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Aliases for PCDH1 Gene

Aliases for PCDH1 Gene

  • Protocadherin 1 2 3
  • PC42 3 4 6
  • Cadherin-Like Protein 1 3 4
  • Protocadherin-42 3 4
  • Protocadherin 1 (Cadherin-Like 1) 2
  • Protocadherin 42 3
  • Cadherin-Like 1 3
  • Protocadherin-1 3
  • PCDH42 3

External Ids for PCDH1 Gene

Previous GeneCards Identifiers for PCDH1 Gene

  • GC05M141056
  • GC05M141816
  • GC05M141215
  • GC05M141261
  • GC05M141212
  • GC05M136376
  • GC05M141232

Summaries for PCDH1 Gene

Entrez Gene Summary for PCDH1 Gene

  • This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDH1 Gene

PCDH1 (Protocadherin 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDH1 Gene

  • May be involved in cell-cell interaction processes and in cell adhesion

Gene Wiki entry for PCDH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDH1 Gene

Genomics for PCDH1 Gene

Regulatory Elements for PCDH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCDH1 Gene

141,853,090 bp from pter
141,879,246 bp from pter
26,157 bases
Minus strand

Genomic View for PCDH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDH1 Gene

Proteins for PCDH1 Gene

  • Protein details for PCDH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8IUP2

    Protein attributes for PCDH1 Gene

    1060 amino acids
    Molecular mass:
    114743 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA36419.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCDH1 Gene


neXtProt entry for PCDH1 Gene

Proteomics data for PCDH1 Gene at MOPED

Post-translational modifications for PCDH1 Gene

  • Glycosylation at Asn305, Asn403, Asn618, Asn662, Asn720, Asn813, and Asn818
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PCDH1 (Protocadherin-1)

No data available for DME Specific Peptides for PCDH1 Gene

Domains for PCDH1 Gene

Gene Families for PCDH1 Gene

Suggested Antigen Peptide Sequences for PCDH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 cadherin domains.
  • Contains 7 cadherin domains.
genes like me logo Genes that share domains with PCDH1: view

Function for PCDH1 Gene

Molecular function for PCDH1 Gene

GENATLAS Biochemistry:
protocadherin 1,cadherin-related neuronal receptor,component of the PCDHG cluster,member C3,expressed in the brain,localized at the synaptic junction and putatively involved in specific neuronal connections and signal transduction
UniProtKB/Swiss-Prot Function:
May be involved in cell-cell interaction processes and in cell adhesion

Gene Ontology (GO) - Molecular Function for PCDH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PCDH1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDH1 Gene

Localization for PCDH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDH1 Gene

Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.

Subcellular locations from

Jensen Localization Image for PCDH1 Gene COMPARTMENTS Subcellular localization image for PCDH1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PCDH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 8508762
GO:0005887 integral component of plasma membrane TAS 8508762
GO:0005911 cell-cell junction TAS 8508762
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with PCDH1: view

Pathways for PCDH1 Gene

SuperPathways for PCDH1 Gene

No Data Available

Interacting Proteins for PCDH1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q08174-PCDH1_HUMAN ENSP00000287008 for PCDH1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for PCDH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling TAS 8508762
GO:0007399 nervous system development TAS 8508762
genes like me logo Genes that share ontologies with PCDH1: view

No data available for Pathways by source for PCDH1 Gene

Transcripts for PCDH1 Gene

Unigene Clusters for PCDH1 Gene

Protocadherin 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDH1 Gene

No ASD Table

Relevant External Links for PCDH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDH1 Gene

mRNA expression in normal human tissues for PCDH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PCDH1 Gene

This gene is overexpressed in Heart (29.2) and Frontal cortex (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDH1 Gene

SOURCE GeneReport for Unigene cluster for PCDH1 Gene Hs.79769

mRNA Expression by UniProt/SwissProt for PCDH1 Gene

Tissue specificity: Highly expressed in the brain and neuro-glial cells
genes like me logo Genes that share expressions with PCDH1: view

Expression partners for PCDH1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PCDH1 Gene

Orthologs for PCDH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PCDH1 35
  • 90.75 (n)
  • 96.32 (a)
PCDH1 36
  • 95 (a)
(Canis familiaris)
Mammalia PCDH1 35
  • 92.48 (n)
  • 97.08 (a)
PCDH1 36
  • 97 (a)
(Mus musculus)
Mammalia Pcdh1 35
  • 88.7 (n)
  • 96.25 (a)
Pcdh1 16
Pcdh1 36
  • 95 (a)
(Pan troglodytes)
Mammalia PCDH1 35
  • 99.65 (n)
  • 99.6 (a)
PCDH1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pcdh1 35
  • 88.97 (n)
  • 96.96 (a)
(Monodelphis domestica)
Mammalia PCDH1 36
  • 94 (a)
(Gallus gallus)
Aves PCDH1 35
  • 78.4 (n)
  • 83.93 (a)
PCDH1 36
  • 82 (a)
(Anolis carolinensis)
Reptilia PCDH1 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcdh1 35
  • 69.56 (n)
  • 75.36 (a)
Str.20430 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12097 35
(Danio rerio)
Actinopterygii Dr.26174 35
pcdh1 35
  • 66.89 (n)
  • 70.06 (a)
pcdh1a 36
  • 68 (a)
pcdh1b 36
  • 68 (a)
Species with no ortholog for PCDH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDH1 Gene

Gene Tree for PCDH1 (if available)
Gene Tree for PCDH1 (if available)

Paralogs for PCDH1 Gene

genes like me logo Genes that share paralogs with PCDH1: view

Variants for PCDH1 Gene

Sequence variations from dbSNP and Humsavar for PCDH1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs14359 -- 141,863,068(-) TCACC(C/G)GGCAC utr-variant-3-prime, intron-variant
rs3797054 -- 141,864,081(-) AATGC(C/T)GAGCT synonymous-codon, reference
rs4995946 -- 141,853,211(+) CACCC(A/C)CATCC utr-variant-3-prime
rs6899007 -- 141,856,351(+) GGGCC(C/T)GGGAG intron-variant
rs10054186 -- 141,867,249(+) TCCAT(C/G)CTCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PCDH1 Gene

Variant ID Type Subtype PubMed ID
nsv509093 CNV Insertion 20534489

Relevant External Links for PCDH1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDH1 Gene

Disorders for PCDH1 Gene

No disorders were found for PCDH1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PCDH1 Gene

Publications for PCDH1 Gene

  1. Protocadherins: a large family of cadherin-related molecules in central nervous system. (PMID: 8508762) Sano K. … Suzuki S. (EMBO J. 1993) 2 3 4
  2. Expression of cadherin superfamily genes in brain vascular development. (PMID: 19189440) Krishna-K . … Redies C. (J. Cereb. Blood Flow Metab. 2009) 23
  3. delta-Protocadherins: unique structures and functions. (PMID: 16261259) Redies C. … Roy F.v. (Cell. Mol. Life Sci. 2005) 23
  4. Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung. (PMID: 12842817) Favre C.J. … McDonald D.M. (Am. J. Physiol. Heart Circ. Physiol. 2003) 23
  5. Axial protocadherin is a mediator of prenotochord cell sorting in Xenopus. (PMID: 11944936) Kuroda H. … Asashima M. (Dev. Biol. 2002) 23

Products for PCDH1 Gene

Sources for PCDH1 Gene

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