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Aliases for PCBP2 Gene

Aliases for PCBP2 Gene

  • Poly(RC) Binding Protein 2 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein E2 3 4
  • Heterogenous Nuclear Ribonucleoprotein E2 2 3
  • Alpha-CP2 3 4
  • HnRNP E2 3 4
  • Poly(RC)-Binding Protein 2 2
  • HnRNP-E2 3
  • HNRNPE2 3
  • HNRPE2 3

External Ids for PCBP2 Gene

Previous GeneCards Identifiers for PCBP2 Gene

  • GC12P053844
  • GC12P053960
  • GC12P053562
  • GC12P052132
  • GC12P050885

Summaries for PCBP2 Gene

Entrez Gene Summary for PCBP2 Gene

  • The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCBP2 Gene

PCBP2 (Poly(RC) Binding Protein 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Immune System. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for PCBP2 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Gene Wiki entry for PCBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCBP2 Gene

Genomics for PCBP2 Gene

Regulatory Elements for PCBP2 Gene

Promoters for PCBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCBP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCBP2 Gene

Chromosome:
12
Start:
53,452,102 bp from pter
End:
53,481,162 bp from pter
Size:
29,061 bases
Orientation:
Plus strand

Genomic View for PCBP2 Gene

Genes around PCBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP2 Gene

Proteins for PCBP2 Gene

  • Protein details for PCBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15366-PCBP2_HUMAN
    Recommended name:
    Poly(rC)-binding protein 2
    Protein Accession:
    Q15366
    Secondary Accessions:
    • A8K7X6
    • B4DXP5
    • F8VYL7
    • G3V0E8
    • I6L8F9
    • Q32Q82
    • Q59HD4
    • Q68Y55
    • Q6IPF4
    • Q6PKG5

    Protein attributes for PCBP2 Gene

    Size:
    365 amino acids
    Molecular mass:
    38580 Da
    Quaternary structure:
    • Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with IFIH1 and RNF135. Interacts with MAVS (via C-terminus) and ITCH (via WW domains).
    SequenceCaution:
    • Sequence=BAD92062.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCBP2 Gene

    Alternative splice isoforms for PCBP2 Gene

neXtProt entry for PCBP2 Gene

Proteomics data for PCBP2 Gene at MOPED

Post-translational modifications for PCBP2 Gene

  • Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
  • Ubiquitination at Lys 78, Lys 115, and Lys 322
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PCBP2 Gene

Domains & Families for PCBP2 Gene

Protein Domains for PCBP2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15366

UniProtKB/Swiss-Prot:

PCBP2_HUMAN :
  • The KH domains mediates poly(C) binding.
Domain:
  • The KH domains mediates poly(C) binding.
  • Contains 3 KH domains.
genes like me logo Genes that share domains with PCBP2: view

No data available for Gene Families for PCBP2 Gene

Function for PCBP2 Gene

Molecular function for PCBP2 Gene

GENATLAS Biochemistry:
poly(rC)-binding protein 2,expressed in keratinocytes and other cells
UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Gene Ontology (GO) - Molecular Function for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with PCBP2: view
genes like me logo Genes that share phenotypes with PCBP2: view

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCBP2 Gene

Localization for PCBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP2 Gene

Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCBP2 Gene COMPARTMENTS Subcellular localization image for PCBP2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19029303
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PCBP2: view

Pathways & Interactions for PCBP2 Gene

genes like me logo Genes that share pathways with PCBP2: view

Pathways by source for PCBP2 Gene

Gene Ontology (GO) - Biological Process for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010467 gene expression TAS --
GO:0045087 innate immune response IEA,TAS --
GO:0050687 negative regulation of defense response to virus IMP 19881509
genes like me logo Genes that share ontologies with PCBP2: view

No data available for SIGNOR curated interactions for PCBP2 Gene

Drugs & Compounds for PCBP2 Gene

(1) Drugs for PCBP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PCBP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PCBP2: view

Transcripts for PCBP2 Gene

Unigene Clusters for PCBP2 Gene

Poly(rC) binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - - -
SP15: - - - - -
SP16: - - - - - - - -
SP17: -
SP18: - -
SP19:
SP20:
SP21:
SP22:

ExUns: 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP8: - -
SP9:
SP10:
SP11: -
SP12: - -
SP13: - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:
SP22:

Relevant External Links for PCBP2 Gene

GeneLoc Exon Structure for
PCBP2
ECgene alternative splicing isoforms for
PCBP2

Expression for PCBP2 Gene

mRNA expression in normal human tissues for PCBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCBP2 Gene



SOURCE GeneReport for Unigene cluster for PCBP2 Gene Hs.546271

mRNA Expression by UniProt/SwissProt for PCBP2 Gene

Q15366-PCBP2_HUMAN
Tissue specificity: Detected in all tissues examined.
genes like me logo Genes that share expression patterns with PCBP2: view

Protein tissue co-expression partners for PCBP2 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PCBP2 Gene

Orthologs for PCBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCBP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCBP2 35
  • 98.38 (n)
  • 99.71 (a)
PCBP2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCBP2 35
  • 98.81 (n)
  • 100 (a)
-- 36
  • 98 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pcbp2 35
  • 97.6 (n)
  • 100 (a)
Pcbp2 16
Pcbp2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCBP2 35
  • 100 (n)
  • 100 (a)
PCBP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcbp2 35
  • 97.17 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC426023 35
  • 89.77 (n)
  • 97.44 (a)
PCBP2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCBP2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcbp3 35
  • 77.97 (n)
  • 91.59 (a)
Str.8469 35
zebrafish
(Danio rerio)
Actinopterygii pcbp2 35
  • 77.15 (n)
  • 89.31 (a)
PCBP2 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mub 37
  • 46 (a)
Species with no ortholog for PCBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCBP2 Gene

ENSEMBL:
Gene Tree for PCBP2 (if available)
TreeFam:
Gene Tree for PCBP2 (if available)

Paralogs for PCBP2 Gene

Paralogs for PCBP2 Gene

Pseudogenes.org Pseudogenes for PCBP2 Gene

genes like me logo Genes that share paralogs with PCBP2: view

Variants for PCBP2 Gene

Sequence variations from dbSNP and Humsavar for PCBP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs729037 -- 53,478,666(+) GGGAG(C/T)GGTGG intron-variant
rs734901 -- 53,479,016(-) GAATA(C/T)CAGTT intron-variant
rs784563 -- 53,472,835(+) ATCTT(G/T)AGGTG intron-variant
rs1716967 -- 53,471,565(+) TGGGG(G/T)GGGGG intron-variant
rs2046432 -- 53,458,290(-) aaAAC(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCBP2 Gene

Variant ID Type Subtype PubMed ID
nsv714 CNV Insertion 18451855

Variation tolerance for PCBP2 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCBP2 Gene

HapMap Linkage Disequilibrium report
PCBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCBP2 Gene

Disorders for PCBP2 Gene

Relevant External Links for PCBP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCBP2

No disorders were found for PCBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCBP2 Gene

Publications for PCBP2 Gene

  1. Structure of a construct of a human poly(C)-binding protein containing the first and second KH domains reveals insights into its regulatory mechanisms. (PMID: 18701464) Du Z. … James T.L. (J. Biol. Chem. 2008) 3 4 23 67
  2. Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A. (PMID: 8833161) Tommerup N. … Leffers H. (Genomics 1996) 2 3 23
  3. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. (PMID: 20211135) Eiring A.M. … Perrotti D. (Cell 2010) 3 23
  4. Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. (PMID: 19211566) Waggoner S.A. … Liebhaber S.A. (J. Biol. Chem. 2009) 3 23
  5. Selective localization of PCBP2 to cytoplasmic processing bodies. (PMID: 19230839) Fujimura K. … Murata M. (Biochim. Biophys. Acta 2009) 3 23

Products for PCBP2 Gene

Sources for PCBP2 Gene

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