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Aliases for PBX4 Gene

Aliases for PBX4 Gene

  • PBX Homeobox 4 2 3 5
  • Pre-B-Cell Leukemia Transcription Factor 4 2
  • Pre-B-Cell Leukemia Homeobox 4 2
  • Homeobox Protein PBX4 4

External Ids for PBX4 Gene

Previous GeneCards Identifiers for PBX4 Gene

  • GC19M020166
  • GC19M020063
  • GC19M019517
  • GC19M019533
  • GC19M019672
  • GC19M019234

Summaries for PBX4 Gene

Entrez Gene Summary for PBX4 Gene

  • This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for PBX4 Gene

PBX4 (PBX Homeobox 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is PBX2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBX4 Gene

Genomics for PBX4 Gene

Regulatory Elements for PBX4 Gene

Enhancers for PBX4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F019589 1.4 FANTOM5 Ensembl ENCODE 17.4 +27.6 27624 3.2 HDGF PKNOX1 ZNF146 WRNIP1 JUN MAX EBF1 RELA RFX5 POLR2A GATAD2A PBX4 GMIP LPAR2 ATP13A1 RFXANK ZNF14 MAU2 ZNF506 PHF5CP
GH19F019575 0.2 ENCODE 12 +43.2 43193 0.6 POLR2A PBX4 LPAR2 GMIP ATP13A1 GC19P019572 GC19M019588
GH19F019530 0.2 ENCODE 11.9 +88.3 88330 0.2 CTCF ZFHX2 POLR2A SPI1 PBX4 LPAR2 GMIP ATP13A1 YJEFN3 GC19M019535
GH19F019865 1.1 FANTOM5 Ensembl ENCODE 9.4 -247.9 -247891 3.2 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 GATA2 CBX5 ZNF93 ZNF506 GMIP ZNF14 LPAR2 PBX4 ZNF253 ENSG00000267268 ZNF101 ZNF682
GH19F019594 1.2 FANTOM5 Ensembl ENCODE 5.4 +20.0 19987 9.1 HDGF PKNOX1 ATF1 YY1 CBX5 ELK1 ZNF548 JUNB TBX21 PBX2 LPAR2 GATAD2A ATP13A1 GMIP ZNF90 UPF1 PBX4 NDUFA13 RFXANK ZNF14
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PBX4 on UCSC Golden Path with GeneCards custom track

Promoters for PBX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141472 416 1401 HDGF TBP PKNOX1 SIN3A DEAF1 BMI1 RFX5 EGR1 ZNF366 ZNF143

Genomic Location for PBX4 Gene

Chromosome:
19
Start:
19,561,707 bp from pter
End:
19,618,916 bp from pter
Size:
57,210 bases
Orientation:
Minus strand

Genomic View for PBX4 Gene

Genes around PBX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PBX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PBX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBX4 Gene

Proteins for PBX4 Gene

  • Protein details for PBX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYU1-PBX4_HUMAN
    Recommended name:
    Pre-B-cell leukemia transcription factor 4
    Protein Accession:
    Q9BYU1
    Secondary Accessions:
    • A5D8Y0
    • B3KUK9

    Protein attributes for PBX4 Gene

    Size:
    374 amino acids
    Molecular mass:
    40854 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC033067; Type=Frameshift; Positions=137; Evidence={ECO:0000305};

neXtProt entry for PBX4 Gene

Post-translational modifications for PBX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PBX4 Gene

Domains & Families for PBX4 Gene

Gene Families for PBX4 Gene

Protein Domains for PBX4 Gene

Suggested Antigen Peptide Sequences for PBX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYU1

UniProtKB/Swiss-Prot:

PBX4_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/PBX homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/PBX homeobox family.
genes like me logo Genes that share domains with PBX4: view

Function for PBX4 Gene

Gene Ontology (GO) - Molecular Function for PBX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS 11335119
genes like me logo Genes that share ontologies with PBX4: view
genes like me logo Genes that share phenotypes with PBX4: view

Animal Model Products

miRNA for PBX4 Gene

miRTarBase miRNAs that target PBX4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PBX4 Gene

Localization for PBX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBX4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PBX4 Gene COMPARTMENTS Subcellular localization image for PBX4 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PBX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001741 XY body IEA --
GO:0005634 nucleus IEA,IC 11335119
genes like me logo Genes that share ontologies with PBX4: view

Pathways & Interactions for PBX4 Gene

SuperPathways for PBX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PBX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IC 11335119
GO:0045893 positive regulation of transcription, DNA-templated IC 11335119
genes like me logo Genes that share ontologies with PBX4: view

No data available for Pathways by source and SIGNOR curated interactions for PBX4 Gene

Transcripts for PBX4 Gene

Unigene Clusters for PBX4 Gene

Pre-B-cell leukemia homeobox 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PBX4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for PBX4 Gene

GeneLoc Exon Structure for
PBX4
ECgene alternative splicing isoforms for
PBX4

Expression for PBX4 Gene

mRNA expression in normal human tissues for PBX4 Gene

mRNA differential expression in normal tissues according to GTEx for PBX4 Gene

This gene is overexpressed in Thyroid (x10.5).

Protein differential expression in normal tissues from HIPED for PBX4 Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PBX4 Gene



Protein tissue co-expression partners for PBX4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PBX4 Gene:

PBX4

SOURCE GeneReport for Unigene cluster for PBX4 Gene:

Hs.466257
genes like me logo Genes that share expression patterns with PBX4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PBX4 Gene

Orthologs for PBX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PBX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PBX4 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia PBX4 34 35
  • 87.3 (n)
rat
(Rattus norvegicus)
Mammalia Pbx4 34
  • 83.62 (n)
mouse
(Mus musculus)
Mammalia Pbx4 34 16 35
  • 83.19 (n)
cow
(Bos Taurus)
Mammalia PBX4 34 35
  • 82.77 (n)
oppossum
(Monodelphis domestica)
Mammalia PBX4 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PBX4 34 35
  • 79.44 (n)
lizard
(Anolis carolinensis)
Reptilia PBX4 35
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PBX4 (2 of 2) 35
  • 81 (a)
OneToMany
pbx4 35
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta exd 36 35
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-20 36 35
  • 60 (a)
ceh-40 36 35
  • 35 (a)
ceh-60 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8721 35
  • 50 (a)
OneToMany
Species where no ortholog for PBX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PBX4 Gene

ENSEMBL:
Gene Tree for PBX4 (if available)
TreeFam:
Gene Tree for PBX4 (if available)

Paralogs for PBX4 Gene

Paralogs for PBX4 Gene

(3) SIMAP similar genes for PBX4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PBX4: view

Variants for PBX4 Gene

Sequence variations from dbSNP and Humsavar for PBX4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs376647012 A colorectal cancer sample 19,565,010(+) TACCC(A/G)TGTAA nc-transcript-variant, reference, missense
rs10221485 -- 19,569,231(+) TTTTT(A/T)AAATT intron-variant
rs10403137 -- 19,593,009(+) CTGCC(C/T)GAGGC intron-variant
rs10403759 -- 19,614,279(+) gtgag(C/T)tgaga intron-variant
rs10410736 -- 19,569,263(+) ctatg(C/T)tgccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBX4 Gene

Variant ID Type Subtype PubMed ID
esv3410221 CNV duplication 20981092
nsv1113987 CNV deletion 24896259
nsv1127663 CNV deletion 24896259
nsv509723 CNV insertion 20534489
nsv509725 CNV insertion 20534489
nsv518076 CNV loss 19592680
nsv952426 CNV deletion 24416366
nsv952427 CNV deletion 24416366
nsv978785 CNV duplication 23825009

Variation tolerance for PBX4 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PBX4 Gene

Human Gene Mutation Database (HGMD)
PBX4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PBX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PBX4 Gene

Disorders for PBX4 Gene

Relevant External Links for PBX4

Genetic Association Database (GAD)
PBX4
Human Genome Epidemiology (HuGE) Navigator
PBX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PBX4

No disorders were found for PBX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PBX4 Gene

Publications for PBX4 Gene

  1. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. (PMID: 18987386) Tai E.S. … Seielstad M. (J. Lipid Res. 2009) 3 46 64
  2. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 46 64
  3. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. (PMID: 18193044) Kathiresan S. … Orho-Melander M. (Nat. Genet. 2008) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PBX4 Gene

Sources for PBX4 Gene

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