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PCDH8 Gene

protein-coding   GIFtS: 56
GCID: GC13M053418

Protocadherin 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protocadherin 81 2
ARCADLIN2
PAPC2
protocadherin-82
Arcadlin3

External Ids:    HGNC: 86601   Entrez Gene: 51002   Ensembl: ENSG000001360997   OMIM: 6035805   UniProtKB: O952063   

Export aliases for PCDH8 gene to outside databases

Previous GC identifers: GC13M051385 GC13M047413 GC13M052354 GC13M051216 GC13M052316 GC13M034132


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PCDH8 Gene:
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an
integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical
cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large
first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region.
Alternative splicing yields isoforms with unique cytoplasmic tails. (provided by RefSeq, Jul 2008)

GeneCards Summary for PCDH8 Gene:
PCDH8 (protocadherin 8) is a protein-coding gene. Diseases associated with PCDH8 include bacteriuria, and breast and colorectal cancer. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHAC1.

UniProtKB/Swiss-Prot: PCDH8_HUMAN, O95206
Function: Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic
reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through
TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe
through its action on CDH2 endocytosis (By similarity)

Gene Wiki entry for PCDH8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the PCDH8 gene promoter:
         AP-1   ATF-2   NRSF form 1   Sox9   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCDH8 promoter sequence
   Search Chromatin IP Primers for PCDH8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCDH8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q21.1   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q21.1

PCDH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCDH8 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M053418:  view genomic region     (about GC identifiers)

Start:
53,418,109 bp from pter      End:
53,422,775 bp from pter
Size:
4,667 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PCDH8_HUMAN, O95206 (See protein sequence)
Recommended Name: Protocadherin-8 precursor  
Size: 1070 amino acids; 113019 Da
Subunit: The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK
via TAOK2 and trigger endocytosis (By similarity). Interacts with CDH2; this interaction may lead to CDH2
cointernalization (By similarity). Interacts with CDH11 (By similarity). Interacts with TAOK2 (By similarity)
Secondary accessions: B4DMV7 Q5TAN1 Q5TAN2 Q8IYE9 Q96SF1
Alternative splicing: 3 isoforms:  O95206-1   O95206-2   O95206-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PCDH8: NX_O95206

Explore proteomics data for PCDH8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn70, Asn464, Asn616
  • Modification sites at PhosphoSitePlus

  • See PCDH8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002581.2  NP_116567.1  

    ENSEMBL proteins: 
     ENSP00000367177   ENSP00000341350  

    PCDH8 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PCDH8

    PCDH8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PCDH8
    R&D Systems Antibodies for PCDH8 (Protocadherin-8)
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    Cloud-Clone Corp. ELISAs for PCDH8
    Cloud-Clone Corp. CLIAs for PCDH8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PCDHN: Cadherins / Protocadherins : Non-clustered

    4 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR013164 Cadherin_N
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry O95206

    ProtoNet protein and cluster: O95206

    UniProtKB/Swiss-Prot: PCDH8_HUMAN, O95206
    Similarity: Contains 6 cadherin domains


    PCDH8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCDH8_HUMAN, O95206
    Function: Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic
    reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through
    TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe
    through its action on CDH2 endocytosis (By similarity)

         Genatlas biochemistry entry for PCDH8:
    BH protocadherin 8,cadherin-related neuronal receptor,predominantly expressed in brain,localizing to synaptic
    junctions and putatively involved in specific neuronal connections and signal transduction,cadherin superfamily
    of calcium dependent cell-cell adhesion glycoproteins

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    PCDH8 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pcdh8):
     normal 

    PCDH8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pcdh8tm1Emdr for PCDH8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCDH8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PCDH8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCDH8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PCDH8

    miRNA
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    miRTarBase miRNAs that target PCDH8:
    hsa-mir-200a-3p (MIRT000773)

    Block miRNA regulation of human, mouse, rat PCDH8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCDH8 (see all 31):
    hsa-miR-323-3p hsa-miR-448 hsa-miR-300 hsa-miR-429 hsa-miR-1271 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidPCDH8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PCDH8
    Predesigned siRNA for gene silencing in human, mouse, rat PCDH8

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for PCDH8 (see all 13)
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    GenScript: all cDNA clones in your preferred vector (see all 2): PCDH8 (NM_032949)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDH8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PCDH8_HUMAN, O95206: Cell membrane; Single-pass type I membrane protein (By similarity). Cell projection,
    dendrite (By similarity). Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic
    cell membrane. Note=Also expressed in neuronal cell bodies (By similarity). Localized to excitatory, but not with
    inhibitory, synapses (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9787079
    GO:0005887integral component of plasma membrane TAS9787079
    GO:0016020membrane ----
    GO:0030054cell junction IEA--
    GO:0030425dendrite IEA--

    PCDH8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including PCDH8: 
              Notch Signaling Targets in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PCDH8

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PCDH8 (O952062, 3 ENSP000003671774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2972, 3, ENSP000003592064MINT-8249729 I2D: score=2 STRING: ENSP00000359206
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2861586 I2D: score=3 STRING: ENSP00000357292
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001756somitogenesis IEA--
    GO:0007156homophilic cell adhesion IEA--
    GO:0007267cell-cell signaling TAS9787079
    GO:0007268synaptic transmission IEA--
    GO:0016331morphogenesis of embryonic epithelium IEA--

    PCDH8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCDH8

    1 HMDB Compound for PCDH8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PCDH8 gene (2 alternative transcripts): 
    NM_002590.3  NM_032949.2  

    Unigene Cluster for PCDH8:

    Protocadherin 8
    Hs.19492  [show with all ESTs]
    Unigene Representative Sequence: NM_002590
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377942(uc001vhi.3 uc001vhj.3) ENST00000338862
    miRNA
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    Block miRNA regulation of human, mouse, rat PCDH8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCDH8 (see all 31):
    hsa-miR-323-3p hsa-miR-448 hsa-miR-300 hsa-miR-429 hsa-miR-1271 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidPCDH8 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector (see all 2): PCDH8 (NM_032949)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDH8
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PCDH8
      QuantiFast Probe-based Assays in human, mouse, rat PCDH8

    Additional mRNA sequence: 

    AF061573.2 AK293747.1 AY013873.1 BC036025.1 

    2 DOTS entries:

    DT.305773  DT.95159950 

    16 AceView cDNA sequences:

    NM_032949 AY013873 BC036025 BI755978 NM_002590 AF061573 CA397561 BI669686 
    BI457955 BI546620 R05468 BI553836 BI550551 H29216 AA780138 AW135620 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PCDH8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:                    -                           
    SP2:              -     -                           
    SP3:                                                


    ECgene alternative splicing isoforms for PCDH8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PCDH8 expression in normal human tissues (normalized intensities)      PCDH8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGAAGA
    PCDH8 Expression
    About this image


    PCDH8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Epiphyseal End
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
    PCDH8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCDH8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.19492
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PCDH8: 
              Notch Signaling Targets in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDH8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PCDH8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcdh81 , 5 protocadherin 81, 5 87.86(n)1
    94.38(a)1
      14 (42.76 cM)5
    185301  NM_021543.41  NP_067518.21 
     797667725 
    chicken
    (Gallus gallus)
    Aves PCDH81 protocadherin 8 71.4(n)
    68.08(a)
      428065  NM_001098609.1  NP_001092079.1 
    lizard
    (Anolis carolinensis)
    Reptilia PCDH86
    protocadherin 8
    45(a)
    1 ↔ 1
    3(71400062-71401904)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525532 similar to protocadherin 18 70.56(n)    BC047955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pcdh82 protocadherin 8 74.27(n)   30456  AF042191.1 


    ENSEMBL Gene Tree for PCDH8 (if available)
    TreeFam Gene Tree for PCDH8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PCDH8 gene
    PCDHAC12  PCDHA22  PCDH72  PCDH202  PCDH12  PCDHA122  PCDH11Y2  PCDHA52  
    PCDH122  PCDHA112  PCDHA12  PCDH182  PCDH92  PCDH192  PCDH172  PCDHGC32  
    PCDHA72  PCDH11X2  PCDHA62  PCDHA82  PCDH102  PCDHA102  PCDHA132  PCDHA92  
    PCDHA32  PCDHA42  
    Selected SIMAP similar genes for PCDH8 using alignment to 1 protein entry:     PCDH8_HUMAN(see all similar genes):
    PCDHGA3    PCDH10    PCDH12    PCDHB17    PCDHB7    PCDHGA12
    PCDHAC2    PCDHA10    PCDHA8    PCDHAC1    PCDHB16    PCDHB3
    PCDH18    PCDHA3    PCDHGC4    PCDH17    PCDHA5    PCDHA7

    PCDH8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PCDH8
    PGOHUM00000248601


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PCDH8 (see all 180)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361084
    A breast cancer sample4--see VAR_0361082 K N mis40--------
    rs1999062931,2
    Cuntested153418722(+) TTCTTC/TGGGGA 4 P syn11Minor allele frequency- T:0.00EU 1321
    rs1856704971,2
    --53417629(+) ACAGAA/CTGTAG 2 -- ds50010--------
    rs1916173941,2
    --53417631(+) AGAATA/GTAGTG 2 -- ds50010--------
    rs1473053751,2
    --53417752(+) GAGGAA/GGAGGT 2 -- ds50010--------
    rs1170526151,2
    F--53417947(+) TAATAC/ATTGGG 2 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1816126051,2
    --53418158(+) GACACA/GGTTTA 2 -- ut310--------
    rs1872995351,2
    --53418379(+) AAAATA/GTAACA 2 -- ut310--------
    rs2005582901,2
    --53418656(+) TTCTCA/GGAGTG 2 -- ut310--------
    rs2000128301,2
    --53418682(+) AAGACA/GTGCAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PCDH8 (53418109 - 53422775 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PCDH8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv455889CNV Loss19166990
    esv29405CNV Loss19812545
    nsv900089CNV Loss21882294
    nsv523092CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603580    OMIM disorders: --

    11 diseases for PCDH8:    About MalaCards
    bacteriuria    breast and colorectal cancer    cystitis    pyelonephritis
    schizophrenia    nasopharyngitis    retinoblastoma    ataxia
    neuronitis    colorectal cancer    breast cancer


    PCDH8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PCDH8

    Export disorders for PCDH8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PCDH8 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with PCDH8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14. (PubMed id 9787079)1, 2, 3, 9 Strehl S.... Lalande M. (Genomics 1998)
    2. Screening the human protocadherin 8 (PCDH8) gene in schizophrenia. (PubMed id 12884975)1, 2, 9 Bray N.J.... Owen M.J. (Genes Brain Behav. 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PubMed id 11230163)1, 2 Wu Q.... Maniatis T. (Genome Res. 2001)
    5. High-resolution analysis of DNA replication domain organization across an R/G-band boundary. (PubMed id 9315676)1, 3 Strehl S....Lalande M. (Mol. Cell. Biol. 1997)
    6. PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer. (PubMed id 18408767)1, 9 Yu J.S....Parsons R. (Oncogene 2008)
    7. Arcadlin is a neural activity-regulated cadherin involved in long term potentiation. (PubMed id 10383464)1, 9 Yamagata K....Worley P.F. (J. Biol. Chem. 1999)
    8. Clinical significance of protocadherin-8 (PCDH8) promoter methylation in bladder cancer. (PubMed id 23569129)1 Lin Y.L....Li Z.G. (J. Int. Med. Res. 2013)
    9. Fine mapping of whole RB1 gene deletions in retinoblastoma patients confirms PCDH8 as a candidate gene for psychomotor delay. (PubMed id 22909775)1 CastAcra L....Houdayer C. (Eur. J. Hum. Genet. 2013)
    10. A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. (PubMed id 22658931)1 Pajewski N.M....Kaslow R.A. (Vaccine 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5100 HGNC: 8660 AceView: PCDH8 Ensembl:ENSG00000136099 euGenes: HUgn5100
    ECgene: PCDH8 H-InvDB: PCDH8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PCDH8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PCDH8 gene:
    Search GeneIP for patents involving PCDH8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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