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Aliases for PBXIP1 Gene

Aliases for PBXIP1 Gene

  • Pre-B-Cell Leukemia Homeobox Interacting Protein 1 2 3
  • Pre-B-Cell Leukemia Transcription Factor Interacting Protein 1 2 3
  • Hematopoietic PBX-Interacting Protein 3 4
  • HPIP 3 4
  • Pre-B-Cell Leukemia Transcription Factor-Interacting Protein 1 3

External Ids for PBXIP1 Gene

Summaries for PBXIP1 Gene

GeneCards Summary for PBXIP1 Gene

PBXIP1 (Pre-B-Cell Leukemia Homeobox Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is CCPG1.

UniProtKB/Swiss-Prot for PBXIP1 Gene

  • Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBXIP1 Gene

Genomics for PBXIP1 Gene

Genomic Location for PBXIP1 Gene

Start:
154,944,076 bp from pter
End:
154,956,123 bp from pter
Size:
12,048 bases
Orientation:
Minus strand

Genomic View for PBXIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PBXIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBXIP1 Gene

Regulatory Elements for PBXIP1 Gene

Proteins for PBXIP1 Gene

  • Protein details for PBXIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AQ6-PBIP1_HUMAN
    Recommended name:
    Pre-B-cell leukemia transcription factor-interacting protein 1
    Protein Accession:
    Q96AQ6
    Secondary Accessions:
    • Q5T174
    • Q5T176
    • Q9H8X6
    • Q9HA02
    • Q9HD85

    Protein attributes for PBXIP1 Gene

    Size:
    731 amino acids
    Molecular mass:
    80643 Da
    Quaternary structure:
    • Interacts with TEX11 (By similarity). Interacts with ESR1, PBX1, PBX2 and PBX3.

    Alternative splice isoforms for PBXIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PBXIP1 Gene

Proteomics data for PBXIP1 Gene at MOPED

Post-translational modifications for PBXIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PBXIP1 Gene

No data available for DME Specific Peptides for PBXIP1 Gene

Domains for PBXIP1 Gene

Protein Domains for PBXIP1 Gene

ProtoNet:

UniProtKB/Swiss-Prot:

PBIP1_HUMAN
Domain:
  • The C-terminal domain (AA 443-731) contains a nuclear export signal:
    • Q96AQ6
  • Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218):
    • Q96AQ6
genes like me logo Genes that share domains with PBXIP1: view

No data available for Gene Families for PBXIP1 Gene

Function for PBXIP1 Gene

Molecular function for PBXIP1 Gene

UniProtKB/Swiss-Prot Function: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.

Gene Ontology (GO) - Molecular Function for PBXIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity NAS 10825160
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PBXIP1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PBXIP1 Gene

Localization for PBXIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBXIP1 Gene

Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PBXIP1 Gene COMPARTMENTS Subcellular localization image for PBXIP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PBXIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10825160
GO:0005829 cytosol NAS 10825160
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with PBXIP1: view

Pathways for PBXIP1 Gene

SuperPathways for PBXIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PBXIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development NAS 10825160
GO:0030154 cell differentiation NAS 10825160
GO:0045892 negative regulation of transcription, DNA-templated NAS 10825160
genes like me logo Genes that share ontologies with PBXIP1: view

No data available for Pathways by source for PBXIP1 Gene

Transcripts for PBXIP1 Gene

Unigene Clusters for PBXIP1 Gene

Pre-B-cell leukemia homeobox interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PBXIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - -
SP21: - - - - - - -
SP22: - - - - - - - - -
SP23: - - - -
SP24: - -
SP25: - - -
SP26: -

ExUns: 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15
SP1: -
SP2: -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

Relevant External Links for PBXIP1 Gene

GeneLoc Exon Structure for
PBXIP1
ECgene alternative splicing isoforms for
PBXIP1

Expression for PBXIP1 Gene

mRNA expression in normal human tissues for PBXIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PBXIP1 Gene

SOURCE GeneReport for Unigene cluster for PBXIP1 Gene Hs.505806

mRNA Expression by UniProt/SwissProt for PBXIP1 Gene

Q96AQ6-PBIP1_HUMAN
Tissue specificity: Expressed in early hematopoietic precursors.
genes like me logo Genes that share expressions with PBXIP1: view

Orthologs for PBXIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PBXIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PBXIP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PBXIP1 36
  • 84.57 (n)
  • 79.22 (a)
PBXIP1 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PBXIP1 36
  • 81.1 (n)
  • 73.79 (a)
PBXIP1 37
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pbxip1 36
  • 79.34 (n)
  • 72.11 (a)
Pbxip1 16
Pbxip1 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PBXIP1 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PBXIP1 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pbxip1 36
  • 79.1 (n)
  • 72.88 (a)
zebrafish
(Danio rerio)
Actinopterygii PBXIP1 37
  • 21 (a)
OneToMany
Species with no ortholog for PBXIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PBXIP1 Gene

ENSEMBL:
Gene Tree for PBXIP1 (if available)
TreeFam:
Gene Tree for PBXIP1 (if available)

Paralogs for PBXIP1 Gene

Paralogs for PBXIP1 Gene

Pseudogenes.org Pseudogenes for PBXIP1 Gene

genes like me logo Genes that share paralogs with PBXIP1: view

Variants for PBXIP1 Gene

Sequence variations from dbSNP and Humsavar for PBXIP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9236 -- 154,944,126(-) AAGGC(G/T)ATGGA utr-variant-3-prime
rs10533 -- 154,944,469(+) GATCT(G/T)AGTCT utr-variant-3-prime
rs705094 -- 154,944,838(+) GCAAC(A/G)CAGGT utr-variant-3-prime
rs906594 -- 154,945,225(+) GCACC(A/G)CCAAG intron-variant
rs1218593 -- 154,953,513(+) CCTGA(C/T)CTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBXIP1 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872453 CNV Loss 21882294
nsv872454 CNV Loss 21882294
esv2718374 CNV Deletion 23290073

Relevant External Links for PBXIP1 Gene

HapMap Linkage Disequilibrium report
PBXIP1

Disorders for PBXIP1 Gene

No disorders were found for PBXIP1 Gene.

No data available for UniProtKB/Swiss-Prot for PBXIP1 Gene

Publications for PBXIP1 Gene

  1. Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP). (PMID: 12360403) Abramovich C. … Humphries R.K. (Oncogene 2002) 3 4 23
  2. Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA. (PMID: 10825160) Abramovich C. … Humphries R.K. (J. Biol. Chem. 2000) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes. (PMID: 7505766) Epplen C. … Epplen J.T. (Hum. Genet. 1994) 2 3
  5. An inherent role of microtubule network in the action of nuclear receptor. (PMID: 17043237) Manavathi B. … Kumar R. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4

Products for PBXIP1 Gene

Sources for PBXIP1 Gene

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