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Aliases for PBX4 Gene

Aliases for PBX4 Gene

  • Pre-B-Cell Leukemia Homeobox 4 2 3
  • Pre-B-Cell Leukemia Transcription Factor 4 2
  • Homeobox Protein PBX4 4

External Ids for PBX4 Gene

Summaries for PBX4 Gene

Entrez Gene Summary for PBX4 Gene

  • This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for PBX4 Gene

PBX4 (Pre-B-Cell Leukemia Homeobox 4) is a Protein Coding gene. Diseases associated with PBX4 include leukemia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is PBX3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBX4 Gene

Genomics for PBX4 Gene

Genomic Location for PBX4 Gene

Start:
19,561,707 bp from pter
End:
19,618,916 bp from pter
Size:
57,210 bases
Orientation:
Minus strand

Genomic View for PBX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PBX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBX4 Gene

Regulatory Elements for PBX4 Gene

Proteins for PBX4 Gene

  • Protein details for PBX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYU1-PBX4_HUMAN
    Recommended name:
    Pre-B-cell leukemia transcription factor 4
    Protein Accession:
    Q9BYU1
    Secondary Accessions:
    • A5D8Y0
    • B3KUK9

    Protein attributes for PBX4 Gene

    Size:
    374 amino acids
    Molecular mass:
    40854 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC033067; Type=Frameshift; Positions=137; Evidence={ECO:0000305};

neXtProt entry for PBX4 Gene

Proteomics data for PBX4 Gene at MOPED

Post-translational modifications for PBX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PBX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PBX4 Gene

Domains for PBX4 Gene

Gene Families for PBX4 Gene

HGNC:
  • TALE :Homeoboxes / TALE class

Protein Domains for PBX4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PBX4_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q9BYU1
Family:
  • Belongs to the TALE/PBX homeobox family.:
    • Q9BYU1
genes like me logo Genes that share domains with PBX4: view

Function for PBX4 Gene

Gene Ontology (GO) - Molecular Function for PBX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS 11335119
genes like me logo Genes that share ontologies with PBX4: view

miRNA for PBX4 Gene

miRTarBase miRNAs that target PBX4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PBX4 Gene

Localization for PBX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBX4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PBX4 Gene COMPARTMENTS Subcellular localization image for PBX4 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PBX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001741 XY body IEA --
GO:0005634 nucleus IC 11335119
genes like me logo Genes that share ontologies with PBX4: view

Pathways for PBX4 Gene

SuperPathways for PBX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PBX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IC 11335119
GO:0045893 positive regulation of transcription, DNA-templated IC 11335119
genes like me logo Genes that share ontologies with PBX4: view

No data available for Pathways by source for PBX4 Gene

Transcripts for PBX4 Gene

Unigene Clusters for PBX4 Gene

Pre-B-cell leukemia homeobox 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PBX4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for PBX4 Gene

GeneLoc Exon Structure for
PBX4
ECgene alternative splicing isoforms for
PBX4

Expression for PBX4 Gene

mRNA expression in normal human tissues for PBX4 Gene

mRNA differential expression in normal tissues according to GTEx for PBX4 Gene

This gene is overexpressed in Thyroid (10.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PBX4 Gene

SOURCE GeneReport for Unigene cluster for PBX4 Gene Hs.466257

genes like me logo Genes that share expressions with PBX4: view

Orthologs for PBX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PBX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PBX4 36
  • 99.2 (n)
  • 98.66 (a)
PBX4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PBX4 36
  • 82.77 (n)
  • 78.81 (a)
PBX4 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PBX4 36
  • 87.3 (n)
  • 84.87 (a)
PBX4 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pbx4 36
  • 83.19 (n)
  • 80.69 (a)
Pbx4 16
Pbx4 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PBX4 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pbx4 36
  • 83.62 (n)
  • 81.92 (a)
chicken
(Gallus gallus)
Aves PBX4 36
  • 79.44 (n)
  • 81.13 (a)
PBX4 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PBX4 37
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pbx4 37
  • 68 (a)
OneToMany
PBX4 (2 of 2) 37
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta exd 37
  • 60 (a)
OneToMany
exd 38
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-20 37
  • 52 (a)
ManyToMany
ceh-40 37
  • 32 (a)
ManyToMany
ceh-60 37
  • 23 (a)
ManyToMany
ceh-40 38
  • 35 (a)
ceh-20 38
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8721 37
  • 50 (a)
OneToMany
Species with no ortholog for PBX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PBX4 Gene

ENSEMBL:
Gene Tree for PBX4 (if available)
TreeFam:
Gene Tree for PBX4 (if available)

Paralogs for PBX4 Gene

Paralogs for PBX4 Gene

Selected SIMAP similar genes for PBX4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PBX4: view

Variants for PBX4 Gene

Sequence variations from dbSNP and Humsavar for PBX4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs739461 -- 19,604,985(-) ATACC(A/G)CTTCT intron-variant
rs750215 -- 19,561,508(-) agcac(A/T)ttgag downstream-variant-500B
rs750216 -- 19,561,458(-) GACCC(A/G)TCTGG downstream-variant-500B
rs1476459 -- 19,609,219(+) AACTA(A/C)CCTCC intron-variant, utr-variant-5-prime
rs1865035 -- 19,567,073(-) AGAGC(A/G)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBX4 Gene

Variant ID Type Subtype PubMed ID
nsv509723 CNV Insertion 20534489
nsv518076 CNV Loss 19592680
nsv509725 CNV Insertion 20534489
nsv911309 CNV Loss 21882294

Relevant External Links for PBX4 Gene

HapMap Linkage Disequilibrium report
PBX4
Human Gene Mutation Database (HGMD)
PBX4

Disorders for PBX4 Gene

(1) MalaCards Diseases for PBX4 Gene

Search for PBX4 Gene in MalaCards »

Relevant External Links for PBX4

Genetic Association Database (GAD)
PBX4
Human Genome Epidemiology (HuGE) Navigator
PBX4
genes like me logo Genes that share disorders with PBX4: view

No data available for UniProtKB/Swiss-Prot for PBX4 Gene

Publications for PBX4 Gene

  1. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. (PMID: 18193044) Kathiresan S. … Orho-Melander M. (Nat. Genet. 2008) 3 49
  2. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. (PMID: 18987386) Tai E.S. … Seielstad M. (J. Lipid Res. 2009) 3 49
  3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 49
  4. Pbx4, a new Pbx family member on mouse chromosome 8 is expressed during spermatogenesis. (PMID: 11335119) Wagner K. … Poepperl H. (Mech. Dev. 2001) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for PBX4 Gene

Sources for PBX4 Gene

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