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PCDH18 Gene

protein-coding   GIFtS: 57
GCID: GC04M138440

Protocadherin 18

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protocadherin 181 2
KIAA15623 5
PCDH68L2
Protocadherin 68-Like Protein2
protocadherin-182

External Ids:    HGNC: 142681   Entrez Gene: 545102   Ensembl: ENSG000001891847   OMIM: 6082875   UniProtKB: Q9HCL03   

Export aliases for PCDH18 gene to outside databases

Previous GC identifers: GC04U990099 GC04M9M0022 GC04M138798 GC04M138660 GC04M134169


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PCDH18 Gene:
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a
protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing
from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related
neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections
in the brain. (provided by RefSeq, Jul 2008)

GeneCards Summary for PCDH18 Gene:
PCDH18 (protocadherin 18) is a protein-coding gene. Diseases associated with PCDH18 include systemic lupus erythematosus, and parkinson's disease. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHAC1.

UniProtKB/Swiss-Prot: PCD18_HUMAN, Q9HCL0
Function: Potential calcium-dependent cell-adhesion protein

Gene Wiki entry for PCDH18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PCDH18 gene promoter:
         E2F-4   E2F-3a   E2F-5   CUTL1   E2F-2   AREB6   POU2F1   E2F   E2F-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCDH18 promoter sequence
   Search Chromatin IP Primers for PCDH18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCDH18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q28.3   HGNC cytogenetic band: 4q28.3

PCDH18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCDH18 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M138440:  view genomic region     (about GC identifiers)

Start:
138,440,072 bp from pter      End:
138,453,648 bp from pter
Size:
13,577 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PCD18_HUMAN, Q9HCL0 (See protein sequence)
Recommended Name: Protocadherin-18 precursor  
Size: 1135 amino acids; 126149 Da
Subunit: Interacts with DAB1 (By similarity)
Sequence caution: Sequence=BAB13388.1; Type=Erroneous initiation;
Secondary accessions: A8K7K3 B7ZKT1 Q52LS2
Alternative splicing: 2 isoforms:  Q9HCL0-1   Q9HCL0-2   

Explore the universe of human proteins at neXtProt for PCDH18: NX_Q9HCL0

Explore proteomics data for PCDH18 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn103, Asn269, Asn420, Asn559, Asn583, Asn641
  • Modification sites at PhosphoSitePlus

  • See PCDH18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061908.1  
    ENSEMBL proteins: 
     ENSP00000390688   ENSP00000355082   ENSP00000425903   ENSP00000425647   ENSP00000424269  

    PCDH18 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PCDH18

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PCDHN: Cadherins / Protocadherins : Non-clustered

    4 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR013164 Cadherin_N
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9HCL0

    ProtoNet protein and cluster: Q9HCL0

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: PCD18_HUMAN, Q9HCL0
    Similarity: Contains 6 cadherin domains


    PCDH18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCD18_HUMAN, Q9HCL0
    Function: Potential calcium-dependent cell-adhesion protein

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    PCDH18 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PCDH18:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         1 MGI phenotypic allele for Pcdh18 (no phenotypes)

    PCDH18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCDH18
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCDH18
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    miRNA
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    Block miRNA regulation of human, mouse, rat PCDH18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCDH18 (see all 38):
    hsa-miR-100* hsa-miR-4272 hsa-miR-16-1* hsa-miR-488 hsa-miR-889 hsa-miR-34b hsa-miR-642b hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmidPCDH18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PCDH18

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    Sino Biological Human cDNA Clone for PCDH18
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDH18

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDH18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PCD18_HUMAN, Q9HCL0: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    PCDH18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCDH18
    Interactions:

        Search GeneGlobe Interaction Network for PCDH18

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for PCDH18 (Q9HCL03 ENSP000003550824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP1P516933, ENSP000002218914I2D: score=1 STRING: ENSP00000221891
    ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
    DAB1O755533I2D: score=2 
    --ENSP000003602774STRING: ENSP00000360277
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--
    GO:0007420brain development ISS--

    PCDH18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCDH18 (PCD18)

    1 HMDB Compound for PCDH18    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PCDH18 gene: 
    NM_019035.3  

    Unigene Cluster for PCDH18:

    Protocadherin 18
    Hs.591691  [show with all ESTs]
    Unigene Representative Sequence: NM_019035
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412923 ENST00000344876(uc003ihe.4 uc003ihf.4 uc011cgz.2 uc003ihg.4 uc011cha.2)
    ENST00000507846 ENST00000511115 ENST00000510305
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PCDH18 (see all 38):
    hsa-miR-100* hsa-miR-4272 hsa-miR-16-1* hsa-miR-488 hsa-miR-889 hsa-miR-34b hsa-miR-642b hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmidPCDH18 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PCDH18 (NM_019035)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCDH18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDH18
    Primer
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    OriGene qPCR primer pairs and template standards for PCDH18
    OriGene qSTAR qPCR primer pairs in human, mouse for PCDH18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCDH18
      QuantiTect SYBR Green Assays in human, mouse, rat PCDH18
      QuantiFast Probe-based Assays in human, mouse, rat PCDH18

    Additional mRNA sequence: 

    AB046782.1 AK292018.1 AK298607.1 AL137471.1 BC022227.2 BC071581.1 BC093815.1 BC143361.1 
    BX647786.1 

    4 DOTS entries:

    DT.444047  DT.97765645  DT.100784808  DT.95158627 

    Selected AceView cDNA sequences (see all 127):

    AA292131 AL699731 BC071581 BU147090 H88271 AA375083 CA412450 BX642427 
    BM564364 NM_019035 AA961517 W76069 BM474840 CB215948 BM562546 H88539 
    CD657084 BM562516 BM564386 BU616108 W72511 AA604083 AB046782 BQ948400 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PCDH18 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                    -     -     -           -                                       
    SP2:                    -     -     -     -     -                                       
    SP3:                                            -                                       
    SP4:                                                                                    
    SP5:                                            -                                       


    ECgene alternative splicing isoforms for PCDH18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PCDH18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTCATATT
    PCDH18 Expression
    About this image


    PCDH18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Ventricular Zone
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Limb (Muscoskeletal System)
             Limb Bud
    PCDH18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCDH18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591691

    UniProtKB/Swiss-Prot: PCD18_HUMAN, Q9HCL0
    Tissue specificity: Expressed in all tissues, with highest expression in lung and ovary

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PCDH18 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcdh181 , 5 protocadherin 181, 5 86.92(n)1
    92.68(a)1
      3 (21.67 cM)5
    731731  NM_130448.31  NP_569715.31 
     497432965 
    chicken
    (Gallus gallus)
    Aves PCDH181 protocadherin 18 78.96(n)
    86.3(a)
      422438  XM_004940935.1  XP_004940992.1 
    lizard
    (Anolis carolinensis)
    Reptilia PCDH186
    protocadherin 18
    83(a)
    1 ↔ 1
    5(121202585-121211577)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX712004.12   -- 79.05(n)    BX712004.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.194412 Transcribed sequence with moderate similarity to protein more 74.5(n)    AL730880.1 


    ENSEMBL Gene Tree for PCDH18 (if available)
    TreeFam Gene Tree for PCDH18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PCDH18 gene
    PCDHAC12  PCDHA22  PCDH72  PCDH202  PCDH12  PCDHA122  PCDH11Y2  PCDHA52  
    PCDH122  PCDHA112  PCDHA12  PCDH92  PCDH192  PCDH82  PCDH172  PCDHGC32  
    PCDHA72  PCDH11X2  PCDHA62  PCDHA82  PCDH102  PCDHA102  PCDHA132  PCDHA92  
    PCDHA32  PCDHA42  
    Selected SIMAP similar genes for PCDH18 using alignment to 5 protein entries:     PCD18_HUMAN (see all proteins) (see all similar genes):
    DKFZp434B0923    ME4    PCDHB17    ME6    PCDHAC2    PCDHGA4
    PCDHGB4    ME1    PCDHGA10    PCDHA1    PCDHA3    PCDHGA1
    PCDHGA11    PCDHGA12    PCDHGA5    PCDHGA8    PCDHGA9    PCDHGB5

    PCDH18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PCDH18 (see all 407)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878298511,2
    --138439610(+) AATTTA/GAAGAA 1 -- ds50010--------
    rs93303531,2
    C,F--138439630(+) TCATCA/TTTCTA 1 -- ds500114Minor allele frequency- T:0.40NA WA CSA EA 558
    rs1492633861,2
    --138439801(+) AAGTGC/TTTTTT 1 -- ds50010--------
    rs97151051,2
    C,F,H--138440012(+) AGAAGG/TCTGGA 1 -- ds50018Minor allele frequency- T:0.14NS NA WA 914
    rs11352201,2
    C,F--138440122(-) CCGCTA/CTTTTG 1 -- ut315Minor allele frequency- C:0.26NA CSA EA 245
    rs11352191,2
    C,F--138440200(-) CATTAA/GGAAAA 1 -- ut316Minor allele frequency- G:0.23MN NA CSA EA 429
    rs1924018571,2
    --138440265(+) TTAGCA/GTTTGT 1 -- ut310--------
    rs1850033341,2
    --138440287(+) ACTGAA/CAAATA 1 -- ut310--------
    rs1892754281,2
    --138440367(+) ATTCTA/GTTTAA 1 -- ut310--------
    rs1129016341,2
    C--138440470(+) AGGGAC/TGATAA 1 -- ut311Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for PCDH18 (138440072 - 138453648 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PCDH18:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516176CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): PCDH18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PCDH18
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608287    OMIM disorders: --

    5 diseases for PCDH18:    
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    systemic lupus erythematosus    parkinson's disease    lupus erythematosus    neuronitis
    obesity


    PCDH18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PCDH18
    Human Genome Epidemiology (HuGE) Navigator: PCDH18 (1 document)

    Export disorders for PCDH18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PCDH18 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with PCDH18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of three members of a novel subclass of protocadherins. (PubMed id 11549318)1, 2, 3, 9 Wolverton T. and Lalande M. (Genomics 2001)
    2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)1, 3 Nollet F....van Roy F. (J. Mol. Biol. 2000)
    4. Disabled-1 interacts with a novel developmentally regulated protocadherin. (PubMed id 11716507)1, 9 Homayouni R....Curran T. (Biochem. Biophys. Res. Commun. 2001)
    5. Genome-wide association study of retinopathy in individuals without diabetes. (PubMed id 23393555)1 Jensen R.A....Wong T.Y. (PLoS ONE 2013)
    6. Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer. (PubMed id 23719583)1 Kerns S.L....Ostrer H. (Radiother Oncol 2013)
    7. A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. (PubMed id 22832960)1 Service S.K....Freimer N.B. (Transl Psychiatry 2012)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. (PubMed id 19165918)4 Graham R.R....Gaffney P.M. (Nat. Genet. 2008)
    10. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54510 HGNC: 14268 AceView: PCDH18 Ensembl:ENSG00000189184 euGenes: HUgn54510
    ECgene: PCDH18 H-InvDB: PCDH18

    (According to HUGE)
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    HUGE: KIAA1562

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PCDH18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PCDH18 gene:
    Search GeneIP for patents involving PCDH18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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