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Aliases for PCDH12 Gene

Aliases for PCDH12 Gene

  • Protocadherin 12 2 3
  • Vascular Endothelial Cadherin-2 3 4
  • Vascular Cadherin-2 3 4
  • VE-Cadherin-2 3 4
  • VE-Cad-2 3 4
  • VECAD2 3 6
  • Vascular Endothelial Cadherin 2 3
  • Protocadherin-12 3
  • VE-Cadherin 2 3

External Ids for PCDH12 Gene

Previous GeneCards Identifiers for PCDH12 Gene

  • GC05M141146
  • GC05M141907
  • GC05M141307
  • GC05M141353
  • GC05M141305
  • GC05M136467

Summaries for PCDH12 Gene

Entrez Gene Summary for PCDH12 Gene

  • This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDH12 Gene

PCDH12 (Protocadherin 12) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDH12 Gene

  • Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).

Gene Wiki entry for PCDH12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDH12 Gene

Genomics for PCDH12 Gene

Regulatory Elements for PCDH12 Gene

Genomic Location for PCDH12 Gene

Start:
141,943,585 bp from pter
End:
141,969,741 bp from pter
Size:
26,157 bases
Orientation:
Minus strand

Genomic View for PCDH12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDH12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDH12 Gene

Proteins for PCDH12 Gene

  • Protein details for PCDH12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPG4-PCD12_HUMAN
    Recommended name:
    Protocadherin-12
    Protein Accession:
    Q9NPG4
    Secondary Accessions:
    • Q6UXB6
    • Q96KB8
    • Q9H7Y6
    • Q9H8E0

    Protein attributes for PCDH12 Gene

    Size:
    1184 amino acids
    Molecular mass:
    128995 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PCDH12 Gene

Proteomics data for PCDH12 Gene at MOPED

Post-translational modifications for PCDH12 Gene

  • Glycosylation at Asn415, Asn582, Asn659, and Asn662
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDH12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PCDH12 (Protocadherin-12)

No data available for DME Specific Peptides for PCDH12 Gene

Domains for PCDH12 Gene

Gene Families for PCDH12 Gene

HGNC:
  • PCDHN :Cadherins / Protocadherins : Non-clustered

Protein Domains for PCDH12 Gene

Suggested Antigen Peptide Sequences for PCDH12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPG4

UniProtKB/Swiss-Prot:

PCD12_HUMAN :
  • Q9NPG4
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDH12: view

Function for PCDH12 Gene

Molecular function for PCDH12 Gene

UniProtKB/Swiss-Prot Function: Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).

Gene Ontology (GO) - Molecular Function for PCDH12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDH12: view

Phenotypes for PCDH12 Gene

MGI mutant phenotypes for PCDH12:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PCDH12: view

Animal Models for PCDH12 Gene

MGI Knock Outs for PCDH12:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PCDH12 Gene

Localization for PCDH12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDH12 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDH12 Gene COMPARTMENTS Subcellular localization image for PCDH12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PCDH12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 10380929
GO:0005887 integral component of plasma membrane TAS 10716726
GO:0005911 cell-cell junction IEA --
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PCDH12: view

Pathways for PCDH12 Gene

SuperPathways for PCDH12 Gene

No Data Available

Interacting Proteins for PCDH12 Gene

Gene Ontology (GO) - Biological Process for PCDH12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005977 glycogen metabolic process IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0008038 neuron recognition TAS 10380929
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0060711 labyrinthine layer development IEA --
genes like me logo Genes that share ontologies with PCDH12: view

No data available for Pathways by source for PCDH12 Gene

Compounds for PCDH12 Gene

(1) HMDB Compounds for PCDH12 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDH12: view

Transcripts for PCDH12 Gene

mRNA/cDNA for PCDH12 Gene

Unigene Clusters for PCDH12 Gene

Protocadherin 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDH12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1:
SP2:

Relevant External Links for PCDH12 Gene

GeneLoc Exon Structure for
PCDH12
ECgene alternative splicing isoforms for
PCDH12

Expression for PCDH12 Gene

mRNA expression in normal human tissues for PCDH12 Gene

mRNA differential expression in normal tissues according to GTEx for PCDH12 Gene

This gene is overexpressed in Spleen (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDH12 Gene

SOURCE GeneReport for Unigene cluster for PCDH12 Gene Hs.439474

mRNA Expression by UniProt/SwissProt for PCDH12 Gene

Q9NPG4-PCD12_HUMAN
Tissue specificity: Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression. Prominent expression in the spleen
genes like me logo Genes that share expressions with PCDH12: view

In Situ Assay Products

Orthologs for PCDH12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDH12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDH12 35
  • 99.32 (n)
  • 99.49 (a)
PCDH12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PCDH12 35
  • 87.31 (n)
  • 87.54 (a)
PCDH12 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCDH12 35
  • 86.82 (n)
  • 87.6 (a)
PCDH12 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcdh12 35
  • 82.73 (n)
  • 81.74 (a)
Pcdh12 16
Pcdh12 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCDH12 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcdh12 35
  • 82.29 (n)
  • 81.71 (a)
chicken
(Gallus gallus)
Aves PCDH12 35
  • 62.04 (n)
  • 56.85 (a)
PCDH12 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcdh12 35
  • 57.49 (n)
  • 53.71 (a)
zebrafish
(Danio rerio)
Actinopterygii pcdh12 35
  • 53.6 (n)
  • 47.47 (a)
PCDH12 36
  • 42 (a)
OneToOne
Species with no ortholog for PCDH12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDH12 Gene

ENSEMBL:
Gene Tree for PCDH12 (if available)
TreeFam:
Gene Tree for PCDH12 (if available)

Paralogs for PCDH12 Gene

genes like me logo Genes that share paralogs with PCDH12: view

Variants for PCDH12 Gene

Sequence variations from dbSNP and Humsavar for PCDH12 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs164073 -- 141,955,676(-) TACTG(C/T)TGGGC synonymous-codon, reference
rs164074 -- 141,955,719(-) GGGGC(C/T)TTGAG reference, synonymous-codon
rs164075 - 141,956,699(-) CAGGA(A/C)ACAAT missense, reference
rs164076 -- 141,957,561(-) CAGCT(A/G)TGCCG synonymous-codon, reference
rs164077 -- 141,957,660(-) GGGGC(C/T)GCCTT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for PCDH12 Gene

Variant ID Type Subtype PubMed ID
nsv526702 CNV Loss 19592680

Relevant External Links for PCDH12 Gene

HapMap Linkage Disequilibrium report
PCDH12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDH12 Gene

Disorders for PCDH12 Gene

Relevant External Links for PCDH12

Genetic Association Database (GAD)
PCDH12
Human Genome Epidemiology (HuGE) Navigator
PCDH12
genes like me logo Genes that share disorders with PCDH12: view

No data available for UniProtKB/Swiss-Prot for PCDH12 Gene

Publications for PCDH12 Gene

  1. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23
  2. cDNA cloning, chromosomal mapping, and expression analysis of human VE-cadherin-2. (PMID: 11063261) Ludwig D. … Pytowski B. (Mamm. Genome 2000) 3 4 23
  3. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PMID: 19054571) GregA^rio S.P. … Dias-Neto E. (Psychiatry Res 2009) 3 23 48
  4. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for PCDH12 Gene

Sources for PCDH12 Gene

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