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Aliases for PCDH8 Gene

Aliases for PCDH8 Gene

  • Protocadherin 8 2 3
  • ARCADLIN 3 4
  • Protocadherin-8 3
  • PAPC 3

External Ids for PCDH8 Gene

Summaries for PCDH8 Gene

Entrez Gene Summary for PCDH8 Gene

  • This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDH8 Gene

PCDH8 (Protocadherin 8) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDH8 Gene

  • Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity).

Gene Wiki entry for PCDH8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDH8 Gene

Genomics for PCDH8 Gene

Genomic Location for PCDH8 Gene

Start:
52,842,889 bp from pter
End:
52,848,641 bp from pter
Size:
5,753 bases
Orientation:
Minus strand

Genomic View for PCDH8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDH8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDH8 Gene

Regulatory Elements for PCDH8 Gene

Proteins for PCDH8 Gene

  • Protein details for PCDH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95206-PCDH8_HUMAN
    Recommended name:
    Protocadherin-8
    Protein Accession:
    O95206
    Secondary Accessions:
    • B4DMV7
    • Q5TAN1
    • Q5TAN2
    • Q8IYE9
    • Q96SF1

    Protein attributes for PCDH8 Gene

    Size:
    1070 amino acids
    Molecular mass:
    113019 Da
    Quaternary structure:
    • The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis. Interacts with CDH2; this interaction may lead to CDH2 cointernalization. Interacts with CDH11. Interacts with TAOK2.
    SequenceCaution:
    • Sequence=BAG60019.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCDH8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDH8 Gene

Proteomics data for PCDH8 Gene at MOPED

Post-translational modifications for PCDH8 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn70, Asn464, and Asn616

Other Protein References for PCDH8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDH8 Gene

Domains for PCDH8 Gene

Gene Families for PCDH8 Gene

HGNC:
  • PCDHN :Cadherins / Protocadherins : Non-clustered

Protein Domains for PCDH8 Gene

UniProtKB/Swiss-Prot:

PCDH8_HUMAN
Domain:
  • Contains 6 cadherin domains.:
    • O95206
genes like me logo Genes that share domains with PCDH8: view

Function for PCDH8 Gene

Molecular function for PCDH8 Gene

GENATLAS Biochemistry: BH protocadherin 8,cadherin-related neuronal receptor,predominantly expressed in brain,localizing to synaptic junctions and putatively involved in specific neuronal connections and signal transduction,cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
UniProtKB/Swiss-Prot Function: Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity).

Gene Ontology (GO) - Molecular Function for PCDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDH8: view

Phenotypes for PCDH8 Gene

MGI mutant phenotypes for PCDH8:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PCDH8: view

Animal Models for PCDH8 Gene

MGI Knock Outs for PCDH8:

miRNA for PCDH8 Gene

miRTarBase miRNAs that target PCDH8

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PCDH8 Gene

Localization for PCDH8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDH8 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDH8 Gene COMPARTMENTS Subcellular localization image for PCDH8 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PCDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9787079
GO:0005887 integral component of plasma membrane TAS 9787079
GO:0016020 membrane --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with PCDH8: view

Pathways for PCDH8 Gene

SuperPathways for PCDH8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling TAS 9787079
GO:0007268 synaptic transmission IEA --
GO:0016331 morphogenesis of embryonic epithelium IEA --
genes like me logo Genes that share ontologies with PCDH8: view

No data available for Pathways by source for PCDH8 Gene

Compounds for PCDH8 Gene

(1) HMDB Compounds for PCDH8 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDH8: view

Transcripts for PCDH8 Gene

mRNA/cDNA for PCDH8 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCDH8 Gene

Protocadherin 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCDH8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for PCDH8 Gene

GeneLoc Exon Structure for
PCDH8
ECgene alternative splicing isoforms for
PCDH8

Expression for PCDH8 Gene

mRNA expression in normal human tissues for PCDH8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCDH8 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.7), Brain - Anterior cingulate cortex (BA24) (7.0), Brain - Frontal Cortex (BA9) (6.7), Brain - Hippocampus (5.6), Brain - Caudate (basal ganglia) (5.2), and Brain - Cortex (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDH8 Gene

SOURCE GeneReport for Unigene cluster for PCDH8 Gene Hs.19492

genes like me logo Genes that share expressions with PCDH8: view

Orthologs for PCDH8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDH8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDH8 36
  • 99.52 (n)
  • 99.49 (a)
PCDH8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PCDH8 36
  • 90.14 (n)
  • 94.29 (a)
PCDH8 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCDH8 36
  • 91.71 (n)
  • 95.7 (a)
PCDH8 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcdh8 36
  • 87.86 (n)
  • 94.38 (a)
Pcdh8 16
Pcdh8 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCDH8 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcdh8 36
  • 87.31 (n)
  • 94.75 (a)
chicken
(Gallus gallus)
Aves PCDH8 36
  • 71.4 (n)
  • 68.08 (a)
PCDH8 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCDH8 37
  • 45 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52553 36
tropical clawed frog
(Silurana tropicalis)
Amphibia pcdh8 36
  • 64.69 (n)
  • 62.82 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100002026 36
  • 52.93 (n)
  • 43.17 (a)
pcdh8 36
pcdh8 37
  • 38 (a)
OneToOne
Species with no ortholog for PCDH8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDH8 Gene

ENSEMBL:
Gene Tree for PCDH8 (if available)
TreeFam:
Gene Tree for PCDH8 (if available)

Paralogs for PCDH8 Gene

Pseudogenes.org Pseudogenes for PCDH8 Gene

genes like me logo Genes that share paralogs with PCDH8: view

Variants for PCDH8 Gene

Sequence variations from dbSNP and Humsavar for PCDH8 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs693209 -- 52,848,970(-) AAACC(C/T)CAGCG upstream-variant-2KB
rs2068599 -- 52,849,920(+) GGGCG(A/C/G)TGCGC upstream-variant-2KB
rs2068600 -- 52,850,016(+) ACTGA(A/T)GGGCT upstream-variant-2KB
rs2236363 -- 52,845,004(-) TGCTG(A/C)AGATG intron-variant
rs3742299 -- 52,844,843(+) GAGGC(A/G)ATGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PCDH8 Gene

Variant ID Type Subtype PubMed ID
nsv900089 CNV Loss 21882294
nsv523092 CNV Loss 19592680
nsv455889 CNV Loss 19166990
esv29405 CNV Loss 19812545

Relevant External Links for PCDH8 Gene

HapMap Linkage Disequilibrium report
PCDH8

Disorders for PCDH8 Gene

Relevant External Links for PCDH8

Genetic Association Database (GAD)
PCDH8
genes like me logo Genes that share disorders with PCDH8: view

No data available for UniProtKB/Swiss-Prot for PCDH8 Gene

Publications for PCDH8 Gene

  1. Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14. (PMID: 9787079) Strehl S. … Lalande M. (Genomics 1998) 2 3 4 23
  2. Screening the human protocadherin 8 (PCDH8) gene in schizophrenia. (PMID: 12884975) Bray N.J. … Owen M.J. (Genes Brain Behav. 2002) 3 4 23
  3. PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer. (PMID: 18408767) Yu J.S. … Parsons R. (Oncogene 2008) 3 23
  4. Arcadlin is a neural activity-regulated cadherin involved in long term potentiation. (PMID: 10383464) Yamagata K. … Worley P.F. (J. Biol. Chem. 1999) 3 23
  5. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3 4

Products for PCDH8 Gene

Sources for PCDH8 Gene

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