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Aliases for PBXIP1 Gene

Aliases for PBXIP1 Gene

  • PBX Homeobox Interacting Protein 1 2 3 5
  • Pre-B-Cell Leukemia Homeobox Interacting Protein 1 2 3
  • Hematopoietic PBX-Interacting Protein 3 4
  • HPIP 3 4
  • Pre-B-Cell Leukemia Transcription Factor Interacting Protein 1 2
  • Pre-B-Cell Leukemia Transcription Factor-Interacting Protein 1 3

External Ids for PBXIP1 Gene

Previous GeneCards Identifiers for PBXIP1 Gene

  • GC01M151691
  • GC01M152133
  • GC01M151729
  • GC01M153183
  • GC01M154916
  • GC01M126278

Summaries for PBXIP1 Gene

Entrez Gene Summary for PBXIP1 Gene

  • The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]

GeneCards Summary for PBXIP1 Gene

PBXIP1 (PBX Homeobox Interacting Protein 1) is a Protein Coding gene. Diseases associated with PBXIP1 include Leukemia. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is MIR628.

UniProtKB/Swiss-Prot for PBXIP1 Gene

  • Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBXIP1 Gene

Genomics for PBXIP1 Gene

Regulatory Elements for PBXIP1 Gene

Enhancers for PBXIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F154855 1.6 FANTOM5 Ensembl ENCODE 7.5 +95.9 95934 8.8 HDGF PKNOX1 ATF1 WRNIP1 SIN3A GLIS2 GATA2 ELK1 ZNF143 JUNB KCNN3 ADAR UBE2Q1 UBE2Q1-AS1 PBXIP1 RUSC1 MUC1 FDPS ADAM15 PMVK
GH01F154935 1.5 FANTOM5 ENCODE 6.1 +18.5 18472 3.8 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC LOC101928120 KRTCAP2 ASH1L RAB13 TDRD10 ENSG00000272654 RPS27 MSTO2P ASH1L-AS1 KIAA0907
GH01F154606 1.5 FANTOM5 ENCODE 3.9 +347.7 347659 4.1 HDGF WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 ZNF207 ZNF263 ENSG00000271267 CHRNB2 MIR4258 DAP3P1 RUSC1-AS1 NUP210L CHTOP DPM3 EFNA4 UBE2Q1
GH01F155084 1.1 ENCODE 4.3 -129.2 -129155 2.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ADAM15 ASH1L PYGO2 EFNA1 SLC50A1 KRTCAP2 MIR92B MUC1 MTX1 THBS3
GH01F154790 1.1 Ensembl ENCODE 4.2 +164.5 164470 1.6 PKNOX1 TBL1XR1 WRNIP1 ZNF335 EGR1 SCRT2 ETV6 CREM ZNF362 CBFB KCNN3 UBE2Q1 UBE2Q1-AS1 ADAM15 DCST1-AS1 PBXIP1 PIR50309 PIR49202
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PBXIP1 on UCSC Golden Path with GeneCards custom track

Promoters for PBXIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750376 223 1401 ZNF493 ZFP64 SIN3A ARID4B SLC30A9 GLIS2 KLF7 FOS ZNF263 ZNF202

Genomic Location for PBXIP1 Gene

Chromosome:
1
Start:
154,944,076 bp from pter
End:
154,956,123 bp from pter
Size:
12,048 bases
Orientation:
Minus strand

Genomic View for PBXIP1 Gene

Genes around PBXIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PBXIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PBXIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBXIP1 Gene

Proteins for PBXIP1 Gene

  • Protein details for PBXIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AQ6-PBIP1_HUMAN
    Recommended name:
    Pre-B-cell leukemia transcription factor-interacting protein 1
    Protein Accession:
    Q96AQ6
    Secondary Accessions:
    • Q5T174
    • Q5T176
    • Q9H8X6
    • Q9HA02
    • Q9HD85

    Protein attributes for PBXIP1 Gene

    Size:
    731 amino acids
    Molecular mass:
    80643 Da
    Quaternary structure:
    • Interacts with TEX11 (By similarity). Interacts with ESR1, PBX1, PBX2 and PBX3.

    Alternative splice isoforms for PBXIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PBXIP1 Gene

Post-translational modifications for PBXIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PBXIP1 Gene

No data available for DME Specific Peptides for PBXIP1 Gene

Domains & Families for PBXIP1 Gene

Protein Domains for PBXIP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96AQ6

UniProtKB/Swiss-Prot:

PBIP1_HUMAN :
  • The C-terminal domain (AA 443-731) contains a nuclear export signal.
Domain:
  • The C-terminal domain (AA 443-731) contains a nuclear export signal.
  • Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).
genes like me logo Genes that share domains with PBXIP1: view

No data available for Gene Families for PBXIP1 Gene

Function for PBXIP1 Gene

Molecular function for PBXIP1 Gene

UniProtKB/Swiss-Prot Function:
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.

Gene Ontology (GO) - Molecular Function for PBXIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity NAS 10825160
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PBXIP1: view
genes like me logo Genes that share phenotypes with PBXIP1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PBXIP1 Gene

Localization for PBXIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBXIP1 Gene

Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PBXIP1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 2
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PBXIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10825160
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol NAS 10825160
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with PBXIP1: view

Pathways & Interactions for PBXIP1 Gene

SuperPathways for PBXIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PBXIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development NAS 10825160
GO:0030154 cell differentiation IEA,NAS 10825160
GO:0045892 negative regulation of transcription, DNA-templated IEA,NAS 10825160
genes like me logo Genes that share ontologies with PBXIP1: view

No data available for Pathways by source and SIGNOR curated interactions for PBXIP1 Gene

Transcripts for PBXIP1 Gene

Unigene Clusters for PBXIP1 Gene

Pre-B-cell leukemia homeobox interacting protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PBXIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - -
SP21: - - - - - - -
SP22: - - - - - - - - -
SP23: - - - -
SP24: - -
SP25: - - -
SP26: -

ExUns: 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15
SP1: -
SP2: -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

Relevant External Links for PBXIP1 Gene

GeneLoc Exon Structure for
PBXIP1
ECgene alternative splicing isoforms for
PBXIP1

Expression for PBXIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PBXIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PBXIP1 Gene

This gene is overexpressed in Nasal epithelium (22.3), Spinal cord (7.4), and Retina (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PBXIP1 Gene



Protein tissue co-expression partners for PBXIP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PBXIP1 Gene:

PBXIP1

SOURCE GeneReport for Unigene cluster for PBXIP1 Gene:

Hs.505806

mRNA Expression by UniProt/SwissProt for PBXIP1 Gene:

Q96AQ6-PBIP1_HUMAN
Tissue specificity: Expressed in early hematopoietic precursors.
genes like me logo Genes that share expression patterns with PBXIP1: view

No data available for mRNA differential expression in normal tissues for PBXIP1 Gene

Orthologs for PBXIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PBXIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PBXIP1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PBXIP1 34 35
  • 84.57 (n)
dog
(Canis familiaris)
Mammalia PBXIP1 34 35
  • 81.1 (n)
mouse
(Mus musculus)
Mammalia Pbxip1 34 16 35
  • 79.34 (n)
rat
(Rattus norvegicus)
Mammalia Pbxip1 34
  • 79.1 (n)
oppossum
(Monodelphis domestica)
Mammalia PBXIP1 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PBXIP1 35
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PBXIP1 35
  • 21 (a)
OneToMany
Species where no ortholog for PBXIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PBXIP1 Gene

ENSEMBL:
Gene Tree for PBXIP1 (if available)
TreeFam:
Gene Tree for PBXIP1 (if available)

Paralogs for PBXIP1 Gene

Paralogs for PBXIP1 Gene

Pseudogenes.org Pseudogenes for PBXIP1 Gene

genes like me logo Genes that share paralogs with PBXIP1: view

Variants for PBXIP1 Gene

Sequence variations from dbSNP and Humsavar for PBXIP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10533 -- 154,944,469(+) GATCT(G/T)AGTCT upstream-variant-2KB, utr-variant-3-prime
rs111281706 -- 154,954,532(+) TAATC(A/G)CCAGA intron-variant
rs111290363 -- 154,948,945(+) ACTGC(C/T)CTGCA intron-variant
rs111434745 -- 154,945,275(+) CAGTC(A/G)GGGAG intron-variant
rs112127184 -- 154,957,760(+) CCGCC(A/G)CATCC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PBXIP1 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV insertion 20534489
esv2718374 CNV deletion 23290073

Variation tolerance for PBXIP1 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PBXIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PBXIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PBXIP1 Gene

Disorders for PBXIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PBXIP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leukemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PBXIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PBXIP1
genes like me logo Genes that share disorders with PBXIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PBXIP1 Gene

Publications for PBXIP1 Gene

  1. Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP). (PMID: 12360403) Abramovich C. … Humphries R.K. (Oncogene 2002) 3 4 22 64
  2. Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA. (PMID: 10825160) Abramovich C. … Humphries R.K. (J. Biol. Chem. 2000) 2 3 4 64
  3. The estrogen receptor-interacting protein HPIP increases estrogen-responsive gene expression through activation of MAPK and AKT. (PMID: 18302941) Wang X. … Ye Q. (Biochim. Biophys. Acta 2008) 3 22 64
  4. An inherent role of microtubule network in the action of nuclear receptor. (PMID: 17043237) Manavathi B. … Kumar R. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for PBXIP1 Gene

Sources for PBXIP1 Gene

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