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Aliases for PBX2 Gene

Aliases for PBX2 Gene

  • Pre-B-Cell Leukemia Homeobox 2 2 3
  • G17 3 4 6
  • Pre-B-Cell Leukemia Transcription Factor 2 2 3
  • Homeobox Protein PBX2 3 4
  • HOX12 3 6
  • Homeobox 12 3
  • Protein G17 4
  • PBX2MHC 3

External Ids for PBX2 Gene

Summaries for PBX2 Gene

Entrez Gene Summary for PBX2 Gene

  • This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for PBX2 Gene

PBX2 (Pre-B-Cell Leukemia Homeobox 2) is a Protein Coding gene. Diseases associated with PBX2 include t-cell leukemia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is PBX3.

UniProtKB/Swiss-Prot for PBX2 Gene

  • Transcriptional activator that binds the sequence 5-ATCAATCAA-3. Activates transcription of PF4 in complex with MEIS1.

Gene Wiki entry for PBX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBX2 Gene

Genomics for PBX2 Gene

Genomic Location for PBX2 Gene

Start:
32,184,733 bp from pter
End:
32,190,186 bp from pter
Size:
5,454 bases
Orientation:
Minus strand

Genomic View for PBX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for PBX2 Gene

Proteins for PBX2 Gene

  • Protein details for PBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40425-PBX2_HUMAN
    Recommended name:
    Pre-B-cell leukemia transcription factor 2
    Protein Accession:
    P40425
    Secondary Accessions:
    • A2BFJ2

    Protein attributes for PBX2 Gene

    Size:
    430 amino acids
    Molecular mass:
    45881 Da
    Quaternary structure:
    • Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1.

neXtProt entry for PBX2 Gene

Proteomics data for PBX2 Gene at MOPED

Post-translational modifications for PBX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PBX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PBX2 Gene

Domains for PBX2 Gene

Gene Families for PBX2 Gene

HGNC:
  • TALE :Homeoboxes / TALE class

UniProtKB/Swiss-Prot:

PBX2_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • P40425
Family:
  • Belongs to the TALE/PBX homeobox family.:
    • P40425
genes like me logo Genes that share domains with PBX2: view

Function for PBX2 Gene

Molecular function for PBX2 Gene

GENATLAS Biochemistry: transcription factor,with a homeo domain,homologous to PBX1,expressed in most tissues,fetal and adult,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function: Transcriptional activator that binds the sequence 5-ATCAATCAA-3. Activates transcription of PF4 in complex with MEIS1.

Gene Ontology (GO) - Molecular Function for PBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008134 transcription factor binding IPI 18973687
genes like me logo Genes that share ontologies with PBX2: view
genes like me logo Genes that share phenotypes with PBX2: view

Animal Models for PBX2 Gene

MGI Knock Outs for PBX2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PBX2 Gene

Localization for PBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PBX2 Gene COMPARTMENTS Subcellular localization image for PBX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18973687
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with PBX2: view

Pathways for PBX2 Gene

SuperPathways for PBX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0009954 proximal/distal pattern formation IEA --
GO:0030326 embryonic limb morphogenesis IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with PBX2: view

No data available for Pathways by source for PBX2 Gene

Transcripts for PBX2 Gene

Unigene Clusters for PBX2 Gene

Pre-B-cell leukemia homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PBX2 Gene

No ASD Table

Relevant External Links for PBX2 Gene

GeneLoc Exon Structure for
PBX2
ECgene alternative splicing isoforms for
PBX2

Expression for PBX2 Gene

mRNA expression in normal human tissues for PBX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PBX2 Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PBX2 Gene

SOURCE GeneReport for Unigene cluster for PBX2 Gene Hs.509545

mRNA Expression by UniProt/SwissProt for PBX2 Gene

P40425-PBX2_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with PBX2: view

Orthologs for PBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PBX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PBX2 36
  • 99.84 (n)
  • 100 (a)
PBX2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PBX2 36
  • 93.41 (n)
  • 99.3 (a)
PBX2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PBX2 36
  • 92.52 (n)
  • 99.46 (a)
PBX2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pbx2 36
  • 90.93 (n)
  • 97.91 (a)
Pbx2 16
Pbx2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PBX2 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PBX2 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pbx2 36
  • 91.47 (n)
  • 98.14 (a)
lizard
(Anolis carolinensis)
Reptilia PBX2 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pbx2 36
  • 78.28 (n)
  • 91.82 (a)
Str.6454 36
zebrafish
(Danio rerio)
Actinopterygii pbx2 37
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta exd 37
  • 68 (a)
OneToMany
exd 38
  • 80 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-20 37
  • 58 (a)
ManyToMany
ceh-40 37
  • 35 (a)
ManyToMany
ceh-60 37
  • 26 (a)
ManyToMany
ceh-40 38
  • 34 (a)
ceh-20 38
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8721 37
  • 60 (a)
OneToMany
Species with no ortholog for PBX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PBX2 Gene

ENSEMBL:
Gene Tree for PBX2 (if available)
TreeFam:
Gene Tree for PBX2 (if available)

Paralogs for PBX2 Gene

Paralogs for PBX2 Gene

Selected SIMAP similar genes for PBX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PBX2: view

Variants for PBX2 Gene

Sequence variations from dbSNP and Humsavar for PBX2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs169503 -- 32,189,862(-) ggccT(A/G)GGATT synonymous-codon, reference
rs204992 -- 32,189,131(+) ACAGA(A/G)GCTGG intron-variant
rs204993 -- 32,187,804(-) CTCAC(C/T)GCTCT intron-variant
rs204994 -- 32,187,221(-) ACCCC(A/G)GCTGA intron-variant
rs204995 -- 32,186,508(-) GGGCT(C/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBX2 Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv462877 CNV Loss 19166990
dgv6643n71 CNV Loss 21882294
dgv6644n71 CNV Loss 21882294
dgv6645n71 CNV Loss 21882294
nsv884712 CNV Loss 21882294

Relevant External Links for PBX2 Gene

HapMap Linkage Disequilibrium report
PBX2

Disorders for PBX2 Gene

(1) MalaCards Diseases for PBX2 Gene

Search for PBX2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for PBX2 Gene

Disease -log(P) Hits PubMed IDs
leukemia pre-b-cell 95.3 2

Relevant External Links for PBX2

Genetic Association Database (GAD)
PBX2
Human Genome Epidemiology (HuGE) Navigator
PBX2
genes like me logo Genes that share disorders with PBX2: view

No data available for UniProtKB/Swiss-Prot for PBX2 Gene

Publications for PBX2 Gene

  1. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PMID: 7835890) Sugaya K. … Ikemura T. (Genomics 1994) 2 3 4 23
  2. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. (PMID: 7910944) Lu Q. … Kamps M.P. (Mol. Cell. Biol. 1994) 3 4 23
  3. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. (PMID: 1682799) Monica K. … Cleary M.L. (Mol. Cell. Biol. 1991) 3 4 23
  4. The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein. (PMID: 7759099) Aguado B. … Campbell R.D. (Genomics 1995) 3 4 23
  5. Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PMID: 12609849) Okada Y. … Doi T. (Blood 2003) 3 4 23

Products for PBX2 Gene

Sources for PBX2 Gene

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