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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PBX2 Gene

protein-coding GIFtS: 53
GCID: GC06M032151

pre-B-cell leukemia homeobox 2

(Previous name: pre-B-cell leukemia transcription factor 2 )

Explore 14 diseases affiliated with
PBX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Pre-B-Cell Leukemia Homeobox 2¹ ²		Pre-B-Cell Leukemia Transcription Factor 2¹ ²
G17¹ ² ³ ⁵		Homeobox Protein PBX2² ³
HOX12¹ ² ⁵		Homeobox 12²
PBX2MHC¹ ²		Protein G17³

External Ids:	HGNC: 8633¹	Entrez Gene: 5089²	Ensembl: ENSG00000204304⁷	OMIM: 176311⁵	UniProtKB: P40425³

Export aliases for PBX2 gene to outside databases

Previous GC identifers: GC06M032179 GC06M031923 GC06M032223 GC06M032260 GC06M031907

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PBX2:

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity

to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a

transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility

complex (MHC) on chromosome 6. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425

Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex

with MEIS1

Gene Wiki entry for PBX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167246.1 NT_167247.1 NT_167248.1

NT_167249.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PBX2 gene promoter:
CREB HEN1 Pax-5 deltaCREB STAT3 ITF-2 Tal-1beta
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PBX2 promoter sequence

Search SABiosciences Chromatin IP Primers for PBX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PBX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.32

PBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PBX2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M032151: view genomic region (about GC identifiers)

Start:	32,151,966 bp from pter	End:	32,157,963 bp from pter
Size:	5,998 bases	Orientation:	minus strand

6 alternative locations:

Chr6-,ALT_REF_LOCI_4 32,114,993-32,120,443	Chr6-,ALT_REF_LOCI_1 32,163,854-32,177,604	Chr6-,ALT_REF_LOCI_2 32,100,987-32,145,625
Chr6-,ALT_REF_LOCI_6 32,110,133-32,151,165	Chr6-,ALT_REF_LOCI_5 32,143,760-32,149,210	Chr6-,ALT_REF_LOCI_7 32,089,703-32,095,154

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425 (See protein sequence)

Recommended Name: Pre-B-cell leukemia transcription factor 2

Size: 430 amino acids; 45881 Da

Subunit: Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1

Subcellular location: Nucleus (Probable)

Secondary accessions: A2BFJ2

Explore the universe of human proteins at neXtProt for PBX2: NX_P40425

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P40425

PBX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002577.2

ENSEMBL proteins:

ENSP00000364190

Human Recombinant Protein Products for PBX2:

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	Novus Biologicals PBX2 Proteins Novus Biologicals PBX2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PBX2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18973687
GO:0005667	transcription factor complex	IEA	--

PBX2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PBX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PBX2 for domains About GeneDecksing

4 InterPro domains/families:

IPR005542 PBX

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P40425

ProtoNet protein and cluster: P40425

2 Blocks protein families:

IPB000047 Lambda and other repressor helix-turn-helix signature

IPB005542 PBX domain

UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425

Similarity: Belongs to the TALE/PBX homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PBX2_HUMAN, P40425

Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex

with MEIS1

Genatlas biochemistry entry for PBX2:

transcription factor,with a homeo domain,homologous to PBX1,expressed in most tissues,fetal and adult,binding DNA

cooperatively with the heterodimer E2A/myogenic transcription factors

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	--	--
GO:0008134	transcription factor binding	IPI	18973687
GO:0043565	sequence-specific DNA binding	IEA	--

PBX2 for ontologies About GeneDecksing

Phenotypes:
11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pbx2):

cellular	craniofacial	digestive/alimentary	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	nervous system	normal	respiratory system
skeleton

PBX2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Pbx2^tm1Mlc for PBX2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PBX2

miRNA Products:		OriGene 3'-UTR Clone: PBX2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PBX2
		8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate PBX2 (see all 76):
		hsa-miR-548j hsa-miR-1914* hsa-miR-146a hsa-miR-10b* hsa-miR-1244 hsa-miR-3150b-3p hsa-miR-548a-5p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: PBX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PBX2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PBX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/32 Interacting proteins for PBX2 (P40425^{2, 3} ENSP00000364190⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DCTN3	O75935²^,³, ENSP00000259632⁴	MINT-62576 MINT-62674 MINT-62750 I2D: score=4 STRING: ENSP00000259632
MCRS1	Q96EZ8²^,³, ENSP00000349640⁴	MINT-62569 MINT-62667 MINT-62743 I2D: score=4 STRING: ENSP00000349640
MLKL	Q8NB16²^,³	MINT-62574 MINT-62748 MINT-62672 I2D: score=2
SMYD3	Q9H7B4²^,³, ENSP00000373637⁴	MINT-62527 I2D: score=4 STRING: ENSP00000373637
BAIAP2	Q9UQB8²^,³, ENSP00000316338⁴	MINT-62572 MINT-62670 MINT-62746 I2D: score=4 STRING: ENSP00000316338

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0009954	proximal/distal pattern formation	IEA	--
GO:0030326	embryonic limb morphogenesis	IEA	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA	--

PBX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PBX2
Search CenterWatch for drugs/clinical trials and news about PBX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PBX2 gene:

NM_002586.4

Unigene Cluster for PBX2:

Pre-B-cell leukemia homeobox 2

Hs.509545 [show with all ESTs]

Unigene Representative Sequence: X59842

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375050(uc003oav.1) ENST00000495300 ENST00000478678(uc003oaw.3)

ENST00000496171 ENST00000480254

miRNA Products:		OriGene 3'-UTR Clone: PBX2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PBX2
		8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate PBX2 (see all 76):
		hsa-miR-548j hsa-miR-1914* hsa-miR-146a hsa-miR-10b* hsa-miR-1244 hsa-miR-3150b-3p hsa-miR-548a-5p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: PBX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PBX2 (see all 7) OriGene shRNA RFP: PBX2 OriGene siRNA: PBX2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PBX2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PBX2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PBX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for PBX2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PBX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PBX2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PBX2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PBX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PBX2

Additional cDNA sequence:

BC082261.1 BT009823.1 X59842.1

18 DOTS entries:

DT.100781048 DT.121378260 DT.445917 DT.100027239 DT.100781053 DT.100699252 DT.86814814 DT.121378333

DT.95202672 DT.121378477 DT.121378356 DT.100735855 DT.100772866 DT.102839412 DT.121378335 DT.91780433

DT.91942501 DT.99962343

24/307 AceView cDNA sequences (see all 307):

BU521990 AI057090 BM714937 BU188403 BU899237 CD722009 CA428962 BC082261

BQ023810 AW177610 CD251257 AB036432 BQ690225 BF476466 BU622208 AW150393

CD722431 BM726610 BM894006 BM702297 BC003111 AI620218 AB061668 NM_002586

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PBX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCGGGGGC

About this image

PBX2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Selective marker (cell-identifying gene)

Mesoderm

Bone

Autopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Bone

Stylopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Bone

Zeugopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Lateral Plate Mesoderm

Lateral Plate Mesoderm Cells

Mesoderm

Limb

Autopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Stylopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PBX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PBX2

SOURCE GeneReport for Unigene cluster: Hs.509545

UniProtKB/Swiss-Prot: PBX2_HUMAN, P40425

Tissue specificity: Ubiquitously expressed

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PBX2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	PBX2⁶	--	81(a)	1 ↔ 1	2(198449536-198497758)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.6454²	Transcribed sequence with moderate similarity to protein more	80.03(n)		BX733561.1
zebrafish (Danio rerio)	Actinopterygii	pbx2⁶ CU467620.1⁶	--	67(a) 53(a)	1 ↔ 1 possible ortholog	16(51950122-51977259) 2(19615653-19618709)
fruit fly (Drosophila melanogaster)	Insecta	exd³	brain development specific RNA polymerase II transcription more	80(a)		14A5 --
worm (Caenorhabditis elegans)	Secernentea	ceh-20³	--	57(a) (best of 2)		III(7051642-7053281) --

ENSEMBL Gene Tree for PBX2 (if available)
TreeFam Gene Tree for PBX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PBX2 gene

PBX3² PBX4² PBX1²

9 SIMAP similar genes for PBX2 using alignment to 5 protein entries: PBX2_HUMAN (see all proteins):

E2A/PBX1 fusion PBX1 PBX3 DKFZp686B09108 PBX4 PKNOX1

TGIF1 POU6F1 WUGSC

PBX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2078167^1,2	C	--	32154128(-)	`GGGGGC/GTCTCA`	1	--	ut3¹ ese³		0	--	--	--	--
rs149145442^1,2	F	--	32154210(+)	`GATGTC/TACTGA`	2	V	syn¹		1		NA	4540
rs204995^1,2	C,F,H	--	32154285(-)	`GGGCTT/CTCTCT`	1	--	int¹		32		EA NA MN NS WA CSA	3301
rs142133022^1,2		--	32154314(+)	`ACAACA/GTTACT`	1	--	int¹		0	--	--	--	--
rs143220345^1,2	C,F	--	32154416(+)	`TCCCCC/TGAGGT`	2	R G	mis¹		2		NA EU	5859
rs180946541^1,2	C	--	32154448(+)	`CCATCA/GAGTGT`	2	S L	mis¹		0	--	--	--	--
rs200789414^1,2		--	32154506(+)	`AGAAGA/CCTCAG`	1	--	int¹		0	--	--	--	--
rs114025084^1,2	C,F	--	32154569(+)	`TATTCG/CAGAGG`	1	--	int¹		2		NA EU	713
rs138507194^1,2	C	--	32154639(+)	`GAAACA/GTGTCT`	2	T M	mis¹		1		NA	4552
rs199945790^1,2		--	32154684(+)	`CTTGTC/GGGGGC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PBX2 (32151966 - 32157963 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PBX2
1 CNV: 3602

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PBX2

DNA2.0 Custom Variant and Variant Library Synthesis for PBX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PBX2 for disorders           About GeneDecksing

OMIM gene information: 176311    OMIM disorders: --

14 diseases for PBX2:    About MalaCards

t-cell leukemia leukemia non-small cell lung carcinoma esophageal squamous cell carcinoma

systemic lupus erythematosus squamous cell carcinoma lupus erythematosus ulcerative colitis

teratocarcinoma lung carcinoma gastric adenocarcinoma esophagitis

carcinoma adenocarcinoma

1 Novoseek disease relationship for PBX2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia pre-b-cell	95.3	3	1682799 (1), 7759099 (1)

Human Genome Epidemiology (HuGE) Navigator: PBX2 (9 documents)

Export disorders for PBX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PBX2 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with PBX2)

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Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PubMed id 7835890)^{1, 2, 3, 9} Sugaya K.... Ikemura T. (1994)
The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein. (PubMed id 7759099)^{1, 2, 9} Aguado B. and Campbell R.D. (1995)
PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. (PubMed id 1682799)^{1, 2, 9} Monica K.... Cleary M.L. (1991)
Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PubMed id 12609849)^{1, 2, 9} Okada Y....Doi T. (2003)
Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. (PubMed id 7910944)^{1, 2, 9} Lu Q.... Kamps M.P. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)^{1, 2} Xie T.... Hood L. (2003)
Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. (PubMed id 12871956)^{1, 9} Longobardi E. and Blasi F. (2003)
Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma. (PubMed id 22374608)¹ Qiu Y....Morii E. (2012)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5089	HGNC: 8633	AceView: AGERandPBX2	Ensembl:ENSG00000204304	euGenes: HUgn5089
ECgene: PBX2	H-InvDB: PBX2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
PharmGKB entry for PBX2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PBX2	Genetics and Cytogenetics in Oncology and Haematology

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