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PBX3 Gene

protein-coding   GIFtS: 61
GCID: GC09P128513

Pre-B-Cell Leukemia Homeobox 3

(Previous name: pre-B-cell leukemia transcription factor 3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pre-B-Cell Leukemia Homeobox 31 2
Pre-B-Cell Leukemia Transcription Factor 31 2
Homeobox Protein PBX32 3

External Ids:    HGNC: 86341   Entrez Gene: 50902   Ensembl: ENSG000001670817   OMIM: 1763125   UniProtKB: P404263   

Export aliases for PBX3 gene to outside databases

Previous GC identifers: GC09P119624 GC09P120156 GC09P121963 GC09P123885 GC09P125589 GC09P127549 GC09P128508 GC09P098122 GC09P128511


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PBX3 Gene:
PBX3 (pre-B-cell leukemia homeobox 3) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PBX4.

UniProtKB/Swiss-Prot: PBX3_HUMAN, P40426
Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'

Gene Wiki entry for PBX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PBX3 gene promoter:
         MZF-1   AREB6   RFX1   HSF2   POU3F2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PBX3 promoter sequence
   Search Chromatin IP Primers for PBX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PBX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

PBX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PBX3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P128513:  view genomic region     (about GC identifiers)

Start:
128,509,617 bp from pter      End:
128,729,656 bp from pter
Size:
220,040 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PBX3

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PBX3_HUMAN, P40426 (See protein sequence)
Recommended Name: Pre-B-cell leukemia transcription factor 3  
Size: 434 amino acids; 47190 Da
Subunit: Interacts with PBXIP1
Secondary accessions: E9PB27 Q5JSA0 Q5JSA1 Q5VXL3 Q96PF9 Q96PG0
Alternative splicing: 5 isoforms:  P40426-1   P40426-2   P40426-3   P40426-4   P40426-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PBX3: NX_P40426

Explore proteomics data for PBX3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PBX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128250.1  NP_006186.1  

    ENSEMBL proteins: 
     ENSP00000341990   ENSP00000362586   ENSP00000362588   ENSP00000362591   ENSP00000362581  
     ENSP00000475679   ENSP00000387456   ENSP00000397903   ENSP00000362582  

    PBX3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PBX3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PBX3
    GenScript Custom Purified and Recombinant Proteins Services for PBX3
    Novus Biologicals PBX3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PBX3

     
    Search eBioscience for Proteins for PBX3 

     
    antibodies-online proteins for PBX3 (4 products) 

     
    antibodies-online peptides for PBX3

    PBX3 Antibody Products:

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    Novus Biologicals PBX3 Antibodies
    Abcam antibodies for PBX3
    Cloud-Clone Corp. Antibodies for PBX3
    Search ThermoFisher Antibodies for PBX3
    antibodies-online antibodies for PBX3 (42 products) 

    PBX3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PBX3
    Cloud-Clone Corp. CLIAs for PBX3
    Search eBioscience for ELISAs for PBX3 
    antibodies-online kits for PBX3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    4 InterPro protein domains:
     IPR005542 PBX
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P40426

    ProtoNet protein and cluster: P40426

    1 Blocks protein domain: IPB005542 PBX domain

    UniProtKB/Swiss-Prot: PBX3_HUMAN, P40426
    Similarity: Belongs to the TALE/PBX homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with PBX3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PBX3_HUMAN, P40426
    Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'

         Genatlas biochemistry entry for PBX3:
    transcription factor,with an atypical homeo domain,homologous to PBX1,expressed in most tissues,fetal and
    adult,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with PBX3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PBX3:
     Decreased viability with carbo 

         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Pbx3):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size/body 
     homeostasis/metabolism  integument  mortality/aging  nervous system  respiratory system 
     skeleton 

    Find genes that share phenotypes with PBX3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PBX3: Pbx3tm1.1Og Pbx3tm1Mlc

       genOway: Develop your customized and physiologically relevant rodent model for PBX3

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CCTGTCAATCAN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PBX3:
    hsa-mir-495-3p (MIRT007194), hsa-mir-760 (MIRT036717), hsa-mir-26b-5p (MIRT029508), hsa-mir-93-5p (MIRT028007), hsa-mir-615-3p (MIRT016146)

    Block miRNA regulation of human, mouse, rat PBX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PBX3 (see all 95):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-93 hsa-miR-200b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidPBX3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PBX3
    Predesigned siRNA for gene silencing in human, mouse, rat PBX3

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for PBX3 (see all 11)
    OriGene ORF clones in mouse, rat for PBX3
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    GenScript: all cDNA clones in your preferred vector (see all 2): PBX3 (NM_006195)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PBX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX3
    Addgene plasmids for PBX3 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PBX3
    Browse ESI BIO Cell Lines and PureStem Progenitors for PBX3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PBX3_HUMAN, P40426: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with PBX3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PBX3 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with PBX3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for PBX3):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PBX3
    Interactions:

        GeneGlobe Interaction Network for PBX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for PBX3 (P404263 ENSP000003625884) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXC4P090173, ENSP000003059734I2D: score=1 STRING: ENSP00000305973
    AGTRAPQ6RW133, ENSP000003197134I2D: score=3 STRING: ENSP00000319713
    HOXB8P174813, ENSP000002391444I2D: score=3 STRING: ENSP00000239144
    MEIS1O004703, ENSP000002723694I2D: score=3 STRING: ENSP00000272369
    ENSG00000273266P090173I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002087regulation of respiratory gaseous exchange by neurological system process IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007387anterior compartment pattern formation TAS1682799
    GO:0007388posterior compartment specification TAS1682799

    Find genes that share ontologies with PBX3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PBX3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PBX3 gene (2 alternative transcripts): 
    NM_001134778.1  NM_006195.5  

    Unigene Cluster for PBX3:

    Pre-B-cell leukemia homeobox 3
    Hs.428027  [show with all ESTs]
    Unigene Representative Sequence: NM_006195
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342287(uc004bqd.3 uc011lzx.2) ENST00000497091 ENST00000373487(uc004bqb.3 uc004bqc.3 uc011lzw.2 uc004bqe.3)
    ENST00000373489 ENST00000373492 ENST00000373482 ENST00000491787 ENST00000447726
    ENST00000492314 ENST00000538998 ENST00000491160 ENST00000428092 ENST00000373483

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PBX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PBX3 (see all 95):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-93 hsa-miR-200b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidPBX3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PBX3
    Predesigned siRNA for gene silencing in human, mouse, rat PBX3
    Clone
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    OriGene ORF clones in mouse, rat for PBX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PBX3 (NM_006195)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PBX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX3
    Addgene plasmids for PBX3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PBX3
    OriGene qSTAR qPCR primer pairs in human, mouse for PBX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PBX3
      QuantiTect SYBR Green Assays in human, mouse, rat PBX3
      QuantiFast Probe-based Assays in human, mouse, rat PBX3

    Additional mRNA sequence: 

    AF355141.1 AF355142.1 AJ420602.1 AK092148.1 AK289376.1 AK297093.1 AK299267.1 AK309713.1 
    AK312717.1 BC016977.1 BC094883.1 NR_024122.1 NR_024123.1 X59841.1 

    13 DOTS entries:

    DT.92425630  DT.97842063  DT.121206854  DT.316523  DT.92425627  DT.100782983  DT.100698485  DT.100782985 
    DT.92425628  DT.95170790  DT.121206865  DT.75179227  DT.95170788 

    Selected AceView cDNA sequences (see all 176):

    CA771056 AV660739 BE551128 CD675622 AW263437 AA385153 N64346 AW997602 
    AW949443 BX094842 AI863223 AI038293 AL522115 BQ575713 AU279511 AI041724 
    BC016977 BE047582 CA438767 BP340711 CR620669 CA413848 F05662 CA867804 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PBX3 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
    SP1:              -     -           -     -     -     -     -     -                                               -                                       
    SP2:                                                                                                                                                      
    SP3:              -     -           -     -     -     -     -     -     -     -                                   -                                       
    SP4:              -     -           -     -     -     -     -     -     -     -                                   -                 -                     
    SP5:              -     -           -     -     -     -     -     -           -                                   -                                       


    ECgene alternative splicing isoforms for PBX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PBX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAAAAAAA
    PBX3 Expression
    About this image


    PBX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 13 entries
             Osteochondro Mesenchymal Cells Rib
             Maxillary Process
     
     Cartilage (Muscoskeletal System)    fully expand to see all 12 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Limb (Muscoskeletal System)    fully expand to see all 7 entries
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Limb Bud Mesenchyme Cells Limb Bud
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
    PBX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PBX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.428027

    UniProtKB/Swiss-Prot: PBX3_HUMAN, P40426
    Tissue specificity: Ubiquitously expressed

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    QuantiFast Probe-based Assays in human, mouse, rat PBX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PBX3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pbx31 , 5 pre B cell leukemia homeobox 31, 5 96.01(n)1
    99.77(a)1
      2 (22.84 cM)5
    185161  NM_016768.11  NP_058048.11 
     341714575 
    chicken
    (Gallus gallus)
    Aves PBX31 pre-B-cell leukemia homeobox 3 91.53(n)
    99.54(a)
      417093  NM_001030678.1  NP_001025849.1 
    lizard
    (Anolis carolinensis)
    Reptilia PBX36
    pre-B-cell leukemia homeobox 3
    99(a)
    1 ↔ 1
    GL343601.1(1703-19134)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.114162 Transcribed sequence with strong similarity to protein more 86.16(n)    137722967 
    zebrafish
    (Danio rerio)
    Actinopterygii pbx3b2 pre-B-cell leukemia transcription factor 3b 79.11(n)   58140  AJ245964.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta exd3 brain development specific RNA
    polymerase II transcription more
    78(a)   14A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-203   -- 65(a)
    (best of 2)
      III(7051642-7053281)   --


    ENSEMBL Gene Tree for PBX3 (if available)
    TreeFam Gene Tree for PBX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PBX3 gene
    PBX42  PBX22  PBX12  
    6 SIMAP similar genes for PBX3 using alignment to 6 protein entries:     PBX3_HUMAN (see all proteins):
    DKFZp686B09108    E2A/PBX1 fusion    PBX1    PBX2    PBX4    TGIF1

    Find genes that share paralogs with PBX3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PBX3 (see all 3874)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21499891,2
    C,F,Huntested1128678115(-) CTGAAA/G/TAACCT 6 S F mis1 int18NS EA 1170
    rs1998660101,2
    --128510895(+) AAAGAC/GAAAAC 6 D E mis10--------
    rs1841657011,2
    C,F--128510918(+) GCGCCC/TCGCAG 4 -- int11Minor allele frequency- T:0.01EU 985
    rs2021349341,2
    --128510924(+) CGCAGG/TGGGCC 4 -- int10--------
    rs1885693741,2
    C--128510948(+) GGTGGA/GGGTCG 4 -- int10--------
    rs1490829611,2
    C--128511000(+) GGGCAC/TCGCCA 4 -- int10--------
    rs1460477801,2
    --128511030(+) TCCCAC/TGTCCT 4 -- int10--------
    rs1911293361,2
    --128511041(+) GATCTC/TGAGAA 4 -- int10--------
    rs123478191,2
    C,F--128511236(+) AAGGAG/ACAACG 4 -- int11Minor allele frequency- A:0.03NA 120
    rs1391255971,2
    C--128511276(+) GGAGAA/GGCATC 4 -- int10--------

    HapMap Linkage Disequilibrium report for PBX3 (128509617 - 128729656 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PBX3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678016CNV Deletion23128226
    esv2739043CNV Deletion23290073
    esv268501CNV Insertion20981092
    esv987876CNV Insertion20482838
    nsv6715CNV Insertion18451855
    esv1270380CNV Insertion17803354
    esv26440CNV Loss19812545
    dgv8281n71CNV Loss21882294
    nsv416676CNV Loss16902084
    nsv825079CNV Gain20364138

    Human Gene Mutation Database (HGMD): PBX3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PBX3
    DNA2.0 Custom Variant and Variant Library Synthesis for PBX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176312    OMIM disorders: --


    Find genes that share disorders with PBX3           About GenesLikeMe

    Genetic Association Database (GAD): PBX3
    Human Genome Epidemiology (HuGE) Navigator: PBX3 (7 documents)

    Export disorders for PBX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PBX3 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with PBX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. (PubMed id 1682799)1, 2, 3 Monica K.... Cleary M.L. (Mol. Cell. Biol. 1991)
    2. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Lack of replication of celiac disease risk variants reported in a Spanish population using an independent Spanish sample. (PubMed id 19626039)1, 4 Dema B....NA_A+ez C. (Genes Immun. 2009)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. (PubMed id 23161775)1 Ho C.Y....Rodriguez F.J. (Neuro-oncology 2013)
    9. Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. (PubMed id 24009623)1 Jiang J....Wang L. (Front Genet 2013)
    10. PBX3 is an important cofactor of HOXA9 in leukemogenesis. (PubMed id 23264595)1 Li Z....Chen J. (Blood 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5090 HGNC: 8634 AceView: PBX3 Ensembl:ENSG00000167081 euGenes: HUgn5090
    ECgene: PBX3 Kegg: 5090 H-InvDB: PBX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PBX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PBX3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PBX3 gene:
    Search GeneIP for patents involving PBX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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