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Aliases for PCDH18 Gene

Aliases for PCDH18 Gene

  • Protocadherin 18 2 3
  • KIAA1562 4 6
  • Protocadherin 68-Like Protein 3
  • Protocadherin-18 3
  • PCDH68L 3

External Ids for PCDH18 Gene

Previous GeneCards Identifiers for PCDH18 Gene

  • GC04U990099
  • GC04M9M0022
  • GC04M138798
  • GC04M138660
  • GC04M138440
  • GC04M134169

Summaries for PCDH18 Gene

Entrez Gene Summary for PCDH18 Gene

  • This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDH18 Gene

PCDH18 (Protocadherin 18) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDH18 Gene

  • Potential calcium-dependent cell-adhesion protein

Gene Wiki entry for PCDH18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDH18 Gene

Genomics for PCDH18 Gene

Regulatory Elements for PCDH18 Gene

Genomic Location for PCDH18 Gene

137,518,918 bp from pter
137,532,494 bp from pter
13,577 bases
Minus strand

Genomic View for PCDH18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDH18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDH18 Gene

Proteins for PCDH18 Gene

  • Protein details for PCDH18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K7K3
    • B7ZKT1
    • Q52LS2

    Protein attributes for PCDH18 Gene

    1135 amino acids
    Molecular mass:
    126149 Da
    Quaternary structure:
    • Interacts with DAB1.
    • Sequence=BAB13388.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCDH18 Gene


neXtProt entry for PCDH18 Gene

Proteomics data for PCDH18 Gene at MOPED

Post-translational modifications for PCDH18 Gene

  • Glycosylation at Asn103, Asn269, Asn420, Asn559, Asn583, and Asn641
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDH18 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PCDH18

No data available for DME Specific Peptides for PCDH18 Gene

Domains for PCDH18 Gene

Gene Families for PCDH18 Gene

Protein Domains for PCDH18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 cadherin domains.
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDH18: view

Function for PCDH18 Gene

Molecular function for PCDH18 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein

Gene Ontology (GO) - Molecular Function for PCDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PCDH18: view

Phenotypes for PCDH18 Gene

genes like me logo Genes that share phenotypes with PCDH18: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDH18 Gene

Localization for PCDH18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDH18 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PCDH18 Gene COMPARTMENTS Subcellular localization image for PCDH18 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PCDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDH18: view

Pathways for PCDH18 Gene

SuperPathways for PCDH18 Gene

No Data Available

Interacting Proteins for PCDH18 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
Selected Interacting proteins: ENSP00000355082 Q9HCL0-PCD18_HUMAN for PCDH18 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PCDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007420 brain development ISS --
genes like me logo Genes that share ontologies with PCDH18: view

No data available for Pathways by source for PCDH18 Gene

Drugs for PCDH18 Gene

(1) HMDB Compounds for PCDH18 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with PCDH18: view

Transcripts for PCDH18 Gene

Unigene Clusters for PCDH18 Gene

Protocadherin 18:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDH18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - -
SP3: -
SP5: -
SP6: - -

Relevant External Links for PCDH18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDH18 Gene

mRNA expression in normal human tissues for PCDH18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PCDH18 Gene

This gene is overexpressed in Plasma (66.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDH18 Gene

SOURCE GeneReport for Unigene cluster for PCDH18 Gene Hs.591691

mRNA Expression by UniProt/SwissProt for PCDH18 Gene

Tissue specificity: Expressed in all tissues, with highest expression in lung and ovary.
genes like me logo Genes that share expressions with PCDH18: view

Expression partners for PCDH18 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PCDH18 Gene

Orthologs for PCDH18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDH18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PCDH18 35
  • 92.68 (n)
  • 97.27 (a)
PCDH18 36
  • 97 (a)
(Canis familiaris)
Mammalia PCDH18 35
  • 82.19 (n)
  • 91.95 (a)
PCDH18 36
  • 90 (a)
(Mus musculus)
Mammalia Pcdh18 35
  • 86.92 (n)
  • 92.68 (a)
Pcdh18 16
Pcdh18 36
  • 93 (a)
(Pan troglodytes)
Mammalia PCDH18 35
  • 99.74 (n)
  • 100 (a)
PCDH18 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pcdh18 35
  • 86.73 (n)
  • 92.07 (a)
(Monodelphis domestica)
Mammalia PCDH18 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia PCDH18 36
  • 52 (a)
(Gallus gallus)
Aves PCDH18 35
  • 78.96 (n)
  • 86.3 (a)
PCDH18 36
  • 85 (a)
(Anolis carolinensis)
Reptilia PCDH18 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcdh18 35
  • 73.88 (n)
  • 80.79 (a)
(Danio rerio)
Actinopterygii Dr.19441 35
pcdh18a 36
  • 68 (a)
pcdh18b 36
  • 67 (a)
Species with no ortholog for PCDH18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDH18 Gene

Gene Tree for PCDH18 (if available)
Gene Tree for PCDH18 (if available)

Paralogs for PCDH18 Gene

genes like me logo Genes that share paralogs with PCDH18: view

Variants for PCDH18 Gene

Sequence variations from dbSNP and Humsavar for PCDH18 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1128422 -- 137,520,077(-) AATCT(C/T)CCCTT utr-variant-3-prime
rs1135219 -- 137,519,046(-) CATTA(A/G)GAAAA utr-variant-3-prime
rs1135220 -- 137,518,968(-) CCGCT(A/C)TTTTG utr-variant-3-prime
rs7436190 -- 137,533,973(+) TTTCC(A/C)AAAAA upstream-variant-2KB
rs7440183 -- 137,533,442(+) GGCTA(A/G)TCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PCDH18 Gene

Variant ID Type Subtype PubMed ID
nsv516176 CNV Gain+Loss 19592680

Relevant External Links for PCDH18 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDH18 Gene

Disorders for PCDH18 Gene

Relevant External Links for PCDH18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PCDH18 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PCDH18 Gene

Publications for PCDH18 Gene

  1. Identification and characterization of three members of a novel subclass of protocadherins. (PMID: 11549318) Wolverton T. … Lalande M. (Genomics 2001) 2 3 4 23
  2. Disabled-1 interacts with a novel developmentally regulated protocadherin. (PMID: 11716507) Homayouni R. … Curran T. (Biochem. Biophys. Res. Commun. 2001) 3 23
  3. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PMID: 10835267) Nollet F. … van Roy F. (J. Mol. Biol. 2000) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Recent progress in protocadherin research. (PMID: 11082270) Suzuki S.T. (Exp. Cell Res. 2000) 3

Products for PCDH18 Gene

Sources for PCDH18 Gene

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