHA10 Gene

No Data Available

Interacting Proteins for PCDHA10 Gene

Gene Ontology (GO) - Biological Process for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 10380929
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007399 nervous system development TAS 10380929
genes like me logo Genes that share ontologies with PCDHA10: view

No data available for Pathways by source for PCDHA10 Gene

Compounds for PCDHA10 Gene

(1) HMDB Compounds for PCDHA10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDHA10: view

Transcripts for PCDHA10 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHA10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PCDHA10
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHA10 Gene

No ASD Table

Relevant External Links for PCDHA10 Gene

GeneLoc Exon Structure for
PCDHA10
ECgene alternative splicing isoforms for
PCDHA10

Expression for PCDHA10 Gene

mRNA expression in normal human tissues for PCDHA10 Gene

mRNA differential expression in normal tissues according to GTEx for PCDHA10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.2) and Brain - Cerebellar Hemisphere (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDHA10 Gene

genes like me logo Genes that share expressions with PCDHA10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PCDHA10 Gene

Orthologs for PCDHA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHA10 35
  • 99.29 (n)
  • 98.99 (a)
PCDHA10 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCDHA10 35
  • 88.19 (n)
  • 86.34 (a)
mouse
(Mus musculus)
Mammalia Pcdha10 16
Pcdha9 35
  • 83.14 (n)
  • 83.42 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pcdha10 35
  • 83.1 (n)
  • 83.63 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 47 (a)
ManyToMany
PCDHA11 36
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii AL929558.3 36
  • 39 (a)
ManyToMany
AL929558.4 36
  • 41 (a)
ManyToMany
CABZ01112358.1 36
  • 36 (a)
ManyToMany
CR847851.1 36
  • 39 (a)
ManyToMany
CR847851.3 36
  • 40 (a)
ManyToMany
CR847851.4 36
  • 40 (a)
ManyToMany
CR847851.5 36
  • 40 (a)
ManyToMany
CR847851.5 36
  • 39 (a)
ManyToMany
CR847851.6 36
  • 40 (a)
ManyToMany
CR847851.8 36
  • 40 (a)
ManyToMany
CT573264.4 36
  • 40 (a)
ManyToMany
CT573264.5 36
  • 41 (a)
ManyToMany
pcdh1a3 36
  • 41 (a)
ManyToMany
pcdh1a6 36
  • 42 (a)
ManyToMany
pcdh2aa1 36
  • 40 (a)
ManyToMany
pcdh2aa1 36
  • 40 (a)
ManyToMany
pcdh2aa15 36
  • 40 (a)
ManyToMany
pcdh2aa3 36
  • 39 (a)
ManyToMany
pcdh2aa3 36
  • 39 (a)
ManyToMany
pcdh2ab1 36
  • 42 (a)
ManyToMany
pcdh2ab10 36
  • 40 (a)
ManyToMany
pcdh2ab11 36
  • 42 (a)
ManyToMany
pcdh2ab12 36
  • 39 (a)
ManyToMany
pcdh2ab12 36
  • 42 (a)
ManyToMany
pcdh2ab2 36
  • 40 (a)
ManyToMany
pcdh2ab2 36
  • 40 (a)
ManyToMany
pcdh2ab3 36
  • 42 (a)
ManyToMany
pcdh2ab6 36
  • 41 (a)
ManyToMany
pcdh2ab7 36
  • 41 (a)
ManyToMany
pcdh2ab8 36
  • 42 (a)
ManyToMany
pcdh2ab9 36
  • 40 (a)
ManyToMany
pcdh2ac 36
  • 38 (a)
ManyToMany
pcdhb 36
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
CSA.7308 36
  • 19 (a)
ManyToMany
Species with no ortholog for PCDHA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDHA10 Gene

ENSEMBL:
Gene Tree for PCDHA10 (if available)
TreeFam:
Gene Tree for PCDHA10 (if available)

Paralogs for PCDHA10 Gene

genes like me logo Genes that share paralogs with PCDHA10: view

Variants for PCDHA10 Gene

Sequence variations from dbSNP and Humsavar for PCDHA10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_048535 -
VAR_048536 -
VAR_048537 -

Structural Variations from Database of Genomic Variants (DGV) for PCDHA10 Gene

Variant ID Type Subtype PubMed ID
nsv830508 CNV Loss 17160897
dgv6343n71 CNV Loss 21882294
dgv1856e1 CNV Complex 17122850
dgv1857e1 CNV Complex 17122850
dgv6344n71 CNV Loss 21882294
nsv882956 CNV Loss 21882294
nsv882957 CNV Loss 21882294
esv33939 CNV Gain+Loss 17666407
dgv6347n71 CNV Loss 21882294
dgv1043e199 CNV Deletion 23128226
esv2730839 CNV Deletion 23290073
esv26168 CNV Gain 19812545
dgv971n67 CNV Loss 20364138
nsv820841 CNV Deletion 20802225
nsv10753 CNV Gain 18304495
nsv819207 CNV Gain 19587683
esv29977 CNV Gain 17803354
nsv514324 CNV Loss 21397061
esv2421858 CNV Deletion 20811451
nsv442962 CNV CNV 18776908
nsv823262 CNV Gain 20364138
nsv823263 CNV Gain 20364138
nsv823264 CNV Gain 20364138
nsv882970 CNV Loss 21882294
nsv10754 CNV Gain 18304495
esv2505753 CNV Deletion 19546169

Relevant External Links for PCDHA10 Gene

HapMap Linkage Disequilibrium report
PCDHA10
Human Gene Mutation Database (HGMD)
PCDHA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHA10 Gene

Disorders for PCDHA10 Gene

Relevant External Links for PCDHA10

Genetic Association Database (GAD)
PCDHA10
genes like me logo Genes that share disorders with PCDHA10: view

No data available for UniProtKB/Swiss-Prot for PCDHA10 Gene

Publications for PCDHA10 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3

Products for PCDHA10 Gene

Sources for PCDHA10 Gene

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