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PCCB Gene

protein-coding GIFtS: 62

GC03P137451

propionyl Coenzyme A carboxylase, beta polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp451E113 ^²
EC 6.4.1.3 ^³

Descriptions
PCCase subunit beta ^², ³
Propanoyl-CoA:carbon dioxide ligase subunit beta ^², ³
propionyl Coenzyme A carboxylase, beta polypeptide ^²

External Ids
HGNC: 8654¹
Entrez Gene: 5096²
UniProtKB: P05166³
Ensembl: ENSG00000114054⁷

Search outside databases for aliases for PCCB gene

Previous GC identifers: GC03U990060 GC03P136720 GC03P137250 GC03P137290

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for PCCB:

The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which

is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts

as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of

PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PCCB gene

Entrez Gene cytogenetic band: 3q21-q22 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q21-q22

PCCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P137451: (about GC identifiers)

Start:	137,451,857 bp from pter
End:	137,531,701 bp from pter
Size:	79,845 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166 (See protein sequence)

Recommended Name: Propionyl-CoA carboxylase beta chain, mitochondrial precursor

Size: 539 amino acids; 58216 Da

Subunit: Probably a dodecamer composed of six biotin-containing alpha subunits and six beta

subunits

Subcellular location: Mitochondrion matrix

Secondary accessions: Q16813 Q96CX0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000523.2

ENSEMBL proteins:

ENSP00000251654

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PCCB)
	Human Recombinant Proteins from Abnova (PCCB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	8188292
GO:0005759	mitochondrial matrix	IEA	--

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Antibodies for PCCB:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PCCB
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PCCB), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PCCB)
	Novus Biologicals Antibodies for PCCB

Assays for PCCB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P05166

ProtoNet protein and cluster: P05166

1 Blocks protein family: IPB000022 Carboxyl transferase family

UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166

Similarity: Belongs to the accD/PCCB family

Similarity: Contains 1 carboxyltransferase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PCCB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000532

Applied Biosystems Silencer® siRNAs for PCCB

Sigma-Aldrich siRNA and siRNA Panels for PCCB

Sigma-Aldrich shRNA for PCCB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PCCB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000532
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000532
untagged cDNA clones in CMV expression vector (see all 2): NM_000532

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000532

UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166

Catalytic activity: ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA

Enzyme Number (IUBMB): EC 6.4.1.3

Genatlas biochemistry entry for PCCB:

propionyl-CoA carboxylase,beta polypeptide,biotin-dependent,mitochondrial conversion of propionyl

CoA TO methylmalonyl CoA,branched chain valine,isoleucine catabolism,energy pathway

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004658	propionyl-CoA carboxylase activity	TAS	8188292
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for PCCB (Your Favorite Gene powered by Ingenuity)

Valine, Leucine and Isoleucine Degradation
Propanoate Metabolism
Fatty Acid Biosynthesis

GeneDecks PCCB for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166

Pathway: Metabolic intermediate metabolism; propionyl-CoA degradation; succinyl-CoA from

propionyl-CoA: step 1/3

5/16 Interacting proteins for PCCB (ENSP00000251654³ P05166²) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PCCA	ENSP00000365463³	STRING (score=.999)
MCEE	ENSP00000244217³	STRING (score=.99)
MCCC1	ENSP00000265594³	STRING (score=.967)
MUT	ENSP00000274813³	STRING (score=.955)
ACAA1	ENSP00000333664³	STRING (score=.926)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PCCB
2 Novoseek chemical compound relationships for PCCB gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pcca	99.18	62	10502773 (6), 19099776 (5), 9311592 (4), 15059621 (4) (see all 29)
propionyl coa	90.81	6	11245989 (2), 15949719 (1), 10094392 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PCCB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000532

Sigma-Aldrich siRNA and siRNA Panels for PCCB

Sigma-Aldrich shRNA for PCCB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000532

REFSEQ mRNAs for PCCB gene:

NM_000532.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000532

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000532
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000532
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000532

Additional cDNA sequence:

AB209009.1 AF217984.1 AF251189.1 AF251191.1 AK130359.1 AK225215.1 AK225733.1 AK295312.1

AK302522.1 AK303079.1 AL831978.2 BC005909.1 BC013768.1 BC018013.1 BC053661.1 CR601703.1

CR603056.1 CR607835.1 CR609162.1 CR614392.1 CR618864.1 CR621266.1 CR624803.1 M13573.1

S67325.1 X73424.1

24/28 DOTS entries (see all 28 ):

DT.415386 DT.95335905 DT.101964909 DT.92441646 DT.95283426 DT.101984715 DT.101984718 DT.97865771

DT.120900467 DT.120900469 DT.101984719 DT.75185376 DT.100045524 DT.97811438 DT.100720585 DT.116168

DT.92441652 DT.95283416 DT.95283428 DT.100045521 DT.95283423 DT.95283427 DT.95317646 DT.100864986

24/272 AceView cDNA sequences (see all 272 ):

AU119871 BM741634 M13573 BQ646566 BQ343596 AI559324 CB159480 CR603056

BP348752 BF211289 BM743274 BG563542 BM558262 BI908664 BU849561 AA677084

BI831455 BM712844 AI924286 CR624803 BF982603 BG287632 AA680161 BE408707

highest scoring ESTs for PCCB:

X73424 AA147098 AA223335 AA419435 AA459122 AA506483 AA507321 AA553631 AA639000 AA680161

Unigene Cluster for PCCB:

Propionyl Coenzyme A carboxylase, beta polypeptide

Hs.63788 [show with all ESTs]

Unigene Representative Sequence: AB209009

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PCCB (see all 16 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	·	9d	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^
SP1:									-		-										-		-														-						-
SP2:									-		-										-		-		-												-						-
SP3:									-		-										-		-		-												-
SP4:									-		-										-		-		-												-						-
SP5:									-		-						-		-		-		-		-												-						-

ExUns:	16	^	17	^	18	^	19	^	20	^	21	^	22
SP1:			-
SP2:
SP3:			-
SP4:			-
SP5:			-

About this scheme

ECgene alternative splicing isoforms for PCCB

1 Ensembl transcript including schematic representation:

ENST00000251654

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PCCB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PCCB

¹ / ² / ³

4 probe-sets matching PCCB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36561_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.98	X73424	1.00	1.00	1.00	1
59950_at²^{, 3}	U95-C	1	1.00	1.00	0.95	1.02	W02561	0.20	1.00	0.72	1
212694_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000532	0.60	1.00	0.82	1
212694_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PCCB for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAACCTGGGA

SOURCE GeneReport for Unigene cluster: Hs.63788
Expression variation in blood from EXPOLDB for PCCB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PCCB gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PCCB¹	--	propionyl Coenzyme A carboxylase, beta polypeptide	91.47(n) 95.18(a)	477076 XM_534271.2 XP_534271.2
chimpanzee (Pan troglodytes)	PCCB¹	--	propionyl Coenzyme A carboxylase, beta polypeptide	99.57(n) 99.63(a)	744850 XM_001150022.1 XP_001150022.1
cow (Bos taurus)	PCCB¹	--	propionyl Coenzyme A carboxylase, beta polypeptide	91.09(n) 96.1(a)	515902 NM_001038548.1 NP_001033637.1
rat (Rattus norvegicus)	Pccb¹	--	propionyl coenzyme A carboxylase, beta polypeptide	86.77(n) 91.47(a)	24624 NM_017030.1 NP_058726.1
mouse (Mus musculus)	Pccb^{1, 5}	9⁵	propionyl Coenzyme A carboxylase, beta polypeptide^{1, 5}	87.51(n)¹ 92.76(a)¹	66904¹ NM_025835.2¹ NP_080111.1¹ AF327060⁵ AI314687⁵ (see all 16)

About this table Species with no ortholog for PCCB

ENSEMBL Gene Tree for PCCB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PCCB gene

MCCC2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/347 NCBI SNPs in PCCB are shown (see all 347 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3755636^1,2	C,F,H	137451518(-)	`taaatG/Caagca`	1	--	ng5¹ tfbs³		4	EU EA WA	418
	rs16843806^1,2	F	137451768(+)	`ACTCTC/GACGCC`	1	--	ng5¹ tfbs³		3	NA	142
--	rs2228310^1,2	F	137499579(+)	`CGGCTC/TCCGTC`	1	P/S	mis¹ ese³		5	MN EU EA WA	480
	rs548288^1,2	A,C,F,H,O	137452445(-)	`CTATCG/ATTTTG`	1	--	int¹		18	EA NA EU WA	1686
	rs1153877^1,2	A,C,F,H,O	137487615(-)	`AGACAG/ATTTTA`	1	--	int¹		11	EU EA WA NA	918
	rs1711171^1,2	A,C,F,H,O	137503231(-)	`TCACGG/ATGTGT`	1	--	int¹		8	EU EA WA	838
	rs1279425^1,2	A,C,F,H	137489674(+)	`cttttC/Tgtatg`	1	--	int¹		7	EU EA WA NA	558
	rs2290131^1,2	C,F,H,O	137463363(-)	`AGGCAA/GTAACA`	1	--	int¹		17	EA NA EU WA	2910
	rs589092^1,2	A,C,F,H	137462388(-)	`agatcC/Tactgc`	1	--	int¹		3	EA WA	292
	rs483465^1,2	A,C,F,H	137530667(+)	`ACTCAG/ACAGCT`	1	--	int¹		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for PCCB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 232050 disorders: 606054

UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166

Defects in PCCB are the cause of propionic acidemia type II (PA-2) [MIM:606054]. PA-2 is a

life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia,

periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to

protein

3 Novoseek disease relationships for PCCB gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
propionic acidemia	98.51	31	8188292 (2), 11749052 (2), 12757933 (2), 15059621 (2) (see all 22)
enzyme deficiency	60.85	2	12743028 (1), 15059621 (1)
metabolic disorder	56.03	4	9683601 (1), 8188292 (1), 11749052 (1), 10101253 (1)

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Genatlas disease: PCCB

hyperglycinemia,ketotic,propionic acidemia B

Human Gene Mutation Database: PCCB

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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17/58 PubMed articles for PCCB gene (see all 58 ):

Overview of mutations in the PCCA and PCCB genes causing propionic acidemia. (PubMed id 10502773)^{1, 3, 4} Ugarte M.... Gravel R.A. (1999)
Mutation spectrum of the PCCA and PCCB genes in Japanese patients with propionic acidemia. (PubMed id 15059621)^{1, 3, 4} Yang X.... Ohura T. (2004)
Effect of PCCB gene mutations on the heteromeric and homomeric assembly of propionyl-CoA carboxylase. (PubMed id 11749052)^{1, 3, 4} Muro S.... Ugarte M. (2001)
Propionic acidemia: identification of twenty-four novel mutations in Europe and North America. (PubMed id 12559849)^{1, 3, 4} Perez B.... Ugarte M. (2003)
Identification of novel mutations in the PCCB gene in European propionic acidemia patients. (PubMed id 10447268)^{1, 3, 4} Muro S.... Ugarte M. (1999)
Human propionyl-CoA carboxylase beta subunit gene: exon-intron definition and mutation spectrum in Spanish and Latin American propionic acidemia patients. (PubMed id 9683601)^{1, 3, 4} Rodriguez-Pombo P.... Ugarte M. (1998)
Correction of the metabolic defect in propionic acidemia fibroblasts by microinjection of a full-length cDNA or RNA transcript encoding the propionyl-CoA carboxylase beta subunit. (PubMed id 8188292)^{1, 3, 4} Lamhonwah A.-M.... Gravel R.A. (1994)
Unexpectedly high prevalence of the mild form of propionic acidemia in Japan: presence of a common mutation and possible clinical implications. (PubMed id 12189489)^{1, 3, 4} Yorifuji T.... Nakahata T. (2002)
Three independent mutations in the same exon of the PCCB gene: differences between Caucasian and Japanese propionic acidaemia. (PubMed id 8411997)^{1, 3, 4} Tahara T.... Fenton W.A. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Isolation of cDNA clones coding for the alpha and beta chains of human propionyl-CoA carboxylase: chromosomal assignments and DNA polymorphisms associated with PCCA and PCCB genes. (PubMed id 3460076)^{3, 4} Lamhonwah A.-M.... Gravel R.A. (1986)
Transfection screening for defects in the PCCA and PCCB genes encoding propionyl-CoA carboxylase subunits. (PubMed id 11914040)¹ Rodriguez-Pombo P....Rodriguez-Pombo P. (2002)
Three novel splice mutations in the PCCA gene causing identical exon skipping in propionic acidemia patients. (PubMed id 9385377)¹ Richard E....Ugarte M. (1997)
High frequency of large genomic deletions in the PCCA gene causing propionic acidemia. (PubMed id 19157943)¹ Desviat L.R....Ugarte M. (2009)
Functional characterization of PCCA mutations causing propionic acidemia. (PubMed id 12385775)¹ Clavero S....Desviat L.R. (2002)
Structure of the PCCA gene and distribution of mutations causing propionic acidemia. (PubMed id 11592820)¹ Campeau E....Gravel R.A. (2001)
Detection of a normally rare transcript in propionic acidemia patients with mRNA destabilizing mutations in the PCCA gene. (PubMed id 9887338)¹ Campeau E....Gravel R.A. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Search String
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5096	HGNC: 8654	AceView: PCCB	Ensembl:ENSG00000114054	euGenes: HUgn5096
ECgene: PCCB	H-InvDB: PCCB

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=PCCB

Licensable Technologies for PCCB
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PCCB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PCCB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PCCB		Antibodies for PCCB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PCCB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PCCB)
	Antibodies (PCCB)
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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for PCCB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PCCB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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PCCB Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for PCCB

Summaries
for PCCB

Genomic Location
for PCCB

Proteins
for PCCB

Protein Domains/
Families
for PCCB

Gene Function
for PCCB

Pathways & Interactions
for PCCB

Drugs & Compounds
for PCCB

Transcripts
for PCCB

Expression
for PCCB

Orthologs
for PCCB

Paralogs
for PCCB

SNPs/Variants
for PCCB

Disorders & Mutations
for PCCB

Medical News
for PCCB

Publications
for PCCB

Search for PCCB

Genome Databases showing PCCB

Other Databases showing PCCB

Specialized Databases showing PCCB

Licensable Technologies
for PCCB

Services
for PCCB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PCCB Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor PCCB

Summariesfor PCCB

Genomic Locationfor PCCB

Proteinsfor PCCB

Protein Domains/Familiesfor PCCB

Gene Functionfor PCCB

Pathways & Interactionsfor PCCB

Drugs & Compoundsfor PCCB

Transcriptsfor PCCB

Expression for PCCB

Orthologsfor PCCB

Paralogsfor PCCB

SNPs/Variantsfor PCCB

Disorders & Mutationsfor PCCB

Medical Newsfor PCCB

Publicationsfor PCCB

Search for PCCB

Genome Databases showing PCCB

Other Databases showing PCCB

Specialized Databases showing PCCB

Licensable Technologiesfor PCCB

Servicesfor PCCB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PCCB

Summaries
for PCCB

Genomic Location
for PCCB

Proteins
for PCCB

Protein Domains/
Families
for PCCB

Gene Function
for PCCB

Pathways & Interactions
for PCCB

Drugs & Compounds
for PCCB

Transcripts
for PCCB

Expression
for PCCB

Orthologs
for PCCB

Paralogs
for PCCB

SNPs/Variants
for PCCB

Disorders & Mutations
for PCCB

Medical News
for PCCB

Publications
for PCCB

Licensable Technologies
for PCCB

Services
for PCCB