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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PCBP1 Gene

protein-coding GIFtS: 57
GCID: GC02P070314

poly(rC) binding protein 1

(Previous name: poly(rC)-binding protein 1 )

Explore 13 diseases affiliated with
PCBP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Poly(RC) Binding Protein 1¹ ²		Nucleic Acid-Binding Protein SUB2.3² ³
HNRPE1¹ ²		Alpha-CP1³
HNRPX¹ ²		Heterogenous Nuclear Ribonucleoprotein E1²
HnRNP-E1¹		Heterogenous Nuclear Ribonucleoprotein X²
HnRNP-X¹		Alpha-CP1³
Poly(RC)-Binding Protein 1¹ ²		HnRNP E1³
Heterogeneous Nuclear Ribonucleoprotein E1² ³

External Ids:	HGNC: 8647¹	Entrez Gene: 5093²	Ensembl: ENSG00000169564⁷	OMIM: 601209⁵	UniProtKB: Q15365³

Export aliases for PCBP1 gene to outside databases

Previous GC identifers: GC02P070324 GC02P070525 GC02P070272 GC02P070289 GC02P070226 GC02P070168 GC02P070052

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PCBP1:

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This

gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events

of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK

corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be

involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of

poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA

replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control

of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is

also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with

alpha-globin mRNA stability. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PCBP1_HUMAN, Q15365

Function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC

Gene Wiki entry for PCBP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PCBP1 gene promoter:
ER-alpha C/EBPbeta GATA-3 Pax-2 Lmo2 CUTL1 Pax-2a AREB6 SRY Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PCBP1 promoter sequence

Search SABiosciences Chromatin IP Primers for PCBP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCBP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13-p12 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p13-p12

PCBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCBP1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P070314: view genomic region (about GC identifiers)

Start:	70,314,585 bp from pter	End:	70,316,335 bp from pter
Size:	1,751 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PCBP1_HUMAN, Q15365 (See protein sequence)

Recommended Name: Poly(rC)-binding protein 1

Size: 356 amino acids; 37498 Da

Subcellular location: Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the

cytoplasm

Sequence caution: Sequence=CAA82631.1; Type=Frameshift; Positions=301;

3 PDB 3D structures from and Proteopedia for PCBP1:

1WVN (3D)

1ZTG (3D)

3VKE (3D)

Secondary accessions: Q13157 Q14975

Explore the universe of human proteins at neXtProt for PCBP1: NX_Q15365

Post-translational modifications:

Phosphorylated; lowers poly(rC)-binding activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15365

PCBP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006187.2

ENSEMBL proteins:

ENSP00000305556

Reactome Protein details: Q15365
Human Recombinant Protein Products:

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	Uscn Proteins for PCBP1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	NAS	--
GO:0030529	ribonucleoprotein complex	IEA	--

PCBP1 for ontologies About GeneDecksing

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	ThermoFisher Antibodies for PCBP1

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	Uscn ELISAs and CLIAs for PCBP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PCBP1 for domains About GeneDecksing

2 InterPro domains/families:

IPR004087 KH_dom

IPR004088 KH_dom_type_1

Graphical View of Domain Structure for InterPro Entry Q15365

ProtoNet protein and cluster: Q15365

1 Blocks protein family: IPB004087 KH domain

UniProtKB/Swiss-Prot: PCBP1_HUMAN, Q15365

Similarity: Contains 3 KH domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PCBP1_HUMAN, Q15365

Function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC

Genatlas biochemistry entry for PCBP1:

poly(rC)-binding protein 1,expressed in keratinocytes and other cells

miRNA Products:		miRTarBase miRNAs that target PCBP1: hsa-mir-21 (MIRT004814)

		OriGene 3'-UTR Clone: PCBP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PCBP1
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate PCBP1 (see all 34):
		hsa-miR-323-3p hsa-miR-142-5p hsa-miR-607 hsa-miR-489 hsa-miR-34b hsa-miR-490-3p hsa-miR-3163 hsa-miR-548am

		SwitchGear 3'UTR luciferase reporter plasmid: PCBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PCBP1 (see all 4) OriGene shRNA RFP: PCBP1 OriGene siRNA: PCBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCBP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PCBP1

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PCBP1
		Search LifeMap BioReagents cell lines for PCBP1

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PCBP1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003697	single-stranded DNA binding	IDA	8152927
GO:0003723	RNA binding	IDA	7556077
GO:0005515	protein binding	IPI	16713569

PCBP1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing - Major Pathway	1.00	mRNA Processing	0.82
mRNA Splicing	1.00	Spliceosome	0.31
Processing of Capped Intron-Containing Pre-mRNA	0.96

Translational Control

Translational Control

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for PCBP1

Translational Control

5 Reactome Pathways for PCBP1

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	Processing of Capped Intron-Containing Pre-mRNA

1 Kegg Pathway (Kegg details for PCBP1):

Spliceosome

PCBP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PCBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/679 Interacting proteins for PCBP1 (Q15365^{1, 2, 3} ENSP00000305556⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 679)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTBP1	P26599¹^,²^,³, ENSP00000349428⁴	EBI-946095,EBI-744534 MINT-2855482 MINT-2862164 MINT-7947479 I2D: score=3 STRING: ENSP00000349428
PCBP2	Q15366¹^,²^,³, ENSP00000352438⁴	EBI-946095,EBI-2555278 MINT-2861523 MINT-2856274 MINT-7947479 I2D: score=2 STRING: ENSP00000352438
MATR3	P43243²^,³, ENSP00000354346⁴	MINT-2867539 MINT-2867520 MINT-7947479 I2D: score=3 STRING: ENSP00000354346
HNRNPK	P61978²^,³, ENSP00000365439⁴	MINT-2859758 MINT-7947479 I2D: score=3 STRING: ENSP00000365439
NOVA1	P51513²^,³, ENSP00000267422⁴	MINT-2861259 MINT-2861278 I2D: score=3 STRING: ENSP00000267422

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--
GO:0016071	mRNA metabolic process	NAS	--

PCBP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PCBP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PCBP1
3 Novoseek chemical compound relationships for PCBP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
p-cbp	90.5	5	9712894 (2), 12600897 (1)
poly c	82.2	2	10606523 (1), 12527772 (1)
tyrosine	0	1	10606523 (1)

Search CenterWatch for drugs/clinical trials and news about PCBP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PCBP1 gene:

NM_006196.3

Unigene Cluster for PCBP1:

Poly(rC) binding protein 1

Hs.2853 [show with all ESTs]

Unigene Representative Sequence: NM_006196

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000303577(uc002sgf.3)

miRNA Products:		OriGene 3'-UTR Clone: PCBP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PCBP1
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate PCBP1 (see all 34):
		hsa-miR-323-3p hsa-miR-142-5p hsa-miR-607 hsa-miR-489 hsa-miR-34b hsa-miR-490-3p hsa-miR-3163 hsa-miR-548am

		SwitchGear 3'UTR luciferase reporter plasmid: PCBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PCBP1 (see all 4) OriGene shRNA RFP: PCBP1 OriGene siRNA: PCBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCBP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCBP1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCBP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PCBP1 (NM_006196)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCBP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCBP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCBP1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCBP1

Additional cDNA sequence:

AK130439.1 AK314225.1 BC039742.1 U24223.1 X78137.1 Z29505.1

24/26 DOTS entries (see all 26):

DT.100044978 DT.450482 DT.97862686 DT.100664043 DT.95269559 DT.100852833 DT.121002866 DT.86999400

DT.100664045 DT.100664046 DT.100664050 DT.92459565 DT.97862696 DT.100044979 DT.100044989 DT.100853545

DT.87017971 DT.100664053 DT.100849151 DT.121002851 DT.92459566 DT.95269596 DT.95269640 DT.121002788

24/724 AceView cDNA sequences (see all 724):

CR618539 BU161413 BE538685 BQ668942 CR620735 AK130439 F26824 BQ228486

AW583092 BU681874 W48787 BM351928 AI275692 BP374599 BU146174 AA136883

BQ771972 BQ894450 AI859612 R69578 CD678889 BM695329 AA427586 BU176820

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PCBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTTTATTT

About this image

PCBP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PCBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PCBP1

SOURCE GeneReport for Unigene cluster: Hs.2853

UniProtKB/Swiss-Prot: PCBP1_HUMAN, Q15365

Tissue specificity: Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower

expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands

SABiosciences Custom PCR Arrays for PCBP1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCBP1

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PCBP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCBP1 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FUBP3⁶	--	2(a)	possible ortholog	Un(63862637-63863565)
zebrafish (Danio rerio)	Actinopterygii	pcbp2⁶ zgc:110045⁶	zgc:110045	80(a) 66(a)	1 ↔ many possible ortholog	9(220332-231565) 13(16279529-16306819)
fruit fly (Drosophila melanogaster)	Insecta	mub³	poly(rC) binding	46(a)		--
worm (Caenorhabditis elegans)	Secernentea	pes-4⁶	Protein PES-4	30(a)	1 → many	III(1215968-1222064)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G25970⁶ AT4G10070⁶ (see all 3)	KH domain-containing protein (see all 3)	8(a) 6(a) (see all 3)	possible ortholog possible ortholog (see all 3)	2(11071651-11075669) 4(6295608-6299836)
rice (Oryza sativa)	Liliopsida	-- --	KH domain-containing protein, putative, expressed	6(a) 6(a)	possible ortholog possible ortholog	8(571856-577417) 2(6979511-6985051)

ENSEMBL Gene Tree for PCBP1 (if available)
TreeFam Gene Tree for PCBP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PCBP1 gene

FUBP1² PCBP4² HNRNPK² KHSRP² PCBP3² PCBP2² NOVA2² NOVA1²

FUBP3²

3 SIMAP similar genes for PCBP1 using alignment to 2 protein entries: PCBP1_HUMAN (see all proteins):

PCBP2 PCBP3 PCBP4

PCBP1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for PCBP1
PGOHUM00000244138 PGOHUM00000237837 PGOHUM00000236694

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56898175^1,2	C,F,	--	70049166(+)	`TGTGTG/AACCTT`	1	--	us2k¹		3		WA CSA	122
rs11884681^1,2	C,F,H,	--	70049329(+)	`TGCACA/CATAAA`	1	--	us2k¹		11		NS EA NA WA	1386
rs75369327^1,2		--	70049483(+)	`AGGAAG/ATCTAG`	1	--	us2k¹		2		CSA WA	120
rs7589221^1,2	C,	--	70049502(+)	`TAACTC/TATCTC`	1	--	us2k¹ tfbs³		1		CSA	1
rs111653127^1,2		--	70049670(+)	`AATTAG/AAGGGA`	1	--	us2k¹		1		CSA	2
rs75286265^1,2	F,	--	70049997(+)	`GAAAAG/AGCAGA`	1	--	us2k¹		1		WA	118
rs113066692^1,2		--	70050091(+)	`CCTGAC/AGGGGC`	1	--	us2k¹		1		CSA	2
rs76076787^1,2		--	70050366(+)	`TGGACA/GCCATT`	1	--	us2k¹		0	--	--	--	--
rs112867587^1,2	C,	--	70050519(+)	`CGGACG/TCCGGG`	1	--	us2k¹		2		WA	120
rs111940323^1,2		--	70050664(+)	`GCGCAC/TGTTTT`	1	--	us2k¹		1		CSA	2

HapMap Linkage Disequilibrium report for PCBP1 (70314585 - 70316335 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PCBP1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCBP1

DNA2.0 Custom Variant and Variant Library Synthesis for PCBP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PCBP1 for disorders           About GeneDecksing

OMIM gene information: 601209    OMIM disorders: --

13 diseases for PCBP1:    About MalaCards

hepatitis a hepatitis kaposi's sarcoma pandas

stomatitis sarcoma breast cancer ataxia

cervicitis thyroiditis malaria prostatitis

prostate cancer

Export disorders for PCBP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PCBP1 gene, integrated from 9 sources (see all 103):
(articles sorted by number of sources associating them with PCBP1)

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Identification of two KH domain proteins in the alpha-globin mRNP stability complex. (PubMed id 7556077)^{1, 2, 9} Kiledjian M.... Liebhaber S.A. (1995)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A. (PubMed id 8833161)^{1, 3} Tommerup N. and Leffers H. (1996)
Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains. (PubMed id 7607214)^{1, 2} Leffers H.... Celis J.E. (1995)
Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K. (PubMed id 8152927)^{1, 2} Aasheim H.-C.... Smeland E.B. (1994)
PCBP-1 regulates alternative splicing of the CD44 gen e and inhibits invasion in human hepatoma cell line HepG2 cells. (PubMed id 20361869)^{1, 9} Zhang T....Yang X.M. (2010)
Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. (PubMed id 19211566)^{1, 9} Waggoner S.A....Liebhaber S.A. (2009)
A posttranscriptional regulator of Kaposi's sarcoma-associated herpesvirus interacts with RNA-binding protein PCBP1 and controls gene expression through the IRES. (PubMed id 15246275)^{1, 9} Nishimura K....Yamanishi K. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5093	HGNC: 8647	AceView: PCBP1	Ensembl:ENSG00000169564	euGenes: HUgn5093
ECgene: PCBP1	Kegg: 5093	H-InvDB: PCBP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PCBP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PCBP1 gene
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Patent Information for PCBP1 gene:
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poly(rC) binding protein 1

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poly(rC) binding protein 1

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