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Aliases for PCBP2 Gene

Aliases for PCBP2 Gene

  • Poly(RC) Binding Protein 2 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein E2 3 4
  • Heterogenous Nuclear Ribonucleoprotein E2 2 3
  • Poly(RC)-Binding Protein 2 2 3
  • Alpha-CP2 3 4
  • HnRNP E2 3 4
  • HnRNP-E2 3
  • HNRNPE2 3
  • HNRPE2 3

External Ids for PCBP2 Gene

Previous GeneCards Identifiers for PCBP2 Gene

  • GC12P053844
  • GC12P053960
  • GC12P053562
  • GC12P052132
  • GC12P050885

Summaries for PCBP2 Gene

Entrez Gene Summary for PCBP2 Gene

  • The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCBP2 Gene

PCBP2 (Poly(RC) Binding Protein 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Innate Immune System. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP1.

UniProtKB/Swiss-Prot for PCBP2 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).

  • (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Gene Wiki entry for PCBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCBP2 Gene

Genomics for PCBP2 Gene

Regulatory Elements for PCBP2 Gene

Enhancers for PCBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G053415 1 Ensembl ENCODE 12.8 -36.7 -36670 1.3 CTCF PKNOX1 TAL1 RAD21 TCF12 SLC30A9 ZFHX2 NCOR1 ZBTB48 CREM PRR13 PCBP2 SP7 AAAS TARBP2 MAP3K12 NPFF C12orf10 PFDN5 GC12M053411
GH12G053414 0.8 ENCODE 12.8 -37.7 -37734 0.2 SAP130 MAX THRB ZNF644 RAD21 YY1 TEAD3 RARA SLC30A9 NR2F6 PRR13 PCBP2 AAAS TARBP2 MAP3K12 C12orf10 PFDN5 GC12P053422 GC12M053411
GH12G052964 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -487.0 -486958 1.7 ESRRA ZNF687 NFIB DDX20 TEAD4 DPF2 PTTG1 ZBTB40 NR2F2 ZNF592 KRT78 KRT79 KRT84 KRT86 KRT71 KRT4 KRT87P PCBP2 AMHR2 KRT18
GH12G053755 0.9 FANTOM5 ENCODE 1.7 +303.8 303843 0.5 SCRT1 CTCF PKNOX1 SCRT2 PRDM10 ZIC2 ETS1 PCBP2 ATP5G2 HOXC11 HOXC13 LOC105378250 CISTR
GH12G053452 1.2 ENCODE 0.7 +0.8 830 3.1 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MAP3K12 SP1 AAAS AMHR2 ENSG00000258344 TARBP2 NPFF PRR13 LOC100652999 C12orf10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCBP2 on UCSC Golden Path with GeneCards custom track

Promoters for PCBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052197 498 2001 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for PCBP2 Gene

Chromosome:
12
Start:
53,452,102 bp from pter
End:
53,481,162 bp from pter
Size:
29,061 bases
Orientation:
Plus strand

Genomic View for PCBP2 Gene

Genes around PCBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP2 Gene

Proteins for PCBP2 Gene

  • Protein details for PCBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15366-PCBP2_HUMAN
    Recommended name:
    Poly(rC)-binding protein 2
    Protein Accession:
    Q15366
    Secondary Accessions:
    • A8K7X6
    • B4DXP5
    • F8VYL7
    • G3V0E8
    • I6L8F9
    • Q32Q82
    • Q59HD4
    • Q68Y55
    • Q6IPF4
    • Q6PKG5

    Protein attributes for PCBP2 Gene

    Size:
    365 amino acids
    Molecular mass:
    38580 Da
    Quaternary structure:
    • Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with IFIH1 and RNF135. Interacts with MAVS (via C-terminus) and ITCH (via WW domains).
    SequenceCaution:
    • Sequence=BAD92062.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCBP2 Gene

    Alternative splice isoforms for PCBP2 Gene

neXtProt entry for PCBP2 Gene

Post-translational modifications for PCBP2 Gene

  • (Microbial infection) Proteolyticaly cleaved by picornavirus proteinase 3CD.
  • Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
  • Ubiquitination at Lys78, posLast=115115, and posLast=322322
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PCBP2 (hnRNP E2)

No data available for DME Specific Peptides for PCBP2 Gene

Domains & Families for PCBP2 Gene

Protein Domains for PCBP2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15366

UniProtKB/Swiss-Prot:

PCBP2_HUMAN :
  • The KH domains mediates poly(C) binding.
Domain:
  • The KH domains mediates poly(C) binding.
genes like me logo Genes that share domains with PCBP2: view

No data available for Gene Families for PCBP2 Gene

Function for PCBP2 Gene

Molecular function for PCBP2 Gene

GENATLAS Biochemistry:
poly(rC)-binding protein 2,expressed in keratinocytes and other cells
UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Gene Ontology (GO) - Molecular Function for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA 7607214
GO:0005515 protein binding IPI 16713569
GO:0019899 enzyme binding IPI 19881509
genes like me logo Genes that share ontologies with PCBP2: view
genes like me logo Genes that share phenotypes with PCBP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCBP2 Gene

Localization for PCBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP2 Gene

Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCBP2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 19029303
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PCBP2: view

Pathways & Interactions for PCBP2 Gene

genes like me logo Genes that share pathways with PCBP2: view

Pathways by source for PCBP2 Gene

2 Cell Signaling Technology pathways for PCBP2 Gene
1 BioSystems pathway for PCBP2 Gene
1 KEGG pathway for PCBP2 Gene

Gene Ontology (GO) - Biological Process for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0002376 immune system process IEA --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process TAS --
GO:0016071 mRNA metabolic process NAS 7556077
genes like me logo Genes that share ontologies with PCBP2: view

No data available for SIGNOR curated interactions for PCBP2 Gene

Drugs & Compounds for PCBP2 Gene

(1) Drugs for PCBP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PCBP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PCBP2: view

Transcripts for PCBP2 Gene

Unigene Clusters for PCBP2 Gene

Poly(rC) binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - - -
SP15: - - - - -
SP16: - - - - - - - -
SP17: -
SP18: - -
SP19:
SP20:
SP21:
SP22:

ExUns: 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP8: - -
SP9:
SP10:
SP11: -
SP12: - -
SP13: - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:
SP22:

Relevant External Links for PCBP2 Gene

GeneLoc Exon Structure for
PCBP2
ECgene alternative splicing isoforms for
PCBP2

Expression for PCBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCBP2 Gene



Protein tissue co-expression partners for PCBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCBP2 Gene:

PCBP2

SOURCE GeneReport for Unigene cluster for PCBP2 Gene:

Hs.546271

mRNA Expression by UniProt/SwissProt for PCBP2 Gene:

Q15366-PCBP2_HUMAN
Tissue specificity: Detected in all tissues examined.

Evidence on tissue expression from TISSUES for PCBP2 Gene

  • Liver(4.8)
  • Lung(4.8)
  • Nervous system(4.8)
  • Eye(4.7)
  • Blood(3.7)
  • Intestine(3.6)
  • Skin(2.7)
  • Bone marrow(2.4)
  • Kidney(2.3)
  • Lymph node(2.3)
  • Thyroid gland(2.3)
  • Adrenal gland(2.2)
  • Gall bladder(2.2)
  • Muscle(2.2)
  • Spleen(2.2)
  • Stomach(2.2)
  • Heart(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PCBP2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCBP2 Gene

Orthologs for PCBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCBP2 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
OneToMany
PCBP2 34
  • 98.81 (n)
-- 35
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PCBP2 34 35
  • 98.38 (n)
mouse
(Mus musculus)
Mammalia Pcbp2 34 16 35
  • 97.6 (n)
rat
(Rattus norvegicus)
Mammalia Pcbp2 34
  • 97.17 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 93 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC426023 34
  • 89.77 (n)
PCBP2 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCBP2 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcbp3 34
  • 77.97 (n)
Str.8469 34
zebrafish
(Danio rerio)
Actinopterygii pcbp2 34
  • 77.15 (n)
PCBP2 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mub 36
  • 46 (a)
Species where no ortholog for PCBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCBP2 Gene

ENSEMBL:
Gene Tree for PCBP2 (if available)
TreeFam:
Gene Tree for PCBP2 (if available)

Paralogs for PCBP2 Gene

Variants for PCBP2 Gene

Sequence variations from dbSNP and Humsavar for PCBP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000006052 -- 53,454,645(+) AGAAA(A/G)TATTG intron-variant
rs1000042479 -- 53,454,954(+) CATCA(C/G)ATTAG intron-variant
rs1000180832 -- 53,461,302(+) CCTAG(C/T)TTTGA intron-variant
rs1000269022 -- 53,460,905(+) AAGAT(G/T)GGAAA intron-variant
rs1000339968 -- 53,477,895(+) TAATC(A/C)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCBP2 Gene

Variant ID Type Subtype PubMed ID
esv3629541 CNV loss 21293372
nsv714 CNV insertion 18451855

Variation tolerance for PCBP2 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCBP2 Gene

Disorders for PCBP2 Gene

Relevant External Links for PCBP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCBP2

No disorders were found for PCBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCBP2 Gene

Publications for PCBP2 Gene

  1. Structure of a construct of a human poly(C)-binding protein containing the first and second KH domains reveals insights into its regulatory mechanisms. (PMID: 18701464) Du Z. … James T.L. (J. Biol. Chem. 2008) 3 4 22 64
  2. X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. (PMID: 17526645) Du Z. … James T.L. (RNA 2007) 3 4 22 64
  3. Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A. (PMID: 8833161) Tommerup N. … Leffers H. (Genomics 1996) 2 3 22 64
  4. Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication. (PMID: 24371074) Chase A.J. … Semler B.L. (J. Virol. 2014) 3 4 64
  5. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. (PMID: 20211135) Eiring A.M. … Perrotti D. (Cell 2010) 3 22 64

Products for PCBP2 Gene

Sources for PCBP2 Gene

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