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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PBX2 Gene

protein-coding   GIFtS: 54
GCID: GC06M032153

Pre-B-Cell Leukemia Homeobox 2

(Previous name: pre-B-cell leukemia transcription factor 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pre-B-Cell Leukemia Homeobox 21 2     HOX122 5
G172 3 5     PBX2MHC2
Pre-B-Cell Leukemia Transcription Factor 21 2     Homeobox 122
Homeobox Protein PBX22 3     Protein G173

External Ids:    HGNC: 86331   Entrez Gene: 50892   Ensembl: ENSG000002043047   OMIM: 1763115   UniProtKB: P404253   

Export aliases for PBX2 gene to outside databases

Previous GC identifers: GC06M032179 GC06M031923 GC06M032223 GC06M032260 GC06M031907 GC06M032151


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PBX2 Gene:
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its
similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This
protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major
histocompatibility complex (MHC) on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for PBX2 Gene: 
PBX2 (pre-B-cell leukemia homeobox 2) is a protein-coding gene. Diseases associated with PBX2 include t-cell leukemia, and gastric adenocarcinoma. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PBX3.

UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425
Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in
complex with MEIS1

Gene Wiki entry for PBX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PBX2 gene promoter:
         CREB   HEN1   Pax-5   deltaCREB   STAT3   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPBX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PBX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PBX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.32

PBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PBX2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032153:  view genomic region     (about GC identifiers)

Start:
32,152,510 bp from pter      End:
32,157,963 bp from pter
Size:
5,454 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167247 3,532,337-3,537,787      Chr6-,NT_167249 3,500,238-3,505,689      Chr6-,NT_167248 3,413,530-3,418,981     
Chr6-,NT_167246 3,495,334-3,500,784      Chr6-,NT_167244 3,467,251-3,472,701      Chr6-,NT_113891.2 3,623,191-3,628,641     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425 (See protein sequence)
Recommended Name: Pre-B-cell leukemia transcription factor 2  
Size: 430 amino acids; 45881 Da
Subunit: Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1
Subcellular location: Nucleus (Probable)
Secondary accessions: A2BFJ2

Explore the universe of human proteins at neXtProt for PBX2: NX_P40425

Explore proteomics data for PBX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40425

  • PBX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PBX2 Protein Expression
    REFSEQ proteins: NP_002577.2  
    ENSEMBL proteins: 
     ENSP00000364190  

    Human Recombinant Protein Products for PBX2: 
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    Novus Biologicals PBX2 Proteins
    Novus Biologicals PBX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PBX2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18973687
    GO:0005667transcription factor complex IEA--

    PBX2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for PBX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TALE: Homeoboxes / TALE class

    4 InterPro protein domains:
     IPR005542 PBX
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P40425

    ProtoNet protein and cluster: P40425

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB005542 PBX domain


    UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425
    Similarity: Belongs to the TALE/PBX homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    PBX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PBX2_HUMAN, P40425
    Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in
    complex with MEIS1

         Genatlas biochemistry entry for PBX2:
    transcription factor,with a homeo domain,homologous to PBX1,expressed in most tissues,fetal and adult,binding DNA
    cooperatively with the heterodimer E2A/myogenic transcription factors

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008134transcription factor binding IPI18973687
         
    PBX2 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pbx2):
     cellular  craniofacial  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  normal  respiratory system 
     skeleton 

    PBX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pbx2tm1Mlc for PBX2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PBX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PBX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PBX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PBX2 

    miRNA
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    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate PBX2 (see all 76):
    hsa-miR-548j hsa-miR-1914* hsa-miR-146a hsa-miR-10b* hsa-miR-1244 hsa-miR-3150b-3p hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidPBX2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of PBX2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PBX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/32 Interacting proteins for PBX2 (P404252, 3 ENSP000003641904) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN3O759352, 3, ENSP000002596324MINT-62576 MINT-62674 MINT-62750 I2D: score=4 STRING: ENSP00000259632
    MCRS1Q96EZ82, 3, ENSP000003496404MINT-62569 MINT-62667 MINT-62743 I2D: score=4 STRING: ENSP00000349640
    MLKLQ8NB162, 3MINT-62574 MINT-62748 MINT-62672 I2D: score=2 
    SMYD3Q9H7B42, 3, ENSP000003736374MINT-62527 I2D: score=4 STRING: ENSP00000373637
    BAIAP2Q9UQB82, 3, ENSP000003163384MINT-62572 MINT-62670 MINT-62746 I2D: score=4 STRING: ENSP00000316338
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0009954proximal/distal pattern formation IEA--
    GO:0030326embryonic limb morphogenesis IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    PBX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PBX2

    Search CenterWatch for drugs/clinical trials and news about PBX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PBX2 gene: 
    NM_002586.4  

    Unigene Cluster for PBX2:

    Pre-B-cell leukemia homeobox 2
    Hs.509545  [show with all ESTs]
    Unigene Representative Sequence: X59842
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375050(uc003oav.1) ENST00000559458 ENST00000495300 ENST00000478678(uc003oaw.3)
    ENST00000496171 ENST00000480254
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PBX2
    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate PBX2 (see all 76):
    hsa-miR-548j hsa-miR-1914* hsa-miR-146a hsa-miR-10b* hsa-miR-1244 hsa-miR-3150b-3p hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidPBX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PBX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PBX2
    Clone
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    OriGene ORF clones in mouse, rat for PBX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for PBX2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PBX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX2
    Sirion Biotech Customized lentivirus for stable overexpression of PBX2 
                         Customized lentivirus expression plasmids for stable overexpression of PBX2 
    Primer
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    OriGene qPCR primer pairs and template standards for PBX2
    OriGene qSTAR qPCR primer pairs in human, mouse for PBX2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PBX2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PBX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PBX2

    Additional mRNA sequence: 

    BC082261.1 BT009823.1 X59842.1 

    18 DOTS entries:

    DT.100781048  DT.121378260  DT.445917  DT.100027239  DT.100781053  DT.121378333  DT.86814814  DT.100699252 
    DT.121378477  DT.95202672  DT.121378356  DT.100735855  DT.100772866  DT.102839412  DT.121378335  DT.91780433 
    DT.91942501  DT.99962343 

    24/307 AceView cDNA sequences (see all 307):

    NM_002586 AB061668 CD615126 BU187209 R78183 BX092491 CA308771 AW177609 
    BU188403 BM967099 BF205468 CR601493 CA428962 BU899237 AW177610 BF309711 
    AI620218 BF476466 BU622208 CK818977 CD364731 BM547314 BU677612 CA449935 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PBX2 expression in normal human tissues (normalized intensities)      PBX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCGGGGGC
    PBX2 Expression
    About this image


    PBX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Chondrocytes Stylopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Brain (Nervous System)
             Ciliary Ganglion   

    See PBX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PBX2

    SOURCE GeneReport for Unigene cluster: Hs.509545

    UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PBX2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pbx21 , 5 pre B cell leukemia homeobox 21, 5 90.93(n)1
    97.91(a)1
      17 (18.17 cM)5
    185151  NM_017463.21  NP_059491.11 
     345912665 
    lizard
    (Anolis carolinensis)
    Reptilia PBX26
    Uncharacterized protein
    82(a)
    1 ↔ 1
    2(198449536-198497758)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.64542 Transcribed sequence with moderate similarity to protein more 80.03(n)    BX733561.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pbx26
    pre-B-cell leukemia transcription factor 2
    65(a)
    1 ↔ 1
    16(51950122-51977259)
    fruit fly
    (Drosophila melanogaster)
    Insecta exd3 brain development specific RNA
    polymerase II transcription more
    80(a)   14A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-203   -- 57(a)
    (best of 2)
      III(7051642-7053281)   --


    ENSEMBL Gene Tree for PBX2 (if available)
    TreeFam Gene Tree for PBX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PBX2 gene
    PBX32  PBX42  PBX12  
    4 SIMAP similar genes for PBX2 using alignment to 1 protein entry:     PBX2_HUMAN:
    PBX1    PBX3    PBX4    POU6F1

    PBX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/126 SNPs in PBX2 are shown (see all 126)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20781671,2
    C--32154128(-) GGGGGC/GTCTCA 1 -- ut31 ese30--------
    rs1491454421,2
    F--32154210(+) GATGTC/TACTGA 2 V syn11Minor allele frequency- T:0.00NA 4540
    rs2049951,2
    C,F,H--32154285(-) GGGCTT/CTCTCT 1 -- int132Minor allele frequency- C:0.28EA NA MN NS WA CSA 3301
    rs1421330221,2
    C--32154314(+) ACAACA/GTTACT 1 -- int10--------
    rs1432203451,2
    C,F--32154416(+) TCCCCC/TGAGGT 2 R G mis12Minor allele frequency- T:0.00NA EU 5859
    rs1809465411,2
    C--32154448(+) CCATCA/GAGTGT 2 S L mis10--------
    rs2007894141,2
    --32154506(+) AGAAGA/CCTCAG 1 -- int10--------
    rs1140250841,2
    C,F--32154569(+) TATTCG/CAGAGG 1 -- int12Minor allele frequency- C:0.01NA EU 713
    rs1385071941,2
    C--32154639(+) GAAACA/GTGTCT 2 T M mis11Minor allele frequency- G:0.00NA 4552
    rs1999457901,2
    --32154684(+) CTTGTC/GGGGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PBX2 (32152510 - 32157963 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PBX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6643n71CNV Loss21882294
    nsv884712CNV Loss21882294
    dgv6645n71CNV Loss21882294
    dgv6644n71CNV Loss21882294
    nsv830629CNV Loss17160897
    nsv462877CNV Loss19166990
    dgv1929e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176311    OMIM disorders: --

    14 diseases for PBX2:    About MalaCards
    t-cell leukemia    gastric adenocarcinoma    leukemia    non-small cell lung carcinoma
    teratocarcinoma    esophageal squamous cell carcinoma    ulcerative colitis    gingivitis
    systemic lupus erythematosus    esophagitis    squamous cell carcinoma    lupus erythematosus
    asthma    adenocarcinoma


    PBX2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PBX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia pre-b-cell 95.3 3 1682799 (1), 7759099 (1)

    Genetic Association Database (GAD): PBX2
    Human Genome Epidemiology (HuGE) Navigator: PBX2 (9 documents)

    Export disorders for PBX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PBX2 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with PBX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PubMed id 7835890)1, 2, 3, 9 Sugaya K.... Ikemura T. (1994)
    2. The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein. (PubMed id 7759099)1, 2, 9 Aguado B. and Campbell R.D. (1995)
    3. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. (PubMed id 1682799)1, 2, 9 Monica K.... Cleary M.L. (1991)
    4. Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PubMed id 12609849)1, 2, 9 Okada Y....Doi T. (2003)
    5. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. (PubMed id 7910944)1, 2, 9 Lu Q.... Kamps M.P. (1994)
    6. Genome-wide association study identifies three new sus ceptibility loci for adult asthma in the Japanese population. (PubMed id 21804548)1, 4 Hirota T....Tamari M. (2011)
    7. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    8. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Confirmation of the novel association at the BTNL2 lo cus with ulcerative colitis. (PubMed id 19659809)1, 4 Pathan S....Jewell D.P. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5089 HGNC: 8633 AceView: AGERandPBX2 Ensembl:ENSG00000204304 euGenes: HUgn5089
    ECgene: PBX2 H-InvDB: PBX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PBX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PBX2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PBX2 gene:
    Search GeneIP for patents involving PBX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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