Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PBX2 Gene

Aliases for PBX2 Gene

  • Pre-B-Cell Leukemia Homeobox 2 2 3 5
  • Homeobox Protein PBX2 3 4
  • G17 3 4
  • Pre-B-Cell Leukemia Transcription Factor 2 2
  • XXbac-BPG300A18.13 3
  • Homeobox 12 3
  • Protein G17 4
  • PBX2MHC 3
  • HOX12 3

External Ids for PBX2 Gene

Previous GeneCards Identifiers for PBX2 Gene

  • GC06M032179
  • GC06M031923
  • GC06M032223
  • GC06M032260
  • GC06M031907
  • GC06M032151
  • GC06M032153
  • GC06M032158

Summaries for PBX2 Gene

Entrez Gene Summary for PBX2 Gene

  • This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for PBX2 Gene

PBX2 (Pre-B-Cell Leukemia Homeobox 2) is a Protein Coding gene. Diseases associated with PBX2 include Duodenal Gastrinoma and Pancreatic Gastrinoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is PBX3.

UniProtKB/Swiss-Prot for PBX2 Gene

  • Transcriptional activator that binds the sequence 5-ATCAATCAA-3. Activates transcription of PF4 in complex with MEIS1.

Gene Wiki entry for PBX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBX2 Gene

Genomics for PBX2 Gene

Regulatory Elements for PBX2 Gene

Enhancers for PBX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PBX2 on UCSC Golden Path with GeneCards custom track

Promoters for PBX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PBX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PBX2 Gene

32,184,733 bp from pter
32,190,186 bp from pter
5,454 bases
Minus strand

Genomic View for PBX2 Gene

Genes around PBX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PBX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PBX2 Gene

  • Protein details for PBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-B-cell leukemia transcription factor 2
    Protein Accession:
    Secondary Accessions:
    • A2BFJ2

    Protein attributes for PBX2 Gene

    430 amino acids
    Molecular mass:
    45881 Da
    Quaternary structure:
    • Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1.

neXtProt entry for PBX2 Gene

Proteomics data for PBX2 Gene at MOPED

Post-translational modifications for PBX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PBX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PBX2 Gene

Domains & Families for PBX2 Gene

Gene Families for PBX2 Gene

Suggested Antigen Peptide Sequences for PBX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/PBX homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/PBX homeobox family.
genes like me logo Genes that share domains with PBX2: view

Function for PBX2 Gene

Molecular function for PBX2 Gene

GENATLAS Biochemistry:
transcription factor,with a homeo domain,homologous to PBX1,expressed in most tissues,fetal and adult,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds the sequence 5-ATCAATCAA-3. Activates transcription of PF4 in complex with MEIS1.

Gene Ontology (GO) - Molecular Function for PBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
GO:0008134 transcription factor binding IPI 18973687
genes like me logo Genes that share ontologies with PBX2: view
genes like me logo Genes that share phenotypes with PBX2: view

Animal Models for PBX2 Gene

MGI Knock Outs for PBX2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PBX2 Gene

Localization for PBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBX2 Gene

Subcellular locations from

Jensen Localization Image for PBX2 Gene COMPARTMENTS Subcellular localization image for PBX2 gene
Compartment Confidence
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PBX2 Gene

Pathways & Interactions for PBX2 Gene

SuperPathways for PBX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030326 embryonic limb morphogenesis IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with PBX2: view

No data available for Pathways by source and SIGNOR curated interactions for PBX2 Gene

Drugs & Compounds for PBX2 Gene

No Compound Related Data Available

Transcripts for PBX2 Gene

Unigene Clusters for PBX2 Gene

Pre-B-cell leukemia homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PBX2 Gene

No ASD Table

Relevant External Links for PBX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PBX2 Gene

mRNA expression in normal human tissues for PBX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PBX2 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for PBX2 Gene

This gene is overexpressed in Blymphocyte (40.7) and CD8 Tcells (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PBX2 Gene

SOURCE GeneReport for Unigene cluster for PBX2 Gene Hs.509545

mRNA Expression by UniProt/SwissProt for PBX2 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with PBX2: view

Protein tissue co-expression partners for PBX2 Gene

- Elite partner

Primer Products

Orthologs for PBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PBX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PBX2 35
  • 93.41 (n)
  • 99.3 (a)
PBX2 36
  • 99 (a)
(Canis familiaris)
Mammalia PBX2 35
  • 92.52 (n)
  • 99.46 (a)
PBX2 36
  • 98 (a)
(Mus musculus)
Mammalia Pbx2 35
  • 90.93 (n)
  • 97.91 (a)
Pbx2 16
Pbx2 36
  • 98 (a)
(Pan troglodytes)
Mammalia PBX2 35
  • 99.84 (n)
  • 100 (a)
PBX2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pbx2 35
  • 91.47 (n)
  • 98.14 (a)
(Monodelphis domestica)
Mammalia PBX2 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia PBX2 36
  • 99 (a)
(Anolis carolinensis)
Reptilia PBX2 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pbx2 35
  • 78.28 (n)
  • 91.82 (a)
Str.6454 35
(Danio rerio)
Actinopterygii pbx2 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta exd 37
  • 80 (a)
exd 36
  • 68 (a)
(Caenorhabditis elegans)
Secernentea ceh-20 37
  • 57 (a)
ceh-40 37
  • 34 (a)
ceh-20 36
  • 58 (a)
ceh-40 36
  • 35 (a)
ceh-60 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8721 36
  • 60 (a)
Species with no ortholog for PBX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PBX2 Gene

Gene Tree for PBX2 (if available)
Gene Tree for PBX2 (if available)

Paralogs for PBX2 Gene

Paralogs for PBX2 Gene

(4) SIMAP similar genes for PBX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PBX2: view

Variants for PBX2 Gene

Sequence variations from dbSNP and Humsavar for PBX2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2022059 -- 32,188,712(-) TGGGC(A/C/G)CCCCC intron-variant
rs169503 -- 32,189,862(-) ggccT(A/G)GGATT upstream-variant-2KB, reference, synonymous-codon
rs2071292 -- 32,188,171(-) CCCAC(C/T)GGCCC intron-variant
rs2078167 -- 32,186,351(+) GGGGG(A/C/G)TCTCA utr-variant-3-prime
rs204992 -- 32,189,131(+) ACAGA(A/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBX2 Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv462877 CNV Loss 19166990
dgv6643n71 CNV Loss 21882294
dgv6644n71 CNV Loss 21882294
dgv6645n71 CNV Loss 21882294
nsv884712 CNV Loss 21882294

Variation tolerance for PBX2 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PBX2 Gene

Disorders for PBX2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PBX2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
duodenal gastrinoma
  • duodenal g-cell gastrin producing tumor
pancreatic gastrinoma
  • pancreatic g-cell tumor
- elite association - COSMIC cancer census association via MalaCards
Search PBX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PBX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PBX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PBX2 Gene

Publications for PBX2 Gene

  1. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PMID: 7835890) Sugaya K. … Ikemura T. (Genomics 1994) 2 3 4 23 67
  2. Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PMID: 12609849) Okada Y. … Doi T. (Blood 2003) 3 23
  3. Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. (PMID: 12871956) Longobardi E. … Blasi F. (J. Biol. Chem. 2003) 3 23
  4. The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein. (PMID: 7759099) Aguado B. … Campbell R.D. (Genomics 1995) 3 23
  5. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. (PMID: 7910944) Lu Q. … Kamps M.P. (Mol. Cell. Biol. 1994) 3 23

Products for PBX2 Gene

Sources for PBX2 Gene