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PBX2 Gene

protein-coding   GIFtS: 54
GCID: GC06M032158

Pre-B-Cell Leukemia Homeobox 2

(Previous name: pre-B-cell leukemia transcription factor 2)
  See PBX2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pre-B-Cell Leukemia Homeobox 21 2     HOX122 5
G172 3 5     PBX2MHC2
Pre-B-Cell Leukemia Transcription Factor 21 2     Homeobox 122
Homeobox Protein PBX22 3     Protein G173

External Ids:    HGNC: 86331   Entrez Gene: 50892   Ensembl: ENSG000002043047   OMIM: 1763115   UniProtKB: P404253   

Export aliases for PBX2 gene to outside databases

Previous GC identifers: GC06M032179 GC06M031923 GC06M032223 GC06M032260 GC06M031907 GC06M032151 GC06M032153


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PBX2 Gene:
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its
similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This
protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major
histocompatibility complex (MHC) on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for PBX2 Gene:
PBX2 (pre-B-cell leukemia homeobox 2) is a protein-coding gene. Diseases associated with PBX2 include t-cell leukemia. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PBX3.

UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425
Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in
complex with MEIS1

Gene Wiki entry for PBX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PBX2 gene promoter:
         CREB   HEN1   Pax-5   deltaCREB   STAT3   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPBX2 promoter sequence
   Search Chromatin IP Primers for PBX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PBX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.32

PBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PBX2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032158:  view genomic region     (about GC identifiers)

Start:
32,152,510 bp from pter      End:
32,157,963 bp from pter
Size:
5,454 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167247 3,532,337-3,537,787      Chr6-,NT_113891.2 3,623,191-3,628,641      Chr6-,NT_167249 3,500,238-3,505,689     
Chr6-,NT_167246 3,495,334-3,500,784      Chr6-,NT_167244 3,467,251-3,472,701      Chr6-,NT_167248 3,413,530-3,418,981     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425 (See protein sequence)
Recommended Name: Pre-B-cell leukemia transcription factor 2  
Size: 430 amino acids; 45881 Da
Subunit: Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1
Secondary accessions: A2BFJ2

Explore the universe of human proteins at neXtProt for PBX2: NX_P40425

Explore proteomics data for PBX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PBX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002577.2  
    ENSEMBL proteins: 
     ENSP00000364190  

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    antibodies-online proteins for PBX2 (6 products) 

     
    antibodies-online peptides for PBX2

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    antibodies-online antibodies for PBX2 (46 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    4 InterPro protein domains:
     IPR005542 PBX
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P40425

    ProtoNet protein and cluster: P40425

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB005542 PBX domain


    UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425
    Similarity: Belongs to the TALE/PBX homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with PBX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PBX2_HUMAN, P40425
    Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in
    complex with MEIS1

         Genatlas biochemistry entry for PBX2:
    transcription factor,with a homeo domain,homologous to PBX1,expressed in most tissues,fetal and adult,binding DNA
    cooperatively with the heterodimer E2A/myogenic transcription factors

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008134transcription factor binding IPI18973687
         
    Find genes that share ontologies with PBX2           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pbx2):
     cellular  craniofacial  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  normal  respiratory system 
     skeleton 

    Find genes that share phenotypes with PBX2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pbx2tm1Mlc for PBX2

       genOway: Develop your customized and physiologically relevant rodent model for PBX2

    miRNA
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    miRTarBase miRNAs that target PBX2:
    hsa-mir-222-3p (MIRT046804), hsa-mir-185-5p (MIRT045365), hsa-mir-197-3p (MIRT048088), hsa-mir-326 (MIRT043641), hsa-mir-760 (MIRT036763), hsa-mir-92a-3p (MIRT049093), hsa-mir-181d-5p (MIRT041169)

    Block miRNA regulation of human, mouse, rat PBX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PBX2 (see all 76):
    hsa-miR-548j hsa-miR-1914* hsa-miR-146a hsa-miR-10b* hsa-miR-1244 hsa-miR-3150b-3p hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidPBX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PBX2

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    Addgene plasmids for PBX2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PBX2_HUMAN, P40425: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18973687
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with PBX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PBX2
    Interactions:

        GeneGlobe Interaction Network for PBX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PBX2 (P404252, 3 ENSP000003641904) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN3O759352, 3, ENSP000002596324MINT-62576 MINT-62674 MINT-62750 I2D: score=4 STRING: ENSP00000259632
    MCRS1Q96EZ82, 3, ENSP000003496404MINT-62569 MINT-62667 MINT-62743 I2D: score=4 STRING: ENSP00000349640
    MLKLQ8NB162, 3MINT-62574 MINT-62748 MINT-62672 I2D: score=2 
    SMYD3Q9H7B42, 3, ENSP000003736374MINT-62527 I2D: score=4 STRING: ENSP00000373637
    BAIAP2Q9UQB82, 3, ENSP000003163384MINT-62572 MINT-62670 MINT-62746 I2D: score=4 STRING: ENSP00000316338
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0009954proximal/distal pattern formation IEA--
    GO:0030326embryonic limb morphogenesis IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    Find genes that share ontologies with PBX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PBX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PBX2 gene: 
    NM_002586.4  

    Unigene Cluster for PBX2:

    Pre-B-cell leukemia homeobox 2
    Hs.509545  [show with all ESTs]
    Unigene Representative Sequence: X59842
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375050(uc003oav.1) ENST00000495300 ENST00000478678(uc003oaw.3)
    ENST00000496171 ENST00000480254
    miRNA
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    Block miRNA regulation of human, mouse, rat PBX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PBX2 (see all 76):
    hsa-miR-548j hsa-miR-1914* hsa-miR-146a hsa-miR-10b* hsa-miR-1244 hsa-miR-3150b-3p hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidPBX2 3' UTR sequence
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    OriGene qPCR primer pairs and template standards for PBX2
    OriGene qSTAR qPCR primer pairs in human, mouse for PBX2
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      QuantiTect SYBR Green Assays in human, mouse, rat PBX2
      QuantiFast Probe-based Assays in human, mouse, rat PBX2

    Additional mRNA sequence: 

    BC082261.1 BT009823.1 X59842.1 

    18 DOTS entries:

    DT.100781048  DT.121378260  DT.445917  DT.100027239  DT.100781053  DT.121378333  DT.86814814  DT.100699252 
    DT.121378477  DT.95202672  DT.121378356  DT.100735855  DT.100772866  DT.102839412  DT.121378335  DT.91780433 
    DT.91942501  DT.99962343 

    Selected AceView cDNA sequences (see all 307):

    CD364731 BU677612 CD251257 BM547314 AB036432 BM992910 BC082261 BM726610 
    BU622208 AW177611 CD722431 BU899237 CA428962 AW177610 BM702297 CA449935 
    CD722009 AI057090 BQ024657 BM894006 BM714937 BC003111 NM_002586 AB061668 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PBX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCGGGGGC
    PBX2 Expression
    About this image


    PBX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Limb Bud Mesenchyme Cells Limb Bud
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Chondrocytes Stylopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    PBX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PBX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.509545

    UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PBX2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pbx21 , 5 pre B cell leukemia homeobox 21, 5 90.93(n)1
    97.91(a)1
      17 (18.17 cM)5
    185151  NM_017463.21  NP_059491.11 
     345912665 
    lizard
    (Anolis carolinensis)
    Reptilia PBX26
    pre-B-cell leukemia homeobox 2
    82(a)
    1 ↔ 1
    2(198449536-198497758)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.64542 Transcribed sequence with moderate similarity to protein more 80.03(n)    BX733561.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pbx26
    pre-B-cell leukemia transcription factor 2
    68(a)
    1 ↔ 1
    16(51950122-51977260) ENSDARG00000019717
    fruit fly
    (Drosophila melanogaster)
    Insecta exd3 brain development specific RNA
    polymerase II transcription more
    80(a)   14A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-203   -- 57(a)
    (best of 2)
      III(7051642-7053281)   --


    ENSEMBL Gene Tree for PBX2 (if available)
    TreeFam Gene Tree for PBX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PBX2 gene
    PBX32  PBX42  PBX12  
    4 SIMAP similar genes for PBX2 using alignment to 1 protein entry:     PBX2_HUMAN:
    PBX1    PBX3    PBX4    POU6F1

    Find genes that share paralogs with PBX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PBX2 (see all 126)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20781671,2
    C--32154128(-) GGGGGC/GTCTCA 1 -- ut31 ese30--------
    rs1491454421,2
    F--32154210(+) GATGTC/TACTGA 2 V syn11Minor allele frequency- T:0.00NA 4540
    rs2049951,2
    C,F,H--32154285(-) GGGCTT/CTCTCT 1 -- int132Minor allele frequency- C:0.28EA NA MN NS WA CSA 3301
    rs1421330221,2
    C--32154314(+) ACAACA/GTTACT 1 -- int10--------
    rs1432203451,2
    C,F--32154416(+) TCCCCC/TGAGGT 2 R G mis12Minor allele frequency- T:0.00NA EU 5859
    rs1809465411,2
    C--32154448(+) CCATCA/GAGTGT 2 S L mis10--------
    rs2007894141,2
    --32154506(+) AGAAGA/CCTCAG 1 -- int10--------
    rs1140250841,2
    C,F--32154569(+) TATTCG/CAGAGG 1 -- int12Minor allele frequency- C:0.01NA EU 713
    rs1385071941,2
    C--32154639(+) GAAACA/GTGTCT 2 T M mis11Minor allele frequency- G:0.00NA 4552
    rs1999457901,2
    --32154684(+) CTTGTC/GGGGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PBX2 (32152510 - 32157963 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PBX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6643n71CNV Loss21882294
    nsv884712CNV Loss21882294
    dgv6645n71CNV Loss21882294
    dgv6644n71CNV Loss21882294
    nsv830629CNV Loss17160897
    nsv462877CNV Loss19166990
    dgv1929e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176311    OMIM disorders: --

    1 disease for PBX2:    
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    t-cell leukemia


    Find genes that share disorders with PBX2           About GenesLikeMe

    1 Novoseek inferred disease relationship for PBX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia pre-b-cell 95.3 3 1682799 (1), 7759099 (1)

    Genetic Association Database (GAD): PBX2
    Human Genome Epidemiology (HuGE) Navigator: PBX2 (9 documents)

    Export disorders for PBX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PBX2 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with PBX2)
        Utopia: connect your pdf to the dynamic
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    1. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PubMed id 7835890)1, 2, 3, 9 Sugaya K.... Ikemura T. (Genomics 1994)
    2. The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein. (PubMed id 7759099)1, 2, 9 Aguado B. and Campbell R.D. (Genomics 1995)
    3. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. (PubMed id 1682799)1, 2, 9 Monica K.... Cleary M.L. (Mol. Cell. Biol. 1991)
    4. Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PubMed id 12609849)1, 2, 9 Okada Y....Doi T. (Blood 2003)
    5. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. (PubMed id 7910944)1, 2, 9 Lu Q.... Kamps M.P. (Mol. Cell. Biol. 1994)
    6. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. (PubMed id 21804548)1, 4 Hirota T....Tamari M. (Nat. Genet. 2011)
    7. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    8. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. (PubMed id 19659809)1, 4 Pathan S....Jewell D.P. (Tissue Antigens 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5089 HGNC: 8633 AceView: AGERandPBX2 Ensembl:ENSG00000204304 euGenes: HUgn5089
    ECgene: PBX2 H-InvDB: PBX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PBX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PBX2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PBX2 gene:
    Search GeneIP for patents involving PBX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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