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Aliases for PCBP4 Gene

Aliases for PCBP4 Gene

  • Poly(RC) Binding Protein 4 2 3 5
  • Poly(RC)-Binding Protein 4 2 3
  • RNA Binding Protein MCG10 2 3
  • LYST-Interacting Protein 2 3
  • Alpha-CP4 3 4
  • AlphaCP-4 Protein 2
  • MCG10 3
  • LIP4 3
  • CBP 3

External Ids for PCBP4 Gene

Previous GeneCards Identifiers for PCBP4 Gene

  • GC03M051084
  • GC03M051245
  • GC03M051848
  • GC03M051950
  • GC03M051967

Summaries for PCBP4 Gene

Entrez Gene Summary for PCBP4 Gene

  • This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCBP4 Gene

PCBP4 (Poly(RC) Binding Protein 4) is a Protein Coding gene. Among its related pathways are Transcriptional activation of cell cycle inhibitor p21 and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for PCBP4 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

Gene Wiki entry for PCBP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCBP4 Gene

Genomics for PCBP4 Gene

Regulatory Elements for PCBP4 Gene

Enhancers for PCBP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G052044 2 FANTOM5 Ensembl ENCODE dbSUPER 11 -77.6 -77607 14.0 HDGF FOXA2 PKNOX1 CREB3L1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 ZNF416 GPR62 RAD54L2 NT5DC2 RPL29 DUSP7 PCBP4 WDR82 TWF2 ACY1 LOC105377089
GH03G052040 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11 -66.0 -66038 1.1 DMAP1 RARA EGR1 PCBP1 CREM THAP11 SP5 NFYC CEBPB MIER2 GPR62 RPL29 PCBP4 LOC105377088 LOC105377089
GH03G052108 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -135.5 -135472 2.9 HDGF CTCF MXI1 RB1 SIN3A ARID4B RAD21 NCOR1 SCRT2 ZNF143 DUSP7 ABHD14B ABHD14A-ACY1 PCBP4 ABHD14A GPR62 WDR82 GLYCTK MIR135A1 GLYCTK-AS1
GH03G052086 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -115.5 -115548 6.2 HDGF RB1 ARID4B ZSCAN9 RAD21 EGR1 SCRT2 ZNF143 FOS RELB GPR62 DUSP7 PCBP4 ABHD14B PPM1M GLYCTK LINC00696 POC1A
GH03G052187 1.4 Ensembl ENCODE dbSUPER 10 -215.5 -215513 3.6 HDAC1 PKNOX1 TBL1XR1 NFIB YY1 TCF12 ZNF766 GATA2 EGR2 SMARCA5 POC1A DUSP7 GLYCTK WDR82 MIR135A1 GLYCTK-AS1 PCBP4 GPR62 PBRM1 RFT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCBP4 on UCSC Golden Path with GeneCards custom track

Promoters for PCBP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152458 -134 1201 AGO1 SIN3A ARID4B ZNF48 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 ZNF143

Genomic Location for PCBP4 Gene

Chromosome:
3
Start:
51,957,454 bp from pter
End:
51,974,016 bp from pter
Size:
16,563 bases
Orientation:
Minus strand

Genomic View for PCBP4 Gene

Genes around PCBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP4 Gene

Proteins for PCBP4 Gene

  • Protein details for PCBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57723-PCBP4_HUMAN
    Recommended name:
    Poly(rC)-binding protein 4
    Protein Accession:
    P57723
    Secondary Accessions:
    • Q96AH7

    Protein attributes for PCBP4 Gene

    Size:
    403 amino acids
    Molecular mass:
    41482 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCBP4 Gene

Post-translational modifications for PCBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCBP4 Gene

Domains & Families for PCBP4 Gene

Protein Domains for PCBP4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCBP4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PCBP4 Gene

Function for PCBP4 Gene

Molecular function for PCBP4 Gene

UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

Gene Ontology (GO) - Molecular Function for PCBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding NAS 10936052
GO:0003730 mRNA 3-UTR binding IDA 20817677
genes like me logo Genes that share ontologies with PCBP4: view
genes like me logo Genes that share phenotypes with PCBP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCBP4 Gene

Localization for PCBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCBP4 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PCBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with PCBP4: view

Pathways & Interactions for PCBP4 Gene

genes like me logo Genes that share pathways with PCBP4: view

Pathways by source for PCBP4 Gene

Gene Ontology (GO) - Biological Process for PCBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0043488 regulation of mRNA stability IDA 20817677
genes like me logo Genes that share ontologies with PCBP4: view

No data available for SIGNOR curated interactions for PCBP4 Gene

Drugs & Compounds for PCBP4 Gene

No Compound Related Data Available

Transcripts for PCBP4 Gene

Unigene Clusters for PCBP4 Gene

Poly(rC) binding protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^
SP1:
SP2:
SP3:
SP4: - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8:
SP9: - - - -
SP10: - -
SP11:
SP12: - - -
SP13: -
SP14: - - - -
SP15: - - -
SP16: - -
SP17: - -

ExUns: 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
SP1:
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PCBP4 Gene

GeneLoc Exon Structure for
PCBP4
ECgene alternative splicing isoforms for
PCBP4

Expression for PCBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCBP4 Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for PCBP4 Gene

This gene is overexpressed in Retina (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCBP4 Gene



Protein tissue co-expression partners for PCBP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCBP4 Gene:

PCBP4

SOURCE GeneReport for Unigene cluster for PCBP4 Gene:

Hs.20930

Evidence on tissue expression from TISSUES for PCBP4 Gene

  • Nervous system(5)
  • Lung(4.3)
  • Eye(4.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with PCBP4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCBP4 Gene

Orthologs for PCBP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PCBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCBP4 34
  • 99.67 (n)
-- 35
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
OneToMany
PCBP4 34
  • 93.05 (n)
cow
(Bos Taurus)
Mammalia PCBP4 34 35
  • 92.8 (n)
mouse
(Mus musculus)
Mammalia Pcbp4 34 16 35
  • 92.06 (n)
rat
(Rattus norvegicus)
Mammalia Pcbp4 34
  • 92.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 80 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:65870 34
  • 66.24 (n)
PCBP4 35
  • 55 (a)
OneToMany
wufc68f03 34
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL018C 34
  • 46.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 34
  • 42.15 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10703g 34
  • 41.12 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09237 34
  • 49.25 (n)
Species where no ortholog for PCBP4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCBP4 Gene

ENSEMBL:
Gene Tree for PCBP4 (if available)
TreeFam:
Gene Tree for PCBP4 (if available)

Paralogs for PCBP4 Gene

Paralogs for PCBP4 Gene

genes like me logo Genes that share paralogs with PCBP4: view

Variants for PCBP4 Gene

Sequence variations from dbSNP and Humsavar for PCBP4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000387144 -- 51,962,201(+) ACTTA(C/T)AAAAT intron-variant
rs1000596514 -- 51,966,673(+) GGGGC(C/T)GGGTG intron-variant
rs1000651797 -- 51,957,116(+) GCCAA(G/T)CAGGG downstream-variant-500B, utr-variant-3-prime
rs1000663011 -- 51,959,748(+) CCAGG(A/G)AAATG intron-variant
rs1000814477 -- 51,963,546(+) CTGAC(A/T)TTGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PCBP4 Gene

Variant ID Type Subtype PubMed ID
esv3365586 CNV duplication 20981092
nsv1003453 CNV gain 25217958
nsv1073642 CNV deletion 25765185
nsv508922 CNV insertion 20534489
nsv520211 CNV gain 19592680
nsv954857 CNV deletion 24416366

Variation tolerance for PCBP4 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 59.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCBP4 Gene

Disorders for PCBP4 Gene

Relevant External Links for PCBP4

Genetic Association Database (GAD)
PCBP4
Human Genome Epidemiology (HuGE) Navigator
PCBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCBP4

No disorders were found for PCBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCBP4 Gene

Publications for PCBP4 Gene

  1. Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. (PMID: 10936052) Makeyev A.V. … Liebhaber S.A. (Genomics 2000) 2 3 4 22 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer. (PMID: 15205328) Pio R. … Montuenga L.M. (Cancer Res. 2004) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PCBP4 Gene

Sources for PCBP4 Gene

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