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Aliases for PBX4 Gene

Aliases for PBX4 Gene

  • Pre-B-Cell Leukemia Homeobox 4 2 3 5
  • Pre-B-Cell Leukemia Transcription Factor 4 2
  • Homeobox Protein PBX4 4

External Ids for PBX4 Gene

Previous GeneCards Identifiers for PBX4 Gene

  • GC19M020166
  • GC19M020063
  • GC19M019517
  • GC19M019533
  • GC19M019672
  • GC19M019234

Summaries for PBX4 Gene

Entrez Gene Summary for PBX4 Gene

  • This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for PBX4 Gene

PBX4 (Pre-B-Cell Leukemia Homeobox 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is PBX3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBX4 Gene

Genomics for PBX4 Gene

Regulatory Elements for PBX4 Gene

Enhancers for PBX4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PBX4 on UCSC Golden Path with GeneCards custom track

Promoters for PBX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PBX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PBX4 Gene

19,561,707 bp from pter
19,618,916 bp from pter
57,210 bases
Minus strand

Genomic View for PBX4 Gene

Genes around PBX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PBX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PBX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBX4 Gene

Proteins for PBX4 Gene

  • Protein details for PBX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-B-cell leukemia transcription factor 4
    Protein Accession:
    Secondary Accessions:
    • A5D8Y0
    • B3KUK9

    Protein attributes for PBX4 Gene

    374 amino acids
    Molecular mass:
    40854 Da
    Quaternary structure:
    No Data Available
    • Sequence=BC033067; Type=Frameshift; Positions=137; Evidence={ECO:0000305};

neXtProt entry for PBX4 Gene

Proteomics data for PBX4 Gene at MOPED

Post-translational modifications for PBX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PBX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PBX4 Gene

Domains & Families for PBX4 Gene

Gene Families for PBX4 Gene

Protein Domains for PBX4 Gene


Suggested Antigen Peptide Sequences for PBX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/PBX homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/PBX homeobox family.
genes like me logo Genes that share domains with PBX4: view

Function for PBX4 Gene

Gene Ontology (GO) - Molecular Function for PBX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA,ISS 11335119
genes like me logo Genes that share ontologies with PBX4: view
genes like me logo Genes that share phenotypes with PBX4: view

Animal Model Products

miRNA for PBX4 Gene

miRTarBase miRNAs that target PBX4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PBX4 Gene

Localization for PBX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBX4 Gene

Subcellular locations from

Jensen Localization Image for PBX4 Gene COMPARTMENTS Subcellular localization image for PBX4 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PBX4 Gene

Pathways & Interactions for PBX4 Gene

SuperPathways for PBX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PBX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for PBX4 Gene

Drugs & Compounds for PBX4 Gene

No Compound Related Data Available

Transcripts for PBX4 Gene

Unigene Clusters for PBX4 Gene

Pre-B-cell leukemia homeobox 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PBX4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3: - -

Relevant External Links for PBX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PBX4 Gene

mRNA expression in normal human tissues for PBX4 Gene

mRNA differential expression in normal tissues according to GTEx for PBX4 Gene

This gene is overexpressed in Thyroid (x10.5).

Protein differential expression in normal tissues from HIPED for PBX4 Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PBX4 Gene

SOURCE GeneReport for Unigene cluster for PBX4 Gene Hs.466257

genes like me logo Genes that share expression patterns with PBX4: view

Protein tissue co-expression partners for PBX4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PBX4 Gene

Orthologs for PBX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PBX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PBX4 35
  • 82.77 (n)
  • 78.81 (a)
PBX4 36
  • 76 (a)
(Canis familiaris)
Mammalia PBX4 35
  • 87.3 (n)
  • 84.87 (a)
PBX4 36
  • 73 (a)
(Mus musculus)
Mammalia Pbx4 35
  • 83.19 (n)
  • 80.69 (a)
Pbx4 16
Pbx4 36
  • 75 (a)
(Pan troglodytes)
Mammalia PBX4 35
  • 99.2 (n)
  • 98.66 (a)
PBX4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pbx4 35
  • 83.62 (n)
  • 81.92 (a)
(Monodelphis domestica)
Mammalia PBX4 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
(Gallus gallus)
Aves PBX4 35
  • 79.44 (n)
  • 81.13 (a)
PBX4 36
  • 69 (a)
(Anolis carolinensis)
Reptilia PBX4 36
  • 66 (a)
(Danio rerio)
Actinopterygii pbx4 36
  • 68 (a)
PBX4 (2 of 2) 36
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta exd 37
  • 77 (a)
exd 36
  • 60 (a)
(Caenorhabditis elegans)
Secernentea ceh-20 37
  • 60 (a)
ceh-40 37
  • 35 (a)
ceh-20 36
  • 52 (a)
ceh-40 36
  • 32 (a)
ceh-60 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8721 36
  • 50 (a)
Species with no ortholog for PBX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PBX4 Gene

Gene Tree for PBX4 (if available)
Gene Tree for PBX4 (if available)

Paralogs for PBX4 Gene

Paralogs for PBX4 Gene

(3) SIMAP similar genes for PBX4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PBX4: view

Variants for PBX4 Gene

Sequence variations from dbSNP and Humsavar for PBX4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036439 A colorectal cancer sample
rs8108180 - 19,570,236(+) GGAGA(C/T)AGGCC nc-transcript-variant, downstream-variant-500B, reference, missense
rs8108981 - 19,570,212(+) GACCA(C/T)GCGCT nc-transcript-variant, downstream-variant-500B, reference, missense
rs12975747 -- 19,572,012(+) ggggg(G/T)ataga intron-variant
rs12975755 -- 19,572,020(+) agaga(C/G)acccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBX4 Gene

Variant ID Type Subtype PubMed ID
nsv509723 CNV Insertion 20534489
nsv518076 CNV Loss 19592680
nsv509725 CNV Insertion 20534489
nsv911309 CNV Loss 21882294

Variation tolerance for PBX4 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PBX4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PBX4 Gene

Disorders for PBX4 Gene

Relevant External Links for PBX4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PBX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PBX4 Gene

Publications for PBX4 Gene

  1. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. (PMID: 18987386) Tai E.S. … Seielstad M. (J. Lipid Res. 2009) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3

Products for PBX4 Gene

Sources for PBX4 Gene