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Aliases for PCBP1 Gene

Aliases for PCBP1 Gene

  • Poly(RC) Binding Protein 1 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein E1 2 3 4
  • Nucleic Acid-Binding Protein SUB2.3 3 4
  • Poly(RC)-Binding Protein 1 2 3
  • Alpha-CP1 3 4
  • Heterogenous Nuclear Ribonucleoprotein E1 3
  • Heterogenous Nuclear Ribonucleoprotein X 3
  • Epididymis Secretory Protein Li 85 3
  • HEL-S-85 3
  • HnRNP-E1 3
  • HnRNP E1 4
  • HnRNP-X 3
  • HNRPE1 3
  • HNRPX 3

External Ids for PCBP1 Gene

Previous GeneCards Identifiers for PCBP1 Gene

  • GC02P070324
  • GC02P070525
  • GC02P070272
  • GC02P070289
  • GC02P070226
  • GC02P070168
  • GC02P070314

Summaries for PCBP1 Gene

Entrez Gene Summary for PCBP1 Gene

  • This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCBP1 Gene

PCBP1 (Poly(RC) Binding Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP2.

UniProtKB/Swiss-Prot for PCBP1 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Gene Wiki entry for PCBP1 Gene

Additional gene information for PCBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCBP1 Gene

Genomics for PCBP1 Gene

GeneHancer (GH) Regulatory Elements for PCBP1 Gene

Promoters and enhancers for PCBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I070080 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.1 -1062 11.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 MEF2D PCBP1 TIA1 PCBP1-AS1 TEX261 CLEC4F GMCL1 ANKRD53 C2orf42 MXD1 SNRNP27
GH02I069911 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.3 -172.1 -172115 7.4 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 MXD1 SNRNP27 ASPRV1 PCBP1-AS1 GMCL1 PCBP1 PIR33848 GC02P069822
GH02I069931 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -153.5 -153517 4.7 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 ETS1 FOS ATF7 RUNX3 MXD1 SNRNP27 ASPRV1 PCBP1 PCBP1-AS1 GMCL1 C2orf42 PIR33848 GC02P069822
GH02I069945 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -140.5 -140521 4.3 PKNOX1 FOXA2 FOS RUNX3 DEK SP5 NCOA1 REST ZNF592 NFIL3 MXD1 SNRNP27 ASPRV1 TIA1 PCBP1 GMCL1 SNRPG PIR33848 GC02P069822
GH02I069974 Enhancer 1.6 FANTOM5 Ensembl ENCODE 8.6 -109.9 -109918 6 HDGF FOXA2 PKNOX1 CLOCK ARNT NEUROD1 YBX1 DMAP1 ZBTB7B YY1 PIR52583 MXD1 PCBP1-AS1 TIA1 C2orf42 CLEC4F FAM136A SNRNP27 ASPRV1 PCBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PCBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PCBP1 gene promoter:

Genomic Locations for PCBP1 Gene

Genomic Locations for PCBP1 Gene
chr2:70,087,453-70,089,203
(GRCh38/hg38)
Size:
1,751 bases
Orientation:
Plus strand
chr2:70,314,585-70,316,335
(GRCh37/hg19)

Genomic View for PCBP1 Gene

Genes around PCBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP1 Gene

Proteins for PCBP1 Gene

  • Protein details for PCBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15365-PCBP1_HUMAN
    Recommended name:
    Poly(rC)-binding protein 1
    Protein Accession:
    Q15365
    Secondary Accessions:
    • Q13157
    • Q14975

    Protein attributes for PCBP1 Gene

    Size:
    356 amino acids
    Molecular mass:
    37498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA82631.1; Type=Frameshift; Positions=301; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCBP1 Gene

neXtProt entry for PCBP1 Gene

Post-translational modifications for PCBP1 Gene

  • Phosphorylated; lowers poly(rC)-binding activity.
  • Ubiquitination at isoforms=237, isoforms=314, and Lys351

Other Protein References for PCBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCBP1 Gene

Domains & Families for PCBP1 Gene

Gene Families for PCBP1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PCBP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCBP1: view

No data available for UniProtKB/Swiss-Prot for PCBP1 Gene

Function for PCBP1 Gene

Molecular function for PCBP1 Gene

GENATLAS Biochemistry:
poly(rC)-binding protein 1,expressed in keratinocytes and other cells
UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Phenotypes From GWAS Catalog for PCBP1 Gene

Gene Ontology (GO) - Molecular Function for PCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IDA,IEA 8152927
GO:0003723 RNA binding IDA 7556077
genes like me logo Genes that share ontologies with PCBP1: view
genes like me logo Genes that share phenotypes with PCBP1: view

Clone Products

  • Addgene plasmids for PCBP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCBP1 Gene

Localization for PCBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP1 Gene

Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCBP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (4)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 25468996
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with PCBP1: view

Pathways & Interactions for PCBP1 Gene

genes like me logo Genes that share pathways with PCBP1: view

Pathways by source for PCBP1 Gene

1 Cell Signaling Technology pathway for PCBP1 Gene
2 KEGG pathways for PCBP1 Gene

Gene Ontology (GO) - Biological Process for PCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0016070 RNA metabolic process TAS --
GO:0039694 viral RNA genome replication IDA 12414943
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with PCBP1: view

No data available for SIGNOR curated interactions for PCBP1 Gene

Drugs & Compounds for PCBP1 Gene

(1) Drugs for PCBP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PCBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PCBP1: view

Transcripts for PCBP1 Gene

mRNA/cDNA for PCBP1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(724) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCBP1 Gene

Poly(rC) binding protein 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for PCBP1

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP1 Gene

No ASD Table

Relevant External Links for PCBP1 Gene

GeneLoc Exon Structure for
PCBP1
ECgene alternative splicing isoforms for
PCBP1

Expression for PCBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCBP1 Gene



Protein tissue co-expression partners for PCBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCBP1 Gene:

PCBP1

SOURCE GeneReport for Unigene cluster for PCBP1 Gene:

Hs.2853

mRNA Expression by UniProt/SwissProt for PCBP1 Gene:

Q15365-PCBP1_HUMAN
Tissue specificity: Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.

Evidence on tissue expression from TISSUES for PCBP1 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Skin(4.7)
  • Blood(4.5)
  • Lung(3.9)
  • Pancreas(3.8)
  • Muscle(3.6)
  • Eye(3.5)
  • Intestine(3.3)
  • Kidney(2.9)
  • Heart(2.8)
  • Stomach(2.8)
  • Bone marrow(2.1)
  • Lymph node(2.1)
  • Spleen(2.1)
  • Adrenal gland(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PCBP1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCBP1 Gene

Orthologs for PCBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCBP1 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia PCBP1 33 34
  • 98.41 (n)
rat
(Rattus norvegicus)
Mammalia Pcbp1 33
  • 94.6 (n)
mouse
(Mus musculus)
Mammalia Pcbp1 33 16 34
  • 94.1 (n)
dog
(Canis familiaris)
Mammalia PCBP1 33 34
  • 92.6 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 61 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii pcbp2 34
  • 80 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta mub 35
  • 46 (a)
Species where no ortholog for PCBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCBP1 Gene

ENSEMBL:
Gene Tree for PCBP1 (if available)
TreeFam:
Gene Tree for PCBP1 (if available)

Paralogs for PCBP1 Gene

Paralogs for PCBP1 Gene

(3) SIMAP similar genes for PCBP1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PCBP1 Gene

genes like me logo Genes that share paralogs with PCBP1: view

Variants for PCBP1 Gene

Sequence variations from dbSNP and Humsavar for PCBP1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs797044899 likely-pathogenic, Inborn genetic diseases 70,088,293(+) C/T coding_sequence_variant, stop_gained
rs1000225671 -- 70,086,135(+) C/A upstream_transcript_variant
rs1001541706 -- 70,087,062(+) G/T upstream_transcript_variant
rs1001644000 -- 70,087,510(+) C/T 5_prime_UTR_variant
rs1001991713 -- 70,087,371(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PCBP1 Gene

Variant ID Type Subtype PubMed ID
nsv582178 CNV loss 21841781

Variation tolerance for PCBP1 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCBP1 Gene

Human Gene Mutation Database (HGMD)
PCBP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCBP1 Gene

Disorders for PCBP1 Gene

Additional Disease Information for PCBP1

No disorders were found for PCBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCBP1 Gene

Publications for PCBP1 Gene

  1. Identification of two KH domain proteins in the alpha-globin mRNP stability complex. (PMID: 7556077) Kiledjian M … Liebhaber SA (The EMBO journal 1995) 3 4 22 58
  2. PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells. (PMID: 20361869) Zhang T … Yang XM (Molecular cancer 2010) 3 22 58
  3. Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. (PMID: 19211566) Waggoner SA … Liebhaber SA (The Journal of biological chemistry 2009) 3 22 58
  4. Pre-spliceosomal binding of U1 small nuclear ribonucleoprotein (RNP) and heterogenous nuclear RNP E1 is associated with suppression of a growth hormone receptor pseudoexon. (PMID: 17622584) Akker SA … Chew SL (Molecular endocrinology (Baltimore, Md.) 2007) 3 22 58
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58

Products for PCBP1 Gene

Sources for PCBP1 Gene

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