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PCBP1 Gene

protein-coding   GIFtS: 60
GCID: GC02P070314

Poly(RC) Binding Protein 1

(Previous name: poly(rC)-binding protein 1)
  See PCBP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poly(RC) Binding Protein 11 2     Epididymis Secretory Protein Li 852
Heterogeneous Nuclear Ribonucleoprotein E11 2 3     Heterogenous Nuclear Ribonucleoprotein E12
Poly(RC)-Binding Protein 11 2     Heterogenous Nuclear Ribonucleoprotein X2
Nucleic Acid-Binding Protein SUB2.32 3     hnRNP-E12
HEL-S-852     hnRNP-X2
HNRPE12     Alpha-CP13
HNRPX2     HnRNP E13
alpha-CP12     

External Ids:    HGNC: 86471   Entrez Gene: 50932   Ensembl: ENSG000001695647   OMIM: 6012095   UniProtKB: Q153653   

Export aliases for PCBP1 gene to outside databases

Previous GC identifers: GC02P070324 GC02P070525 GC02P070272 GC02P070289 GC02P070226 GC02P070168 GC02P070052


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PCBP1 Gene:
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA.
This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of
duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with
PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH)
domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as
translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES
and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been
implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and
hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific
alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. (provided by RefSeq, Jul 2008)

GeneCards Summary for PCBP1 Gene:
PCBP1 (poly(rC) binding protein 1) is a protein-coding gene. Diseases associated with PCBP1 include hepatitis. GO annotations related to this gene include single-stranded DNA binding and RNA binding. An important paralog of this gene is PCBP2.

UniProtKB/Swiss-Prot: PCBP1_HUMAN, Q15365
Function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC

Gene Wiki entry for PCBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PCBP1 gene promoter:
         ER-alpha   C/EBPbeta   GATA-3   Pax-2   Lmo2   CUTL1   Pax-2a   AREB6   SRY   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCBP1 promoter sequence
   Search Chromatin IP Primers for PCBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13-p12   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13-p12

PCBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCBP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P070314:  view genomic region     (about GC identifiers)

Start:
70,314,585 bp from pter      End:
70,316,335 bp from pter
Size:
1,751 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PCBP1_HUMAN, Q15365 (See protein sequence)
Recommended Name: Poly(rC)-binding protein 1  
Size: 356 amino acids; 37498 Da
Sequence caution: Sequence=CAA82631.1; Type=Frameshift; Positions=301;
3 PDB 3D structures from and Proteopedia for PCBP1:
1WVN (3D)        1ZTG (3D)        3VKE (3D)    
Secondary accessions: Q13157 Q14975

Explore the universe of human proteins at neXtProt for PCBP1: NX_Q15365

Explore proteomics data for PCBP1 at MOPED

Post-translational modifications: 

  • Phosphorylated; lowers poly(rC)-binding activity1
  • Ubiquitination2 at Lys23, Lys237, Lys314, Lys351
  • Modification sites at PhosphoSitePlus

  • See PCBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006187.2  
    ENSEMBL proteins: 
     ENSP00000305556  
    Reactome Protein details: Q15365

    PCBP1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PCBP1

     
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    PCBP1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for PCBP1

    PCBP1 Assay Products:

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    Cloud-Clone Corp. ELISAs for PCBP1
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    Search eBioscience for ELISAs for PCBP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004087 KH_dom
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry Q15365

    ProtoNet protein and cluster: Q15365

    1 Blocks protein domain: IPB004087 KH domain

    UniProtKB/Swiss-Prot: PCBP1_HUMAN, Q15365
    Similarity: Contains 3 KH domains


    Find genes that share domains with PCBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCBP1_HUMAN, Q15365
    Function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC

         Genatlas biochemistry entry for PCBP1:
    poly(rC)-binding protein 1,expressed in keratinocytes and other cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697single-stranded DNA binding IDA8152927
    GO:0003723RNA binding IDA7556077
    GO:0005515protein binding IPI16713569
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with PCBP1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCBP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PCBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCBP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PCBP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PCBP1:
    hsa-mir-100-5p (MIRT048509), hsa-mir-423-5p (MIRT038098), hsa-mir-21-5p (MIRT004814), hsa-mir-1296-5p (MIRT036126), hsa-mir-1180-3p (MIRT035937)

    Block miRNA regulation of human, mouse, rat PCBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCBP1 (see all 34):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-607 hsa-miR-489 hsa-miR-34b hsa-miR-490-3p hsa-miR-3163 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidPCBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PCBP1
    Predesigned siRNA for gene silencing in human, mouse, rat PCBP1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for PCBP1 (see all 6)
    OriGene ORF clones in mouse, rat for PCBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PCBP1 (NM_006196)
    Sino Biological Human cDNA Clone for PCBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCBP1
    Addgene plasmids for PCBP1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PCBP1_HUMAN, Q15365: Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and
    the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PCBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PCBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    2Gene Expression
    Gene Expression0.40
    3Translational Control
    Translational Control
    4Spliceosome
    Spliceosome


    Find genes that share SuperPaths with PCBP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PCBP1
        Translational Control


    2 Reactome Pathways for PCBP1
        mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA


    1 Kegg Pathway  (Kegg details for PCBP1):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCBP1
    Interactions:

        GeneGlobe Interaction Network for PCBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PCBP1 (Q153651, 2, 3 ENSP000003055564) via UniProtKB, MINT, STRING, and/or I2D (see all 774)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTBP1P265991, 2, 3, ENSP000003494284EBI-946095,EBI-350540 MINT-2855482 MINT-2862164 MINT-7947479 I2D: score=3 STRING: ENSP00000349428
    PCBP2Q153661, 2, 3, ENSP000003524384EBI-946095,EBI-945799 MINT-2861523 MINT-2856274 MINT-7947479 I2D: score=2 STRING: ENSP00000352438
    THAP11Q96EK41, 2, ENSP000003046894EBI-946095,EBI-1790529 MINT-8362615 MINT-8362628 MINT-8362650 MINT-8362672 STRING: ENSP00000304689
    MATR3P432432, 3, ENSP000003543464MINT-2867539 MINT-2867520 MINT-7947479 I2D: score=3 STRING: ENSP00000354346
    PRPF8Q6P2Q91, 2, ENSP000003043504EBI-946095,EBI-538479 MINT-8336034 MINT-8331866 MINT-7947479 STRING: ENSP00000304350
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0016071mRNA metabolic process ----

    Find genes that share ontologies with PCBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCBP1

    3 Novoseek inferred chemical compound relationships for PCBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    p-cbp 90.5 5 9712894 (2), 12600897 (1)
    poly c 82.2 2 10606523 (1), 12527772 (1)
    tyrosine 0 1 10606523 (1)



    Find genes that share compounds with PCBP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PCBP1 gene: 
    NM_006196.3  

    Unigene Cluster for PCBP1:

    Poly(rC) binding protein 1
    Hs.2853  [show with all ESTs]
    Unigene Representative Sequence: NM_006196
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303577(uc002sgf.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat PCBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCBP1 (see all 34):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-607 hsa-miR-489 hsa-miR-34b hsa-miR-490-3p hsa-miR-3163 hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidPCBP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PCBP1
    Predesigned siRNA for gene silencing in human, mouse, rat PCBP1
    Clone
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    OriGene clones in human, mouse for PCBP1 (see all 6)
    OriGene ORF clones in mouse, rat for PCBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PCBP1 (NM_006196)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCBP1
    Addgene plasmids for PCBP1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PCBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCBP1
      QuantiTect SYBR Green Assays in human, mouse, rat PCBP1
      QuantiFast Probe-based Assays in human, mouse, rat PCBP1

    Additional mRNA sequence: 

    AK130439.1 AK314225.1 BC039742.1 U24223.1 X78137.1 Z29505.1 

    Selected DOTS entries (see all 26):

    DT.100044978  DT.450482  DT.97862686  DT.100664043  DT.95269559  DT.100852833  DT.121002866  DT.86999400 
    DT.100664045  DT.100664046  DT.100664050  DT.92459565  DT.97862696  DT.100044979  DT.100044989  DT.100853545 
    DT.87017971  DT.100664053  DT.100849151  DT.121002851  DT.92459566  DT.95269596  DT.95269640  DT.121002788 

    Selected AceView cDNA sequences (see all 724):

    AA535686 N91017 AI183598 BM760689 BM800495 AI719971 BU731960 BG036562 
    AW771376 H50562 BU581395 AA887884 BM845151 BM770677 AI129563 BP370622 
    BM829397 CR613158 BM762726 BE122829 AW949546 BM835522 X78137 CA440933 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PCBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTATTT
    PCBP1 Expression
    About this image


    PCBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    PCBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2853

    UniProtKB/Swiss-Prot: PCBP1_HUMAN, Q15365
    Tissue specificity: Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower
    expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid
    glands

        Custom PCR Arrays for PCBP1
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat PCBP1
    QuantiFast Probe-based Assays in human, mouse, rat PCBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PCBP1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcbp11 , 5 poly(rC) binding protein 11, 5 94.1(n)1
    100(a)1
      6 (37.72 cM)5
    239831  NM_011865.31  NP_035995.11 
     865244925 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    61(a)
    many ↔ many
    AADN03015665.1(397-1799)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    many ↔ many
    6(56688182-56788271)
    zebrafish
    (Danio rerio)
    Actinopterygii pcbp26
    poly(rC) binding protein 2
    80(a)
    many ↔ many
    9(220332-231565) ENSDARG00000013184


    ENSEMBL Gene Tree for PCBP1 (if available)
    TreeFam Gene Tree for PCBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PCBP1 gene
    PCBP22  NOVA22  PCBP42  ENSG000002727622  HNRNPK2  NOVA12  PCBP32  
    3 SIMAP similar genes for PCBP1 using alignment to 2 protein entries:     PCBP1_HUMAN (see all proteins):
    PCBP2    PCBP3    PCBP4

    Find genes that share paralogs with PCBP1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PCBP1
    PGOHUM00000244138 PGOHUM00000237837 PGOHUM00000236694


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PCBP1 (see all 112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500171301,2
    --70179881(+) TTACAC/GAAAAA 1 -- us2k10--------
    rs568981751,2
    C,F--70179943(+) TGTGTG/AACCTT 1 -- us2k13Minor allele frequency- A:0.09WA CSA 122
    rs38321551,2
    C--70179992(-) TCTCTCT/-TTTAA 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs118846811,2
    C,F,H--70180106(+) TGCACA/CATAAA 1 -- us2k111Minor allele frequency- C:0.05NS EA NA WA 1386
    rs65465681,2
    C,F,A,H--70180206(+) AGGCAC/TTGTAG 1 -- us2k121Minor allele frequency- T:0.35NA NS EA WA CSA 2339
    rs1443305301,2
    --70180235(+) TCTCTC/GCAGCA 1 -- us2k10--------
    rs1810829421,2
    C--70180257(+) GCTAGA/GAAGTC 1 -- us2k10--------
    rs753693271,2
    C,F--70180260(+) AGGAAG/ATCTAG 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs75892211,2
    C,F--70180279(+) TAACTC/TATCTC 1 -- us2k1 tfbs31Minor allele frequency- T:0.00CSA 1
    rs1488629081,2
    C--70180279(+) AACTT-/AGATCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PCBP1 (70314585 - 70316335 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PCBP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PCBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for PCBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601209    OMIM disorders: --

    1 disease for PCBP1:    
    About MalaCards
    hepatitis


    Find genes that share disorders with PCBP1           About GenesLikeMe


    Export disorders for PCBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PCBP1 gene, integrated from 10 sources (see all 130):
    (articles sorted by number of sources associating them with PCBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two KH domain proteins in the alpha-globin mRNP stability complex. (PubMed id 7556077)1, 2, 9 Kiledjian M.... Liebhaber S.A. (EMBO J. 1995)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A. (PubMed id 8833161)1, 3 Tommerup N. and Leffers H. (Genomics 1996)
    6. Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains. (PubMed id 7607214)1, 2 Leffers H.... Celis J.E. (Eur. J. Biochem. 1995)
    7. Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K. (PubMed id 8152927)1, 2 Aasheim H.-C.... Smeland E.B. (Nucleic Acids Res. 1994)
    8. PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells. (PubMed id 20361869)1, 9 Zhang T....Yang X.M. (Mol. Cancer 2010)
    9. Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. (PubMed id 19211566)1, 9 Waggoner S.A....Liebhaber S.A. (J. Biol. Chem. 2009)
    10. A posttranscriptional regulator of Kaposi's sarcoma-associated herpesvirus interacts with RNA-binding protein PCBP1 and controls gene expression through the IRES. (PubMed id 15246275)1, 9 Nishimura K....Yamanishi K. (Virology 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5093 HGNC: 8647 AceView: PCBP1 Ensembl:ENSG00000169564 euGenes: HUgn5093
    ECgene: PCBP1 Kegg: 5093 H-InvDB: PCBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PCBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PCBP1 gene:
    Search GeneIP for patents involving PCBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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