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Aliases for PCBP1 Gene

Aliases for PCBP1 Gene

  • Poly(RC) Binding Protein 1 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein E1 2 3 4
  • Nucleic Acid-Binding Protein SUB2.3 3 4
  • Poly(RC)-Binding Protein 1 2 3
  • Alpha-CP1 3 4
  • Heterogenous Nuclear Ribonucleoprotein E1 3
  • Heterogenous Nuclear Ribonucleoprotein X 3
  • Epididymis Secretory Protein Li 85 3
  • HEL-S-85 3
  • HnRNP-E1 3
  • HnRNP E1 4
  • HnRNP-X 3
  • HNRPE1 3
  • HNRPX 3

External Ids for PCBP1 Gene

Previous GeneCards Identifiers for PCBP1 Gene

  • GC02P070324
  • GC02P070525
  • GC02P070272
  • GC02P070289
  • GC02P070226
  • GC02P070168
  • GC02P070314

Summaries for PCBP1 Gene

Entrez Gene Summary for PCBP1 Gene

  • This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCBP1 Gene

PCBP1 (Poly(RC) Binding Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Translational Control. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP2.

UniProtKB/Swiss-Prot for PCBP1 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Gene Wiki entry for PCBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCBP1 Gene

Genomics for PCBP1 Gene

Regulatory Elements for PCBP1 Gene

Enhancers for PCBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G069931 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -153.5 -153518 4.7 PKNOX1 FOXA2 ATF1 MLX ARNT ARID4B DMAP1 GATA2 FOS SP5 MXD1 SNRNP27 ASPRV1 PCBP1 PCBP1-AS1 GMCL1 C2orf42 PIR33848
GH02G069945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -140.5 -140521 4.3 PKNOX1 FOXA2 ATF1 ELK1 FOS DEK SP5 NCOA1 REST ZNF592 MXD1 SNRNP27 ASPRV1 PCBP1 GMCL1 SNRPG PIR33848
GH02G069911 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -172.1 -172115 7.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SNRNP27 MXD1 ASPRV1 PCBP1-AS1 GMCL1 CLEC4F CD207 PCBP1 PIR33848
GH02G069974 1.8 FANTOM5 Ensembl ENCODE 8.6 -109.9 -109919 6.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT YBX1 DMAP1 ZBTB7B YY1 ZNF766 MXD1 PCBP1-AS1 C2orf42 FAM136A SNRNP27 ASPRV1 PCBP1 GMCL1 PIR52583 PIR41837
GH02G070042 1.6 FANTOM5 Ensembl ENCODE 9.5 -43.6 -43579 3.5 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF121 SP5 MXD1 PCBP1-AS1 PCBP1 ASPRV1 C2orf42 RN7SL470P PIR47967
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCBP1 on UCSC Golden Path with GeneCards custom track

Promoters for PCBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000118659 547 3601 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21

Genomic Location for PCBP1 Gene

70,087,453 bp from pter
70,089,203 bp from pter
1,751 bases
Plus strand

Genomic View for PCBP1 Gene

Genes around PCBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP1 Gene

Proteins for PCBP1 Gene

  • Protein details for PCBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Poly(rC)-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q13157
    • Q14975

    Protein attributes for PCBP1 Gene

    356 amino acids
    Molecular mass:
    37498 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA82631.1; Type=Frameshift; Positions=301; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCBP1 Gene

neXtProt entry for PCBP1 Gene

Post-translational modifications for PCBP1 Gene

  • Phosphorylated; lowers poly(rC)-binding activity.
  • Ubiquitination at Lys237, Lys314, and Lys351
  • Modification sites at PhosphoSitePlus

Other Protein References for PCBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PCBP1 (hnRNP E1)

No data available for DME Specific Peptides for PCBP1 Gene

Domains & Families for PCBP1 Gene

Protein Domains for PCBP1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PCBP1 Gene

Function for PCBP1 Gene

Molecular function for PCBP1 Gene

GENATLAS Biochemistry:
poly(rC)-binding protein 1,expressed in keratinocytes and other cells
UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Gene Ontology (GO) - Molecular Function for PCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IDA 8152927
GO:0003723 RNA binding IDA 7556077
genes like me logo Genes that share ontologies with PCBP1: view
genes like me logo Genes that share phenotypes with PCBP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PCBP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCBP1 Gene

Localization for PCBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP1 Gene

Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCBP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 25468996
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PCBP1: view

Pathways & Interactions for PCBP1 Gene

genes like me logo Genes that share pathways with PCBP1: view

Pathways by source for PCBP1 Gene

1 Cell Signaling Technology pathway for PCBP1 Gene
2 KEGG pathways for PCBP1 Gene

Gene Ontology (GO) - Biological Process for PCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process TAS --
GO:0039694 viral RNA genome replication IDA 12414943
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with PCBP1: view

No data available for SIGNOR curated interactions for PCBP1 Gene

Drugs & Compounds for PCBP1 Gene

(1) Drugs for PCBP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PCBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PCBP1: view

Transcripts for PCBP1 Gene

mRNA/cDNA for PCBP1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(724) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCBP1 Gene

Poly(rC) binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PCBP1

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP1 Gene

No ASD Table

Relevant External Links for PCBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCBP1 Gene

Protein tissue co-expression partners for PCBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCBP1 Gene:


SOURCE GeneReport for Unigene cluster for PCBP1 Gene:


mRNA Expression by UniProt/SwissProt for PCBP1 Gene:

Tissue specificity: Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.

Evidence on tissue expression from TISSUES for PCBP1 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Skin(4.7)
  • Blood(4.5)
  • Lung(3.9)
  • Pancreas(3.8)
  • Muscle(3.6)
  • Eye(3.5)
  • Intestine(3.3)
  • Kidney(2.9)
  • Heart(2.8)
  • Stomach(2.8)
  • Bone marrow(2.1)
  • Lymph node(2.1)
  • Spleen(2.1)
  • Adrenal gland(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PCBP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCBP1 Gene

Orthologs for PCBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCBP1 34 35
  • 100 (n)
(Bos Taurus)
Mammalia PCBP1 34 35
  • 98.41 (n)
(Rattus norvegicus)
Mammalia Pcbp1 34
  • 94.6 (n)
(Mus musculus)
Mammalia Pcbp1 34 16 35
  • 94.1 (n)
(Canis familiaris)
Mammalia PCBP1 34 35
  • 92.6 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
(Gallus gallus)
Aves -- 35
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
(Danio rerio)
Actinopterygii pcbp2 35
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta mub 36
  • 46 (a)
Species where no ortholog for PCBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCBP1 Gene

Gene Tree for PCBP1 (if available)
Gene Tree for PCBP1 (if available)

Paralogs for PCBP1 Gene

Paralogs for PCBP1 Gene

(3) SIMAP similar genes for PCBP1 Gene using alignment to 2 proteins: Pseudogenes for PCBP1 Gene

genes like me logo Genes that share paralogs with PCBP1: view

Variants for PCBP1 Gene

Sequence variations from dbSNP and Humsavar for PCBP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs797044899 Likely pathogenic 70,088,293(+) CGTAC(C/T)AGCCC upstream-variant-2KB, reference, stop-gained
rs1000225671 -- 70,086,135(+) ACCAG(A/C)CTGTG intron-variant, upstream-variant-2KB
rs1001541706 -- 70,087,062(+) CACGC(G/T)CTCTG upstream-variant-2KB
rs1001644000 -- 70,087,510(+) CACCG(C/T)CGCGC upstream-variant-2KB, utr-variant-5-prime
rs1001991713 -- 70,087,371(+) CTTGT(A/G)ACCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PCBP1 Gene

Variant ID Type Subtype PubMed ID
nsv582178 CNV loss 21841781

Variation tolerance for PCBP1 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCBP1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCBP1 Gene

Disorders for PCBP1 Gene

Relevant External Links for PCBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PCBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCBP1 Gene

Publications for PCBP1 Gene

  1. Identification of two KH domain proteins in the alpha-globin mRNP stability complex. (PMID: 7556077) Kiledjian M. … Liebhaber S.A. (EMBO J. 1995) 3 4 22 64
  2. PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells. (PMID: 20361869) Zhang T. … Yang X.M. (Mol. Cancer 2010) 3 22 64
  3. Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. (PMID: 19211566) Waggoner S.A. … Liebhaber S.A. (J. Biol. Chem. 2009) 3 22 64
  4. Pre-spliceosomal binding of U1 small nuclear ribonucleoprotein (RNP) and heterogenous nuclear RNP E1 is associated with suppression of a growth hormone receptor pseudoexon. (PMID: 17622584) Akker S.A. … Chew S.L. (Mol. Endocrinol. 2007) 3 22 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for PCBP1 Gene

  • Addgene plasmids for PCBP1

Sources for PCBP1 Gene

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