Aliases for PCBP4 Gene
External Ids for PCBP4 Gene
Previous GeneCards Identifiers for PCBP4 Gene
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCBP4 Gene
PCBP4 (Poly(RC) Binding Protein 4) is a Protein Coding gene. Among its related pathways are Transcriptional activation of cell cycle inhibitor p21 and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP3.
UniProtKB/Swiss-Prot for PCBP4 Gene
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.