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PCDH11X Gene

protein-coding   GIFtS: 54
GCID: GC0XP091034

Protocadherin 11 X-Linked

(Previous name: protocadherin 11)
(Previous symbol: PCDH11)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protocadherin 11 X-Linked1 2     Protocadherin 11X2
PCDH111 2 3 5     Protocadherin-11 X-Linked2
PCDHX2 3 5     protocadherin-S2
Protocadherin On The X Chromosome2 3     KIAA13263
PCDH-X2 3     Protocadherin-113
Protocadherin 111     Protocadherin-S3

External Ids:    HGNC: 86561   Entrez Gene: 273282   Ensembl: ENSG000001022907   OMIM: 3002465   UniProtKB: Q9BZA73   

Export aliases for PCDH11X gene to outside databases

Previous GC identifers: GC0XP086306 GC0XP088003 GC0XP089070 GC0XP089806 GC0XP090840 GC0XP090920


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PCDH11X Gene:
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein
consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail
that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its
Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family
member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental
development and function of the central nervous system. Transcripts arising from alternative splicing encode
isoforms with variable cytoplasmic domains. (provided by RefSeq, Jul 2008)

GeneCards Summary for PCDH11X Gene:
PCDH11X (protocadherin 11 X-linked) is a protein-coding gene. Diseases associated with PCDH11X include schizoaffective disorder, and cornelia de lange syndrome. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHAC1.

UniProtKB/Swiss-Prot: PC11X_HUMAN, Q9BZA7
Function: Potential calcium-dependent cell-adhesion protein

Gene Wiki entry for PCDH11X Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PCDH11X gene promoter:
         p53   CUTL1   Egr-2   MEF-2A   POU2F1   POU2F1b   FOXO4   POU2F1a   POU2F1c   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCDH11X promoter sequence
   Search Chromatin IP Primers for PCDH11X

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCDH11X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.3   Ensembl cytogenetic band:  Xq21.31   HGNC cytogenetic band: Xq21.3

PCDH11X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCDH11X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP091034:  view genomic region     (about GC identifiers)

Start:
91,034,260 bp from pter      End:
91,878,229 bp from pter
Size:
843,970 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PC11X_HUMAN, Q9BZA7 (See protein sequence)
Recommended Name: Protocadherin-11 X-linked precursor  
Size: 1347 amino acids; 147558 Da
Secondary accessions: A6NIQ4 Q2TJH0 Q2TJH1 Q2TJH3 Q5JVZ0 Q70LR8 Q70LS7 Q70LS8 Q70LS9 Q70LT7
Q70LT8 Q70LT9 Q70LU0 Q70LU1 Q96RV4 Q96RW0 Q9BZA6 Q9H4E0 Q9P2M0 Q9P2X5
Alternative splicing: 8 isoforms:  Q9BZA7-1   Q9BZA7-2   Q9BZA7-3   Q9BZA7-4   Q9BZA7-5   Q9BZA7-6   Q9BZA7-7   Q9BZA7-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PCDH11X: NX_Q9BZA7

Explore proteomics data for PCDH11X at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn27, Asn48, Asn54, Asn344, Asn553, Asn773, Thr856
  • Modification sites at PhosphoSitePlus

  • See PCDH11X Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001161832.1  NP_001161833.1  NP_001161834.1  NP_001161835.1  NP_055337.1  NP_116749.1  NP_116750.1  NP_116751.1  

    ENSEMBL proteins: 
     ENSP00000378746   ENSP00000355040   ENSP00000362186   ENSP00000362189   ENSP00000355105  
     ENSP00000384758   ENSP00000362180   ENSP00000423762   ENSP00000298274  

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PCDHN: Cadherins / Protocadherins : Non-clustered

    5 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR013164 Cadherin_N
     IPR013585 Protocadherin
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9BZA7

    ProtoNet protein and cluster: Q9BZA7

    2 Blocks protein domains:
    IPB002126 Cadherin
    IPB013585 Protocadherin


    UniProtKB/Swiss-Prot: PC11X_HUMAN, Q9BZA7
    Similarity: Contains 7 cadherin domains


    PCDH11X for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PC11X_HUMAN, Q9BZA7
    Function: Potential calcium-dependent cell-adhesion protein

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    PCDH11X for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PCDH11X:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCDH11X
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCDH11X
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    miRNA
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    Block miRNA regulation of human, mouse, rat PCDH11X using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCDH11X (see all 32):
    hsa-miR-411* hsa-miR-361-5p hsa-miR-379* hsa-miR-520d-5p hsa-miR-25 hsa-miR-139-5p hsa-miR-1285 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): PCDH11X 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PCDH11X

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    Sino Biological Human cDNA Clone for PCDH11X
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCDH11X


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PC11X_HUMAN, Q9BZA7: Cell membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    extracellular2
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS10644456
    GO:0005887integral component of plasma membrane TAS10644456
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    PCDH11X for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCDH11X
    Interactions:

        Search GeneGlobe Interaction Network for PCDH11X

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for PCDH11X (Q9BZA73 ENSP000003621864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KBTBD7Q8WVZ93I2D: score=1 
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--
    GO:0010923negative regulation of phosphatase activity IDA19389623

    PCDH11X for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCDH11X (PC11X)

    1 HMDB Compound for PCDH11X    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PCDH11X gene (8 alternative transcripts): 
    NM_001168360.1  NM_001168361.1  NM_001168362.1  NM_001168363.1  NM_014522.1  NM_032967.2  NM_032968.3  NM_032969.3  

    Unigene Cluster for PCDH11X:

    Protocadherin 11 X-linked
    Hs.655673  [show with all ESTs]
    Unigene Representative Sequence: NM_032968
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395337(uc004efh.2) ENST00000361724(uc004efj.1) ENST00000373094(uc004efk.2 uc010nmv.2 uc004efm.2)
    ENST00000373097(uc004efl.2 uc004efn.2 uc004efo.2) ENST00000361655
    ENST00000406881 ENST00000373088 ENST00000504220 ENST00000298274

    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate PCDH11X (see all 32):
    hsa-miR-411* hsa-miR-361-5p hsa-miR-379* hsa-miR-520d-5p hsa-miR-25 hsa-miR-139-5p hsa-miR-1285 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): PCDH11X 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PCDH11X
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    GenScript: all cDNA clones in your preferred vector (see all 8): PCDH11X (NM_032967)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCDH11X
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCDH11X
    Primer
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    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat PCDH11X
      QuantiTect SYBR Green Assays in human, mouse, rat PCDH11X
      QuantiFast Probe-based Assays in human, mouse, rat PCDH11X

    Additional mRNA sequence: 

    AB026187.1 AB026188.1 AB037747.1 AF206516.1 AF217288.1 AF332218.1 AF332219.1 AJ276804.1 
    AJ564847.1 AJ564855.1 AJ564931.1 AJ564932.1 AJ564933.1 AJ564934.1 AJ564935.1 AJ564936.1 
    AJ564937.1 AJ564942.1 AJ564943.1 AJ564945.1 AJ564946.1 AJ564947.1 AJ564959.1 AK299813.1 
    AK316263.1 AY861432.1 AY861433.1 AY861434.1 AY861435.1 U79247.1 

    9 DOTS entries:

    DT.306379  DT.109547  DT.97840076  DT.121280951  DT.102843434  DT.121280928  DT.95261615  DT.120654526 
    DT.120654534 

    Selected AceView cDNA sequences (see all 51):

    AF332219 AJ564855 AJ564937 U79247 BQ024192 BM722136 AJ564939 AJ564938 
    AJ564847 AJ564933 AJ564932 NM_032968 AJ564947 AB026187 NM_032967 AF332218 
    NM_014522 BM679081 F10902 AJ564934 AJ564942 BQ184367 AJ564945 NM_032969 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PCDH11X expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PCDH11X Expression
    About this image


    PCDH11X expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
             Oligodendrocyte-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
    PCDH11X Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCDH11X Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655673

    UniProtKB/Swiss-Prot: PC11X_HUMAN, Q9BZA7
    Tissue specificity: Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra,
    hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PCDH11X gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcdh11x1 , 5 protocadherin 11 X-linked1, 5 84.7(n)1
    83.35(a)1
      X (49.58 cM)5
    2455781  NM_001271809.11  NP_001258738.11 
     1202902595 
    chicken
    (Gallus gallus)
    Aves LOC4222641 protocadherin-11 X-linked-like 72.52(n)
    72.46(a)
      422264  XM_004940702.1  XP_004940759.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    71(a)
    1 → many
    GL343370.1(105275-295118)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004939381 protocadherin-11 X-linked-like 69.28(n)
    69.64(a)
      100493938  XM_004916890.1  XP_004916947.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pcdh111 protocadherin 11 66.19(n)
    66.13(a)
      100333121  XM_005173191.1  XP_005173248.1 


    ENSEMBL Gene Tree for PCDH11X (if available)
    TreeFam Gene Tree for PCDH11X (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PCDH11X gene
    PCDHAC12  PCDHA22  PCDH72  PCDH202  PCDH12  PCDHA122  PCDH11Y2  PCDHA52  
    PCDH122  PCDHA112  PCDHA12  PCDH182  PCDH92  PCDH192  PCDH82  PCDH172  
    PCDHGC32  PCDHA72  PCDHA62  PCDHA82  PCDH102  PCDHA102  PCDHA132  PCDHA92  
    PCDHA32  PCDHA42  
    Selected SIMAP similar genes for PCDH11X using alignment to 2 protein entries:     PC11X_HUMAN (see all proteins) (see all similar genes):
    PCDHY    PCDH11Y    PCDH9    PCDH1    ME5    PCDH20
    FAT3    PCDHGA3    ME3    PCDH7    PCDHB16    PCDHB17
    PCDHGA1    PCDHGA10    PCDHGA12    ME1    PCDH10    PCDHB18

    PCDH11X for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PCDH11X (see all 12918)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361094
    A colorectal cancer sample4--see VAR_0361092 D G mis40--------
    rs1913886521,2
    --91001446(+) TAATTC/GGTATC 1 -- us2k10--------
    rs38131681,2
    C,F,H--91001585(+) TCATCC/GAGTAT 1 -- us2k111Minor allele frequency- G:0.21NS EA NA WA 736
    rs78815301,2
    C,F--91001674(+) AGAGTA/GCAATG 1 -- us2k13Minor allele frequency- G:0.33NA WA 6
    rs38131701,2
    C--91001739(+) AATAGC/TGAAGT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1458674041,2
    --91001757(+) CACACC/TTGTGC 1 -- us2k10--------
    rs1480574281,2
    --91001810(+) AGCTGA/CGGTGC 1 -- us2k10--------
    rs1882762331,2
    --91002031(+) AACTTA/GTTATA 1 -- us2k10--------
    rs1995012441,2
    --91003091(+) TTAAA-/GGGAAG 1 -- us2k10--------
    rs1912669681,2
    --91004321(+) TAGCTA/GAGAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PCDH11X (91034260 - 91284260 bp, first 250kb of PCDH11X)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PCDH11X (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740323CNV Deletion23290073
    esv2740327CNV Deletion23290073
    esv2675842CNV Deletion23128226
    esv2740330CNV Deletion23290073
    esv2740325CNV Deletion23290073
    esv2740326CNV Deletion23290073
    esv2660593CNV Deletion23128226
    esv2740324CNV Deletion23290073
    esv2656455CNV Deletion23128226
    esv2674815CNV Deletion23128226

    Human Gene Mutation Database (HGMD): PCDH11X
    Locus Specific Mutation Databases (LSDB): PCDH11X

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PCDH11X
    DNA2.0 Custom Variant and Variant Library Synthesis for PCDH11X

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 300246    OMIM disorders: --

    10 diseases for PCDH11X:    
    About MalaCards
    schizoaffective disorder    cornelia de lange syndrome    usher syndrome    vasculitis
    breast and colorectal cancer    cerebritis    schizophrenia    alzheimer's disease
    hiv-1    colorectal cancer


    PCDH11X for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for PCDH11X gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizoaffective disorder 64.4 2 15274028 (1)

    Genetic Association Database (GAD): PCDH11X
    Human Genome Epidemiology (HuGE) Navigator: PCDH11X (8 documents)

    Export disorders for PCDH11X gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PCDH11X gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with PCDH11X)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel protocadherin gene (PCDH11) on the human XY homology region in Xq21.3. (PubMed id 10644456)1, 2, 3, 9 Yoshida K. and Sugano S. (Genomics 1999)
    2. Protocadherin X (PCDHX) and Y (PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains. (PubMed id 14727141)1, 2, 9 Blanco-Arias P.... Affara N.A. (Mamm. Genome 2004)
    3. Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients. (PubMed id 20555150)1, 4 Lescai F....Franceschi C. (J. Alzheimers Dis. 2010)
    4. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PubMed id 20574532)1, 4 Shulman J.M....De Jager P.L. (PLoS ONE 2010)
    5. Lack of association between PCDH11X genetic variation and late-onset Alzheimer's disease in a Han Chinese population. (PubMed id 20707987)1, 4 Wu Z.C....Tan L. (Brain Res. 2010)
    6. Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. (PubMed id 19136949)1, 4 Carrasquillo M.M....Younkin S.G. (Nat. Genet. 2009)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    8. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (Nature 2003)
    9. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    10. Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain. (PubMed id 11003707)1, 2 Blanco P.... Affara N. (Mamm. Genome 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 27328 HGNC: 8656 AceView: PCDH11X Ensembl:ENSG00000102290 euGenes: HUgn27328
    ECgene: PCDH11X H-InvDB: PCDH11X

    (According to HUGE)
    About This Section

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    HUGE: KIAA1326

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PCDH11X Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PCDH11X gene:
    Search GeneIP for patents involving PCDH11X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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