PCCB Gene
protein-coding GIFtS: 65
GCID: GC03P135969
|
|
propionyl CoA carboxylase, beta polypeptide(Previous names: propionyl Coenzyme A carboxylase, beta polypeptide )
| |
Aliases
for PCCB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Propionyl CoA Carboxylase, Beta Polypeptide1 2 | | Propionyl Coenzyme A Carboxylase, Beta Polypeptide1 2 | | Propanoyl-CoA:Carbon Dioxide Ligase Subunit Beta2 3 | | PCCase Subunit Beta2 3 | | EC 6.4.1.33 8 | | Propionyl-CoA Carboxylase Beta Chain, Mitochondrial2 |
Export aliases for PCCB gene to outside databasesPrevious GC identifers: GC03U990060 GC03P136720 GC03P137250 GC03P137290 GC03P137451 GC03P133346 |
Summaries
for PCCB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PCCB:
The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in thecatabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits andsix beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemiatype II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene.(provided byRefSeq, May 2010)
|
Genomic Views
for PCCB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PCCB gene promoter:
STAT5B GR NF-1 STAT5A FOXL1 HSF2 FOXO1a STAT3 GR-alpha FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PCCB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCCB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21-q22 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q21-q22PCCB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P135969: view genomic region
(about GC identifiers)
Start:
|
135,969,148 bp from pter |
End:
|
136,056,738 bp from pter |
Size:
|
87,591 bases |
Orientation:
|
plus strand |
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Proteins
for PCCB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166 (See
protein sequence)Recommended Name: Propionyl-CoA carboxylase beta chain, mitochondrial precursor Size: 539 amino acids; 58216 Da
Subunit: Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits
Subcellular location: Mitochondrion matrix
Secondary accessions: B7Z2Z4 Q16813 Q96CX0Alternative splicing: 2 isoforms: P05166-1 P05166-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PCCB: NX_P05166
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P05166
4/15 DME Specific Peptides for PCCB (P05166) (see all 15)
PCCB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000523.2 NP_001171485.1
ENSEMBL proteins: ENSP00000251654 ENSP00000418307 ENSP00000420639 ENSP00000419129 ENSP00000420391 ENSP00000420158 ENSP00000417937 ENSP00000417253 ENSP00000417549 ENSP00000419027 ENSP00000419263 ENSP00000420759 ENSP00000419563 ENSP00000418020 ENSP00000419293 Reactome Protein details: P05166
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PCCB for ontologies About GeneDecksing
PCCB Antibody Products:
Assay Products for PCCB: |
Protein
Domains /
Families
for PCCB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PCCB for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P05166ProtoNet protein and cluster: P05166 1 Blocks protein family: IPB000022 Carboxyl transferase family
UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166Similarity: Belongs to the AccD/PCCB familySimilarity: Contains 1 carboxyltransferase domain |
Function
for PCCB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166Catalytic activity: ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA Genatlas biochemistry entry for PCCB:propionyl-CoA carboxylase,beta polypeptide,biotin-dependent,mitochondrial conversion of propionyl CoA TO methylmalonylCoA,branched chain valine,isoleucine catabolism,energy pathway
Enzyme Number (IUBMB): EC 6.4.1.31 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCCB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCCB (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PCCB (NM_000532) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCCB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCCB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCCB |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PCCB for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for PCCB:
|
Pathways & Interactions
for PCCB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Branched-chain amino acid catabolism | | | 3 | Glyoxylate and dicarboxylate metabolism | | | 4 | Propionyl-CoA catabolism | | | 5 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for PCCB
4 
Kegg Pathways (Kegg details for PCCB):
UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166Pathway: Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3
PCCB for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCCB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/250 Interacting proteins for PCCB (P051662, 3 ENSP000002516544) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006633 | fatty acid biosynthetic process |
-- | -- | | GO:0006635 | fatty acid beta-oxidation |
TAS | -- | | GO:0019626 | short-chain fatty acid catabolic process |
TAS | -- | | GO:0044255 | cellular lipid metabolic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
PCCB for ontologies About GeneDecksing
|
Drugs & Compounds
for PCCB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PCCB for compounds About GeneDecksing
 Browse Tocris compounds for PCCB
8 HMDB Compounds for PCCB About this table
2 DrugBank Compounds for PCCB About this table
3 Novoseek chemical compound relationships for PCCB gene About this table
Search CenterWatch for drugs/clinical trials and news about PCCB
|
Transcripts
for PCCB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PCCB gene (2 alternative transcripts): NM_000532.4 NM_001178014.1 Unigene Cluster for PCCB: Propionyl CoA carboxylase, beta polypeptide Hs.63788 [show with all ESTs]Unigene Representative Sequence: AB20900918/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000251654(uc003eqy.2) ENST00000490504 ENST00000483687 ENST00000468777
ENST00000462637 ENST00000466072 ENST00000484181 ENST00000482086 ENST00000471595(uc003eqz.1)
ENST00000469217(uc011bmc.2) ENST00000465423 ENST00000478469 ENST00000474833
ENST00000462542 ENST00000494742 ENST00000459873 ENST00000475214(uc011bmd.1)
ENST00000465176
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCCB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCCB (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PCCB (NM_000532) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCCB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCCB |
Additional cDNA sequence: AB209009.1 AF251189.1 AF251191.1 AK130359.1 AK225215.1 AK225733.1 AK295312.1 AK302522.1 AK303079.1 AL831978.2 BC005909.1 BC013768.1 BC018013.1 BC053661.1 M13573.1 S67325.1 X73424.1 24 DOTS entries: DT.415386 DT.95335905 DT.92441646 DT.95283426 DT.101964909 DT.101984718 DT.97865771 DT.120900467 DT.120900469 DT.101984715 DT.101984719 DT.75185376 DT.100045524 DT.100720585 DT.92441652 DT.95283416 DT.100045521 DT.95283423 DT.95283427 DT.95317646 DT.120900475 DT.120900535 DT.446736 DT.97811438 24/272 AceView cDNA sequences (see all 272): CD014123 AI581822 BU616909 CR614392 BE670742 CD014040 CR618864 BI831455 BG674836 BP348752 CR609162 BM746314 CR601703 AK130359 CB159480 AU119871 AA862459 BF982603 CD014043 AA680161 BU849561 CD238580 BU619099 BE408707
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PCCB (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | |
| ExUns: | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for PCCB
|
Expression
for PCCB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PCCB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACCTGGGA
About this image
See PCCB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PCCB
SOURCE GeneReport for Unigene cluster: Hs.63788
SABiosciences Custom PCR Arrays for PCCB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCCB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PCCB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCCB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCCB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCCB |
Orthologs
for PCCB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PCCB gene from 5/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PCCB1 |
propionyl CoA carboxylase, beta polypeptide |
77.65(n)
87.3(a) |
|
768706 XM_001231793.2 XP_001231794.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PCCB6 |
-- |
83(a) |
1 ↔ 1 |
3(34793248-34814923) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC686502 |
propionyl-CoA carboxylase |
76.59(n) |
|
BC046371.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.115182 |
Danio rerio cDNA clone IMAGE3815270 |
76.58(n) |
|
BC058325.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F52E4.1a3
pccb-11 |
propionyl-CoA carboxylase beta3
Protein PCCB-11 |
75(a)
(best of 2)3
67.32(n)1
76.32(a)1 |
|
X(3125737-3127511)3
1805961 NM_171648.21 NP_741743.11 |
ENSEMBL Gene Tree for PCCB (if available)
TreeFam Gene Tree for PCCB (if available) |
Paralogs
for PCCB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PCCB gene
- MCCC22
3 SIMAP similar genes for PCCB using alignment to 15 protein entries: PCCB_HUMAN (see all proteins):DKFZp451E113 L3MBTL2 MCCC2
PCCB for paralogs About GeneDecksing
|
Genomic Variants
for PCCB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PCCB (135969148 - 136056738 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for PCCB
6 CNVs: 63598 36071 91582 36070 6211 62105
1 Indel: 27164
Human Gene Mutation Database (HGMD): PCCB
Locus Specific Mutation Databases (LSDB): PCCB
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCCB |
|
Disorders
/ Diseases
for PCCB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PCCB for disorders About GeneDecksing
OMIM gene information: 232050
OMIM disorders: 606054
UniProtKB/Swiss-Prot: PCCB_HUMAN, P05166
Defects in PCCB are the cause of propionic acidemia type II (PA-2) [MIM:606054]. PA-2 is a life-threateningdisease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia,hypogammaglobulinemia, developmental retardation, and intolerance to protein
9  diseases for PCCB: About MalaCardspropionic acidemia blepharophimosis, ptosis, and epicanthus inversus syndrome biotinidase deficiency blepharophimosis
metabolic disorders ptosis neutropenia cholesterol
adenocarcinoma
1 disease from the University of Copenhagen DISEASES database for PCCB:Propionic acidemia 3 Novoseek disease relationships for PCCB gene About this table
Genatlas disease: PCCB hyperglycinemia,ketotic,propionic acidemia B
Human Genome Epidemiology (HuGE) Navigator: PCCB (6 documents)
Export disorders for PCCB gene to outside databases
|
Publications
for PCCB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PCCB gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with PCCB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Overview of mutations in the PCCA and PCCB genes causing propionic acidemia. (PubMed id 10502773)1, 2, 9 Ugarte M.... Gravel R.A. (1999)
- Mutation spectrum of the PCCA and PCCB genes in Japanese patients with propionic acidemia. (PubMed id 15059621)1, 2, 9 Yang X.... Ohura T. (2004)
- Effect of PCCB gene mutations on the heteromeric and homomeric assembly of propionyl-CoA carboxylase. (PubMed id 11749052)1, 2, 9 Muro S.... Ugarte M. (2001)
- Propionic acidemia: identification of twenty-four novel mutations in Europe and North America. (PubMed id 12559849)1, 2, 9 Perez B.... Ugarte M. (2003)
- Identification of novel mutations in the PCCB gene in European propionic acidemia patients. (PubMed id 10447268)1, 2, 9 Muro S.... Ugarte M. (1999)
- Human propionyl-CoA carboxylase beta subunit gene: exon-intron definition and mutation spectrum in Spanish and Latin American propionic acidemia patients. (PubMed id 9683601)1, 2, 9 Rodriguez-Pombo P.... Ugarte M. (1998)
- Correction of the metabolic defect in propionic acidemia fibroblasts by microinjection of a full-length cDNA or RNA transcript encoding the propionyl-CoA carboxylase beta subunit. (PubMed id 8188292)1, 2, 9 Lamhonwah A.-M.... Gravel R.A. (1994)
- Unexpectedly high prevalence of the mild form of propionic acidemia in Japan: presence of a common mutation and possible clinical implications. (PubMed id 12189489)1, 2, 9 Yorifuji T.... Nakahata T. (2002)
- Three independent mutations in the same exon of the PCCB gene: differences between Caucasian and Japanese propionic acidaemia. (PubMed id 8411997)1, 2, 9 Tahara T.... Fenton W.A. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for PCCB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PCCB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PCCB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PCCB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for PCCB | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PCCB |
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About This Section
| Patent Information for PCCB gene:
Search GeneIP for patents involving PCCB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PCCB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for PCCB | | OriGene shRNA RFP for PCCB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PCCB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCCB | | | OriGene Protein Over-expression Lysate for PCCB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PCCB | | OriGene 3'-UTR Clone for PCCB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCCB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCCB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PCCB | | OriGene Custom Protein Services for PCCB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PCCB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCCB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCCB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCCB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCCB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCCB |
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| | | | Search Tocris compounds for PCCB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCCB |
|  |  |  | | | | ThermoFisher Antibody for PCCB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCCB |
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