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Aliases for PCA3 Gene

Subcategory (RNA class) for PCA3 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for PCA3 Gene

  • Prostate Cancer Associated 3 (Non-Protein Coding) 2 3 5
  • Prostate Cancer Associated Transcript 3 (Non-Protein Coding) 2 3
  • Prostate Cancer Antigen 3 (Non-Protein Coding) 2 3
  • Prostate-Specific Gene DD3 3
  • Non-Protein Coding RNA 19 2
  • Prostate Cancer Antigen 3 2
  • NCRNA00019 3
  • PCAT3 3
  • DD3 3

External Ids for PCA3 Gene

Previous GeneCards Identifiers for PCA3 Gene

  • GC09U990136
  • GC09P079379
  • GC09P049208

Summaries for PCA3 Gene

Entrez Gene Summary for PCA3 Gene

  • This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is used as a specific biomarker for this type of cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes adenosine deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

GeneCards Summary for PCA3 Gene

PCA3 (Prostate Cancer Associated 3 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with PCA3 include Prostate Cancer and Male Reproductive Organ Cancer.

Gene Wiki entry for PCA3 Gene

Additional gene information for PCA3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCA3 Gene

Genomics for PCA3 Gene

Regulatory Elements for PCA3 Gene

Enhancers for PCA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H076768 0.4 FANTOM5 0.7 +4.6 4596 0 PRUNE2 PCA3 ENSG00000274326
GH09H076776 0.3 FANTOM5 0.4 +11.8 11823 0 PRUNE2 ENSG00000274326 PCA3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCA3 Gene

Chromosome:
9
Start:
76,764,436 bp from pter
End:
76,787,569 bp from pter
Size:
23,134 bases
Orientation:
Plus strand

Genomic View for PCA3 Gene

Genes around PCA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCA3 Gene

Proteins for PCA3 Gene

Post-translational modifications for PCA3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PCA3 Gene

Domains & Families for PCA3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCA3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PCA3 Gene

Function for PCA3 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for PCA3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCA3 Gene

Localization for PCA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCA3 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PCA3 Gene

Pathways & Interactions for PCA3 Gene

No Data Available

Interacting Proteins for PCA3 Gene

Gene Ontology (GO) - Biological Process for PCA3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCA3 Gene

Drugs & Compounds for PCA3 Gene

No Compound Related Data Available

Transcripts for PCA3 Gene

mRNA/cDNA for PCA3 Gene

(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCA3 Gene

Prostate cancer antigen 3 (non-protein coding):
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for PCA3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PCA3 Gene

No ASD Table

Relevant External Links for PCA3 Gene

GeneLoc Exon Structure for
PCA3
ECgene alternative splicing isoforms for
PCA3

Expression for PCA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCA3 Gene

mRNA differential expression in normal tissues according to GTEx for PCA3 Gene

This gene is overexpressed in Prostate (x28.6).

NURSA nuclear receptor signaling pathways regulating expression of PCA3 Gene:

PCA3

SOURCE GeneReport for Unigene cluster for PCA3 Gene:

Hs.663766

Evidence on tissue expression from TISSUES for PCA3 Gene

  • Urine(2.8)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with PCA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCA3 Gene

Orthologs for PCA3 Gene

Evolution for PCA3 Gene

ENSEMBL:
Gene Tree for PCA3 (if available)
TreeFam:
Gene Tree for PCA3 (if available)

No data available for Orthologs for PCA3 Gene

Paralogs for PCA3 Gene

No data available for Paralogs for PCA3 Gene

Variants for PCA3 Gene

Sequence variations from dbSNP and Humsavar for PCA3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000035301 -- 76,765,489(+) AGAAT(-/AG)AGACA intron-variant
rs1000085782 -- 76,765,181(+) GGAAC(A/C)AAGCT intron-variant
rs1000249965 -- 76,771,246(+) TAAAT(A/G)TATTT intron-variant
rs1000279992 -- 76,768,083(+) TCCCT(C/G)CCTGG intron-variant
rs1000311059 -- 76,768,308(+) CTACC(A/T)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCA3 Gene

Variant ID Type Subtype PubMed ID
dgv1484e214 CNV gain 21293372
esv2663601 CNV deletion 23128226
esv2738601 CNV deletion 23290073
esv2759697 CNV loss 17122850
esv3620746 CNV loss 21293372
nsv1040363 CNV gain 25217958
nsv824952 CNV loss 20364138

Relevant External Links for PCA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PCA3 Gene

Disorders for PCA3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PCA3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
male reproductive organ cancer
  • male genital cancer
reproductive organ cancer
  • cancer of reproductive system
- elite association - COSMIC cancer census association via MalaCards
Search PCA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PCA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCA3
genes like me logo Genes that share disorders with PCA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCA3 Gene

Publications for PCA3 Gene

  1. DD3: a new prostate-specific gene, highly overexpressed in prostate cancer. (PMID: 10606244) Bussemakers MJ … Isaacs WB (Cancer research 1999) 2 3 22 60
  2. PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. (PMID: 26080435) Salameh A … Arap W (Proceedings of the National Academy of Sciences of the United States of America 2015) 2 3 60
  3. PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling. (PMID: 23130941) Ferreira LB … Gimba ER (BMC cancer 2012) 2 3 60
  4. New genomic structure for prostate cancer specific gene PCA3 within BMCC1: implications for prostate cancer detection and progression. (PMID: 19319183) Clarke RA … Gardiner RA (PloS one 2009) 3 22 60
  5. Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy. (PMID: 18602209) Haese A … Schalken JA (European urology 2008) 3 22 60

Products for PCA3 Gene

Sources for PCA3 Gene

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