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PBX4 Gene

protein-coding   GIFtS: 50
GCID: GC19M019672

Pre-B-Cell Leukemia Homeobox 4

(Previous name: pre-B-cell leukemia transcription factor 4)
  See PBX4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pre-B-Cell Leukemia Homeobox 41 2
Pre-B-Cell Leukemia Transcription Factor 41 2
Homeobox Protein PBX42 3

External Ids:    HGNC: 134031   Entrez Gene: 807142   Ensembl: ENSG000001057177   OMIM: 6081275   UniProtKB: Q9BYU13   

Export aliases for PBX4 gene to outside databases

Previous GC identifers: GC19M020166 GC19M020063 GC19M019517 GC19M019533 GC19M019234


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PBX4 Gene:
This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox
proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and
through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific
functions of the protein have not been determined. Alternatively spliced transcript variants have been observed
for this gene. (provided by RefSeq, May 2011)

GeneCards Summary for PBX4 Gene:
PBX4 (pre-B-cell leukemia homeobox 4) is a protein-coding gene. Diseases associated with PBX4 include leukemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PBX3.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PBX4 gene promoter:
         Max1   PPAR-gamma1   Tal-1   p53   IRF-7A   SEF-1 (1)   Olf-1   PPAR-gamma2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPBX4 promoter sequence
   Search Chromatin IP Primers for PBX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PBX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p12

PBX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PBX4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019672:  view genomic region     (about GC identifiers)

Start:
19,672,516 bp from pter      End:
19,729,725 bp from pter
Size:
57,210 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PBX4_HUMAN, Q9BYU1 (See protein sequence)
Recommended Name: Pre-B-cell leukemia transcription factor 4  
Size: 374 amino acids; 40854 Da
Sequence caution: Sequence=BC033067; Type=Frameshift; Positions=137;
Secondary accessions: A5D8Y0 B3KUK9

Explore the universe of human proteins at neXtProt for PBX4: NX_Q9BYU1

Explore proteomics data for PBX4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PBX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079521.1  
    ENSEMBL proteins: 
     ENSP00000251203   ENSP00000453348   ENSP00000453069  

    PBX4 Human Recombinant Protein Products:

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    Novus Biologicals PBX4 Protein
    Novus Biologicals PBX4 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PBX4

     
    Search eBioscience for Proteins for PBX4 

     
    antibodies-online proteins for PBX4 (4 products) 

     
    antibodies-online peptides for PBX4

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    antibodies-online antibodies for PBX4 (18 products) 

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    Cloud-Clone Corp. ELISAs for PBX4
    Cloud-Clone Corp. CLIAs for PBX4
    Search eBioscience for ELISAs for PBX4 
    antibodies-online kits for PBX4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    3 InterPro protein domains:
     IPR005542 PBX
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9BYU1

    ProtoNet protein and cluster: Q9BYU1

    UniProtKB/Swiss-Prot: PBX4_HUMAN, Q9BYU1
    Similarity: Belongs to the TALE/PBX homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with PBX4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ISS11335119
         
    Find genes that share ontologies with PBX4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PBX4

    miRNA
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    miRTarBase miRNAs that target PBX4:
    hsa-mir-1274a (MIRT035839)

    Block miRNA regulation of human, mouse, rat PBX4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PBX4:
    hsa-miR-3163 hsa-miR-4303
    SwitchGear 3'UTR luciferase reporter plasmidPBX4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PBX4

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    GenScript: all cDNA clones in your preferred vector: PBX4 (NM_025245)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PBX4_HUMAN, Q9BYU1: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001741XY body IEA--
    GO:0005634nucleus IC11335119

    Find genes that share ontologies with PBX4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PBX4
    Interactions:

        Search GeneGlobe Interaction Network for PBX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for PBX4 (Q9BYU13 ENSP000002512034) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
    MEIS3Q996873, ENSP000003335524I2D: score=1 STRING: ENSP00000333552
    PKNOX2Q96KN33, ENSP000002982824I2D: score=1 STRING: ENSP00000298282
    JDP2Q8WYK23I2D: score=1 
    MEIS2O147703I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IC11335119
    GO:0045893positive regulation of transcription, DNA-templated IC11335119

    Find genes that share ontologies with PBX4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PBX4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PBX4 gene: 
    NM_025245.2  

    Unigene Cluster for PBX4:

    Pre-B-cell leukemia homeobox 4
    Hs.466257  [show with all ESTs]
    Unigene Representative Sequence: NM_025245
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558276 ENST00000251203(uc010xra.2 uc002nmy.3 uc010xqz.2)
    ENST00000557978 ENST00000558222 ENST00000559735
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate PBX4:
    hsa-miR-3163 hsa-miR-4303
    SwitchGear 3'UTR luciferase reporter plasmidPBX4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PBX4
    Predesigned siRNA for gene silencing in human, mouse, rat PBX4
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    GenScript: all cDNA clones in your preferred vector: PBX4 (NM_025245)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PBX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PBX4
      QuantiTect SYBR Green Assays in human, mouse, rat PBX4
      QuantiFast Probe-based Assays in human, mouse, rat PBX4

    Additional mRNA sequence: 

    AJ300182.1 AK097427.1 AK301631.1 BC033067.1 BC141859.1 BC143588.1 BC143589.1 NR_038198.1 

    5 DOTS entries:

    DT.40126527  DT.92415764  DT.97810645  DT.105265  DT.121493031 

    Selected AceView cDNA sequences (see all 40):

    AI199900 BG697418 BM474457 AJ300182 BX280620 AK097427 NM_025245 BC033067 
    BE298082 AI652414 BI016693 BQ182920 BU686586 BM969616 BQ189744 BE298279 
    AI659966 BM449730 CK300861 AW248988 BU683358 AA904552 W93274 AW248546 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PBX4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -     -                             -                           
    SP2:                    -     -           -                                             
    SP3:                                      -                 -                           
    SP4:                                                                                    


    ECgene alternative splicing isoforms for PBX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PBX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTGCTGC
    PBX4 Expression
    About this image

    PBX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PBX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466257
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PBX4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pbx41 , 5 pre B cell leukemia homeobox 41, 5 83.19(n)1
    80.69(a)1
      8 (33.92 cM)5
    807201  NM_001024954.11  NP_001020125.11 
     698326245 
    chicken
    (Gallus gallus)
    Aves PBX41 pre-B-cell leukemia homeobox 4 79.44(n)
    81.13(a)
      426087  XM_423764.4  XP_423764.1 
    lizard
    (Anolis carolinensis)
    Reptilia PBX46
    pre-B-cell leukemia homeobox 4
    66(a)
    1 ↔ 1
    GL343198.1(4187159-4227733)
    zebrafish
    (Danio rerio)
    Actinopterygii PBX4 (2 of 2)6
    pbx46
    pre-B-cell leukemia transcription factor 4
    81(a)
    68(a)
    many → 1
    many → 1
    Zv9_NA116(3881-6636) ENSDARG00000091547
    3(53637984-53714491) ENSDARG00000052150
    fruit fly
    (Drosophila melanogaster)
    Insecta exd3 brain development specific RNA
    polymerase II transcription more
    77(a)   14A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-203   -- 60(a)
    (best of 2)
      III(7051642-7053281)   --


    ENSEMBL Gene Tree for PBX4 (if available)
    TreeFam Gene Tree for PBX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PBX4 gene
    PBX32  PBX22  PBX12  
    3 SIMAP similar genes for PBX4 using alignment to 2 protein entries:     PBX4_HUMAN (see all proteins):
    PBX1    PBX3    PBX2

    Find genes that share paralogs with PBX4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PBX4 (see all 1119)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364394
    A colorectal cancer sample4--see VAR_0364392 T M mis40--------
    rs1922729871,2
    --19672026(+) AAACCC/TCATCT 2 -- ds50010--------
    rs1383047911,2
    --19672122(+) TTGAAC/TCTGGG 2 -- ds50010--------
    rs2006345281,2
    --19672197(+) TCTGT-/CCCCCA 2 -- ds50010--------
    rs713383281,2
    C--19672200(+) TCCCC-/ACAAAA 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs20071981,2
    C,F,A--19672201(-) TTTTTT/GGGGGA 2 -- ds50014Minor allele frequency- G:0.25WA NA CSA 8
    rs1897574011,2
    C--19672244(+) GAGACA/GAGGTC 2 -- ds50010--------
    rs7502161,2
    C,F,A--19672267(-) GACCCG/ATCTGG 2 -- ds50015Minor allele frequency- A:0.27NA EA 246
    rs7502151,2
    C,F,A--19672317(-) agcacA/Tttgag 2 -- ds50019Minor allele frequency- T:0.47NA WA CSA EA 254
    rs1170840171,2
    C,F--19672356(+) AGCCAG/AGACAT 2 -- ds50011Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for PBX4 (19672516 - 19729725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PBX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509725CNV Insertion20534489
    nsv509723CNV Insertion20534489
    nsv911309CNV Loss21882294
    nsv518076CNV Loss19592680

    Human Gene Mutation Database (HGMD): PBX4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PBX4
    DNA2.0 Custom Variant and Variant Library Synthesis for PBX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608127    OMIM disorders: --

    1 disease for PBX4:    
    About MalaCards
    leukemia


    Find genes that share disorders with PBX4           About GenesLikeMe

    Genetic Association Database (GAD): PBX4
    Human Genome Epidemiology (HuGE) Navigator: PBX4 (6 documents)

    Export disorders for PBX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PBX4 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with PBX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. (PubMed id 18987386)1, 4 Tai E.S....Seielstad M. (J. Lipid Res. 2009)
    2. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)
    3. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. (PubMed id 18193044)1, 4 Kathiresan S....Orho-Melander M. (Nat. Genet. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Pbx4, a new Pbx family member on mouse chromosome 8 is expressed during spermatogenesis. (PubMed id 11335119)1, 2 Wagner K.... Poepperl H. (Mech. Dev. 2001)
    7. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance. (PubMed id 22185299)1 Rosales-AviA+a J.A....Jave-SuA!rez L.F. (amp 2011)
    10. Sex-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels in the Mulao and Han populations. (PubMed id 22208664)1 Yan T.T....Pan S.L. (Lipids Health Dis 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80714 HGNC: 13403 AceView: PBX4 Ensembl:ENSG00000105717 euGenes: HUgn80714
    ECgene: PBX4 H-InvDB: PBX4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PBX4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PBX4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PBX4 gene:
    Search GeneIP for patents involving PBX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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