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Aliases for PCBP1 Gene

Aliases for PCBP1 Gene

  • Poly(RC) Binding Protein 1 2 3
  • Heterogeneous Nuclear Ribonucleoprotein E1 2 3 4
  • Nucleic Acid-Binding Protein SUB2.3 3 4
  • Alpha-CP1 3 4
  • Heterogenous Nuclear Ribonucleoprotein E1 3
  • Heterogenous Nuclear Ribonucleoprotein X 3
  • Epididymis Secretory Protein Li 85 3
  • Poly(RC)-Binding Protein 1 2
  • HEL-S-85 3
  • HnRNP-E1 3
  • HnRNP E1 4
  • HnRNP-X 3
  • HNRPE1 3
  • HNRPX 3

External Ids for PCBP1 Gene

Previous GeneCards Identifiers for PCBP1 Gene

  • GC02P070324
  • GC02P070525
  • GC02P070272
  • GC02P070289
  • GC02P070226
  • GC02P070168
  • GC02P070314

Summaries for PCBP1 Gene

Entrez Gene Summary for PCBP1 Gene

  • This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCBP1 Gene

PCBP1 (Poly(RC) Binding Protein 1) is a Protein Coding gene. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for PCBP1 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC

Gene Wiki entry for PCBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCBP1 Gene

Genomics for PCBP1 Gene

Regulatory Elements for PCBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCBP1 Gene

Chromosome:
2
Start:
70,087,453 bp from pter
End:
70,089,203 bp from pter
Size:
1,751 bases
Orientation:
Plus strand

Genomic View for PCBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP1 Gene

Proteins for PCBP1 Gene

  • Protein details for PCBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15365-PCBP1_HUMAN
    Recommended name:
    Poly(rC)-binding protein 1
    Protein Accession:
    Q15365
    Secondary Accessions:
    • Q13157
    • Q14975

    Protein attributes for PCBP1 Gene

    Size:
    356 amino acids
    Molecular mass:
    37498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA82631.1; Type=Frameshift; Positions=301; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCBP1 Gene

neXtProt entry for PCBP1 Gene

Proteomics data for PCBP1 Gene at MOPED

Post-translational modifications for PCBP1 Gene

  • Phosphorylated; lowers poly(rC)-binding activity
  • Ubiquitination at Lys 237, Lys 314, and Lys 351
  • Modification sites at PhosphoSitePlus

Other Protein References for PCBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PCBP1 (hnRNP E1)

No data available for DME Specific Peptides for PCBP1 Gene

Domains & Families for PCBP1 Gene

Protein Domains for PCBP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15365

UniProtKB/Swiss-Prot:

PCBP1_HUMAN :
  • Contains 3 KH domains.
Domain:
  • Contains 3 KH domains.
genes like me logo Genes that share domains with PCBP1: view

No data available for Gene Families for PCBP1 Gene

Function for PCBP1 Gene

Molecular function for PCBP1 Gene

GENATLAS Biochemistry:
poly(rC)-binding protein 1,expressed in keratinocytes and other cells
UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC

Gene Ontology (GO) - Molecular Function for PCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003697 single-stranded DNA binding IDA 8152927
GO:0003723 RNA binding IDA 7556077
GO:0003729 mRNA binding IDA 14722620
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with PCBP1: view
genes like me logo Genes that share phenotypes with PCBP1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PCBP1 Gene

Localization for PCBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP1 Gene

Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCBP1 Gene COMPARTMENTS Subcellular localization image for PCBP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
GO:0030529 ribonucleoprotein complex IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with PCBP1: view

Pathways & Interactions for PCBP1 Gene

genes like me logo Genes that share pathways with PCBP1: view

Pathways by source for PCBP1 Gene

1 Cell Signaling Technology pathway for PCBP1 Gene
1 KEGG pathway for PCBP1 Gene

Gene Ontology (GO) - Biological Process for PCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with PCBP1: view

No data available for SIGNOR curated interactions for PCBP1 Gene

Drugs & Compounds for PCBP1 Gene

(1) Drugs for PCBP1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tyrosine Nutra 547

(2) Additional Compounds for PCBP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
p-CBP
poly c
genes like me logo Genes that share compounds with PCBP1: view

Transcripts for PCBP1 Gene

mRNA/cDNA for PCBP1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(724) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCBP1 Gene

Poly(rC) binding protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCBP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP1 Gene

No ASD Table

Relevant External Links for PCBP1 Gene

GeneLoc Exon Structure for
PCBP1
ECgene alternative splicing isoforms for
PCBP1

Expression for PCBP1 Gene

mRNA expression in normal human tissues for PCBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCBP1 Gene



SOURCE GeneReport for Unigene cluster for PCBP1 Gene Hs.2853

mRNA Expression by UniProt/SwissProt for PCBP1 Gene

Q15365-PCBP1_HUMAN
Tissue specificity: Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands
genes like me logo Genes that share expression patterns with PCBP1: view

Protein tissue co-expression partners for PCBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PCBP1 Gene

Orthologs for PCBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCBP1 35
  • 98.41 (n)
  • 100 (a)
PCBP1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCBP1 35
  • 92.6 (n)
  • 99.72 (a)
PCBP1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcbp1 35
  • 94.1 (n)
  • 100 (a)
Pcbp1 16
Pcbp1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCBP1 35
  • 100 (n)
  • 100 (a)
PCBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcbp1 35
  • 94.6 (n)
  • 99.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 61 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii pcbp2 36
  • 80 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta mub 37
  • 46 (a)
Species with no ortholog for PCBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCBP1 Gene

ENSEMBL:
Gene Tree for PCBP1 (if available)
TreeFam:
Gene Tree for PCBP1 (if available)

Paralogs for PCBP1 Gene

Paralogs for PCBP1 Gene

(3) SIMAP similar genes for PCBP1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PCBP1 Gene

genes like me logo Genes that share paralogs with PCBP1: view

Variants for PCBP1 Gene

Sequence variations from dbSNP and Humsavar for PCBP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1043295 -- 70,089,078(+) GATAA(A/G)AAATG utr-variant-3-prime
rs3732261 -- 70,089,232(-) AAAGG(A/G)GAGGG downstream-variant-500B
rs3832153 -- 70,089,206(-) ACAAA(-/A)GAGTT downstream-variant-500B
rs112829683 -- 70,089,226(+) TTTTT(C/T)CCCTC downstream-variant-500B
rs192374454 -- 70,089,695(+) CTAGA(C/G)GGGTC downstream-variant-500B

Variation tolerance for PCBP1 Gene

Residual Variation Intolerance Score: 13.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCBP1 Gene

HapMap Linkage Disequilibrium report
PCBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PCBP1 Gene

Disorders for PCBP1 Gene

Relevant External Links for PCBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCBP1
genes like me logo Genes that share disorders with PCBP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCBP1 Gene

Publications for PCBP1 Gene

  1. PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells. (PMID: 20361869) Zhang T. … Yang X.M. (Mol. Cancer 2010) 23 67
  2. Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. (PMID: 19211566) Waggoner S.A. … Liebhaber S.A. (J. Biol. Chem. 2009) 23 67
  3. Regulation of BAG-1 IRES-mediated translation following chemotoxic stress. (PMID: 17700523) Dobbyn H.C. … Willis A.E. (Oncogene 2008) 23 67
  4. AlphaCP1 mediates stabilization of hTERT mRNA by autocrine human growth hormone. (PMID: 17085453) Emerald B.S. … Lobie P.E. (J. Biol. Chem. 2007) 23 67
  5. Pre-spliceosomal binding of U1 small nuclear ribonucleoprotein (RNP) and heterogenous nuclear RNP E1 is associated with suppression of a growth hormone receptor pseudoexon. (PMID: 17622584) Akker S.A. … Chew S.L. (Mol. Endocrinol. 2007) 23 67

Products for PCBP1 Gene

Sources for PCBP1 Gene

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