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Aliases for PBX3 Gene

Aliases for PBX3 Gene

  • PBX Homeobox 3 2 3 5
  • Pre-B-Cell Leukemia Transcription Factor 3 2
  • Pre-B-Cell Leukemia Homeobox 3 2
  • Homeobox Protein PBX3 4

External Ids for PBX3 Gene

Previous GeneCards Identifiers for PBX3 Gene

  • GC09P119624
  • GC09P120156
  • GC09P121963
  • GC09P123885
  • GC09P125589
  • GC09P127549
  • GC09P128508
  • GC09P098122
  • GC09P128511
  • GC09P128513

Summaries for PBX3 Gene

GeneCards Summary for PBX3 Gene

PBX3 (PBX Homeobox 3) is a Protein Coding gene. Diseases associated with PBX3 include Childhood Pilocytic Astrocytoma and Pilocytic Astrocytoma. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is PBX1.

UniProtKB/Swiss-Prot for PBX3 Gene

  • Transcriptional activator that binds the sequence 5-ATCAATCAA-3.

Gene Wiki entry for PBX3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBX3 Gene

Genomics for PBX3 Gene

Regulatory Elements for PBX3 Gene

Enhancers for PBX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F125783 1 Ensembl ENCODE 25.6 +38.0 38018 2.9 ZNF316 EMSY MAFK PBX3 LOC51145 PPP6C GC09P125762 GC09P125856
GH09F125838 1.1 Ensembl 25.2 +92.2 92163 1.4 MYNN FEZF1 ZNF600 PRDM1 PBX3 LOC51145 SCAI GC09P125856 GC09P125762
GH09F125931 0.2 ENCODE 24.8 +184.9 184944 2.0 JUN TSC22D4 NFXL1 SCRT2 FOSL2 FOS ZNF600 MAFK SCRT1 ZNF362 PBX3 LOC101929116 LOC51145 SCAI GC09P125902 LOC105376273
GH09F125829 2.5 FANTOM5 Ensembl ENCODE 24.5 +82.7 82723 1.5 BCOR PKNOX1 CBX3 ARNT TAL1 RAD21 YY1 FOXK2 NCOR1 POLR2A PBX3 LOC51145 GC09P125856 GC09P125762
GH09F125949 0.4 ENCODE 24 +203.2 203210 2.8 ZNF664 JUND POLR2A BCL11A TEAD4 CTBP2 REST PBX3 LOC51145 GC09P125902 LOC105376273
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PBX3 on UCSC Golden Path with GeneCards custom track

Promoters for PBX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001314406 1562 6201 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for PBX3 Gene

Chromosome:
9
Start:
125,747,338 bp from pter
End:
125,967,377 bp from pter
Size:
220,040 bases
Orientation:
Plus strand

Genomic View for PBX3 Gene

Genes around PBX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PBX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PBX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBX3 Gene

Proteins for PBX3 Gene

  • Protein details for PBX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40426-PBX3_HUMAN
    Recommended name:
    Pre-B-cell leukemia transcription factor 3
    Protein Accession:
    P40426
    Secondary Accessions:
    • E9PB27
    • Q5JSA0
    • Q5JSA1
    • Q5VXL3
    • Q96PF9
    • Q96PG0

    Protein attributes for PBX3 Gene

    Size:
    434 amino acids
    Molecular mass:
    47190 Da
    Quaternary structure:
    • Interacts with PBXIP1.

    Alternative splice isoforms for PBX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PBX3 Gene

Post-translational modifications for PBX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PBX3 Gene

Domains & Families for PBX3 Gene

Gene Families for PBX3 Gene

Protein Domains for PBX3 Gene

Graphical View of Domain Structure for InterPro Entry

P40426

UniProtKB/Swiss-Prot:

PBX3_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/PBX homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/PBX homeobox family.
genes like me logo Genes that share domains with PBX3: view

Function for PBX3 Gene

Molecular function for PBX3 Gene

GENATLAS Biochemistry:
transcription factor,with an atypical homeo domain,homologous to PBX1,expressed in most tissues,fetal and adult,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds the sequence 5-ATCAATCAA-3.

Gene Ontology (GO) - Molecular Function for PBX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with PBX3: view
genes like me logo Genes that share phenotypes with PBX3: view

Animal Models for PBX3 Gene

MGI Knock Outs for PBX3:

Animal Model Products

Targeted motifs for PBX3 Gene
HOMER Transcription Factor Regulatory Elements motif PBX3
  • Consensus sequence: CCTGTCAATCAN Submotif: canonical Cell Type: GM12878 GEO ID: GSE32465

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for PBX3 Gene

Localization for PBX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBX3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PBX3 Gene COMPARTMENTS Subcellular localization image for PBX3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PBX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with PBX3: view

Pathways & Interactions for PBX3 Gene

genes like me logo Genes that share pathways with PBX3: view

Pathways by source for PBX3 Gene

1 KEGG pathway for PBX3 Gene

Gene Ontology (GO) - Biological Process for PBX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007387 anterior compartment pattern formation TAS 1682799
genes like me logo Genes that share ontologies with PBX3: view

No data available for SIGNOR curated interactions for PBX3 Gene

Transcripts for PBX3 Gene

Unigene Clusters for PBX3 Gene

Pre-B-cell leukemia homeobox 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PBX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - - - - - - -
SP2:
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - -
SP7: - -
SP8: - - - -
SP9: - -
SP10: - - - - - -
SP11: - - - - - - -
SP12: - - - - - -

Relevant External Links for PBX3 Gene

GeneLoc Exon Structure for
PBX3
ECgene alternative splicing isoforms for
PBX3

Expression for PBX3 Gene

mRNA expression in normal human tissues for PBX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PBX3 Gene

This gene is overexpressed in Ovary (14.2), Uterus (11.4), Fetal gut (10.9), Fetal ovary (7.6), Islet of Langerhans (6.6), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PBX3 Gene



Protein tissue co-expression partners for PBX3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PBX3 Gene:

PBX3

SOURCE GeneReport for Unigene cluster for PBX3 Gene:

Hs.428027

mRNA Expression by UniProt/SwissProt for PBX3 Gene:

P40426-PBX3_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with PBX3: view

Primer Products

No data available for mRNA differential expression in normal tissues for PBX3 Gene

Orthologs for PBX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PBX3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PBX3 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PBX3 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PBX3 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PBX3 34 35
  • 97.2 (n)
mouse
(Mus musculus)
Mammalia Pbx3 34 16 35
  • 96.01 (n)
chimpanzee
(Pan troglodytes)
Mammalia PBX3 34 35
  • 96.01 (n)
rat
(Rattus norvegicus)
Mammalia Pbx3 34
  • 95.31 (n)
chicken
(Gallus gallus)
Aves PBX3 34 35
  • 91.53 (n)
lizard
(Anolis carolinensis)
Reptilia PBX3 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pbx3 34
  • 83.37 (n)
Str.11416 34
zebrafish
(Danio rerio)
Actinopterygii pbx3a 34 35
  • 74.03 (n)
pbx3b 34
fruit fly
(Drosophila melanogaster)
Insecta exd 36 35
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-20 36 35
  • 65 (a)
ceh-40 36 35
  • 40 (a)
ceh-60 35
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8721 35
  • 60 (a)
OneToMany
Species where no ortholog for PBX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PBX3 Gene

ENSEMBL:
Gene Tree for PBX3 (if available)
TreeFam:
Gene Tree for PBX3 (if available)

Paralogs for PBX3 Gene

Paralogs for PBX3 Gene

(6) SIMAP similar genes for PBX3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PBX3: view

Variants for PBX3 Gene

Sequence variations from dbSNP and Humsavar for PBX3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10114090 -- 125,786,799(+) agctc(A/G)ctgca intron-variant
rs10114213 -- 125,899,056(+) CATCT(A/G)TGGTG intron-variant
rs10115938 -- 125,866,292(+) GTTTT(A/G)TCACA intron-variant
rs10116638 -- 125,812,627(+) GAATA(C/G)agtcg intron-variant
rs10118713 -- 125,890,517(+) TTGCT(C/T)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBX3 Gene

Variant ID Type Subtype PubMed ID
dgv12867n54 CNV gain 21841781
dgv4138n106 CNV deletion 24896259
esv1270380 CNV insertion 17803354
esv26440 CNV loss 19812545
esv2678016 CNV deletion 23128226
esv2739043 CNV deletion 23290073
esv3401032 CNV insertion 20981092
esv3545450 CNV deletion 23714750
esv3576704 CNV gain 25503493
esv3621756 CNV loss 21293372
esv3621757 CNV loss 21293372
esv987876 CNV insertion 20482838
nsv1052626 CNV gain 25217958
nsv1054231 CNV gain 25217958
nsv1110581 CNV duplication 24896259
nsv1137504 CNV deletion 24896259
nsv416676 CNV deletion 16902084
nsv477925 CNV novel sequence insertion 20440878
nsv479202 CNV novel sequence insertion 20440878
nsv480848 CNV novel sequence insertion 20440878
nsv509321 CNV insertion 20534489
nsv615294 CNV loss 21841781
nsv615295 CNV gain 21841781
nsv615300 CNV gain+loss 21841781
nsv615301 CNV loss 21841781
nsv615303 CNV gain 21841781
nsv615306 CNV gain 21841781
nsv615307 CNV gain 21841781
nsv6715 CNV insertion 18451855
nsv825078 CNV gain 20364138
nsv825079 CNV gain 20364138
nsv951761 CNV duplication 24416366

Variation tolerance for PBX3 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PBX3 Gene

Human Gene Mutation Database (HGMD)
PBX3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PBX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PBX3 Gene

Disorders for PBX3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PBX3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
childhood pilocytic astrocytoma
  • pediatric pilocytic astrocytoma
pilocytic astrocytoma
  • grade i astrocytic tumor
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PBX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PBX3

Genetic Association Database (GAD)
PBX3
Human Genome Epidemiology (HuGE) Navigator
PBX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PBX3
genes like me logo Genes that share disorders with PBX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PBX3 Gene

Publications for PBX3 Gene

  1. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. (PMID: 1682799) Monica K. … Cleary M.L. (Mol. Cell. Biol. 1991) 2 3 4 64
  2. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Lack of replication of celiac disease risk variants reported in a Spanish population using an independent Spanish sample. (PMID: 19626039) Dema B. … NA_A+ez C. (Genes Immun. 2009) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for PBX3 Gene

Sources for PBX3 Gene

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