PBX4 Gene
protein-coding GIFtS: 48
GCID: GC19M019672
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pre-B-cell leukemia homeobox 4(Previous name: pre-B-cell leukemia transcription factor 4 )
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Aliases
for PBX4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Pre-B-Cell Leukemia Homeobox 41 2 | | Pre-B-Cell Leukemia Transcription Factor 41 2 | | Homeobox Protein PBX42 3 |
| External Ids: | HGNC: 134031 | Entrez Gene: 807142 | Ensembl: ENSG000001057177 | OMIM: 6081275 | UniProtKB: Q9BYU13 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n410746 | |
Export aliases for PBX4 gene to outside databasesPrevious GC identifers: GC19M020166 GC19M020063 GC19M019517 GC19M019533 GC19M019234
Summaries
for PBX4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PBX4:
This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteinsthat play critical roles in embryonic development and cellular differentiation both as Hox cofactors and throughHox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of theprotein have not been determined. Alternatively spliced transcript variants have been observed for this gene.(provided by RefSeq, May 2011)
|
Genomic Views
for PBX4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PBX4 gene promoter:
Max1 PPAR-gamma1 Tal-1 p53 IRF-7A SEF-1 (1) Olf-1 PPAR-gamma2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for PBX4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PBX4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p12PBX4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M019672: view genomic region
(about GC identifiers)
Start:
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19,672,522 bp from pter |
End:
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19,729,725 bp from pter |
Size:
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57,204 bases |
Orientation:
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minus strand |
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Proteins
for PBX4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PBX4_HUMAN, Q9BYU1 (See
protein sequence)Recommended Name: Pre-B-cell leukemia transcription factor 4 Size: 374 amino acids; 40854 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BC033067; Type=Frameshift; Positions=137;
Secondary accessions: A5D8Y0 B3KUK9Explore the universe of human proteins at neXtProt for PBX4: NX_Q9BYU1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BYU1
PBX4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079521.1
ENSEMBL proteins: ENSP00000251203 ENSP00000453348 ENSP00000453069
Human Recombinant Protein Products for PBX4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PBX4 for ontologies About GeneDecksing
PBX4 Antibody Products:
Assay Products for PBX4: |
Protein
Domains /
Families
for PBX4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PBX4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BYU1ProtoNet protein and cluster: Q9BYU1 UniProtKB/Swiss-Prot: PBX4_HUMAN, Q9BYU1Similarity: Belongs to the TALE/PBX homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for PBX4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
ISS | 11335119 |
PBX4 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PBX4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PBX4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PBX4 (NM_025245) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PBX4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX4 |
|
Pathways & Interactions
for PBX4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PBX4
5/7 Interacting proteins for PBX4 (Q9BYU13) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
PBX4 for ontologies About GeneDecksing
|
Drugs & Compounds
for PBX4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PBX4
Search CenterWatch for drugs/clinical trials and news about PBX4
|
Transcripts
for PBX4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PBX4 gene: NM_025245.2 Unigene Cluster for PBX4: Pre-B-cell leukemia homeobox 4 Hs.466257 [show with all ESTs]Unigene Representative Sequence: NM_0252456 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000558276 ENST00000251203(uc010xra.2 uc002nmy.3 uc010xqz.2)
ENST00000557978 ENST00000559264 ENST00000558222 ENST00000559735
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PBX4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PBX4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PBX4 (NM_025245) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PBX4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX4 |
Additional cDNA sequence: AJ300182.1 AK097427.1 AK301631.1 BC033067.1 BC141859.1 BC143588.1 BC143589.1 NR_038198.1 5 DOTS entries: DT.40126527 DT.92415764 DT.97810645 DT.105265 DT.121493031 24/40 AceView cDNA sequences (see all 40): AJ300182 AI199900 AK097427 NM_025245 BG697418 BM474457 BC033067 BX280620 BU683358 BG683004 BE298082 BI016693 BM969616 AI652414 AA913582 BE298279 BQ189744 AW236536 BM449730 AA904552 W93274 AW248546 BU686586 AI659966
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for PBX4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
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| SP1: | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PBX4
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Expression
for PBX4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PBX4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCTGCTGC
About this image
See PBX4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PBX4
SOURCE GeneReport for Unigene cluster: Hs.466257
SABiosciences Custom PCR Arrays for PBX4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PBX4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PBX4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PBX4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PBX4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX4 |
Orthologs
for PBX4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PBX4 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for PBX4 (if available)
TreeFam Gene Tree for PBX4 (if available) |
Paralogs
for PBX4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PBX4 gene
- PBX32 PBX22 PBX12
4 SIMAP similar genes for PBX4 using alignment to 2 protein entries: PBX4_HUMAN (see all proteins):PBX1 PBX3 PBX2 TGIF1
PBX4 for paralogs About GeneDecksing
|
Genomic Variants
for PBX4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PBX4 (19672522 - 19729725 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PBX4: --
Human Gene Mutation Database (HGMD): PBX4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PBX4 |
|
Disorders
/ Diseases
for PBX4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PBX4 for disorders About GeneDecksing
OMIM gene information: 608127
OMIM disorders: --
3  diseases for PBX4: About MalaCardst-cell leukemia leukemia cholesterol
Human Genome Epidemiology (HuGE) Navigator: PBX4 (6 documents)
Export disorders for PBX4 gene to outside databases
|
Publications
for PBX4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PBX4 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with PBX4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Pbx4, a new Pbx family member on mouse chromosome 8 is expressed during spermatogenesis. (PubMed id 11335119)1, 2 Wagner K.... Poepperl H. (2001)
- Sex-specific association of rs16996148 SNP in the NCAN /CILP2/PBX4 and serum lipid levels in the Mulao and Han populations. (PubMed id 22208664)1 Yan T.T....Pan S.L. (2011)
- MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proli feration and chemotherapy resistance. (PubMed id 22185299)1 Rosales-Avina J.A....Jave-Suarez L.F. (2011)
- Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
- Pharmacogenetic analysis of lipid responses to rosuva statin in Chinese patients. (PubMed id 20679960)1 Hu M....Tomlinson B. (2010)
- Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1 Kathiresan S....Cupples L.A. (2009)
- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. (PubMed id 18193044)1 Kathiresan S....Orho-Melander M. (2008)
- Polymorphisms at newly identified lipid associated loci are associated with blood lipids and cardiovascular disease an Asian Malay population. (PubMed id 18987386)1 Tai E.S....Seielstad M. (2008)
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External Searches for PBX4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PBX4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PBX4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PBX4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PBX4 gene:
Search GeneIP for patents involving PBX4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PBX4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PBX4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PBX4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PBX4 | | | OriGene Protein Over-expression Lysate for PBX4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PBX4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PBX4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PBX4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PBX4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PBX4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PBX4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PBX4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PBX4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PBX4 |
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 |  |  |  | |
| | | | Search Tocris compounds for PBX4 |
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 |
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 | | | PBX4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for PBX4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX4 |
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