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Aliases for PCDH8 Gene

Aliases for PCDH8 Gene

  • Protocadherin 8 2 3
  • ARCADLIN 3 4
  • PAPC 3

External Ids for PCDH8 Gene

Previous GeneCards Identifiers for PCDH8 Gene

  • GC13M051385
  • GC13M047413
  • GC13M052354
  • GC13M051216
  • GC13M052316
  • GC13M053418
  • GC13M034132

Summaries for PCDH8 Gene

Entrez Gene Summary for PCDH8 Gene

  • This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDH8 Gene

PCDH8 (Protocadherin 8) is a Protein Coding gene. Diseases associated with PCDH8 include bladder disease. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDH8 Gene

  • Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity).

Gene Wiki entry for PCDH8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDH8 Gene

Genomics for PCDH8 Gene

Regulatory Elements for PCDH8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCDH8 Gene

Chromosome:
13
Start:
52,842,889 bp from pter
End:
52,848,641 bp from pter
Size:
5,753 bases
Orientation:
Minus strand

Genomic View for PCDH8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDH8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDH8 Gene

Proteins for PCDH8 Gene

  • Protein details for PCDH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95206-PCDH8_HUMAN
    Recommended name:
    Protocadherin-8
    Protein Accession:
    O95206
    Secondary Accessions:
    • B4DMV7
    • Q5TAN1
    • Q5TAN2
    • Q8IYE9
    • Q96SF1

    Protein attributes for PCDH8 Gene

    Size:
    1070 amino acids
    Molecular mass:
    113019 Da
    Quaternary structure:
    • The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis. Interacts with CDH2; this interaction may lead to CDH2 cointernalization. Interacts with CDH11. Interacts with TAOK2.
    SequenceCaution:
    • Sequence=BAG60019.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCDH8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDH8 Gene

Proteomics data for PCDH8 Gene at MOPED

Post-translational modifications for PCDH8 Gene

  • Glycosylation at Asn 70, Asn 464, and Asn 616
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDH8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PCDH8 (Protocadherin-8)

No data available for DME Specific Peptides for PCDH8 Gene

Domains & Families for PCDH8 Gene

Gene Families for PCDH8 Gene

Protein Domains for PCDH8 Gene

Suggested Antigen Peptide Sequences for PCDH8 Gene

Graphical View of Domain Structure for InterPro Entry

O95206

UniProtKB/Swiss-Prot:

PCDH8_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDH8: view

Function for PCDH8 Gene

Molecular function for PCDH8 Gene

GENATLAS Biochemistry:
BH protocadherin 8,cadherin-related neuronal receptor,predominantly expressed in brain,localizing to synaptic junctions and putatively involved in specific neuronal connections and signal transduction,cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
UniProtKB/Swiss-Prot Function:
Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity).

Gene Ontology (GO) - Molecular Function for PCDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDH8: view

Phenotypes for PCDH8 Gene

MGI mutant phenotypes for PCDH8:
inferred from 1 alleles
GenomeRNAi human phenotypes for PCDH8:
genes like me logo Genes that share phenotypes with PCDH8: view

Animal Models for PCDH8 Gene

MGI Knock Outs for PCDH8:

Animal Model Products

miRNA for PCDH8 Gene

miRTarBase miRNAs that target PCDH8

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PCDH8 Gene

Localization for PCDH8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDH8 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDH8 Gene COMPARTMENTS Subcellular localization image for PCDH8 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for PCDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9787079
GO:0005887 integral component of plasma membrane TAS 9787079
GO:0016020 membrane --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with PCDH8: view

Pathways & Interactions for PCDH8 Gene

SuperPathways for PCDH8 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PCDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0007155 cell adhesion --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling TAS 9787079
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with PCDH8: view

No data available for Pathways by source and SIGNOR curated interactions for PCDH8 Gene

Drugs & Compounds for PCDH8 Gene

(1) Drugs for PCDH8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with PCDH8: view

Transcripts for PCDH8 Gene

mRNA/cDNA for PCDH8 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCDH8 Gene

Protocadherin 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDH8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for PCDH8 Gene

GeneLoc Exon Structure for
PCDH8
ECgene alternative splicing isoforms for
PCDH8

Expression for PCDH8 Gene

mRNA expression in normal human tissues for PCDH8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCDH8 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.7), Brain - Anterior cingulate cortex (BA24) (x7.0), Brain - Frontal Cortex (BA9) (x6.7), Brain - Hippocampus (x5.6), Brain - Caudate (basal ganglia) (x5.2), and Brain - Cortex (x5.2).

Protein differential expression in normal tissues from HIPED for PCDH8 Gene

This gene is overexpressed in Adipocyte (56.3) and Heart (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDH8 Gene



SOURCE GeneReport for Unigene cluster for PCDH8 Gene Hs.19492

genes like me logo Genes that share expression patterns with PCDH8: view

Protein tissue co-expression partners for PCDH8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PCDH8 Gene

Orthologs for PCDH8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDH8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCDH8 35
  • 90.14 (n)
  • 94.29 (a)
PCDH8 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCDH8 35
  • 91.71 (n)
  • 95.7 (a)
PCDH8 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcdh8 35
  • 87.86 (n)
  • 94.38 (a)
Pcdh8 16
Pcdh8 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCDH8 35
  • 99.52 (n)
  • 99.49 (a)
PCDH8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcdh8 35
  • 87.31 (n)
  • 94.75 (a)
oppossum
(Monodelphis domestica)
Mammalia PCDH8 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCDH8 35
  • 71.4 (n)
  • 68.08 (a)
PCDH8 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCDH8 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcdh8 35
  • 64.69 (n)
  • 62.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52553 35
zebrafish
(Danio rerio)
Actinopterygii LOC100002026 35
  • 52.93 (n)
  • 43.17 (a)
pcdh8 35
pcdh8 36
  • 38 (a)
OneToOne
Species with no ortholog for PCDH8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDH8 Gene

ENSEMBL:
Gene Tree for PCDH8 (if available)
TreeFam:
Gene Tree for PCDH8 (if available)

Paralogs for PCDH8 Gene

Pseudogenes.org Pseudogenes for PCDH8 Gene

genes like me logo Genes that share paralogs with PCDH8: view

Variants for PCDH8 Gene

Sequence variations from dbSNP and Humsavar for PCDH8 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_017171 -
VAR_017172 -
VAR_017173 -
VAR_036108 A breast cancer sample
VAR_059191 -

Structural Variations from Database of Genomic Variants (DGV) for PCDH8 Gene

Variant ID Type Subtype PubMed ID
nsv900089 CNV Loss 21882294
nsv523092 CNV Loss 19592680
nsv455889 CNV Loss 19166990
esv29405 CNV Loss 19812545

Variation tolerance for PCDH8 Gene

Residual Variation Intolerance Score: 60.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.29; 85.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDH8 Gene

HapMap Linkage Disequilibrium report
PCDH8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDH8 Gene

Disorders for PCDH8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PCDH8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bladder disease
  • urinary bladder disease
- elite association
Search PCDH8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PCDH8

Genetic Association Database (GAD)
PCDH8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCDH8
genes like me logo Genes that share disorders with PCDH8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCDH8 Gene

Publications for PCDH8 Gene

  1. Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14. (PMID: 9787079) Strehl S. … Lalande M. (Genomics 1998) 2 23 67
  2. Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats. (PMID: 20105316) Christensen K.V. … Egebjerg J. (BMC Neurosci 2010) 23 67
  3. Transducing neuronal activity into dendritic spine morphology: new roles for p38 MAP kinase and N-cadherin. (PMID: 19218233) Sugiura H. … Yamagata K. (Neuroscientist 2009) 23 67
  4. A protocadherin-cadherin-FLRT3 complex controls cell adhesion and morphogenesis. (PMID: 20027292) Chen X. … Gumbiner B.M. (PLoS ONE 2009) 23 67
  5. PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer. (PMID: 18408767) Yu J.S. … Parsons R. (Oncogene 2008) 23 67

Products for PCDH8 Gene

Sources for PCDH8 Gene

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