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Aliases for PCBP4 Gene

Aliases for PCBP4 Gene

  • Poly(RC) Binding Protein 4 2 3 5
  • RNA Binding Protein MCG10 2 3
  • LYST-Interacting Protein 2 3
  • Alpha-CP4 3 4
  • Poly(RC)-Binding Protein 4 2
  • AlphaCP-4 Protein 2
  • MCG10 3
  • LIP4 3
  • CBP 3

External Ids for PCBP4 Gene

Previous GeneCards Identifiers for PCBP4 Gene

  • GC03M051084
  • GC03M051245
  • GC03M051848
  • GC03M051950
  • GC03M051967

Summaries for PCBP4 Gene

Entrez Gene Summary for PCBP4 Gene

  • This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCBP4 Gene

PCBP4 (Poly(RC) Binding Protein 4) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle Checkpoints. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for PCBP4 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

Gene Wiki entry for PCBP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCBP4 Gene

Genomics for PCBP4 Gene

Regulatory Elements for PCBP4 Gene

Enhancers for PCBP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCBP4 on UCSC Golden Path with GeneCards custom track

Promoters for PCBP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCBP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCBP4 Gene

Chromosome:
3
Start:
51,957,454 bp from pter
End:
51,974,016 bp from pter
Size:
16,563 bases
Orientation:
Minus strand

Genomic View for PCBP4 Gene

Genes around PCBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP4 Gene

Proteins for PCBP4 Gene

  • Protein details for PCBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57723-PCBP4_HUMAN
    Recommended name:
    Poly(rC)-binding protein 4
    Protein Accession:
    P57723
    Secondary Accessions:
    • Q96AH7

    Protein attributes for PCBP4 Gene

    Size:
    403 amino acids
    Molecular mass:
    41482 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCBP4 Gene

Proteomics data for PCBP4 Gene at MOPED

Post-translational modifications for PCBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PCBP4 Gene

Domains & Families for PCBP4 Gene

Protein Domains for PCBP4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P57723

UniProtKB/Swiss-Prot:

PCBP4_HUMAN :
  • Contains 3 KH domains.
Domain:
  • Contains 3 KH domains.
genes like me logo Genes that share domains with PCBP4: view

No data available for Gene Families for PCBP4 Gene

Function for PCBP4 Gene

Molecular function for PCBP4 Gene

UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

Gene Ontology (GO) - Molecular Function for PCBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,NAS 10936052
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PCBP4: view
genes like me logo Genes that share phenotypes with PCBP4: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCBP4 Gene

Localization for PCBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCBP4 Gene COMPARTMENTS Subcellular localization image for PCBP4 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1
extracellular 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PCBP4 Gene

Pathways & Interactions for PCBP4 Gene

genes like me logo Genes that share pathways with PCBP4: view

Pathways by source for PCBP4 Gene

Gene Ontology (GO) - Biological Process for PCBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043488 regulation of mRNA stability IDA 20817677
genes like me logo Genes that share ontologies with PCBP4: view

No data available for SIGNOR curated interactions for PCBP4 Gene

Drugs & Compounds for PCBP4 Gene

No Compound Related Data Available

Transcripts for PCBP4 Gene

Unigene Clusters for PCBP4 Gene

Poly(rC) binding protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^
SP1:
SP2:
SP3:
SP4: - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8:
SP9: - - - -
SP10: - -
SP11:
SP12: - - -
SP13: -
SP14: - - - -
SP15: - - -
SP16: - -
SP17: - -

ExUns: 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
SP1:
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PCBP4 Gene

GeneLoc Exon Structure for
PCBP4
ECgene alternative splicing isoforms for
PCBP4

Expression for PCBP4 Gene

mRNA expression in normal human tissues for PCBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCBP4 Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for PCBP4 Gene

This gene is overexpressed in Retina (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCBP4 Gene



SOURCE GeneReport for Unigene cluster for PCBP4 Gene Hs.20930

genes like me logo Genes that share expression patterns with PCBP4: view

Protein tissue co-expression partners for PCBP4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PCBP4 Gene

Orthologs for PCBP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PCBP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCBP4 35
  • 92.8 (n)
  • 97.52 (a)
PCBP4 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PCBP4 35
  • 93.05 (n)
  • 98.01 (a)
-- 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pcbp4 35
  • 92.06 (n)
  • 97.52 (a)
Pcbp4 16
Pcbp4 36
  • 98 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PCBP4 35
  • 99.67 (n)
  • 100 (a)
-- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pcbp4 35
  • 92.06 (n)
  • 97.77 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii wufc68f03 35
zgc:65870 35
  • 66.24 (n)
  • 65.63 (a)
PCBP4 36
  • 55 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL018C 35
  • 46.69 (n)
  • 32.12 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10703g 35
  • 41.12 (n)
  • 29.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 35
  • 42.15 (n)
  • 33.55 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09237 35
  • 49.25 (n)
  • 38.75 (a)
Species with no ortholog for PCBP4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCBP4 Gene

ENSEMBL:
Gene Tree for PCBP4 (if available)
TreeFam:
Gene Tree for PCBP4 (if available)

Paralogs for PCBP4 Gene

Paralogs for PCBP4 Gene

genes like me logo Genes that share paralogs with PCBP4: view

Variants for PCBP4 Gene

Sequence variations from dbSNP and Humsavar for PCBP4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs323872 - 51,959,411(-) CACAG(A/G)GCTTC reference, missense
rs323873 -- 51,959,709(-) GGCAG(C/T)TGGGG intron-variant
rs323874 -- 51,960,571(-) ACAGC(A/G)GCTGT reference, synonymous-codon
rs323875 -- 51,964,576(-) TTTGG(G/T)AGTGG intron-variant, upstream-variant-2KB
rs323876 -- 51,965,422(-) GTGGC(A/G)TTTGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PCBP4 Gene

Variant ID Type Subtype PubMed ID
nsv520211 CNV Gain 19592680
nsv508922 CNV Insertion 20534489
nsv876780 CNV Loss 21882294
dgv5134n71 CNV Loss 21882294
dgv5135n71 CNV Loss 21882294

Variation tolerance for PCBP4 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 59.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCBP4 Gene

HapMap Linkage Disequilibrium report
PCBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCBP4 Gene

Disorders for PCBP4 Gene

Relevant External Links for PCBP4

Genetic Association Database (GAD)
PCBP4
Human Genome Epidemiology (HuGE) Navigator
PCBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCBP4

No disorders were found for PCBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCBP4 Gene

Publications for PCBP4 Gene

  1. Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. (PMID: 10936052) Makeyev A.V. … Liebhaber S.A. (Genomics 2000) 2 3 4 23 67
  2. Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer. (PMID: 15205328) Pio R. … Montuenga L.M. (Cancer Res. 2004) 3 23
  3. MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M. (PMID: 10891498) Zhu J. … Chen X. (Mol. Cell. Biol. 2000) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin. (PMID: 23640898) Leidgens S. … Philpott C.C. (J. Biol. Chem. 2013) 3

Products for PCBP4 Gene

Sources for PCBP4 Gene

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